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How can MSI enhance our understanding of ASO distribution?
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-17 DOI: 10.1016/j.drudis.2024.104275
Laura van der Vloet, Pierre Barbier Saint Hilaire, Christophe Bouillod, Emre M Isin, Ron M A Heeren, Michiel Vandenbosch
{"title":"How can MSI enhance our understanding of ASO distribution?","authors":"Laura van der Vloet, Pierre Barbier Saint Hilaire, Christophe Bouillod, Emre M Isin, Ron M A Heeren, Michiel Vandenbosch","doi":"10.1016/j.drudis.2024.104275","DOIUrl":"https://doi.org/10.1016/j.drudis.2024.104275","url":null,"abstract":"<p><p>In the dynamic field of drug discovery and development, a comprehensive understanding of drug absorption, distribution, metabolism, excretion, and toxicity is crucial. Mass spectrometry imaging (MSI) has become a key analytical tool in the pharmaceutical industry, allowing evaluation of drug biodistribution and molecular profiles. Antisense oligonucleotides (ASOs) are emerging drug candidates for treating neurologic diseases. This review explores the potential of MSI in investigating ASOs' spatial distribution within neurological disease models. Here, we focus on multimodal molecular imaging to gain insights into ASO distribution, simultaneously with a better understanding of the molecular pathways affected by ASOs. An improved understanding of therapeutic ASOs in tissue will potentially improve neurologic therapies, emphasizing their importance in patient care.</p>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":" ","pages":"104275"},"PeriodicalIF":6.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142862593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Generative AI: driving productivity and scientific breakthroughs in pharmaceutical R&D.
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-13 DOI: 10.1016/j.drudis.2024.104272
Guy Doron, Sam Genway, Mark Roberts, Sai Jasti
{"title":"Generative AI: driving productivity and scientific breakthroughs in pharmaceutical R&D.","authors":"Guy Doron, Sam Genway, Mark Roberts, Sai Jasti","doi":"10.1016/j.drudis.2024.104272","DOIUrl":"10.1016/j.drudis.2024.104272","url":null,"abstract":"<p><p>The rapid advancement of generative artificial intelligence (AI) is reshaping pharmaceutical research and development (R&D), offering opportunities across drug discovery and development. Generative AI (GenAI) enhances productivity by enabling virtual assistants, which help automate routine tasks. It advances novel small-molecule drug design and drives new machine learning (ML) applications through synthetic data generation. Further impact is anticipated in drug development from improving operational efficiencies to novel digital innovations. Converging technologies enable rich data set capture, and next-generation AI will enable rapid, automated hypothesis generation and testing. Here, we assess the current and future applications, and the mid-term and long-term transformative potential, of GenAI in pharmaceutical R&D.</p>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":" ","pages":"104272"},"PeriodicalIF":6.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AI: An Essential Tool For Managing the Burgeoning Complexity of Clinical Development in Pharmaceutical R&D. 人工智能：管理制药研发领域日益复杂的临床开发工作的重要工具。
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-12 DOI: 10.1016/j.drudis.2024.104271
Subha Madhavan, David Shaywitz
{"title":"AI: An Essential Tool For Managing the Burgeoning Complexity of Clinical Development in Pharmaceutical R&D.","authors":"Subha Madhavan, David Shaywitz","doi":"10.1016/j.drudis.2024.104271","DOIUrl":"https://doi.org/10.1016/j.drudis.2024.104271","url":null,"abstract":"","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":" ","pages":"104271"},"PeriodicalIF":6.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revolutionizing Cancer Care: The Promise of Nanoscale Metal-Organic Frameworks in Theranostics.
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-10 DOI: 10.1016/j.drudis.2024.104270
Tenzin Tsering Dongsar, Tenzin Sonam Dongsar, Garima Gupta, Prashant Kesharwani
{"title":"Revolutionizing Cancer Care: The Promise of Nanoscale Metal-Organic Frameworks in Theranostics.","authors":"Tenzin Tsering Dongsar, Tenzin Sonam Dongsar, Garima Gupta, Prashant Kesharwani","doi":"10.1016/j.drudis.2024.104270","DOIUrl":"10.1016/j.drudis.2024.104270","url":null,"abstract":"","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":" ","pages":"104270"},"PeriodicalIF":6.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Four years after the ranitidine withdrawal by FDA: Is it time for India to act?
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-10 DOI: 10.1016/j.drudis.2024.104269
Devaraj Ezhilarasan
{"title":"Four years after the ranitidine withdrawal by FDA: Is it time for India to act?","authors":"Devaraj Ezhilarasan","doi":"10.1016/j.drudis.2024.104269","DOIUrl":"10.1016/j.drudis.2024.104269","url":null,"abstract":"","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":" ","pages":"104269"},"PeriodicalIF":6.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting spleen tyrosine kinase (SYK): structure, mechanisms and drug discovery.
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-07 DOI: 10.1016/j.drudis.2024.104257
Shuangqian Zhang, Lilin Wang, Yingying Lu, Chuanxin Guo, Tongtong Zhang, Lan Zhang
{"title":"Targeting spleen tyrosine kinase (SYK): structure, mechanisms and drug discovery.","authors":"Shuangqian Zhang, Lilin Wang, Yingying Lu, Chuanxin Guo, Tongtong Zhang, Lan Zhang","doi":"10.1016/j.drudis.2024.104257","DOIUrl":"10.1016/j.drudis.2024.104257","url":null,"abstract":"<p><p>Spleen tyrosine kinase (SYK) is a crucial non-receptor tyrosine kinase involved in signaling pathways that regulate various cellular processes. It is primarily expressed in hematopoietic cells and myeloid cells, which are crucial for B-cell development, maturation and antibody production, and it is a key therapeutic target for autoimmune and allergic diseases. Overexpression of SYK is also associated with cancer and cardiovascular, cerebrovascular and neurodegenerative diseases, contributing to their initiation and progression. SYK is a promising target for drug development, and several inhibitors have already been reported. This review covers the structure and regulatory pathways of SYK, as well as its links to various diseases. It also highlights key small-molecule SYK inhibitors, their design strategies and their potential therapeutic benefits, aiming to enhance our understanding and aid in the discovery of more-effective SYK inhibitors.</p>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":" ","pages":"104257"},"PeriodicalIF":6.5,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping epilepsy biomarkers: a bibliometric and content analysis 绘制癫痫生物标志物：文献计量和内容分析。
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-01 DOI: 10.1016/j.drudis.2024.104247
Irma Wati Ngadimon , Mohd. Farooq Shaikh , Devi Mohan , Wing Loong Cheong , Ching Soong Khoo
{"title":"Mapping epilepsy biomarkers: a bibliometric and content analysis","authors":"Irma Wati Ngadimon ,&nbsp;Mohd. Farooq Shaikh ,&nbsp;Devi Mohan ,&nbsp;Wing Loong Cheong ,&nbsp;Ching Soong Khoo","doi":"10.1016/j.drudis.2024.104247","DOIUrl":"10.1016/j.drudis.2024.104247","url":null,"abstract":"<div><div>Epilepsy, a complex global neurological disorder, has spurred extensive research efforts focused on enhancing diagnostic and therapeutic strategies, with a growing emphasis on the identification of biomarkers. This bibliometric study examines 1,774 publications from 2000 to 2023, revealing a notable increase in research activity, particularly in the past decade. The US, China, and the UK lead contributions, with Asian countries exhibiting growing potential. Keyword co-occurrence analysis reveals a shift towards investigations of neuroinflammatory and genetic biomarkers, as well as emerging areas such as artificial intelligence and epigenetics. Content analysis links specific epilepsy aetiologies to biomarkers, offering promising possibilities for personalised diagnostics and treatments. These findings yield valuable insights into current trends, guiding future research and informing the development of targeted approaches for the diagnosis and treatment of epilepsy.</div></div>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":"29 12","pages":"Article 104247"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Learning from European regulator-initiated studies for regulatory decision making.
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-01 DOI: 10.1016/j.drudis.2024.104256
Stefan Verweij, Just Weemers, Carla Jonker, Anna Maria Gerdina Pasmooij
{"title":"Learning from European regulator-initiated studies for regulatory decision making.","authors":"Stefan Verweij, Just Weemers, Carla Jonker, Anna Maria Gerdina Pasmooij","doi":"10.1016/j.drudis.2024.104256","DOIUrl":"10.1016/j.drudis.2024.104256","url":null,"abstract":"<p><p>Drug developers have displayed a growing interest in using real-word evidence (RWE) in the pre-marketing phase. Together with initiatives like DARWIN EU®, this interest encourages regulators to initiate their own observational clinical studies, which could be included in regulatory decision making. The Regulatory Science Network Netherlands organised an expert meeting in 2022 to discuss scenarios and learnings related to these regulator-initiated studies, of which the main points (e.g., transparency, independency and stakeholder interaction) have been published previously. In this review, the authors add their own views, underlining the importance of reproducibility and stakeholder interaction. Stakeholders should collaborate to embrace regulator-initiated studies in a timely and transparent manner to realise an optimal European framework for generating RWE to be included in the regulatory decision-making process.</p>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":" ","pages":"104256"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highlighting roles of autophagy in human diseases: a perspective from single-cell RNA sequencing analyses 突显自噬在人类疾病中的作用：单细胞 RNA 测序分析的视角。
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-01 DOI: 10.1016/j.drudis.2024.104224
Anis Khalafiyan , Mahmood Fadaie , Fatemeh Khara , Ali Zarrabi , Fariborz Moghadam , Hossein Khanahmad , Marco Cordani , Maryam Boshtam
{"title":"Highlighting roles of autophagy in human diseases: a perspective from single-cell RNA sequencing analyses","authors":"Anis Khalafiyan ,&nbsp;Mahmood Fadaie ,&nbsp;Fatemeh Khara ,&nbsp;Ali Zarrabi ,&nbsp;Fariborz Moghadam ,&nbsp;Hossein Khanahmad ,&nbsp;Marco Cordani ,&nbsp;Maryam Boshtam","doi":"10.1016/j.drudis.2024.104224","DOIUrl":"10.1016/j.drudis.2024.104224","url":null,"abstract":"<div><div>Autophagy, the lysosome-driven breakdown of intracellular components, is pivotal in regulating eukaryotic cellular processes and maintaining homeostasis, making it physiologically important even under normal conditions. Cellular mechanisms involving autophagy include the response to nutrient deprivation, intracellular quality control, early development, and cell differentiation. Despite its established health significance, the role of autophagy in cancer and other diseases remains complex and not fully understood. A comprehensive understanding of autophagy is crucial to facilitate the development of novel therapies and drugs that can protect and improve human health. High-throughput technologies, such as single-cell RNA sequencing (scRNA-seq), have enabled researchers to study transcriptional landscapes at single-cell resolution, significantly advancing our knowledge of autophagy pathways across diverse physiological and pathological contexts. This review discusses the latest advances in scRNA-seq for autophagy research and highlights its potential in the molecular characterization of various diseases.</div></div>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":"29 12","pages":"Article 104224"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142610826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additive manufacturing to fight cancer: Current Applications and Future Directions.
IF 6.5 2区 医学
Drug Discovery Today Pub Date : 2024-12-01 Epub Date: 2024-11-27 DOI: 10.1016/j.drudis.2024.104218
Ishaan Duggal, Joon Kim, Yu Zhang, Jiawei Wang, Anqi Lu, Mohammed Maniruzzaman
{"title":"Additive manufacturing to fight cancer: Current Applications and Future Directions.","authors":"Ishaan Duggal, Joon Kim, Yu Zhang, Jiawei Wang, Anqi Lu, Mohammed Maniruzzaman","doi":"10.1016/j.drudis.2024.104218","DOIUrl":"10.1016/j.drudis.2024.104218","url":null,"abstract":"<p><p>3D printing has emerged as a powerful tool demonstrating effectiveness in early screening and targeted delivery for various types of tumors. Although the applications of additive manufacturing for cancer are widespread, the issues of scaling up, quality control and specificity remain. This review presents a comprehensive analysis of the current landscape of use of additive manufacturing in cancer diagnostics and treatment. Furthermore, it proceeds to elucidate the prominent current and future applications of 4D- and 5D-printed micro-swimmers in cancer treatment with particular emphasis on the significant progress made in magnetic, biological and light-based propulsion microrobots. Lastly, the current limitations and future research directions are enumerated. In summary, this paper serves as a comprehensive exploration of the remarkable contributions of additive manufacturing to the diagnosis and treatment of cancer.</p>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":" ","pages":"104218"},"PeriodicalIF":6.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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