高血糖是恶性高热的不典型表现:1例报告及文献复习。

IF 3.2 3区 医学
Huai-Jhih Sun, Yuan-Yi Chia, Yung-Yun Huang, Jun-Chen Sun, Chun-Hsien Wen
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引用次数: 0

摘要

恶性热疗(MH)是一种罕见但危及生命的疾病,由挥发性麻醉剂或去极化肌肉松弛剂引起。研究报告了高血糖在MH易感患者中的患病率增加。在此,我们报告了一个13个月大的幼儿,他成功地接受了大动脉右转位,由于残留的肺闭锁需要主肺动脉和双侧肺动脉增强术。患者在围手术期表现出不典型的MH表现,包括高血糖和胰岛素反应不足。在服用丹曲林(MH的解毒剂)后,高血糖得到了解决。研究表明,细胞内钙泄漏与人体肌肉中葡萄糖储存减少有关。MH易感患者的代谢改变可能使他们在急性MH发作时易患高血糖。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Hyperglycemia as an atypical finding of malignant hyperthermia: A case report and literature review.

Malignant hyperthermia (MH) is a rare but life-threatening disorder induced by volatile anesthetics or depolarizing muscle relaxants. Studies have reported the increased prevalence of hyperglycemia among patients susceptible to MH. Herein, we present the case of a 13-month-old toddler who had successfully undergone dextro-transposition of the great arteries and required main and bilateral pulmonary artery augmentation because of residual pulmonary atresia. The patient exhibited atypical manifestations of MH including hyperglycemia with an inadequate insulin response during the perioperative period. The hyperglycemia resolved following administration of dantrolene, the antidote for MH. Research has associated intracellular calcium leaks with reduced glucose storage in human muscle. Metabolic alterations in patients susceptible to MH may predispose them to hyperglycemia during acute MH episodes.

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来源期刊
Journal of Diabetes Investigation
Journal of Diabetes Investigation Medicine-Internal Medicine
自引率
9.40%
发文量
218
期刊介绍: Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).
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