Acta dermato-venereologica最新文献

Recurrent Neutrophilic Dermatosis of the Face Successfully Treated with Potassium Iodide.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-26 DOI: 10.2340/actadv.v105.42065

Masakazu Kakurai, Atsushi Oda, Yoshihiro Moriyama

引用次数: 0

A 37-year-old Woman with a Solitary Flaccid Bulla on the Left Wrist: A Quiz.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-26 DOI: 10.2340/actadv.v105.43323

Zhe Wu, Chenglong Wu, Kaili Zhou, Zhirong Yao

引用次数: 0

Safety, Pharmacokinetics, and Efficiency of JS005, a Novel Anti-interleukin-17A Monoclonal Antibody, in Healthy Chinese Adults and Patients with Moderate to Severe Psoriasis.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-26 DOI: 10.2340/actadv.v105.41105

Lin Cai, Huichen Liu, Zhanglei Mu, Xiaohua Tao, Litao Zhang, Chunlei Zhang, Yumei Li, Guoqiang Zhang, Furen Zhang, Xiuqin Dong, Chengxin Li, Aijun Chen, Zhuning Wu, Yuxian Zhu, Mengqi Zhang, Jiangnian Liu, Aiming Li, Jianzhong Zhang

{"title":"Safety, Pharmacokinetics, and Efficiency of JS005, a Novel Anti-interleukin-17A Monoclonal Antibody, in Healthy Chinese Adults and Patients with Moderate to Severe Psoriasis.","authors":"Lin Cai, Huichen Liu, Zhanglei Mu, Xiaohua Tao, Litao Zhang, Chunlei Zhang, Yumei Li, Guoqiang Zhang, Furen Zhang, Xiuqin Dong, Chengxin Li, Aijun Chen, Zhuning Wu, Yuxian Zhu, Mengqi Zhang, Jiangnian Liu, Aiming Li, Jianzhong Zhang","doi":"10.2340/actadv.v105.41105","DOIUrl":"https://doi.org/10.2340/actadv.v105.41105","url":null,"abstract":"JS005 is a novel anti-IL-17A monoclonal antibody. A Phase Ia study (Study 1) in healthy adults, followed by a Phase Ib/II study (Study 2) in patients with moderate to severe plaque psoriasis (PsO), were designed to evaluate the safety, efficacy, and pharmacokinetic characteristics of JS005. Study 1 was a double-blind, randomized, placebo-controlled, single dose-escalation (15, 60, 150, 300, and 600 mg) study. Forty healthy participants were enrolled. Study 2 consisted of a dose-escalation (60, 150, 300, or 600 mg) phase Ib, and a multicentre, double-blind, placebo-controlled phase II administering JS005 150, 300 mg, or placebo once weekly from week 0 to 4 and once every 4 weeks from week 5 to 12. Forty and 143 patients were enrolled in phases Ib and II, respectively. The exposure of JS005 increased linearly with dosage, while the treatment-emergent adverse events did not show this trend. JS005 was well tolerated in both populations. In phase II of Study 2, the proportion of patients with at least a 75% improvement in the Psoriasis Area and Severity Index at week 12 was significantly higher in each JS005 group than in the placebo group (p < 0.001 for all comparisons). JS005 was highly effective in PsO patients.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv41105"},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case of Tertiary Syphilis with Unilateral Pupillary Abnormality.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-20 DOI: 10.2340/actadv.v105.43120

Laura Glismann, Simone Høstgaard, Christos Chistakopoulos, Jørgen Skov Jensen, Kirsten Salado-Rasmussen

引用次数: 0

Basal Cell Nevus Syndrome and Sporadic Basal Cell Carcinoma: A Comparative Study of Clinicopathological Features.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-19 DOI: 10.2340/actadv.v105.40692

Ching-Ya Wang, Chun-Bing Chen, Franchesca Marie D Ilagan, Jing-Yi Lin, Wen-Yi Sung, Lai-Ying Lu, Jau-Yu Liau, Yu-Hsiu Chen, Yi-Hua Liao, Jau-Shiuh Chen, Yi-Shuan Sheen, Yao-Yu Chang, Jin-Bon Hong

{"title":"Basal Cell Nevus Syndrome and Sporadic Basal Cell Carcinoma: A Comparative Study of Clinicopathological Features.","authors":"Ching-Ya Wang, Chun-Bing Chen, Franchesca Marie D Ilagan, Jing-Yi Lin, Wen-Yi Sung, Lai-Ying Lu, Jau-Yu Liau, Yu-Hsiu Chen, Yi-Hua Liao, Jau-Shiuh Chen, Yi-Shuan Sheen, Yao-Yu Chang, Jin-Bon Hong","doi":"10.2340/actadv.v105.40692","DOIUrl":"https://doi.org/10.2340/actadv.v105.40692","url":null,"abstract":"Basal cell nevus syndrome is caused by mutations in the Sonic hedgehog pathway and characterized by early-onset basal cell carcinoma. The features of basal cell carcinoma in basal cell nevus syndrome compared with sporadic basal cell carcinoma have not been explored. This study is a retrospective study of patients with basal cell nevus syndrome in two medical centres in Taiwan from 1991 to 2021 and patients with sporadic basal cell carcinoma excised from 2015 to 2020. An analysis of 18 patients with basal cell nevus syndrome showed an older mean age at the first diagnosis of basal cell carcinoma (37.5 years) than reported in Western countries. The majority of basal cell carcinomas were located in the head and neck region (80.7%), with nodular BCC being the most common tumour type (47.0%). Compared with sporadic basal cell carcinomas, basal cell carcinomas in basal cell nevus syndrome patients occurred more frequently on the scalp (34.7% vs 6.1%, p < 0.001). In addition, the superficial type of basal cell carcinoma was more likely to be seen in basal cell nevus syndrome (24.7% vs 10.4%, p < 0.001). The limitations were that some features of the basal cell nevus syndrome patients might not have been present yet at the time of examination or they did not receive thorough screening. In conclusion, the distinct features of basal cell carcinomas in basal cell nevus syndrome patients have important implications for the prevention, diagnosis, and management of basal cell carcinoma in basal cell nevus syndrome patients.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv40692"},"PeriodicalIF":3.5,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology of Psoriasis: A Worldwide Global Study.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-18 DOI: 10.2340/actadv.v105.42945

Charbel Skayem, Charles Taieb, Bruno Halioua, Catherine Baissac, Marketa Saint Aroman

引用次数: 0

Successful Treatment with Dupilumab of Acquired Reactive Perforating Collagenosis with End-stage Renal Disease.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-18 DOI: 10.2340/actadv.v105.43108

Shanglin Jin, Xiaoyao Fan, Jin Chen, Ying Ma

引用次数: 0

Flare-ups: New Insights into the Burden of Pain in Hidradenitis Suppurativa.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-18 DOI: 10.2340/actadv.v105.43124

Florian Regensberger, Fiona André, Matthias Schmuth

引用次数: 0

Widespread Rash with Localized Sparing: A Quiz.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-18 DOI: 10.2340/actadv.v105.43058

Outi Varpuluoma

引用次数: 0

Systemic Targeted Therapies in Patients with Relapsed/Refractory Advanced Stage Cutaneous T-cell Lymphoma: A Real-world Single-centre Case Series.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-03-13 DOI: 10.2340/actadv.v105.40952

Signe Hedebo, Martin B Pedersen, Lise M Lindahl, Aska Drjlevic-Nielsen, Claus Johansen, Francesco D'Amore, Lars Iversen, Rikke Bech

{"title":"Systemic Targeted Therapies in Patients with Relapsed/Refractory Advanced Stage Cutaneous T-cell Lymphoma: A Real-world Single-centre Case Series.","authors":"Signe Hedebo, Martin B Pedersen, Lise M Lindahl, Aska Drjlevic-Nielsen, Claus Johansen, Francesco D'Amore, Lars Iversen, Rikke Bech","doi":"10.2340/actadv.v105.40952","DOIUrl":"https://doi.org/10.2340/actadv.v105.40952","url":null,"abstract":"Cutaneous T-cell lymphomas are a heterogeneous group of non-Hodgkin lymphomas. Early stages are often controlled with skin-directed therapy, such as topical corticosteroids, topical chlormethine gel, or UV therapy, whereas advanced stages often warrant a more aggressive approach with systemic antibody targeted therapy including mogamulizumab, brentuximab vedotin, or alemtuzumab. A retrospective cohort case series of 27 patients from Aarhus University Hospital, Denmark is presented, evaluating real-world outcomes of patients with cutaneous T-cell lymphomas treated with intravenous systemic targeted therapies from 2013 to 2023. The median age was 72 and the majority had Sézary syndrome or mycosis fungoides. All patients had relapsed/refractory advanced stage cutaneous T-cell lymphoma. Six patients received mogamulizumab, 12 patients received brentuximab vedotin, and 15 patients received alemtuzumab. Six patients received more than 1 of the systemic targeted treatments. Overall response rates were 78% for mogamulizumab, 65% for brentuximab vedotin, and 61% for alemtuzumab. Median time to progression was 2.5, 4, and 11 months, respectively. In conclusion, this paper offers a unique perspective on the complexities of clinical practice when managing advanced-stage cutaneous T-cell lymphomas and demonstrates the effectiveness of the therapies described, with particular emphasis on the promising results observed with alemtuzumab administered in a low-dose protocol.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv40952"},"PeriodicalIF":3.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0