Advantages, progress, and future trends in oral medicated jellies/gels: Focus on adherence aspects

Abstract

Poor medication adherence is a pervasive issue in oral administration. Oral medicated jellies/gels are semisolid formulations that leverage the advantages of both solid and liquid formulations and have a promising potential. They help to increase patient comfort, simplify the medication process, and improve the medication experience, thereby improving medication adherence and alleviating many common barriers to adherence. This review analyzes the advantages of oral jellies from the perspective of improving adherence and summarizes the current state of research on this dosage form at five levels: improved bioavailability, drug release, swallowability, palatability, and appearance appeal. Finally, we discuss future research directions for this formulation.