Advanced maternal age is a risk factor for both early and late gestational diabetes mellitus: The Japan Environment and Children's Study.

IF 3.2 3区医学

Journal of Diabetes Investigation Pub Date : 2025-01-11 DOI:10.1111/jdi.14400

Kazuma Tagami, Noriyuki Iwama, Hirotaka Hamada, Hasumi Tomita, Rie Kudo, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura, Chiharu Ota, Takashi Sugiyama, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, Masatoshi Saito

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Abstract

Aims: This study investigated the association between maternal age and early and late gestational diabetes mellitus (GDM).

Methods: In total, 72,270 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early GDM (diagnosed at <24 gestational weeks) and late GDM (diagnosed at ≥24 gestational weeks) were evaluated using a multinomial logistic regression model with possible confounding factors. The reference category was maternal age of 30-34.9 years.

Results: Higher maternal age was associated with higher odds of early and late GDM (P-value for trend <0.0001 and <0.0001, respectively). The adjusted odds ratios (aORs) for early GDM with maternal age of 35-39.9 years and ≥40 were 1.399 (95% confidence interval [CI]: 1.134-1.725) and 2.494 (95% CI: 1.828-3.402), respectively. The aORs for late GDM with maternal age of 35-39 years and ≥40 were 1.603 (95% CI: 1.384-1.857) and 2.276 (95% CI: 1.798-2.881), respectively.

Conclusions: Higher maternal age was associated with an increased risk of GDM regardless of when GDM was diagnosed. The association between maternal age and early GDM was similar to that between maternal age and late GDM.

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高龄产妇是妊娠早期和晚期糖尿病的危险因素：日本环境与儿童研究

目的：研究产妇年龄与妊娠早期和晚期糖尿病（GDM）的关系。方法：这项前瞻性出生队列研究共纳入72270名孕妇。母亲年龄与早期GDM（诊断时间）之间的关联结果：母亲年龄越高，早期和晚期GDM的几率越高（趋势p值）。结论：无论何时诊断GDM，母亲年龄越高，GDM的风险增加。母亲年龄与早期GDM的关系与母亲年龄与晚期GDM的关系相似。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation Medicine-Internal Medicine

自引率

9.40%

发文量

218

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).