Acta dermato-venereologica最新文献

Multiple Acantholytic Acanthomas in Junctional Epidermolysis Bullosa. 交界性表皮松解症中的多发性棘皮溶解性棘瘤

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-19 DOI: 10.2340/actadv.v104.42258

Sota Itamoto, Ken Natsuga, Takashi Seo, Shota Takashima, Hideyuki Ujiie

引用次数: 0

The Role of Dermoscopy in Diagnosing Xeroderma Pigmentosum: A Practical Tool in Low-resource Settings. 皮肤镜在诊断色素性皮肤病中的作用：资源匮乏地区的实用工具。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-19 DOI: 10.2340/actadv.v104.42264

Maëva Boyer, Laura Mengeot, Alice Miquel, Antoine Bertolotti

引用次数: 0

Erythematous Papules with Central Hyperkeratosis in Two Young Women: A Quiz. 两名年轻女性的红斑丘疹伴中央角化过度症：小测验

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-19 DOI: 10.2340/actadv.v104.42217

Nadine Wiedenmayer, Deniz Goecebe, Ines Bertlich, Ferdinand Toberer

引用次数: 0

Exploring the Role of Adipose Tissue Dysregulation in Vitiligo Pathogenesis: A Body Composition Analysis. 探索脂肪组织失调在白癜风发病机制中的作用：身体成分分析。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-19 DOI: 10.2340/actadv.v104.41018

XinYi Shao, Xingyu Pan, Tingqiao Chen, Ziyan Chen, Yuhao Li, Judan Zhong, Ruiyao Wang, Jun Yu, Jin Chen, Yangmei Chen

{"title":"Exploring the Role of Adipose Tissue Dysregulation in Vitiligo Pathogenesis: A Body Composition Analysis.","authors":"XinYi Shao, Xingyu Pan, Tingqiao Chen, Ziyan Chen, Yuhao Li, Judan Zhong, Ruiyao Wang, Jun Yu, Jin Chen, Yangmei Chen","doi":"10.2340/actadv.v104.41018","DOIUrl":"https://doi.org/10.2340/actadv.v104.41018","url":null,"abstract":"Vitiligo is a commonly acquired pigmentary disease characterized by the progressive destruction of melanocytes. The role of adipose tissue in vitiligo remains unclear. To investigate the role of adipose tissue in the pathogenesis of vitiligo, 50 patients newly diagnosed with vitiligo and 40 age- and sex-matched healthy controls were enrolled, and fat mass and distribution using dual-energy X-ray absorptiometry (DXA) and serum adipokine levels using enzyme-linked immunosorbent assay were assessed. The trunk and whole-body fat mass and the trunk/limb fat mass ratio were significantly higher in patients with vitiligo. Higher leptin and resistin levels and lower adiponectin levels were observed. Positive correlation of the trunk fat mass index with vitiligo area scoring index scores (r = 0.38, p = 0.0071) was found. Additionally, plasma adiponectin levels were negatively correlated with vitiligo disease activity scores (r = -0.307, p < 0.05). Receiver operating characteristic curve analysis showed that the percentage of limb lean tissue mass, trunk/limb fat mass ratio, and serum adipokine levels achieved a high area under the curve score for distinguishing patients with vitiligo from healthy controls. In conclusion, the incidence of central obesity and adipokine dysregulation was higher in patients with vitiligo. The potential role of adipose tissue in the pathogenesis of vitiligo should be emphasized.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41018"},"PeriodicalIF":3.5,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two Cases of Fungal Melanonychia. 两例真菌性黑色素瘤。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-19 DOI: 10.2340/actadv.v104.42145

Yoshihito Mima, Masako Yamamoto, Koichi Makimura, Ken Iozumi

引用次数: 0

Risk Factors Associated with Weight Gain during Treatment with Dupilumab among Patients with Moderate to Severe Atopic Dermatitis. 中度至重度特应性皮炎患者在使用杜匹单抗治疗期间体重增加的相关风险因素。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-15 DOI: 10.2340/actadv.v104.40796

Mahsa Tayefi, Axel Svedbom, Lina Ivert, Maria Lundqvist, Jorge Ruas, Maria Bradley, Emma Johansson

{"title":"Risk Factors Associated with Weight Gain during Treatment with Dupilumab among Patients with Moderate to Severe Atopic Dermatitis.","authors":"Mahsa Tayefi, Axel Svedbom, Lina Ivert, Maria Lundqvist, Jorge Ruas, Maria Bradley, Emma Johansson","doi":"10.2340/actadv.v104.40796","DOIUrl":"10.2340/actadv.v104.40796","url":null,"abstract":"This cohort study used prospectively collected data from the Swedish national quality registry, SwedAD, to investigate weight gain as a possible side effect of dupilumab treatment for atopic dermatitis. Patients on dupilumab were compared with patients on other systemic medications, e.g., methotrexate, cyclosporine, or Janus kinase inhibitors, and possible risk factors for weight change during treatment with dupilumab were analysed. All patients aged 18 years or above, included in SwedAD between March 2018 and April 2023, who initiated systemic treatment at or after inclusion and had data on weight at baseline and at least 1 follow-up weight measurement were included (n = 157). After 2 years on dupilumab, patients had a mean weight gain of 1.6 kg (p = 0.007, 95% confidence interval [CI] 0.4-2.7). In the multivariable analysis, controlling for age at start, sex, asthma, and body mass index at start, dupilumab was associated with higher weight gain than other systemic treatments (3.3 kg, p = 0.005 [95% CI 1.0-5.6]). Asthma was associated with weight loss; male sex tended to be associated with weight gain.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40796"},"PeriodicalIF":3.5,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased use of Dermoscopy in Primary Healthcare Following the Implementation of Teledermatology in Southeast Sweden: A Retrospective Cohort Study of 2,137 Patients. 瑞典东南部实施远程皮肤病学后，基层医疗机构增加了皮肤镜的使用：一项针对 2,137 名患者的回顾性队列研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-13 DOI: 10.2340/actadv.v104.40890

Christofer Sahin, Mattias Carlsson, Fredrik Munir Ehrlington, Emanuela Micu, Magnus Falk

{"title":"Increased use of Dermoscopy in Primary Healthcare Following the Implementation of Teledermatology in Southeast Sweden: A Retrospective Cohort Study of 2,137 Patients.","authors":"Christofer Sahin, Mattias Carlsson, Fredrik Munir Ehrlington, Emanuela Micu, Magnus Falk","doi":"10.2340/actadv.v104.40890","DOIUrl":"https://doi.org/10.2340/actadv.v104.40890","url":null,"abstract":"In the last 5 decades there has been a steady increase in skin cancer incidence globally. As patients wait for treatment before or after referral, the prognosis for those with melanoma worsens. Teledermatology was introduced to help reduce waiting times. The objective of this study was to investigate how the introduction of teledermatology affected management of skin tumours, from primary care physicians to dermatologists. A retrospective cohort study was performed 1 year before and 1 year after introduction of teledermatology in Östergötland County, Sweden. Patients were included from 3 primary healthcare centres by 3 independent observers. A total of 2,139 patients were included in the study. The 2 cohorts were well matched. At 2 of the 3 primary healthcare centres there was a significant increase in the use of dermoscopy, and almost 66% of all referrals were teledermatological in the year following its introduction. There was a trend towards higher diagnostic accuracy in the post-teledermatology cohort. No apparent effect on melanoma referral times was observed. The results of this study confirm previous findings showing the value of teledermatology as well as a novel finding of an increase in dermoscopy use in primary healthcare settings.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40890"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric Comorbidities of Childhood-onset Atopic Dermatitis in Relation to Eczema Severity: A Register-based Study among 28,000 Subjects in Finland. 儿童期特应性皮炎的精神并发症与湿疹严重程度的关系：对芬兰 28,000 名受试者进行的登记研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-13 DOI: 10.2340/actadv.v104.40790

Amanda Blanco Sequeiros, Suvi-Päivikki Sinikumpu, Jari Jokelainen, Laura Huilaja

{"title":"Psychiatric Comorbidities of Childhood-onset Atopic Dermatitis in Relation to Eczema Severity: A Register-based Study among 28,000 Subjects in Finland.","authors":"Amanda Blanco Sequeiros, Suvi-Päivikki Sinikumpu, Jari Jokelainen, Laura Huilaja","doi":"10.2340/actadv.v104.40790","DOIUrl":"https://doi.org/10.2340/actadv.v104.40790","url":null,"abstract":"Data on the severity of childhood-onset atopic dermatitis (AD) in relation to psychiatric comorbidities is scarce, even though AD predisposes to psychiatric comorbidities and the commonness of childhood-onset AD and its significance in disease progression are recognized. The purpose of this nationwide, register-based study of child patients diagnosed with AD in Finland between 1987 and 2017 was to determine how psychiatric comorbidities of AD patients differ depending on the disease severity of childhood-onset AD. AD severity was assessed by purchased AD treatment and risk of comorbidities was analyzed by the age of 18 and 30 years. The main finding of our study is that risk of several psychiatric disorders, i.e., depression, anxiety disorders and bipolar disorder, increased by the AD severity in childhood-onset AD already at young age. No difference was found for behavioral disorders, including hyperkinetic disorder, depending on AD severity. Childhood-onset AD is associated with different psychiatric comorbidities depending on AD severity, which supports the importance of mental health evaluation in AD patients.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40790"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intercellular, Linear Direct Immunofluorescence Staining Pattern of Sweat Glands and Hair Follicles may be Used as a Diagnostic Marker for Pemphigus Vulgaris in Cases where Epidermis is Missing. 在表皮缺失的病例中，汗腺和毛囊的细胞间线性直接免疫荧光染色模式可作为丘疹性荨麻疹的诊断标志。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-13 DOI: 10.2340/actadv.v104.40620

Orsolya N Horvath, Michaela Maurer, Vivian Wietzke, Victoria Fischer, Lars E French, Miklós Sárdy

{"title":"Intercellular, Linear Direct Immunofluorescence Staining Pattern of Sweat Glands and Hair Follicles may be Used as a Diagnostic Marker for Pemphigus Vulgaris in Cases where Epidermis is Missing.","authors":"Orsolya N Horvath, Michaela Maurer, Vivian Wietzke, Victoria Fischer, Lars E French, Miklós Sárdy","doi":"10.2340/actadv.v104.40620","DOIUrl":"https://doi.org/10.2340/actadv.v104.40620","url":null,"abstract":"Due to its rarity, it takes months for patients to be correctly diagnosed with pemphigus vulgaris. This delay can be exacerbated by factors such as incorrect biopsy site selection. When the epidermis detaches from the dermis, evaluating fluorescence patterns is impossible. This monocentric, retrospective study aimed to assess the clinical significance of the honeycomb-like staining pattern of adnexal structures in patients with pemphigus vulgaris. The study was conducted in Munich, from 1 January 2012 to 31 December 2020. Forty-four biopsy samples for direct immunofluorescence microscopy from pemphigus patients along with 44 samples from control patients were included. The fluorescence intensity of adnexal structures did not differ significantly from that of the epidermis in pemphigus, except for hair follicles and sweat glands with C3 staining, where the epidermis showed stronger fluorescence. The sensitivity for the characteristic fluorescence pattern of at least 1 adnexal structure was 88.64% (n = 39/44, 95% CI 75.44% to 96.21%), with 100% specificity. The positive predictive value of adnexal fluorescence was 100%, and the negative predictive value was 89.8%. It was found that the honeycomb-like staining pattern of sweat glands, sweat gland ducts, and hair follicles is a highly specific marker for pemphigus vulgaris.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40620"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Melanoma in Elderly Patients over 80 Years. 80 岁以上老年患者的黑色素瘤管理。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-13 DOI: 10.2340/actadv.v104.41029

Héloïse Jourdain, Justine Lavaud, Clémentine Descours, Emilie Auditeau, Philippe Bernard

{"title":"Management of Melanoma in Elderly Patients over 80 Years.","authors":"Héloïse Jourdain, Justine Lavaud, Clémentine Descours, Emilie Auditeau, Philippe Bernard","doi":"10.2340/actadv.v104.41029","DOIUrl":"https://doi.org/10.2340/actadv.v104.41029","url":null,"abstract":"Melanoma is a malignant tumour with a poorer prognosis in stage III and IV patients. Development of effective therapies for the treatment of advanced melanoma has led to an improvement in survival. Furthermore, the French population is ageing, and treatment of melanoma in this population has several specific limitations. This descriptive, retrospective, single-centre study collected data on the diagnostic and therapeutic management of patients with melanoma of Breslow ≥ 1 mm or of unknown primary and metastatic spread, at Limoges University Hospital, between 2018 and 2022, and compared the results obtained between 2 groups: under 80 and over 80 years of age; 344 patients were included. The extension work-up was more frequently complete and the sentinel lymph node technique more frequently performed in patients under 80. Wide excision was more frequently in accordance with guidelines in patients over 80. Adjuvant or first-line metastatic treat-ment was more frequently instituted in patients under 80, but no difference was found as regards the second and third lines, the frequency of adverse events, and the reason for stopping treatment. Our study supports similar management of elderly and young subjects, given the safety profile and efficacy of treatments.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41029"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0