心肌纤维化中染色质可及性动态变化。

IF 7.5 2区医学 Q1 PHARMACOLOGY & PHARMACY

Drug Discovery Today Pub Date : 2025-07-08 DOI:10.1016/j.drudis.2025.104429

Zhen-Yu Liu , Peng Liu , Li-Chan Lin , Jing-Jing Yang , Hui Tao

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引用次数: 0

摘要

心脏纤维化的特征是心脏成纤维细胞被激活并异常增殖为肌成纤维细胞，肌成纤维细胞分泌过量的细胞外基质蛋白。在转录和复制过程中，染色质可及性的动态变化调节着染色质DNA的结构可及性。染色质可接近性通过调节顺式调控元件和反式作用因子之间的相互作用来影响基因表达。在病理条件下，染色质可及性的改变导致纤维化相关基因的表达改变，从而促进心脏纤维化的发生和发展。在这篇综述中，我们总结了目前测量染色质可及性的方法，并研究了染色质动力学和转录因子在心脏纤维化调节中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Dynamic chromatin accessibility landscape changes in cardiac fibrosis

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Dynamic chromatin accessibility landscape changes in cardiac fibrosis

Cardiac fibrosis is characterized by the activation and abnormal proliferation of cardiac fibroblasts into myofibroblasts, which secrete excessive amounts of extracellular matrix proteins. Dynamic changes in chromatin accessibility regulate the structural accessibility of chromatin DNA during transcription and replication. Chromatin accessibility influences gene expression by modulating the interactions between cis-regulatory elements and trans-acting factors. Under pathological conditions, alterations in chromatin accessibility lead to changes in the expression of fibrosis-related genes, thereby contributing to the onset and progression of cardiac fibrosis. In this review, we summarize current methods for measuring chromatin accessibility and examine the roles of chromatin dynamics and transcription factors in the regulation of cardiac fibrosis.

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来源期刊

Drug Discovery Today 医学-药学

CiteScore

14.80

自引率

2.70%

发文量

293

审稿时长

6 months

期刊介绍： Drug Discovery Today delivers informed and highly current reviews for the discovery community. The magazine addresses not only the rapid scientific developments in drug discovery associated technologies but also the management, commercial and regulatory issues that increasingly play a part in how R&D is planned, structured and executed. Features include comment by international experts, news and analysis of important developments, reviews of key scientific and strategic issues, overviews of recent progress in specific therapeutic areas and conference reports.