Acta dermato-venereologica最新文献

Upadacitinib Induces Rapid Remission in Refractory Eosinophilic Pustular Folliculitis with Facial Involvement: A Case Report. Upadacitinib诱导面部受累的难治性嗜酸性脓疱性毛囊炎快速缓解：Aa例报告。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-09-02 DOI: 10.2340/actadv.v106.adv-2026-0701

Yanan Wang, Jinxuan Su, Hongzhong Jin

引用次数: 0

Temporal Inflammatory Profile in Skin Surface after Oronasal Mask Application. 应用口鼻口罩后皮肤表面的暂时性炎症特征。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-31 DOI: 10.2340/actadv.v106.adv-2025-0159

Amanda Feldt, William Lövfors, Elin Nyman, Peter R Worsley, Bijar Ghafouri, Sara Bergstrand

{"title":"Temporal Inflammatory Profile in Skin Surface after Oronasal Mask Application.","authors":"Amanda Feldt, William Lövfors, Elin Nyman, Peter R Worsley, Bijar Ghafouri, Sara Bergstrand","doi":"10.2340/actadv.v106.adv-2025-0159","DOIUrl":"10.2340/actadv.v106.adv-2025-0159","url":null,"abstract":"Skin damage from routine oronasal facemask use is common, but the early molecular changes and timing of inflammatory cytokine responses remain poorly characterized due to limitations in conventional detection methods. Early pressure ulcer formation involves a critical window where physiological changes occur before visible signs. This study addresses this gap, aiming to monitor the temporal inflammatory profile in skin sebumsurface after the standard use of oronasal facemasks. Sebum samples were collected from 11 patients at six6 timepoints up to 180 min post-mask removal. A panel of 71 inflammatory proteins was analysed using multivariate statistics, protein network analysis, and mathematical modelling. Two distinct cytokine response phases were identified: an early phase (0-20 min) and a delayed phase (40-180 min), with 17 cytokines driving this separation. Notably, the delayed phase showed sustained elevation despite the absence of visible erythema, indicating ongoing subclinical inflammation. Network analysis revealed activation of pathways related to angiogenesis, cell death regulation, and tissue remodelling - hallmarks of early wound healing and microvascular stress. These findings enhance understanding of early pressure ulcer pathophysiology, identify optimal biomarker sampling windows, and support the development of point-of-care biosensors for early detection and prevention of pressure-induced skin damage.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13527610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Daylight Photodynamic Therapy with Methyl Aminolevulinate Using an Abbreviated Illumination Protocol with the MultiLite Lamp System in Patients with Actinic Keratoses. 使用短照度和多灯系统的氨酰酸甲酯人工日光光动力疗法治疗光化性角化病患者。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-27 DOI: 10.2340/actadv.v106.adv-2026-0611

Mokone Mengis, Wolfgang G Philipp-Dormston

引用次数: 0

Patient Expectations and Perceived Treatment Benefit in Dermatology: A Sex-specific Analysis in Routine Dermatological Care. 皮肤科患者期望和治疗获益：常规皮肤科护理的性别特异性分析。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-27 DOI: 10.2340/actadv.v106.adv-2026-0668

Sarah Preis, Lucia Westphal, Tilo Biedermann, Sophia Horster, Alexander Zink

引用次数: 0

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-27 DOI: 10.2340/actadv.v106.adv-2026-0553

Célia Delesalle, Aude Huitric, Emilie Brenaut, Laurent Misery, Claire Abasq-Thomas

引用次数: 0

A Delphi Consensus on Tildrakizumab Dosing and Titration in Moderate-to-Severe Plaque Psoriasis. 关于Tildrakizumab给药和滴定治疗中重度斑块型银屑病的德尔菲共识

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-27 DOI: 10.2340/actadv.v106.adv-2026-0593

Julia-Tatjana Maul, Maria Concetta Fargnoli, Spyridon Gkalpakiotis, Jo Lambert, Andreas Pinter, Ricardo Ruiz-Villaverde, Paul Sator, Thrasyvoulos Tzellos

{"title":"A Delphi Consensus on Tildrakizumab Dosing and Titration in Moderate-to-Severe Plaque Psoriasis.","authors":"Julia-Tatjana Maul, Maria Concetta Fargnoli, Spyridon Gkalpakiotis, Jo Lambert, Andreas Pinter, Ricardo Ruiz-Villaverde, Paul Sator, Thrasyvoulos Tzellos","doi":"10.2340/actadv.v106.adv-2026-0593","DOIUrl":"10.2340/actadv.v106.adv-2026-0593","url":null,"abstract":"Tildrakizumab is approved for moderate-to-severe plaque psoriasis in 2 doses, 100 mg and 200 mg, with comparable safety profiles. This study aimed to establish pan-European consensus on optimal tildrakizumab dosing and titration using a modified Delphi methodology. A steering group of 8 European dermatologists developed 48 consensus statements addressing tildrakizumab prescribing, dose selection and titration. The statements were incorporated into an online Likert survey and distributed across 9 European countries to experienced dermatologists. Consensus was predefined as ≥75% agreement. Seventy-two dermatologists completed the survey. Consensus was achieved for 35/48 statements (73%). Based on the results, initiation with the 100 mg dose may be considered in patients weighing <90 kg with a body mass index <25, moderate disease severity or who are biologic-naïve. Initiation with the 200 mg dose may be considered in patients weighing ≥90 kg and/or with a body mass index ≥25, severe disease, high-impact area involvement in the context of severe disease, prior interleukin-23p19 inhibitor failure or failure of ≥2 biologics. Up-titration to 200 mg may be considered for suboptimal response, while down-titration to 100 mg may be considered after ≥1 year of sustained remission. Adoption of this guidance may facilitate more consistent, individualized dosing and improved patient outcomes.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13520585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148823700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Temporal Dissociation Between C-Reactive Protein and Neutrophil Counts After Spesolimab Treatment in Generalized Pustular Psoriasis. Spesolimab治疗广泛性脓疱性银屑病后c反应蛋白和中性粒细胞计数的早期时间解离。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-25 DOI: 10.2340/actadv.v106.adv-2026-0804

Ayu Watanabe, Masahiro Kamata, Yoshiki Okada, Kotaro Hayashi, Yayoi Tada

引用次数: 0

Truncal Acne Is Independently Associated with Stigmatization, Poorer Treatment Adherence and Greater Healthcare Utilization: A 20-country Survey. 躯干痤疮与污名化、较差的治疗依从性和较高的医疗保健利用率独立相关：一项20个国家的调查。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-25 DOI: 10.2340/actadv.v106.adv-2026-0642

Marco Rocha, Valérie Mangeaut, Jean-Daniel Daumont, Virginie Ribet, Charles Taieb, Bruno Halioua

{"title":"Truncal Acne Is Independently Associated with Stigmatization, Poorer Treatment Adherence and Greater Healthcare Utilization: A 20-country Survey.","authors":"Marco Rocha, Valérie Mangeaut, Jean-Daniel Daumont, Virginie Ribet, Charles Taieb, Bruno Halioua","doi":"10.2340/actadv.v106.adv-2026-0642","DOIUrl":"10.2340/actadv.v106.adv-2026-0642","url":null,"abstract":"Truncal acne (TA) affects 40-50% of adults with acne vulgaris and remains understudied despite its psychosocial impact. We aimed to evaluate the association of TA with stigmatization, psychosocial burden, healthcare utilization and treatment adherence, compared with exclusively facial acne (FA). We hypothesized that TA would be independently associated with greater psychosocial burden and healthcare utilization than FA alone. In this cross-sectional international online survey of 1,879 adults with physician-diagnosed acne (FA n=1,075; TA n=804) across 20 countries, multivariable logistic regression adjusted for age, sex and country showed that TA was independently associated with stigmatization (aOR 1.41 [95%CI 1.16-1.71]), hospitalization (aOR 1.73 [1.25-2.38]) and poor treatment adherence (aOR 1.26 [1.03 1.53]). Stigmatization was equally prevalent in truncal-only (49.2%) and combined facial-and truncal (50.5%) patients (aOR 1.00), indicating that it is intrinsic to truncal involvement rather than a consequence of facial disease. Truncal-only patients had lower dermatologist access (63.8% vs 78.9%) yet markedly higher hospitalization and surgical consultation rates. TA is independently associated with psychosocial burden and higher healthcare resource utilization; systematic trunk examination during acne consultations is warranted.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Colostomy May Improve Outcomes in Patients with Severe Anogenital and Gluteal Hidradenitis Suppurativa: Case Series. 结肠造口术可以改善严重肛门生殖器和臀部化脓性汗腺炎患者的预后：病例系列。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-25 DOI: 10.2340/actadv.v106.adv-2026-0533

Valdis Thorhallsdottir, Karin Berggård, Meirav Holmdahl, Martin Lindsten, Louis Banka Johnson, Artur Schmidtchen, Anja Pahlow Mose

引用次数: 0

Cardiovascular Risk Factors in Adults with Atopic Dermatitis: A Cross-sectional Study. 成人特应性皮炎的心血管危险因素：一项横断面研究

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-08-20 DOI: 10.2340/actadv.v106.adv-2026-0452

Raquel Sanabria-de la Torre, Andrés Oliver-Ramírez, Katrina Abuabara, Trinidad Montero-Vílchez, Salvador Arias-Santiago

{"title":"Cardiovascular Risk Factors in Adults with Atopic Dermatitis: A Cross-sectional Study.","authors":"Raquel Sanabria-de la Torre, Andrés Oliver-Ramírez, Katrina Abuabara, Trinidad Montero-Vílchez, Salvador Arias-Santiago","doi":"10.2340/actadv.v106.adv-2026-0452","DOIUrl":"https://doi.org/10.2340/actadv.v106.adv-2026-0452","url":null,"abstract":"Atopic dermatitis (AD) is a chronic inflammatory skin disease linked to systemic comorbidities, although its relationship with cardiovascular risk) remains controversial. The main objective of this study was to evaluate cardiovascular risk-related factors in AD and explore associations with disease severity. A cross-sectional study including adults with AD and healthy controls was conducted. Cardiovascular risk assessment included anthropometric, lifestyle, vascular and laboratory data, with global risk estimated using the PREVENT equations. The study included 100 adults (50 AD patients and 50 controls). Patients had moderate-to-severe disease (SCORAD 49.19±16.41). Compared with controls, AD patients showed higher BMI (27.25 vs 24.63 kg/m², p=0.01), lower Mediterranean diet adherence (p<0.001) and reduced physical activity (p=0.03). Mean arterial pressure (103.67 vs 93.55 mmHg, p=0.001), LDH (215.31 vs 183.88 IU/L; p=0.008) and CRP (7.90 vs 0.84 mg/L, p=0.05) were significantly higher in patients. Higher v-IGA scores were associated with increased fasting glucose and heart rate. Estimated 10 year cardiovascular risk was significantly higher in AD than in controls (p=0.04). Overall, AD patients exhibit an unfavourable cardiometabolic profile. Greater disease severity may be linked to vascular alterations, supporting the need for cardiovascular assessment in AD management.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13492059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0