Acta dermato-venereologica最新文献

Norepinephrine Induces β2-adrenergic Receptor-associated Oxidative Stress and Melanocyte Damage in Organ-cultured Human Scalp Hair Follicles: Implications for Vitiligo-associated Poliosis. 去甲肾上腺素在器官培养的人头皮毛囊中诱导β2-肾上腺素能受体相关的氧化应激和黑素细胞损伤：白癜风相关脊髓灰质炎的意义

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-11-05 DOI: 10.2340/actadv.v106.adv-2025-0122

Shiqi Fu, Yi Wu, Sheng Wan, Xu Liu, Wen Xu, Yetan Shi, Yujie Li, Yeqin Dai, Bo Xie, Xiuzu Song

{"title":"Norepinephrine Induces β2-adrenergic Receptor-associated Oxidative Stress and Melanocyte Damage in Organ-cultured Human Scalp Hair Follicles: Implications for Vitiligo-associated Poliosis.","authors":"Shiqi Fu, Yi Wu, Sheng Wan, Xu Liu, Wen Xu, Yetan Shi, Yujie Li, Yeqin Dai, Bo Xie, Xiuzu Song","doi":"10.2340/actadv.v106.adv-2025-0122","DOIUrl":"10.2340/actadv.v106.adv-2025-0122","url":null,"abstract":"Poliosis in vitiligo is closely linked to loss or dysfunction of melanocytes within hair follicles, but the contribution of adrenergic stress signalling remains poorly understood. We first compared β2-adrenergic receptor immunoreactivity in vitiligo-associated poliosis hair follicles and normally pigmented hair follicles. We then used cultured human scalp hair follicles to examine the temporal effects of 5 μmol/L norepinephrine, with or without the selective β2-adrenergic receptor antagonist ICI-118551, over 1-7 days. Acute norepinephrine exposure (1 day) increased malondialdehyde levels, reduced superoxide dismutase activity, depolarized the mitochondrial membrane, increased 8-hydroxy-2'-deoxyguanosine and reduced B-cell lymphoma 2 immunoreactivity. Longer exposure (5-7 days) increased gamma histone 2 AX and terminal deoxy-nucleotidyl transferase dUTP nick end labelling signals and produced progressive melanocyte ultrastructural injury. Norepinephrine also reduced tyrosinase-related protein 2 and glycoprotein 100 (premelanosome protein, gp100) immunoreactivity, shortened gp100-positive melanocyte dendrites and produced a biphasic change in Masson-Fontana-stained melanin, with an early increase followed by a decline. ICI-118551 attenuated these effects. These findings show that sustained norepinephrine exposure damages the pigmentation of healthy human scalp hair follicles through a pathway involving β2-adrenergic receptor, oxidative stress, DNA damage and apoptosis. Because functional experiments were not performed in vitiligo hair follicles, the relevance of this pathway to vitiligo-associated poliosis remains to be further researched.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13738002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149332056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dupilumab in Atopic Dermatitis - Rate of Poor Responders and Potential Risk Factors from the TREATgermany Registry. 杜匹单抗治疗特应性皮炎-不良反应率和潜在危险因素。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-11-05 DOI: 10.2340/actadv.v106.adv-2026-0806

Annice Heratizadeh, Joëlle Naim, Barbara Kind, Katharina Loennecke, Sascha Fischer, Tatjana Honstein, Stephan Traidl, Eva Moennig, Thomas Birkner, Inken Harder, Caroline Mann, Thomas Schaefer, Susanne Abraham, Matthias Augustin, Jutta Ramaker-Brunke, Andreas Pinter, Kathrin Meinhardt, Sven Quist, Sabine Anders, Beate Schwarz, Michael Schulz-Kiesow, Sabine Steinke, Nicole Adler, Christiane Handrick, Knut Schäkel, Michael Sticherling, Anne Bong, Felix Jacobs, Bernd Großmann, Maren Stahl, Carl-Philipp Buerkle, Hannah Gorriahn-Maiterth, Tilo Biedermann, Stephan Weidinger, Jochen Schmitt, Thomas Werfel

{"title":"Dupilumab in Atopic Dermatitis - Rate of Poor Responders and Potential Risk Factors from the TREATgermany Registry.","authors":"Annice Heratizadeh, Joëlle Naim, Barbara Kind, Katharina Loennecke, Sascha Fischer, Tatjana Honstein, Stephan Traidl, Eva Moennig, Thomas Birkner, Inken Harder, Caroline Mann, Thomas Schaefer, Susanne Abraham, Matthias Augustin, Jutta Ramaker-Brunke, Andreas Pinter, Kathrin Meinhardt, Sven Quist, Sabine Anders, Beate Schwarz, Michael Schulz-Kiesow, Sabine Steinke, Nicole Adler, Christiane Handrick, Knut Schäkel, Michael Sticherling, Anne Bong, Felix Jacobs, Bernd Großmann, Maren Stahl, Carl-Philipp Buerkle, Hannah Gorriahn-Maiterth, Tilo Biedermann, Stephan Weidinger, Jochen Schmitt, Thomas Werfel","doi":"10.2340/actadv.v106.adv-2026-0806","DOIUrl":"10.2340/actadv.v106.adv-2026-0806","url":null,"abstract":"A distinct proportion of patients with atopic dermatitis and dupilumab treatment does not reach the primary endpoint of an eczema area severity index (EASI)-75 or investigator global assessment 0/1 after 16 weeks. Little is known about poor responders to dupilumab in real life scenarios. The study objective was to identify the percentage and characteristics of patients with insufficient treatment response to dupilumab based on \"TREATgermany\" registry data from dermatological routine care. Between 06/2016 and 12/2024, 476 patients matched the study criteria. In total, 4% of patients (n=19) were identified as dupilumab poor responders, i.e. reduction in EASI ≤40% at the 1st follow-up visit after 8 to 20 weeks and a consecutive 2nd follow-up visit up to 52 weeks of treatment. 44% (n=209) were classified as stable responders, i.e. decrease in EASI≥75% at both follow-up visits. Poor responders were significantly more often male, more frequently exhibited smoking, arterial hypertension and a higher body mass index. This TREATgermany data analysis demonstrates a proportion of 4% dupilumab poor responders within the first year of treatment. Male sex, smoking, arterial hypertension and increased body mass index were identified as potential risk factors. Further translational research is needed to confirm these clinical findings.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13738001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149332055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic Sarcoidosis After Polycaprolactone Fillers Successfully Treated with Upadacitinib. Upadacitinib成功治疗聚己内酯填充后的系统性结节病。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-11-04 DOI: 10.2340/actadv.v106.adv-2026-0841

Célestine Behaghel, Lucie Pothen, Thomas Gérard, Liliane Marot, Marie Baeck, Axel De Greef

引用次数: 0

Patient Journey, HS Burden and Unmet Need across Denmark and Norway: Real-World Data from the HISREG Registry. 丹麦和挪威的患者旅程、HS负担和未满足的需求：来自HISREG注册中心的真实数据。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-11-04 DOI: 10.2340/actadv.v106.adv-2026-0505

Anne-Marte Henriksen, Øystein Grimstad, Ana Filipa Macedo, Thrasyvoulos Tzellos, Ditte Marie L Saunte, Inger Marie Skoie, Ingrid Snekvik, Tanja Tran, Johan L Hansen, Aijing Shang, Gregor B Jemec

{"title":"Patient Journey, HS Burden and Unmet Need across Denmark and Norway: Real-World Data from the HISREG Registry.","authors":"Anne-Marte Henriksen, Øystein Grimstad, Ana Filipa Macedo, Thrasyvoulos Tzellos, Ditte Marie L Saunte, Inger Marie Skoie, Ingrid Snekvik, Tanja Tran, Johan L Hansen, Aijing Shang, Gregor B Jemec","doi":"10.2340/actadv.v106.adv-2026-0505","DOIUrl":"10.2340/actadv.v106.adv-2026-0505","url":null,"abstract":"Patients with hidradenitis suppurativa experience considerable disease burden and reduced health-related quality of life (HRQoL). Diagnostic delays are common and may impede timely treatment initiation, contributing to disease progression. This study utilizes data (2010-2022) from the Scandinavian Registry for hidradenitis suppurativa (HISREG) in adult patients with hidradenitis suppurativa. Here, we report time between first hidradenitis suppurativa-related symptom, general practitioner visit and dermatologist visit; Dermatology Life Quality Index (DLQI) score and most impacted items; and hidradenitis suppurativa treatment patterns in Denmark, Norway and both countries combined. Analysis was stratified by Hurley stage. In both countries combined, considerable gaps (≥10 years) were reported between first hidradenitis suppurativa-related symptom and dermatologist visit, with the greatest delay in Hurley stage III patients (14 years). Mean DLQI scores ranged from 8.6 to 14.6; scores were highest in Hurley stage III patients. The most impacted DLQI items were \"Itch/soreness/pain\" or \"Bothered/embarrassed\". Surgery was more common in Hurley stage III vs I patients (30.1% vs 10.6%); 8.6% of Hurley stage III patients did not receive additional intervention for hidradenitis suppurativa (doctor-determined). In conclusion, HISREG-registered patients experienced substantial delays to dermatologist visits, impaired HRQoL and a paucity of effective treatments. These burdens were particularly pronounced for patients with moderate and severe hidradenitis suppurativa.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13733279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Contact Sensitization in Patients with Atopic Dermatitis: A Retrospective Study from China. 中国特应性皮炎患者接触致敏率的回顾性研究

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-11-04 DOI: 10.2340/actadv.v106.adv-2026-0617

Ao Wang, Chengbin Ye, Chengwen Fei, Yingfang Li, Yuelong Ma, Ting Cao, Yue Wu, Yanchun Cheng, Fei Hao, Ying Zou

{"title":"Prevalence of Contact Sensitization in Patients with Atopic Dermatitis: A Retrospective Study from China.","authors":"Ao Wang, Chengbin Ye, Chengwen Fei, Yingfang Li, Yuelong Ma, Ting Cao, Yue Wu, Yanchun Cheng, Fei Hao, Ying Zou","doi":"10.2340/actadv.v106.adv-2026-0617","DOIUrl":"10.2340/actadv.v106.adv-2026-0617","url":null,"abstract":"The prevalence of contact sensitization in atopic dermatitis (AD) has been controversial and remains poorly studied in the Chinese population. This retrospective study aimed to assess the prevalence and differences ofin contact sensitization between AD and non-AD patients undergoing patch testing in China. We analyzedanalysed clinical records of 3,487 patients who underwent patch testing from 2018 to 2023,, including 146 AD patients and 33413,341 non-AD patients. Results demonstrated that contact sensitization prevalence was similar in AD and non-AD groups (82.88% vs 84.71%, p=0.55). Common allergens included nickel, methylisothiazolinone, dodecyl gallate, and cobalt chloride hexahydrate in both groups. AD patients showed higher positive reactions to hexahydro-1,3,5-tris-(2-hydroxyethyl) triazine (11.11% vs 5.85%, p<0.01), methyldibromo glutaronitrile (10.27% vs 4.97%, p<0.01), quaternium-15 (7.53% vs 3.68%, p=0.02), ethylenediamine dihydrochloride (3.42% vs 0.72%, p<0.01), propylene glycol (2.86% vs 0.60%, p=0.01), and 2-bromo-2-nitropropane-1,3-diol (2.74% vs 0.78%, p=0.03), compared to non-AD, particularly females. Contact sensitization prevalence increased with age in both groups. This study showed that the prevalence of contact sensitization was comparable between the AD and non-AD groups in China. However, AD patients exhibited heightened sensitivity to formaldehyde releasers and propylene glycol, commonly found in moisturizers.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13733281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Outcomes Following Mandatory Switching to an Adalimumab Biosimilar in Patients with Psoriasis: A Real-world Single-centre Experience. 银屑病患者强制切换到阿达木单抗生物类似药后的临床结果：真实世界的单中心体验

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-11-02 DOI: 10.2340/actadv.v106.adv-2026-0624

Mariá Simas D'Aquino, Roberto Moreira Amorim Filho, Gustavo Moreira Amorim

引用次数: 0

Explorative Correlation of Atopic Dermatitis Control Tool with Minimal Disease Activity Patient-reported Outcomes in Patients Treated with Upadacitinib: A Retrospective Real-world Study. 在接受Upadacitinib治疗的患者中，特应性皮炎控制工具与最小疾病活动患者报告的结果的探索性相关性：一项回顾性现实世界研究。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-11-02 DOI: 10.2340/actadv.v106.adv-2026-0815

Filomena Russo, Natale Schettini, Giovanni Scaglione, Ester Del Duca, Tommaso Bianchelli, Niccolò Gori, Flavia Margiotta, Laura Calabrese, Elettra Antonelli, Federica Giuliani, Viviana Piras, Sabatino Pallotta, Chiara Bocchi, Edoardo Mortato, Camilla Chello, Helena Gioacchini, Maria Cannizzaro, Marco Romanelli, Laura Lazzeri, Katharina Hansel, Paolo Amerio, Laura Atzori, Marco Galluzzo

{"title":"Explorative Correlation of Atopic Dermatitis Control Tool with Minimal Disease Activity Patient-reported Outcomes in Patients Treated with Upadacitinib: A Retrospective Real-world Study.","authors":"Filomena Russo, Natale Schettini, Giovanni Scaglione, Ester Del Duca, Tommaso Bianchelli, Niccolò Gori, Flavia Margiotta, Laura Calabrese, Elettra Antonelli, Federica Giuliani, Viviana Piras, Sabatino Pallotta, Chiara Bocchi, Edoardo Mortato, Camilla Chello, Helena Gioacchini, Maria Cannizzaro, Marco Romanelli, Laura Lazzeri, Katharina Hansel, Paolo Amerio, Laura Atzori, Marco Galluzzo","doi":"10.2340/actadv.v106.adv-2026-0815","DOIUrl":"10.2340/actadv.v106.adv-2026-0815","url":null,"abstract":"Atopic dermatitisis a chronic skin disease that requires long-term monitoring, which can be assessed using Atopic Dermatitis Control Tool (ADCT). Achieving minimal disease activity is also becoming an important issue in the treatment of atopic dermatitis. We aimed to identify which minimal disease sctivity patient-reported outcomes most closely reflect ADCT-defined disease control. We conducted a multicentric, observational retrospective study in patients with moderate-to-severe atopic dermatitis treated with upadacitinib. Outcome measures were collected at different time points (Week 0, 4, 16, 32, 52). Longitudinal changes were assessed with the paired Wilcoxon signedrank test; cross-sectional ADCT-patient-reported outcomes associations were evaluated at each visit using Spearman rank correlation coefficient (ρ). A total of 212 were included. All outcomes improved significantly from Week 4 onwards (all p<0.001). An ADCT score<7 was reached by 84.6% of evaluable patients at Week 4 and 90.1% at Week 52. At each timepoint, ADCT showed the strongest correlation with POEM (ρ range: 0.64-0.64) compared to other minimal disease sctivity patient-reported outcomes. These findings indicate that, among the minimal disease sctivity patient-reported outcomes, POEM most closely reflects the patient's perception of atopic dermatitis control assessed by ADCT. Larger prospective studies are warranted to confirm these preliminary observations.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13725904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenomic Characterization of Fibroblasts in Darier Disease Identifies Cross-cell-type Regulatory Gene Signatures. Darier病成纤维细胞的表观基因组特征鉴定了跨细胞型调控基因特征。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-10-28 DOI: 10.2340/actadv.v106.adv-2026-0626

Nuoqi Wang, Matthew Hunt, Monica Torres, Etty Bachar-Wikstrom, Jakob D Wikstrom

{"title":"Epigenomic Characterization of Fibroblasts in Darier Disease Identifies Cross-cell-type Regulatory Gene Signatures.","authors":"Nuoqi Wang, Matthew Hunt, Monica Torres, Etty Bachar-Wikstrom, Jakob D Wikstrom","doi":"10.2340/actadv.v106.adv-2026-0626","DOIUrl":"10.2340/actadv.v106.adv-2026-0626","url":null,"abstract":"Darier disease is a monogenic acantholytic derma-tosis caused by mutations in ATP2A2 that primarily disrupt keratinocyte calcium homeostasis. Whether dermal fibroblasts harborharbour disease-associated epigenetic alterations remainremains uncharacterized. In this study, we performed genome-wide DNA methy-lation profiling on primary fibroblasts from lesional and non-lesional skin, followed by STRING protein-protein interaction network analysis to identify regulatory hub genes. Hub gene expression was validated by qPCR and cross-referenced with single-cell RNA-seq data from healthy skin and published RNA-seq data from Darier disease keratinocytes. Lesional fibroblasts showed consistent, site-specific hyper- and hypomethylation converging on inter-connected regulatory hubs. Hypomethylated hub genes included transcription factors and signalingsignalling integrators while hypermethylated hub genes comprised growth-regulatory and adhesion-related genes. Methylation direction predicted transcriptional output at 10 of 12 hub genes by qPCR. These hub genes are expressed across both fibroblast and keratinocyte populations in healthy skin, and lesional keratinocyte RNA-seq data showed directionally concordant expression changes, indicating shared transcriptional dysregulation across compartments. These findings suggest that Darier disease involves a stable fibroblast epigenetic state with cross-cell-type transcriptional relevance, potentially contributing to dermal-epidermal regulatory disruption in lesional skin.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13714876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149284441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "Reported Penicillin Allergy Affects the Length of Hospital Stay in Patients with Erysipelas". 对“报道青霉素过敏影响丹毒患者住院时间”的评论。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-10-27 DOI: 10.2340/actadv.v106.adv-2026-1009

Ewan A Langan

引用次数: 0

Subcorneal Pustular Dermatosis as a Complication of Upadacitinib Therapy in a Patient with Atopic Dermatitis: A Case Report. 角膜下脓疱性皮肤病是特应性皮炎患者Upadacitinib治疗的并发症：1例报告。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-10-27 DOI: 10.2340/actadv.v106.adv-2026-0900

Fatimah Budair, Jana AlZamil, Yara AlNashwan

引用次数: 0