Acta dermato-venereologica最新文献

An International Examination of Skin Concerns Impacting Self-Confidence Among 5,138 Males.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-13 DOI: 10.2340/actadv.v104.42016

Frederic Flament, Aurelie Maudet, Caroline Delaunay, David Amar, Muriel Bayer-Vanmoen, Audrey Imbert Legrain, Charles Taieb, Charbel Skayem, Laurence Lebarbanchon

引用次数: 0

Impact of Skin Type and Sensitivity on Dermatological Concerns and Self-confidence: Insights from an International Study of 14,317 Women.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-13 DOI: 10.2340/actadv.v104.42424

Frederic Flament, Aurelie Maudet, Caroline Delauney, David Amar, Muriel Bayer-Vanmoen, Audrey Imbert Legrain, Charles Taieb, Charbel Skayem, Laurence Lebarbanchon

引用次数: 0

Effect of Therapeutic Patient Education in Adults with Atopic Dermatitis: Analysis of Efficacy and Treatment Needs.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-12 DOI: 10.2340/actadv.v104.41184

Marine Fargeas, Mathieu Fauvernier, Marie Tauber, Julien Seneschal, Virginie Verdu, Magali Bourrel Bouttaz, Florence Hacard, Anne-Sophie Darrigade, Audrey Nosbaum

{"title":"Effect of Therapeutic Patient Education in Adults with Atopic Dermatitis: Analysis of Efficacy and Treatment Needs.","authors":"Marine Fargeas, Mathieu Fauvernier, Marie Tauber, Julien Seneschal, Virginie Verdu, Magali Bourrel Bouttaz, Florence Hacard, Anne-Sophie Darrigade, Audrey Nosbaum","doi":"10.2340/actadv.v104.41184","DOIUrl":"https://doi.org/10.2340/actadv.v104.41184","url":null,"abstract":"In the era of biological treatments and small molecules, this study assessed therapeutic patient education (TPE) in managing adult atopic dermatitis (AD), focusing on disease severity, quality of life, and the use of systemic treatments. This multicentre study included 260 adult AD patients, with 184 undergoing a full TPE programme and 76 control patients. Evaluations included disease severity, quality of life (DLQI), and systemic treatment use. The primary goal was to measure AD improvement, with secondary goals assessing DLQI score changes and systemic treatment use. AD severity improved in 64.7% of TPE patients vs 45.7% of controls (p = 0.008). The mean DLQI score dropped by 5.7 points in the TPE group vs 2.4 points in controls (p = 0.006). Additionally, 69.8% of TPE patients had a DLQI score ≤ 4/30 compared with 50% of controls (p = 0.025). Regarding therapeutics, 83.6% of patients naive to systemic treatment at inclusion were maintained exclusively under topical treatment vs 21.7% in the control group. The likelihood of needing systemic treatment was 66% in controls vs 6% in the TPE group. TPE enhances AD severity and quality of life, ensures better disease control, and reduces systemic treatment use, highlighting its importance in managing adult AD.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41184"},"PeriodicalIF":3.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Tolerability of Tebentafusp in Metastatic Uveal Melanoma: A Real-life Retrospective Multicentre Study.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-12 DOI: 10.2340/actadv.v104.41297

Lucille Vitek, Thomas Goronflot, Caroline Dutriaux, Antoine Deleuze, Yannick Le Corre, Anne-Bénédicte Duval-Modeste, Cécile Fresnard, Géraldine Jeudy, Anouck Lamoureux, Caroline Gaudy-Marqueste, Delphine Legoupil, Barouyr Baroudjian, Jean-Matthieu L'Orphelin, Lucie Peuvrel, Amir Khammari, Laurent Mortier, Gaëlle Quereux

{"title":"Efficacy and Tolerability of Tebentafusp in Metastatic Uveal Melanoma: A Real-life Retrospective Multicentre Study.","authors":"Lucille Vitek, Thomas Goronflot, Caroline Dutriaux, Antoine Deleuze, Yannick Le Corre, Anne-Bénédicte Duval-Modeste, Cécile Fresnard, Géraldine Jeudy, Anouck Lamoureux, Caroline Gaudy-Marqueste, Delphine Legoupil, Barouyr Baroudjian, Jean-Matthieu L'Orphelin, Lucie Peuvrel, Amir Khammari, Laurent Mortier, Gaëlle Quereux","doi":"10.2340/actadv.v104.41297","DOIUrl":"https://doi.org/10.2340/actadv.v104.41297","url":null,"abstract":"Metastatic uveal melanoma is a rare disease with a poor prognosis. Usual treatments have not proven effective. Tebentafusp, a bispecific protein targeting melanoma cells and T lymphocytes, is the first approved treatment with a proven survival benefit in a randomized clinical. Our purpose was to evaluate tebentafusp's real-life efficacy and tolerability for metastatic uveal melanoma. This retrospective study included patients from 14 French centres. Twenty-three patients were included. One-year survival was 66%; median progression-free survival was 5.7 months. Objective response rate was 23% and best overall response was complete remission for 4% of patients; partial remission for 18%, stable disease for 41%, and progressive disease for 36%. The most frequent adverse events were fever, chills, pruritus, and rash; 30% experienced severe adverse events. No death or treatment discontinuation was linked to adverse events. These data showed better overall survival with tebentafusp than that reported in historical cohorts.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41297"},"PeriodicalIF":3.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Varicella-zoster Virus Infections in Patients with Hospital-diagnosed Atopic Dermatitis.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-12 DOI: 10.2340/actadv.v104.42326

Sigrun A J Schmidt, Eskild Kristiansen, Henrik T Sørensen, Christian Vestergaard, Mette S Deleuran

引用次数: 0

Epidermolysis Bullosa Simplex due to a Novel BPAG1-e Homozygous Pathogenic Variant Revealed by Bullous Scabies.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-12 DOI: 10.2340/actadv.v104.40691

Nathalie Pironon, Anne Welfringer-Morin, Stéphanie Leclerc-Mercier, Emmanuelle Bourrat, Alain Hovnanian

引用次数: 0

Suppression of Epidermal Growth Factor Receptor by Erlotinib Attenuates Carvacrol-induced Skin Inflammation.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-09 DOI: 10.2340/actadv.v104.40975

Yujing Wang, Wenjie Huang, Haidong Jia, Qinglian Tang, Qingfei Yin, Yuanyuan Chen, Wumei Wang, Zhengyu Cao

{"title":"Suppression of Epidermal Growth Factor Receptor by Erlotinib Attenuates Carvacrol-induced Skin Inflammation.","authors":"Yujing Wang, Wenjie Huang, Haidong Jia, Qinglian Tang, Qingfei Yin, Yuanyuan Chen, Wumei Wang, Zhengyu Cao","doi":"10.2340/actadv.v104.40975","DOIUrl":"https://doi.org/10.2340/actadv.v104.40975","url":null,"abstract":"Epidermal growth factor receptors (EGFRs) regulate the growth and repair process of epithelia, as well as carcinogenesis. Activation of TRPV3 by carvacrol stimulates skin inflammation and epidermal hyperplasia; the latter can be suppressed by EGFR inhibition. However, whether EGFR signalling is responsible for skin inflammation remains elusive. The current study investigated the effect of erlotinib, an EGFR inhibitor, on skin inflammation in a carvacrol-induced atopic dermatitis mouse model. It was observed that erlotinib significantly attenuated carvacrol-induced overexpression of proinflammatory cytokines and suppressed peripheral blood mononuclear cell recruitment in HaCaT keratinocytes. In addition, it was demonstrated that erlotinib suppressed carvacrol-induced Akt and NF-κB signalling pathways. Furthermore, inhibition of Akt and NF-κB signalling pathways also attenuated the carvacrol-induced keratinocyte proinflammatory response. Finally, it was demonstrated that erlotinib treatment alleviated carvacrol-induced dermatitis. These data demonstrate that erlotinib ameliorates skin inflammation by regulating Akt and NF-κB-mediated keratinocyte proinflammation, suggesting the therapeutic potential of erlotinib, a clinically used EGFR inhibitor, in skin inflammatory diseases.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40975"},"PeriodicalIF":3.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Dermatology Life Quality Index (DLQI) among Patients with Psoriasis.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-05 DOI: 10.2340/actadv.v104.42441

Mikkel Bak Jensen, Nikolai Loft, Claus Zacheriae, Lone Skov

引用次数: 0

A Case of Pemphigus Herpetiformis Strongly Associated with Gastric Cancer.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-05 DOI: 10.2340/actadv.v104.41319

Masakazu Kakurai, Hana Takeshita, Hiroshi Koga, Norito Ishii, Yoshihiro Moriyama

引用次数: 0

Living with Pyoderma Gangrenosum: A Qualitative Study.

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-12-04 DOI: 10.2340/actadv.v104.42018

Jacqueline Jiang, Robert Kelly, Emma Veysey, Susan Rossell, Garry Zhu, Darren Haywood

{"title":"Living with Pyoderma Gangrenosum: A Qualitative Study.","authors":"Jacqueline Jiang, Robert Kelly, Emma Veysey, Susan Rossell, Garry Zhu, Darren Haywood","doi":"10.2340/actadv.v104.42018","DOIUrl":"10.2340/actadv.v104.42018","url":null,"abstract":"Pyoderma gangrenosum is a rare, autoinflammatory disorder characterized by rapidly progressive painful ulcers that are challenging to diagnose and treat. This qualitative study aimed to explore the experiences of patients living with pyoderma gangrenosum. Using an inductive qualitative approach, semi-structured interviews were completed with a purposive sample of 21 patients with pyoderma gangrenosum recruited from a public dermatology outpatient clinic in Melbourne, Australia. A reflexive thematic analysis was performed, yielding 5 themes: pain, physical challenges, social functioning and relationships, mental health, and treatment. The impact of pyoderma gangrenosum on quality of life was multifaceted and varied throughout disease progression, remission, and recurrence. Experiences of delayed diagnosis and misdiagnosis were common, causing distress and resulting in unnecessary treatments including surgery. Severe pain disrupted sleep and limited daily activities, eroding patients' sense of self-control and perpetuating depressed mood and anxiety. Management should include early specialist referral, providing information sheets for managing pain and wound care, and communicating disease expectations. In conclusion, this study has deepened understanding and given personal perspectives on what it is like to live with a condition poorly understood by many health professionals. Increased efforts should be made to increase clinician awareness regarding pyoderma gangrenosum to facilitate early diagnosis.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv42018"},"PeriodicalIF":3.5,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0