Acta dermato-venereologica最新文献

Journey of Patients with Psoriasis in an Italian Tertiary Centre, an 11-year Retrospective Analysis. 意大利三级医疗中心银屑病患者的11年回顾性分析。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-08 DOI: 10.2340/actadv.v105.42503

Elena Ippoliti, Gennaro Marco Falco, Nicoletta Di Giorgi, Jacopo Lenkowitz, Andrea Chiricozzi, Maria Vittoria Cannizzaro, Laura Quattrini, Giacomo Caldarola, Clara De Simone, Alessandra D'Amore, Ketty Peris

{"title":"Journey of Patients with Psoriasis in an Italian Tertiary Centre, an 11-year Retrospective Analysis.","authors":"Elena Ippoliti, Gennaro Marco Falco, Nicoletta Di Giorgi, Jacopo Lenkowitz, Andrea Chiricozzi, Maria Vittoria Cannizzaro, Laura Quattrini, Giacomo Caldarola, Clara De Simone, Alessandra D'Amore, Ketty Peris","doi":"10.2340/actadv.v105.42503","DOIUrl":"https://doi.org/10.2340/actadv.v105.42503","url":null,"abstract":"Despite the improvement of psoriasis treatment achieved with the use of biological therapies, some patients still require hospitalization. A retrospective study was conducted including patients affected by psoriasis hospitalized at Fondazione Policlinico Agostino Gemelli IRCCS in Rome, from 1 January 2012 to 1 August 2023, to describe the psoriasis patient journey. Of the 2.223 patients with psoriasis, 1,500 had it as the primary diagnosis. Some 93.2% (2,071/2,223) of patients were affected by plaque psoriasis, 4.8% (108/2,223) presented with erythrodermic psoriasis, and 2.0% (44/2,223) had generalized pustular psoriasis. 1,455/2,223 (65.5%) reported in their medical history psoriatic arthritis, and 771/2,223 (34.7%) hypertension; 328/2,223 (14.8%) psoriatic patients accessed the emergency department (ED), 291 of whom (13.1%) were subsequently hospitalized in different inpatient clinics, while 37 (1.6%) were then discharged. Inpatient clinic admission after ED was required more frequently in generalized pustular or erythrodermic psoriasis (47.7% and 38% respectively) compared with plaque psoriasis (11%). Patients admitted to an inpatient clinic after ED had a longer recovery compared with those admitted electively to an inpatient clinic (13.6 days vs 7.7 days, p < 0.001). Only 490/2,223 (20.9%) patients were admitted to a dermatology service. This study showed a shift in patient management rather than a reduction in hospitalizations.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42503"},"PeriodicalIF":3.5,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Histopathological Characteristics of Buschke-Ollendorff Syndrome: A Case Series. Buschke-Ollendorff综合征的临床和组织病理学特征：一个病例系列。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-08 DOI: 10.2340/actadv.v105.42531

Yidong Tan, Jinxiang Yang, Xuanyi Chen, Zhirong Yao, Jianying Liang

引用次数: 0

An 81-year-old Woman with a 1-year-old Blue Pigmented Patch on the Right Upper Back: A Quiz. 一位81岁的妇女，右上背部有一年前的蓝色色素斑块：一个小测验。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-08 DOI: 10.2340/actadv.v105.42915

Jin Young Lee, Jun Young Kim

引用次数: 0

Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study. 2型糖尿病影响梅毒治疗效果，是晚期梅毒的危险因素：一项回顾性队列研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-08 DOI: 10.2340/actadv.v105.42210

Yijie Tang, Mengxiao Wu, Wenwen Xu, Jiajie Yu, Dandan Yang, Jiaqin Zhang, Lingyun Shen, Qinghui Xie, Qingqiong Luo

引用次数: 0

Real-world Effectiveness and Safety of Janus Kinase Inhibitors in Alopecia Areata: A Retrospective Cohort Study of 72 Patients. Janus激酶抑制剂治疗斑秃的有效性和安全性：一项72例患者的回顾性队列研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-07 DOI: 10.2340/actadv.v105.42990

Sophie C Van Helmond, Mathias Willaert, Viet-Hoa Nguyen, Tamar Nijsten, Rick Waalboer-Spuij, DirkJan Hijnen

{"title":"Real-world Effectiveness and Safety of Janus Kinase Inhibitors in Alopecia Areata: A Retrospective Cohort Study of 72 Patients.","authors":"Sophie C Van Helmond, Mathias Willaert, Viet-Hoa Nguyen, Tamar Nijsten, Rick Waalboer-Spuij, DirkJan Hijnen","doi":"10.2340/actadv.v105.42990","DOIUrl":"https://doi.org/10.2340/actadv.v105.42990","url":null,"abstract":"Alopecia areata (AA) is an autoimmune hair loss disorder characterized by sudden hair shedding due to immune dysregulation involving the Janus Kinase - Signal Transducer and Activator of Transcription (JAK-STAT) pathway. JAK inhibitors (JAKi) have demonstrated efficacy in clinical trials, but data from real-world settings remain scarce. This retrospective, single-centre cohort study evaluated the real-world effectiveness and safety of JAKi (abrocitinib, baricitinib, ritlecitinib, upadacitinib, and tofacitinib) in 72 patients treated between December 2017 and February 2024. Patients had a mean age of 34 years and a mean disease duration of 8 years. At time points 3, 6, 9, 12, and 18 months substantial regrowth was observed in 18 (25%), 28 (38.9%), 25 (34.7%), 22 (30.6%), and 19 (26.4%) patients respectively. Over a median follow-up of 16 months, 61% achieved substantial regrowth at a median time of 7 months. At 3, 6, 9, and 12 months, the cumulative regrowth rates were 11.1%, 40.2%, 55.6%, and 59.7%, respectively. Among non-responders who switched medications, 75% achieved substantial regrowth. Two serious adverse events occurred (sickle cell crisis and renal failure with pre-existing dysfunction). The findings indicate that JAKi are effective and safe for AA treatment in real-world settings. Further prospective studies are necessary to optimize treatment guidelines.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42990"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgery or Non-invasive Treatment for Superficial Basal Cell Carcinoma: Does a Patient Decision Aid Help to Make a Personalized Treatment Decision? 浅表基底细胞癌的手术或非侵入性治疗：患者的决定是否有助于做出个性化的治疗决定？

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-07 DOI: 10.2340/actadv.v105.41914

Lieke C J Van Delft, Myrthe M G Moermans, Brigitte A B Essers, Patty J Nelemans, Klara Mosterd, Marieke E C Van Winden, Satish F K Lubeek, Nicole W J Kelleners-Smeets

{"title":"Surgery or Non-invasive Treatment for Superficial Basal Cell Carcinoma: Does a Patient Decision Aid Help to Make a Personalized Treatment Decision?","authors":"Lieke C J Van Delft, Myrthe M G Moermans, Brigitte A B Essers, Patty J Nelemans, Klara Mosterd, Marieke E C Van Winden, Satish F K Lubeek, Nicole W J Kelleners-Smeets","doi":"10.2340/actadv.v105.41914","DOIUrl":"https://doi.org/10.2340/actadv.v105.41914","url":null,"abstract":"Patients with a superficial basal cell carcinoma can be treated surgically or non-invasively, all with specific (dis)advantages. An investigation was undertaken into whether the preference for surgery or non-invasive treatment of a superficial basal cell carcinoma differs between patients who used a patient decision aid and a control group. Secondly, whether patients were satisfied with their decision post-treatment was investigated. A prospective observational study was performed comparing patients with a superficial basal cell carcinoma who used a patient decision aid (patient decision aid group) with a control group. The primary outcome was the proportion of patients that chose non-invasive treatment. A secondary outcome was the mean score of \"effective decision-making\" on the Decisional Conflict Scale 3 months post-treatment. In the patient decision aid group, 48.6% (52/109) seemed to prefer non-invasive treatment vs 40.8% (42/103) in the control group (p = 0.255); the result was not significant. Three months post-treatment, the adjusted between-group mean difference in \"effective decision-making\" was -4.10 (p = 0.082) favouring the patient decision aid group (effect size 0.3). To conclude, patients who used a patient decision aid seemed to choose non-invasive therapy over surgery slightly more often but the result was not significant.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv41914"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Polymyxin B Induced Transverse Melanonychia Affecting All 20 Nails. 多粘菌素B致横断性黑甲病1例。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-07 DOI: 10.2340/actadv.v105.43353

Fatmanur Hacınecipoğlu, Gülten Ütebey, Bahriye Nur Dinçer, Selda Pelin Kartal

引用次数: 0

Distinct Impact of Phosphodiesterade-4 (PDE4) Inhibition in Two Pre-clinical Psoriasis Models. 磷酸二酯-4 （PDE4）抑制对两种临床前银屑病模型的不同影响

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-07 DOI: 10.2340/actadv.v105.41972

Sören Dräger, Thorge Mester, Hermann Tenor, Ralf J Ludwig, Katja Bieber

引用次数: 0

Topical Steroid Withdrawal: The Challenging Transition from Patient Self-Diagnosis on Social Media to Medical Science and Care. 局部类固醇戒断：从患者在社交媒体上的自我诊断到医学科学和护理的挑战性转变。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-03 DOI: 10.2340/actadv.v105.43455

Alain Taieb

引用次数: 0

Radiotherapy-induced Angiosarcoma Mimicking Merkel Cell Carcinoma Metastases. 放射治疗诱导的血管肉瘤模拟默克尔细胞癌转移。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-03 DOI: 10.2340/actadv.v105.42509

Franziska Anna Wenz, Anna-Maria Forster, Beda Muehleisen, Alina Miriam Mueller

引用次数: 0