Drug Discovery Today最新文献_第10页

Recent trends in STING modulators: Structures, mechanisms, and therapeutic potential STING调节剂的最新发展趋势:结构、机制和治疗潜力

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-09-01 DOI: 10.1016/j.drudis.2023.103694

Yan Zou , Min Zhang , Jinming Zhou

引用次数: 0

Immunotherapy and immunoevasion of colorectal cancer 结直肠癌的免疫治疗与免疫逃避

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-09-01 DOI: 10.1016/j.drudis.2023.103669

Mohammad Al Zein , Mona Boukhdoud , Hadi Shammaa , Hadi Mouslem , Lemir Majed El Ayoubi , Rabah Iratni , Khodr Issa , Maha Khachab , Hazem I. Assi , Amirhossein Sahebkar , Ali H. Eid

引用次数: 1

Opportunities and challenges in drug discovery targeting the orphan receptor GPR12 孤儿受体GPR12药物发现的机遇和挑战

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-09-01 DOI: 10.1016/j.drudis.2023.103698

Pingyuan Wang , Ling Lv , Haoran Li , Chang-Yun Wang , Jia Zhou

引用次数: 1

Grasping cryptic binding sites to neutralize drug resistance in the field of anticancer 在抗癌领域，抓住隐性结合位点来中和耐药性

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-09-01 DOI: 10.1016/j.drudis.2023.103705

Wei-Cheng Yang , Dao-Hong Gong , Hong Wu , Yang-Yang Gao , Ge-Fei Hao

引用次数: 0

Preclinical investigations on broccoli-derived sulforaphane for the treatment of ophthalmic disease 花椰菜萝卜硫素治疗眼病的临床前研究

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-09-01 DOI: 10.1016/j.drudis.2023.103718

Faith A.A. Kwa , Bang V. Bui , Bruce R. Thompson , Lauren N. Ayton

引用次数: 1

Ocular application of electrospun materials for drug delivery and cellular therapies 电纺丝材料在药物传递和细胞治疗中的眼内应用

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-09-01 DOI: 10.1016/j.drudis.2023.103676

Deepakkumar Mishra , Shilpkala Gade , Varun Pathak , Lalitkumar K Vora , Kiran Mcloughlin , Reinhold Medina , Ryan F Donnelly , Thakur Raghu Raj Singh

{"title":"Ocular application of electrospun materials for drug delivery and cellular therapies","authors":"Deepakkumar Mishra , Shilpkala Gade , Varun Pathak , Lalitkumar K Vora , Kiran Mcloughlin , Reinhold Medina , Ryan F Donnelly , Thakur Raghu Raj Singh","doi":"10.1016/j.drudis.2023.103676","DOIUrl":"10.1016/j.drudis.2023.103676","url":null,"abstract":"<div><p>The constraints of delivering conventional drugs, biologics and cell-based therapeutics to target ocular sites necessitate the fabrication of novel drug delivery systems to treat diverse ocular diseases. Conventional ocular drug delivery approaches are prone to low bioavailability, poor penetration and degradation of therapeutics, including cell-based therapies, leading to the need for frequent topical applications or intraocular injections. However, owing to their exceptional structural properties, nanofibrous and microfibrous electrospun materials have gained significant interest in ocular drug delivery and biomaterial applications. This review covers the recent developments of electrospun fibers for the delivery of drugs, biologics, cells, growth factors and tissue regeneration in treating ocular diseases. The insights from this review can provide a thorough understanding of the selection of materials for the fabrication of nano- and/or micro-fibrous systems for ocular applications, with a particular interest in achieving controlled drug release and cell therapy. A detailed modality for fabricating different types of nano- and micro-fibers produced from electrospinning and factors influencing generation are also discussed.</p></div>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":"28 9","pages":"Article 103676"},"PeriodicalIF":7.4,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1359644623001927/pdfft?md5=d5b3d5b5e9892da5601d699db50700cb&pid=1-s2.0-S1359644623001927-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10198375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

In silico resources help combat cancer drug resistance mediated by target mutations 在硅资源帮助对抗癌症耐药介导的目标突变

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-09-01 DOI: 10.1016/j.drudis.2023.103686

Yuan-Qin Huang , Shuang Wang , Dao-Hong Gong , Vinit Kumar , Ya-Wen Dong , Ge-Fei Hao

引用次数: 0

Antimicrobial and anti-biofilm activities of bio-inspired nanomaterials for wound healing applications 生物启发纳米材料在伤口愈合应用中的抗菌和抗生物膜活性

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-09-01 DOI: 10.1016/j.drudis.2023.103673

Rabia Arshad , Mahtab Razlansari , Seyedeh Maryam Hosseinikhah , Aprajita Tiwari Pandey , Narges Ajalli , Amanda-Lee Ezra Manicum , Nanasaheb Thorat , Abbas Rahdar , Yangzhi Zhu , Tanveer A Tabish

引用次数: 2

Molecular and functional characteristics of receptor-interacting protein kinase 1 (RIPK1) and its therapeutic potential in Alzheimer's disease 受体相互作用蛋白激酶1 (RIPK1)的分子和功能特征及其在阿尔茨海默病中的治疗潜力

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-08-24 DOI: 10.1016/j.drudis.2023.103750

Satyam Pati, Avtar Singh Gautam, Mangaldeep Dey, Aman Tiwari, Rakesh Kumar Singh

{"title":"Molecular and functional characteristics of receptor-interacting protein kinase 1 (RIPK1) and its therapeutic potential in Alzheimer's disease","authors":"Satyam Pati, Avtar Singh Gautam, Mangaldeep Dey, Aman Tiwari, Rakesh Kumar Singh","doi":"10.1016/j.drudis.2023.103750","DOIUrl":"https://doi.org/10.1016/j.drudis.2023.103750","url":null,"abstract":"<div><p>Inflammation and cell death processes positively control the organ homeostasis of an organism. Receptor-interacting protein kinase 1 (RIPK1), a member of the RIPK family, is a crucial regulator of cell death and inflammation, and control homeostasis at the cellular and tissue level. Necroptosis, a programmed form of necrosis-mediated cell death and tumor necrosis factor (TNF)-induced necrotic cell death, is mostly regulated by RIPK1 kinase activity. Thus, RIPK1 has recently emerged as an upstream kinase that controls multiple cellular pathways and participates in regulating inflammation and cell death. All the major cell types in the central nervous system (CNS) have been found to express RIPK1. Selective inhibition of RIPK1 has been shown to prevent neuronal cell death, which could ultimately lead to a significant reduction of neurodegeneration and neuroinflammation. In addition, the kinase structure of RIPK1 is highly conducive to the development of specific pharmacological small-molecule inhibitors. These factors have led to the emergence of RIPK1 as an important therapeutic target for Alzheimer’s disease (AD).</p></div>","PeriodicalId":301,"journal":{"name":"Drug Discovery Today","volume":"28 12","pages":"Article 103750"},"PeriodicalIF":7.4,"publicationDate":"2023-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"3023108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perspectives of data science in preclinical safety assessment 临床前安全性评估中的数据科学视角

IF 7.4 2区医学

Drug Discovery Today Pub Date : 2023-08-01 DOI: 10.1016/j.drudis.2023.103642

Thomas Steger-Hartmann , Annika Kreuchwig , Ken Wang , Fabian Birzele , Dragomir Draganov , Stefano Gaudio , Andreas Rothfuss

引用次数: 2