Acta dermato-venereologica最新文献_第2页

The Regression Heterogeneity Pattern of Infantile Haemangiomas after Treatment with Propranolol: A Multicentre Retrospective Study. 普萘洛尔治疗后婴儿血管瘤的回归异质性：一项多中心回顾性研究。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-23 DOI: 10.2340/actadv.v105.44079

Kaizhi Zhang, Maierhaba Tuersuntuoheti, Wei Shan, Fan Hu, Yi Ji

引用次数: 0

Current Management of Chronic Pruritus by French Dermatologists. 法国皮肤科医生对慢性瘙痒症的当前管理。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-22 DOI: 10.2340/actadv.v105.43561

Emma Encarnaçao Domingos-Ancement, Emilie Brenaut, Laurent Misery

{"title":"Current Management of Chronic Pruritus by French Dermatologists.","authors":"Emma Encarnaçao Domingos-Ancement, Emilie Brenaut, Laurent Misery","doi":"10.2340/actadv.v105.43561","DOIUrl":"10.2340/actadv.v105.43561","url":null,"abstract":"Knowledge concerning pruritus is rapidly evolving and could deeply modify its management. The main objective was to evaluate the management of chronic pruritus by French dermatologists and their current knowledge. This prospective descriptive study used an online questionnaire, which was sent to French dermatologists via the newsletters of 3 dermatological associations. A total of 361 responses to the questionnaire were received, 80.1% from qualified dermatologists, 29.0% from dermatologists with their main practice in hospitals. Only half of respondents considered pruritus chronic after 6 weeks. The initial laboratory work-up included blood count (98.8%), creatinine (93.9%), liver function tests (98.6%), thyroid-stimulating hormone (93.9%), and serum protein electrophoresis (81.7%). There was a significant difference between hospital and non-hospital practitioners in the evaluation of creatinine, fasting blood glucose, viral serologies, syphilis serology, and skin biopsies. Some 34.6% of dermatologists disagreed that pruritus is present in the majority of psoriasis patients. French dermatologists' knowledge of chronic pruritus and its management is satisfactory, but there is still room for improvement and harmonization.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43561"},"PeriodicalIF":3.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LAight Therapy is an Effective and Gentle Treatment in Adolescents Suffering from Hidradenitis Suppurative: Results from 96 Patients Using Real-world Data. 光疗是一种有效且温和的治疗青少年化脓性汗腺炎的方法：来自96例患者使用真实世界数据的结果。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-22 DOI: 10.2340/actadv.v105.43543

Alexandra Strobel, Michael Schultheis, Petra Staubach, Stephan Grabbe, Katharina Hennig, Jacek Szepietowski, Łukasz Matusiak, Esther Von Stebut, Uwe Kirschner, Hans Bayer, Georgios Nikolakis, Simone Garcovich

{"title":"LAight Therapy is an Effective and Gentle Treatment in Adolescents Suffering from Hidradenitis Suppurative: Results from 96 Patients Using Real-world Data.","authors":"Alexandra Strobel, Michael Schultheis, Petra Staubach, Stephan Grabbe, Katharina Hennig, Jacek Szepietowski, Łukasz Matusiak, Esther Von Stebut, Uwe Kirschner, Hans Bayer, Georgios Nikolakis, Simone Garcovich","doi":"10.2340/actadv.v105.43543","DOIUrl":"10.2340/actadv.v105.43543","url":null,"abstract":"Hidradenitis suppurativa (HS) is a chronic skin condition characterized by the formation of painful nodules, abscesses, and tunnels, typically in intertriginous areas. While HS primarily affects adults, it causes in particular severe distress when it affects adolescent patients. Physicians prefer to avoid the use of systemic medications and surgery in children due to the potential side effects, psychological burden, and long-term consequences. The device-based LAight® therapy combines intense pulsed light and radiofrequency and received EU-wide approval in 2017 for the treatment of adults with all severities of HS. Since 2017, 96 adolescent patients in Germany and Austria have been treated off-label with LAight. A mixed model for repeated measures over 36 weeks on the endpoints Hidradenitis Suppurativa Severity Score System (IHS4), NRS Pain, and Dermatology Life Quality Index (DLQI) showed that patients starting treatment with a high burden significantly benefited from treatment, while those starting with a low burden could be effectively stabilized at a low level. HS and its management can cause considerable stress and anxiety for children and their families. Gentle and well-tolerated treatments, such as LAight therapy, can contribute to a more positive experience for patients and consequently improve their quality of life.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43543"},"PeriodicalIF":3.7,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12476048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Week 4 PASI Response Serve as an Early Predictor of Apremilast Efficacy in Psoriasis? A Single-Centre Preliminary Study. 第4周PASI反应可以作为Apremilast治疗银屑病疗效的早期预测指标吗？单中心初步研究。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-16 DOI: 10.2340/actadv.v105.44624

Seyma Nur Erol, Selda Pelin Kartal

引用次数: 0

Cost-effectiveness Analysis of Dupilumab for the Treatment of Adult Patients with Severe Prurigo Nodularis in Italy. 意大利Dupilumab治疗成人严重结节性痒疹的成本-效果分析。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-16 DOI: 10.2340/actadv.v105.43590

Cataldo Patruno, Massimiliano Povero, Andrea Tassone, Maria Paola Pedone, Donia Bahloul, Jules Tavi, Paolo Amerio

{"title":"Cost-effectiveness Analysis of Dupilumab for the Treatment of Adult Patients with Severe Prurigo Nodularis in Italy.","authors":"Cataldo Patruno, Massimiliano Povero, Andrea Tassone, Maria Paola Pedone, Donia Bahloul, Jules Tavi, Paolo Amerio","doi":"10.2340/actadv.v105.43590","DOIUrl":"10.2340/actadv.v105.43590","url":null,"abstract":"Prurigo nodularis is characterized by intensely pruritic nodules that significantly impact patients' quality of life. This study aims to evaluate the cost-effectiveness of dupilumab compared with the best supportive care for the treatment of severe prurigo nodularis from the perspective of the Italian National Health Service. A cost-effectiveness model was developed using a decision tree followed by a Markov approach with a lifetime horizon (30 years). Baseline characteristics, efficacy, and utility data were derived from the pooled analysis of PRIME and PRIME2 trials. Direct healthcare costs based on drug acquisition, adverse event and complications management, and disease-related healthcare resource utilization were considered. Dupilumab improved health outcomes, with an incremental gain of 1.481 quality-adjusted life-years compared with best supportive care. The total cost of dupilumab treatment was €148,964, compared with €70,957 for the best supportive care arm, thus resulting in an incremental cost-effectiveness ratio of €52,661 per quality-adjusted life-year. Scenario analyses indicated that at a discount ≥ 20%, the incremental cost-effectiveness ratio was lower than €40,000/quality-adjusted life-year. Deterministic and probabilistic sensitivity analyses confirmed the robustness of the results. Dupilumab is likely to be a cost-effective treatment for severe prurigo nodularis patients eligible for systemic therapy in Italy, as it reduces disease burden and healthcare costs associated with uncontrolled prurigo nodularis.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43590"},"PeriodicalIF":3.7,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145068837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Children Treated for Slow-flow Vascular Malformations: Overall Description and Focus on Complications Such as Cellulitis. 儿童治疗的慢流血管畸形：总体描述和重点并发症，如蜂窝织炎。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-10 DOI: 10.2340/actadv.v105.43494

Stephanie Bredy, Emilie Coronas, Caroline Degrugillier-Chopinet, Emeline Cailliau, Benoit Catteau, François Dubos

{"title":"Children Treated for Slow-flow Vascular Malformations: Overall Description and Focus on Complications Such as Cellulitis.","authors":"Stephanie Bredy, Emilie Coronas, Caroline Degrugillier-Chopinet, Emeline Cailliau, Benoit Catteau, François Dubos","doi":"10.2340/actadv.v105.43494","DOIUrl":"10.2340/actadv.v105.43494","url":null,"abstract":"Some patients with slow-flow vascular malformations (SFVMs) develop recurring cellulitis. The main objective of this study was to describe SFVMs in children. Other objectives were to determine the frequency of cellulitis episodes, and the factors associated with the occurrence of cellulitis. This retrospective, longitudinal, single-centre study included all children with SFVMs being managed at Lille University Hospital between 1994 and 2020. Data were collected using a standardized questionnaire. After a descriptive analysis, the variables associated with the onset of cellulitis were analysed; 133 patients (median age at diagnosis: 72 months; 53% girls) were included. SFVMs were: venous (81%), lymphatic-venous (10%), capillary-venous (5%), and lymphatic (4%). Nine children had presented at least 1 episode of cellulitis (7%, 95% CI: 4-12) and 29 episodes were reported (median: 3, interquartile range: 2-4; median age at the first episode: 3.5 years). Cellulitis occurred more frequently in young children, with lymphatic and syndromic forms of SFVM, large SFVMs, affecting skin folds, and without long-term SFVM treatment. In conclusion, the occurrence of cellulitis in patients with a SFVM is rare. However, after the first episode, it frequently becomes recurrent, particularly in some patients with identified risk factors, who may require antibiotic prophylaxis.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43494"},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12427584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK1 Inhibition with Upadacitinib in a Patient with Refractory Severe Chronic Spontaneous Urticaria and Concomitant Rheumatoid Arthritis: Complete Resolution of Urticaria and Remission of Rheumatoid Arthritis. Upadacitinib对难治性重度慢性自发性荨麻疹合并类风湿关节炎患者JAK1的抑制作用：荨麻疹的完全解决和类风湿关节炎的缓解

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-10 DOI: 10.2340/actadv.v105.44312

Israel Magen, Iris Leibovich, Eli Magen

引用次数: 0

Impact of Alopecia Areata on Major Life-changing Decisions: Prevalence and Associated Factors. 斑秃对重大生活改变决定的影响：患病率和相关因素。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-10 DOI: 10.2340/actadv.v105.43039

Daniel Muñoz-Barba, Alberto Soto-Moreno, Sofía Haselgruber-de Francisco, Manuel Sánchez-Díaz, Salvador Arias-Santiago

{"title":"Impact of Alopecia Areata on Major Life-changing Decisions: Prevalence and Associated Factors.","authors":"Daniel Muñoz-Barba, Alberto Soto-Moreno, Sofía Haselgruber-de Francisco, Manuel Sánchez-Díaz, Salvador Arias-Santiago","doi":"10.2340/actadv.v105.43039","DOIUrl":"10.2340/actadv.v105.43039","url":null,"abstract":"Alopecia areata is a prevalent autoimmune condition causing non-scarring alopecia, with significant impacts on quality of life. However, the long-term effects on major life-changing decisions remain understudied. A cross-sectional study was performed including patients with alopecia areata who attended the Dermatology Department of the Virgen de las Nieves University Hospital. Patients were asked to complete questionnaires to assess the impact of alopecia areata on major life-changing decisions and quality of life. A total of 70 patients were included: 71% were female and 29% were male. The mean age was 38.70 (SD 14.32). The most affected major life-changing decisions were couple relationships and dressing; followed by job performance, social relationships, lifestyle changes, and sports practice. Female gender, higher therapeutic burden, or Dermatology Life Quality Index scores, and lower World Health Organization Five Well Being Index rating were significantly associated with greater major life-changing decisions impairment (p < 0.05). Disease severity and duration did not correlate with increased impact in most major life-changing decisions (p > 0.10). In conclusion, there are some major life-changing decisions that appear to be significantly affected in patients with alopecia areata. The identification of factors associated such us female gender, therapeutic burden, or alterations in mental well-being is crucial to explore and limit the long-term negative effects of the disease.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43039"},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12427581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Stigmatization on Working Nurses' Willingness to Care for Patients with Psoriasis and Its Mediating Factors. 污名化对在职护士护理银屑病患者意愿的影响及其影响因素。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-10 DOI: 10.2340/actadv.v105.43662

Shuzhen Kong, Haoru Niu, Xinyu Xu, Ruixue Wang, Simeng Cui, Jiarui Xie, Weihua Zou, Jianqiao Ye, Deling Kong, Cong Yao, Huiyun Yang, Baibing Mi, Songmei Geng

{"title":"The Effect of Stigmatization on Working Nurses' Willingness to Care for Patients with Psoriasis and Its Mediating Factors.","authors":"Shuzhen Kong, Haoru Niu, Xinyu Xu, Ruixue Wang, Simeng Cui, Jiarui Xie, Weihua Zou, Jianqiao Ye, Deling Kong, Cong Yao, Huiyun Yang, Baibing Mi, Songmei Geng","doi":"10.2340/actadv.v105.43662","DOIUrl":"10.2340/actadv.v105.43662","url":null,"abstract":"Psoriasis-related stigmatization affects nurses' willingness to provide care, potentially compromising patient outcomes. However, limited research has examined this issue. A cross-sectional survey of 1,873 nurses was conducted, which assessed 4 stigmatization dimensions and their correlation with the willingness to care for patients with psoriasis, and explored the roles of education, working environment, and self-reported psoriasis knowledge. Structural equation modelling and regression analyses were conducted. The results revealed that stigmatization negatively impacted nurses' willingness to provide care (p < 0.001), with social distance exhibiting the strongest effect (r = -0.476, OR = 0.87, 95% CI: 0.85-0.88, p < 0.001). A significant dose-response relationship was observed, where higher stigmatization levels corresponded to lower care willingness (overall trend test: p < 0.001; nonlinear trend test: p < 0.001). Nurses with higher education levels (p < 0.001) or those working in tertiary hospitals (p < 0.001) demonstrated lower willingness to provide care. Interestingly, greater self-reported psoriasis knowledge was associated with increased stigmatization, which in turn reduced care willingness (direct effect: -0.618; 95% CI: -0.814, -0.422; proportion mediated: 29.0%, 95% CI: 0.094, 0.486). These findings underscore the need for targeted training programmes, improved work environments, and stigma-reduction initiatives to enhance nurses' willingness to care for patients with psoriasis.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43662"},"PeriodicalIF":3.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12427992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145028781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

JAK Inhibitors in Down Syndrome: Alopecia Areata Resolution and Vitiligo Improvement with Baricitinib. 唐氏综合征的JAK抑制剂：Baricitinib治疗斑秃和白癜风。

IF 3.7 4区医学

Acta dermato-venereologica Pub Date : 2025-09-10 DOI: 10.2340/actadv.v105.44081

Federica Li Pomi, Mario Vaccaro, Marta Vitale, Roberta Alaimo, Francesco Borgia

引用次数: 0