Acta dermato-venereologica最新文献

A Little Finger with Long-standing Blue Discolouration and Nail Dystrophy. 小指有长期的蓝色变色和指甲营养不良。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-05-04 DOI: 10.2340/actadv.v106.adv-2026-0570

Sui-Jiang Wang, Yu-Dan Jin, Xiao-Fang Li, Hai-Hua Huang

引用次数: 0

Autologous Patch Healing vs Secondary Intent Healing after Mohs Micrographic Surgery: A Randomized Controlled Trial. 莫氏显微摄影手术后自体贴片愈合与二次意图愈合：一项随机对照试验。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-04-29 DOI: 10.2340/actadv.v106.43586

Marie K Hjorth, Ewa A Burian, Tonny Karlsmark, Mette Mogensen, Martin Glud, Anna Ahm Harager, Anthony Rossi, Katrine E Karmisholt

{"title":"Autologous Patch Healing vs Secondary Intent Healing after Mohs Micrographic Surgery: A Randomized Controlled Trial.","authors":"Marie K Hjorth, Ewa A Burian, Tonny Karlsmark, Mette Mogensen, Martin Glud, Anna Ahm Harager, Anthony Rossi, Katrine E Karmisholt","doi":"10.2340/actadv.v106.43586","DOIUrl":"10.2340/actadv.v106.43586","url":null,"abstract":"Secondary intent healing is a viable option for wound closure after facial tumour removal by Mohs micrographic surgery. Secondary intent healing involves prolonged healing time and carries risk of infection and complications related to scarring. Healing with an autologous patch made from the patient's own blood may be beneficial. This study on 22 patients evaluates the effect of applying an autologous patch to the wound after Mohs micrographic surgery. A randomized controlled assessor-blinded trial was carried out. Patients had Mohs micrographic surgery on day 0 and clinical evaluation on day 12, day 19, and after 6 months. Transepidermal water loss was measured on day 12 and day 19. Reflectance confocal microscopy was applied exploratively. At 6 months' follow-up the Patient and Observer Scar Assessment Scale was evaluated. Primary outcome was fully epithelialized wounds on day 19 and secondary outcome was 50% epithelialized wounds on day 12. One wound from each group was fully epithelialized and wound area reduction was higher in the patch group although not significant. Transepidermal water loss decreased to a larger extent, indicating that the patch creates a moist environment. Wound healing with an autologous patch is equivalent to secondary intent healing but may prompt benefits in certain wound healing factors. Patch healing appears safe with high patient satisfaction.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":"adv43586"},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13137085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epidemiology and Comorbidity of Vitiligo in Germany: A Claims Data Analysis. 德国白癜风的流行病学和合并症：索赔数据分析。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-04-29 DOI: 10.2340/actadv.v106.44468

Theresa Klinger, Matthias Augustin, Susanne Baumeister, Jennifer Riedel, Claudia Grellmann, Anja Kamps, Markus Böhm, Kristina Hagenström

{"title":"Epidemiology and Comorbidity of Vitiligo in Germany: A Claims Data Analysis.","authors":"Theresa Klinger, Matthias Augustin, Susanne Baumeister, Jennifer Riedel, Claudia Grellmann, Anja Kamps, Markus Böhm, Kristina Hagenström","doi":"10.2340/actadv.v106.44468","DOIUrl":"10.2340/actadv.v106.44468","url":null,"abstract":"Vitiligo is a chronic skin disease resulting in destruction of melanocytes and loss of pigmentation. Little is known about epidemiology and comorbidity in Germany. This retrospective cohort analysis used nationwide statutory health insurance data (2016 to 2020). Disease rates were calculated using varying case definitions. Comorbidity was assessed against 3 control groups: persons without vitiligo, with atopic dermatitis, and with psoriasis (1:3 propensity score matching). In 2020, 4,631 persons were diagnosed with vitiligo in DAK-Gesundheit (DAK-G, mean age 56.93 years, ~148,437) and 5,820 persons in the German Analysis Database for Evaluation and Health Services Research (~144,855). Prevalence ranged from 0.12% (confidence interval [CI] 0.12-0.12) to 0.20% (CI 0.19-0.20), and incidence from 0.04% (CI 0.03-0.04) to 0.06% (CI 0.06-0.06). Rates increased with age. Women (mean age 58.60 years) were more frequently affected. Vitiligo was associated with alopecia areata (relative risk 7.14, CI 4.63-11.00) and systemic sclerosis (relative risk 3.20, CI 1.58-6.47). Several mental illnesses (depression: relative risk = 1.23, CI 1.15-1.32, anxiety: relative risk = 1.32, CI 1.19-1.47), were linked to skin diseases like vitiligo, atopic dermatitis, or psoriasis. Vitiligo affects a notable proportion of the population, with detected comorbidities supporting prior findings. To ensure reliable results, claims data should be validated through primary data linkage or sensitivity testing.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":"adv44468"},"PeriodicalIF":3.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13136925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the Burden of Acne Vulgaris in China vs Globally: Insights from the Global Burden of Disease Study (2021) and Projections to 2050. 中国与全球寻常性痤疮负担比较：来自2021年全球疾病负担研究的见解及2050年预测。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-04-28 DOI: 10.2340/actadv.v106.adv-2025-0131

Rui Yuan, Haibo Long, Tian Li, Aijun Chen

{"title":"Comparison of the Burden of Acne Vulgaris in China vs Globally: Insights from the Global Burden of Disease Study (2021) and Projections to 2050.","authors":"Rui Yuan, Haibo Long, Tian Li, Aijun Chen","doi":"10.2340/actadv.v106.adv-2025-0131","DOIUrl":"10.2340/actadv.v106.adv-2025-0131","url":null,"abstract":"Acne vulgaris (AV) poses a significant health challenge in China, adversely affecting patients' quality of life and mental health. Updated evidence on acne burden in China integrating temporal trends, China-global comparisons, change-point patterns, and future projections remains limited. This study aimed to provide an updated assessment of AVacne vulgaris burden in China, including temporal trends and future projections, and to clarify its public health implications. Using data from the 2021 Global Burden of Disease (GBD) study, estimated annual percentage changes (EAPCs) for AVacne vulgaris were calculated for China and globally, while change-point patterns were assessed using joinpoint regression. An age-period-cohort (APC) analysis was subsequently performed, followed by Bayesian age-period-cohort (BAPC) projection of China's AVacne vulgaris burden to 2050. From 1990 to 2021, the prevalence, incidence, and disability-adjusted life years (DALYs) associated with AVacne vulgaris in China exhibited sustained increases, outpacing global rates. APCAge-period-cohort analysis revealed a peak incidence at ages 10-14 years. Overall, the main burden was concentrated in adolescence. BAPCBayesian age-period-cohort projections indicated that China's AVacne vulgaris burden will continue to rise from 2022 to 2050,, with a disproportionately greater impact on females. These findings support prioritising evidence-based prevention, early recognition, and management strategies for adolescents and for females in China.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sun Protection Behaviours and Photosensitivity in Japanese Children: Toyama Adjunct Study of Japan Environment and Children's Study (JECS). 日本儿童的防晒行为和光敏性：日本环境与儿童研究（JECS）的Toyama辅助研究。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-04-28 DOI: 10.2340/actadv.v106.adv-2026-0397

Megumi Mizawa, Kenta Matsumura, Teruhiko Makino, Akiko Tsuchida, Hidekuni Inadera, Tadamichi Shimizu

{"title":"Sun Protection Behaviours and Photosensitivity in Japanese Children: Toyama Adjunct Study of Japan Environment and Children's Study (JECS).","authors":"Megumi Mizawa, Kenta Matsumura, Teruhiko Makino, Akiko Tsuchida, Hidekuni Inadera, Tadamichi Shimizu","doi":"10.2340/actadv.v106.adv-2026-0397","DOIUrl":"10.2340/actadv.v106.adv-2026-0397","url":null,"abstract":"Children have up to three3 times the annual sun exposure of adults. This cross-sectional study evaluated sun protection behaviorbehaviour, related factors, and the incidence of photosensitivity in Japanese children. A self-administered questionnaire administered to mothers of second2nd-grade children as part of the Toyama Adjunct Study of the Japan Environment and Children's Study was used and analyzedanalysed (n=1,691). The results showed that 67.5 % of children always or sometimes used sunscreen when going out for a long time, while 73.2 % used at least one method of sun protection when swimming in an outdoor pool. BehaviorsBehaviours related to sun exposure were related to the sex of the child, Fitzpatrick skin phototype, skin symptoms after sun exposure, annual household income, father's highest educational level, and maternal age. The incidence of photosensitivity disorders was 0.5 %. Diagnoses included polymorphous light eruptions in 4 (50%) and solar urticaria in 2 (25%). However, 5.9 % of children had skin symptoms after sun exposure, but were undiagnosed. In general, photosensitivity is rarely encountered in pediatricpaediatric patients; in this study, we determined its prevalence in children in Japan. Six factors appeared to be relevant to behaviorsbehaviours related to sun exposure. Further investigation is required to confirm these findings.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Reddish Nodule on the Scalp: A Quiz. 头皮上的红色结节：一个小测验。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-04-28 DOI: 10.2340/actadv.v106.adv-2026-0426

Yuelin Li, Xiao Tan, Hong Ren, Guangquan Ji, Renqiong Chen

引用次数: 0

Quality of Life in a Swedish Cohort of Patients with Mycosis Fungoides. 瑞典真菌病患者队列的生活质量。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-04-22 DOI: 10.2340/actadv.v106.adv-2026-0364

Daria Hub, Kristina Drott, Emma Belfrage, Andreas Sonesson

{"title":"Quality of Life in a Swedish Cohort of Patients with Mycosis Fungoides.","authors":"Daria Hub, Kristina Drott, Emma Belfrage, Andreas Sonesson","doi":"10.2340/actadv.v106.adv-2026-0364","DOIUrl":"https://doi.org/10.2340/actadv.v106.adv-2026-0364","url":null,"abstract":"Mycosis fungoides (MF) is a disease that evolves slowly over years with few options for curative treatment. Improving health-related quality of life (HRQoL) is therefore an important treatment goal. This study aims to contribute to a better understanding of HRQoL, using a dermatology-adapted HRQoL questionnaire, Dermatology Life Quality Index (DLQI), in patients with MF. Baseline data from a cohort study (BIO-MUSE) of patients with MF wasere used to investigate which aspect of DLQI is the most affected and how DLQI relates to different clinical and physiological parameters. Data from a period of 12 months were used to study how DLQI changes over time. The symptom domain, for example itching, was the aspect of the DLQI that had the greatest impact on HRQoL. Thymus and activation-regulated chemokine (TARC)/ chemokine (C-C) ligand 17 (CCL17) were analysed in blood and were shown to have a positive correlation with DLQI (r=0.482, p=0.043). It was further shown that increased itching at baseline was a strong predictor of a worse DLQI score in the domain of symptoms (r=0.677, p=0.002). Future research in a larger cohort is needed to investigate the effect of itch in HRQoLhealth-related quality of life in patients with MF.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive Skin Surface Sampling Identifies Elevated IL-1β and IL-6 in Paediatric Atopic Dermatitis Patients. 无创皮肤表面取样鉴定儿童特应性皮炎患者IL-1β和IL-6升高

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-04-22 DOI: 10.2340/actadv.v106.adv-2025-0010

Amir Horev, Sapir Gabay, Yuliya Valdman-Grinshpoun, Topaz Alfer, Amir Szitenberg, Navit Ogen-Shtern

{"title":"Noninvasive Skin Surface Sampling Identifies Elevated IL-1β and IL-6 in Paediatric Atopic Dermatitis Patients.","authors":"Amir Horev, Sapir Gabay, Yuliya Valdman-Grinshpoun, Topaz Alfer, Amir Szitenberg, Navit Ogen-Shtern","doi":"10.2340/actadv.v106.adv-2025-0010","DOIUrl":"https://doi.org/10.2340/actadv.v106.adv-2025-0010","url":null,"abstract":"Despite extensive research, the molecular signature in atopic dermatitis (AD) remains underexplored. While previous studies have explored the expressions of pro-inflammatory markers in AD skin using biopsies and tape-stripping techniques, non-invasive sampling from the skin surface in pediatricpaediatric AD patients has not been examined. This study aimed to identify and compare cytokine expression on the skin surface of children with AD and healthy controls. We enrolled 50 children, 40 with mild -to -moderate AD and 10 without AD as controls. Samples were collected using sticky bandages soaked in sterile phosphate-buffered saline, and concentrations of 15 cytokines were measured by a multiplex immunoassay. The effect of various factors on cytokine expression was assessed by redundancy analysis (RDA), while significance among groups was identified by factorial ANOVA. We found higher levels of IL-1β in non-lesional areas of AD patients compared to healthy subjects and increased expression of IL-1β and IL-6 in lesional areas compared to non-lesional skin. Factors such as skin folds and sex were found to affect cytokine secretion. This study demonstrates the feasibility of non-invasive cytokine sampling from the skin surface in pediatricpaediatric AD patients. It underscores its potential for identifying additional biomarkers, complementing research on deeper skin layers.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13103642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reconsidering Efficacy and Safety: A Critical Appraisal of Repurposing Anti-inflammatory Targeted Drugs in Darier disease. 重新考虑有效性和安全性：重新评价抗炎靶向药物在肾脏病中的应用。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-04-22 DOI: 10.2340/actadv.v106.adv-2026-0322

Estelle Burle, Juliette Mazereeuw-Hautier, Maella Severino-Freire

引用次数: 0

The Seasonal Trend of Brittle Nails: A Google Trends Analysis of English-speaking Countries. 脆指甲的季节性趋势：英语国家的bbb趋势分析。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2026-04-22 DOI: 10.2340/actadv.v106.adv-2025-0238

Eric McMullen, Mahan Maazi, Jonathan Berkowitz, Matthew Berkowitz, Jeffrey Donovan

引用次数: 0