The prevalence of hepatitis B infection and anti-HCV antibody in patients with diabetes mellitus

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2025-07-08 DOI:10.1111/jdi.70064

Malihe Naderi, Seyed Masoud Hosseini, Vahideh Hamidi, Abdolvahab Moradi

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引用次数: 0

Abstract

Background

The liver's role in glucose metabolism and hormone regulation links liver infections to diabetes mellitus. Understanding this interaction is crucial for managing diabetes in affected patients.

Objective

Golestan Province has the highest incidence of hepatitis B virus (HBV) infection in the country. The current research aimed to assess the prevalence of HBV infection and anti-HCV antibodies among diabetic patients in the region, providing insights to improve disease management and prevention.

Methods

Data from 31,803 diabetic patients, collected (2019–2023) from the NAB system at Golestan University of Medical Sciences, were used to evaluate the co-occurrence of HBV infection and anti-HCV antibodies in them. Also, this study analyzed the co-occurrence of diabetes in three/two-generation CHB (Chronic Hepatitis B) patients, and recovered patients, demographic factors, liver enzyme, and viral DNA levels. Binary logistic regression was applied to identify factors associated with diabetes.

Results

HBsAg and anti-HCV antibody positivity were found in 2.52% and 0.53% of diabetic individuals, respectively. Diabetic patients with HBV infection (P-value = 0.003) or anti-HCV positivity (P-value = 0.008) had significantly lower BMIs. HBV prevalence was higher among married individuals (78.4%, P-value = 0.01) and rural residents (61.7%, P-value = 0.3). Diabetic patients with two or three generations of HBV/diabetes had higher liver enzyme levels and HBV viral loads compared to those without diabetes (P-value < 0.05).

Conclusions

In individuals with diabetes, compared to those without the disease, there was a correlation between HBV infections and altered liver function indicators, as well as HBV viral load. Additionally, familial susceptibility to HBV infection or anti-HCV antibody positivity was significant.

Abstract Image

查看原文本刊更多论文

糖尿病患者乙型肝炎感染及抗hcv抗体的流行情况。

背景：肝脏在葡萄糖代谢和激素调节中的作用将肝脏感染与糖尿病联系起来。了解这种相互作用对于控制受影响患者的糖尿病至关重要。目的：戈列斯坦省是全国乙型肝炎病毒（HBV）感染发病率最高的省份。目前的研究旨在评估该地区糖尿病患者中HBV感染和抗hcv抗体的流行情况，为改善疾病管理和预防提供见解。方法：采用Golestan医科大学NAB系统收集的31803例糖尿病患者（2019-2023年）的数据，评估他们中HBV感染和抗hcv抗体的共存情况。此外，本研究还分析了三代/二代慢性乙型肝炎（CHB）患者、康复患者、人口统计学因素、肝酶和病毒DNA水平中糖尿病的共发情况。采用二元logistic回归分析糖尿病相关因素。结果：糖尿病患者HBsAg和抗hcv抗体阳性率分别为2.52%和0.53%。伴有HBV感染（p值= 0.003）或抗- hcv阳性（p值= 0.008）的糖尿病患者bmi均显著降低。已婚人群（78.4%，p值= 0.01）和农村居民（61.7%，p值= 0.3）的HBV患病率较高。伴有两代或三代HBV/糖尿病的糖尿病患者的肝酶水平和HBV病毒载量高于无糖尿病患者（p值）。结论：与无糖尿病患者相比，糖尿病患者的HBV感染与肝功能指标改变以及HBV病毒载量之间存在相关性。此外，对HBV感染的家族易感性或抗hcv抗体阳性是显著的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).