Journal of Diabetes Investigation最新文献

{"title":"Circadian metabolic dysfunction in MASLD: Physiological insights and future directions.","authors":"You-Cheol Hwang","doi":"10.1111/jdi.70434","DOIUrl":"10.1111/jdi.70434","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148878641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine GADA screening in Hashimoto's thyroiditis: Evidence gaps in prediction and prevention of LADA.","authors":"Ashish Heerani, Muskan Bai, Noor Un Nisa","doi":"10.1111/jdi.70365","DOIUrl":"10.1111/jdi.70365","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":"1635-1636"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor in response to the article \"Association between thyroid dysfunction and cognitive impairment in type 2 diabetes mellitus: A cross-sectional study\".","authors":"Qun Fang","doi":"10.1111/jdi.70372","DOIUrl":"10.1111/jdi.70372","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":"1637"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13399013/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148292807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological concerns on the predictive performance evaluation of anthropometric indices.","authors":"Xiaoyan Zhang, Wenya Han","doi":"10.1111/jdi.70358","DOIUrl":"10.1111/jdi.70358","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":"1634"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148222223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 diabetes in the era of obesity: Pathophysiology and therapeutic implications.","authors":"Zachary Bloomgarden","doi":"10.1111/jdi.70427","DOIUrl":"10.1111/jdi.70427","url":null,"abstract":"<p><p>Type 1 diabetes is defined by immune-mediated beta-cell failure and dependence on exogenous insulin. That definition is correct, but it may not fully describe many people seen in current clinical practice. Overweight and obesity are now common in type 1 diabetes, leading to variable combinations of high insulin requirement, hypertension, dyslipidemia, metabolic syndrome, metabolic dysfunction-associated steatotic liver disease (MASLD), and increased cardiovascular and renal risk. These features have been termed double diabetes, but that term is descriptive rather than mechanistic. The overlap between type 1 and type 2 diabetes features may reflect overweight or obesity, effects of intensive insulin therapy (with treatment-related hyperinsulinemia leading to disproportionate peripheral vs. hepatic insulin action), inherited or environmental factors leading to insulin resistance, glucagon dysregulation, ectopic fat, and inflammation. This review summarizes the epidemiology, pathophysiology, clinical consequences, and therapeutic implications of insulin-resistant type 1 diabetes, reviewing the established precedent of amylin replacement and potential treatments including incretin receptor agonists and next-generation amylin receptor agonists.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13532683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Effects of short-term tofogliflozin treatment on the insulin secretory capacity of people with type 2 diabetes: A randomized controlled trial, the TOP-2ELM study\".","authors":"","doi":"10.1111/jdi.70391","DOIUrl":"10.1111/jdi.70391","url":null,"abstract":"","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":"1638"},"PeriodicalIF":3.0,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WTAP-mediated m6A RNA methylation promotes diabetic foot ulcer healing under negative pressure wound therapy.","authors":"Yutong Li, Wenhua Chen, Jianhao Lu, Xiaoyue Lin, Ying Tang, Jiaxu Li, Mingwei Chen","doi":"10.1111/jdi.70430","DOIUrl":"10.1111/jdi.70430","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the role of RNA N6-methyladenosine (m6A) methyltransferase Wilms tumor 1-associated protein (WTAP) in negative pressure wound therapy (NPWT) for diabetic foot ulcers (DFU).</p><p><strong>Materials and methods: </strong>We enrolled 46 DFU patients and 16 non-diabetic chronic ulcer patients treated with NPWT. Total m6A levels and the expression of methyltransferases (METTL3, METTL14, and WTAP) in wound margin tissues were measured before and after NPWT. High glucose-induced HaCaT and HDF cell models, alongside an in vitro negative pressure system, were used to evaluate the effect of negative pressure on WTAP expression and the impact of WTAP alteration on cellular functions.</p><p><strong>Results: </strong>Before NPWT, METTL3, METTL14, WTAP and m6A levels were significantly lower in DFU patients than in the non-diabetic chronic ulcer patients. After one week of NPWT, these parameters increased significantly in both groups, and a positive correlation was observed between WTAP and m6A levels. Notably, the increase in WTAP expression exhibited a significant positive correlation with the 4-week healing outcome in DFU patients. In vitro, negative pressure significantly reversed the high glucose-induced WTAP downregulation in both HaCaT and HDF cells, while WTAP knockdown profoundly impaired their proliferation and migration.</p><p><strong>Conclusions: </strong>NPWT is associated with improved DFU healing and the restoration of WTAP-m6A levels, and its effect may be related to negative pressure promoting WTAP expression to enhance wound cell proliferation and migration.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of age on the development of stress hyperglycemia during first-onset ST-elevation myocardial infarction.","authors":"Hon Jen Wong, Joy Xin Yi Au, Yao Hao Teo, Yao Neng Teo, Chen Ee Low, Chun En Yau, Norman H Y Lin, Pei Chia Eng, Li Feng Tan, Reshma A Merchant, Ping Chai, Anand Adinath Ambhore, James W L Yip, Andrew Fu-Wah Ho, David Foo, Pow-Li Chia, Patrick Zhan-Yun Lim, Khung Keong Yeo, Weien Chow, Daniel Thuan Tee Chong, Derek J Hausenloy, Mark Y Y Chan, Ching-Hui Sia","doi":"10.1111/jdi.70429","DOIUrl":"10.1111/jdi.70429","url":null,"abstract":"<p><strong>Introduction: </strong>Stress hyperglycemia is associated with adverse outcomes in ST-elevation myocardial infarction (STEMI), but whether age influences its development or prognostic significance remains unclear. We examined the association between age and stress hyperglycemia and whether age modifies its relationship with mortality.</p><p><strong>Methodology: </strong>We studied non-diabetics with first-onset STEMI from the Singapore Myocardial Infarction Registry (SMIR) (2008-2020). The stress hyperglycemia ratio (SHR) was calculated as random plasma glucose (mmol/L)/[1.59 × HbA1c (%) - 2.59], with stress hyperglycemia defined as SHR ≥1.51. Logistic regression identified factors independently associated with stress hyperglycemia. Restricted cubic splines assessed non-linearity between age and odds of stress hyperglycemia. Multivariate Cox regression evaluated associations with 30-day, 1-year, and 10-year all-cause mortality. Analyses were stratified by age and sex.</p><p><strong>Results: </strong>Among 8,779 patients, 1,718 (19.6%) developed stress hyperglycemia. Patients with stress hyperglycemia were older and more likely to present with advanced heart failure. Increasing age was independently associated with higher odds of stress hyperglycemia, with no evidence of non-linearity. Stress hyperglycemia conferred higher short- and long-term mortality across all age groups, although the relative association attenuated with advancing age (P for interaction <0.001). Similar trends were observed in both sexes.</p><p><strong>Conclusion: </strong>In non-diabetic patients with first-onset STEMI, the likelihood of stress hyperglycemia increased with age. However, stress hyperglycemia was associated with the greatest risk of mortality in younger patients.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13509160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148816819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of glucagon-like peptide-1 receptor agonists is associated with inadequate bowel preparation for colonoscopy in patients with diabetes.","authors":"Osamu Ogawa","doi":"10.1111/jdi.70426","DOIUrl":"10.1111/jdi.70426","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Glucagon-like peptide-1 receptor agonists (GLP-1RAs) delay gastric emptying and may impair bowel preparation for colonoscopy. However, evidence in Asian populations is limited, and the impact of dosing frequency remains unclear. We examined the association between GLP-1RA use and inadequate bowel preparation in Japanese patients with diabetes and compared weekly and daily formulations.</p><p><strong>Materials and methods: </strong>This single-center retrospective observational study included Japanese patients with diabetes who underwent colonoscopy at Kameda Medical Center between October 2021 and September 2024. Bowel preparation quality was assessed using the Aronchick scale; fair, poor, and inadequate were classified as inadequate preparation. Propensity score matching was performed using age, sex, chronic kidney disease, HbA1c, and insulin use. Additional multivariable logistic regression and sensitivity analyses were performed.</p><p><strong>Results: </strong>Among 997 eligible patients, 90 propensity score-matched pairs were identified. Inadequate preparation was more frequent in GLP-1RA users than non-users after matching (32.2% vs 16.7%; relative risk 1.933, 95% CI 1.115-3.353; P = 0.024). Additional analyses showed similar directional associations, although statistical significance was attenuated. Weekly formulations were associated with a higher rate of inadequate preparation than daily formulations (44.2% vs 22.9%; relative risk 1.928, 95% CI 1.039-3.577; P = 0.044).</p><p><strong>Conclusions: </strong>In Japanese patients with diabetes, GLP-1RA use was associated with a higher rate of inadequate bowel preparation in the propensity score-matched analysis, although additional adjusted analyses were not statistically significant. The finding for weekly formulations should be interpreted cautiously.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13502145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underweight at age 20 and pre-pregnancy and large-for-gestational-age births in Japanese women with gestational diabetes mellitus: Hamamatsu GRACE Study 4.","authors":"Shinya Furukawa, Ayumi Kanamoto, Yukino Toyama, Kei Takeshita, Takuya Hashimoto, Teruki Miyake, Daisuke Tsuriya","doi":"10.1111/jdi.70393","DOIUrl":"10.1111/jdi.70393","url":null,"abstract":"<p><strong>Aims/introduction: </strong>While maternal obesity is a well-established risk factor for large-for-gestational-age (LGA) infants, the impact of maternal underweight on LGA in women with gestational diabetes mellitus (GDM) remains inconsistent. This issue is particularly relevant in Japan, given the high prevalence of underweight women. We investigated the association between maternal weight and body mass index (BMI) at age 20 and pre-pregnancy and the risk of LGA in Japanese women with GDM.</p><p><strong>Materials and methods: </strong>This retrospective study analyzed 537 Japanese women with GDM. Participants were categorized by BMI (underweight <18.5 kg/m², normal, and obesity ≥25.0 kg/m²) and by weight quartiles at age 20 and pre-pregnancy. Multivariable logistic regression analyses were performed to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for the association between underweight at age 20 and pre-pregnancy and LGA.</p><p><strong>Results: </strong>The prevalence of underweight at age 20, underweight pre-pregnancy, and LGA was 30.4%, 13.4%, and 9.7%, respectively. After adjustment for confounders, underweight based on BMI at age 20 (adjusted OR 0.22, 95% CI: 0.06-0.75) and pre-pregnancy (adjusted OR 0.17, 95% CI: 0.03-0.64) was significantly and inversely associated with LGA compared with obesity. Similarly, the lowest weight quartiles at both time points were independently associated with a low risk of LGA.</p><p><strong>Conclusions: </strong>Maternal underweight at age 20 and pre-pregnancy was significantly associated with a lower risk of LGA in Japanese women with GDM. These findings suggest that weight status from early adulthood may play a crucial role in fetal growth outcomes.</p>","PeriodicalId":190,"journal":{"name":"Journal of Diabetes Investigation","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2026-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13500029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}