Sonja Molin, Emma Guttman-Yassky, Jacob P Thyssen, Anthony Bewley
{"title":"Chronic Hand Eczema, Real World, and Patient Centricity: A Narrative Review.","authors":"Sonja Molin, Emma Guttman-Yassky, Jacob P Thyssen, Anthony Bewley","doi":"10.2340/actadv.v105.42596","DOIUrl":"10.2340/actadv.v105.42596","url":null,"abstract":"<p><p>Chronic hand eczema is a multifactorial, fluctuating, inflammatory skin disease of the hands and wrists, defined as hand eczema that persists for at least 3 months or recurs at least twice within 1 year. Chronic hand eczema is heterogeneous in nature with different clinical manifestations. This chronic condition can significantly impact daily activities and health-related quality of life for patients, including notable physical, psychosocial, occupational, and socioeconomic burdens. However, awareness of the disease and the patient experience remains poor. This review aims to improve understanding of chronic hand eczema in the context of its underlying pathogenesis, clinical subtypes and presentation, and risk factors. Additionally, an overview of the patient experience of the disease, including health-related quality of life and socioeconomic implications, is provided. Improved understanding of chronic hand eczema will support optimal patient care by empowering healthcare providers to more quickly and correctly diagnose this disease with high unmet treatment needs and subsequently offer appropriate holistic care.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42596"},"PeriodicalIF":3.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lucia Fuentes-Barragán, Carmen García-Moronta, Raquel Sanabria-de la Torre, Francisco Javier León-Pérez, Alejandro Molina-Leyva, Salvador Arias-Santiago, Trinidad Montero-Vílchez
{"title":"Impact on Major Life-changing Decisions in Patients with Atopic Dermatitis.","authors":"Lucia Fuentes-Barragán, Carmen García-Moronta, Raquel Sanabria-de la Torre, Francisco Javier León-Pérez, Alejandro Molina-Leyva, Salvador Arias-Santiago, Trinidad Montero-Vílchez","doi":"10.2340/actadv.v105.42241","DOIUrl":"10.2340/actadv.v105.42241","url":null,"abstract":"<p><p>Atopic dermatitis (AD) is a chronic skin disease that significantly affects patients' quality of life. While other dermatological conditions like psoriasis are known to impact major life-changing decisions (MLCD), no prior studies have evaluated this in AD. A descriptive cross-sectional study was conducted in patients with AD of at least 6 months' duration. Sociodemographic and clinical characteristics of the patients, as well as severity from both the physician's and patient's point of view, were assessed using different rating scales such as the Eczema Area and Severity Index (EASI). Subsequently, patients were divided according to disease severity into severe AD (EASI ≥ 21) or mild-moderate AD (EASI < 21). Life decisions were evaluated across several areas, including work, education, social life, reproduction, recreation, housing, and lifestyle, using a 4-point Likert scale. A total of 104 patients, with an average disease duration of 20.36 years, were included. The results showed significant MLCD impairment, especially in clothing choices (52.9%), lifestyle (48.1%), and sports activities (41.4%). Severe AD was associated with greater social and emotional challenges, such as difficulties in social interactions (48.6% vs 26.1%) and romantic relationships (48.5% vs 18.8%) compared with mild-moderate AD. These findings highlight the profound impact of AD on daily life, emphasizing the need for comprehensive management strategies that address physical, psychological, and social aspects.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42241"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Uncovering the Life-long Impact of Skin Disease on Major Life Changing Decisions.","authors":"Faraz M Ali, Andrew Y Finlay","doi":"10.2340/actadv.v105.43472","DOIUrl":"10.2340/actadv.v105.43472","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43472"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiple Nail Dystrophy Associated with Human Papillomavirus Type 29 (HPV-29).","authors":"Tomoko Hirano, Gyohei Egawa, Takashi Nomura, Kenji Kabashima","doi":"10.2340/actadv.v105.43160","DOIUrl":"10.2340/actadv.v105.43160","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43160"},"PeriodicalIF":3.5,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacek C Szepietowski, Katarzyna M Jankowska, Dmitry Bashmakov, Piotr K Krajewski, Tatyana Svyatenko
{"title":"Chronic Itch Among Soldiers and Civilians: A Cross-sectional Study During the War in Ukraine.","authors":"Jacek C Szepietowski, Katarzyna M Jankowska, Dmitry Bashmakov, Piotr K Krajewski, Tatyana Svyatenko","doi":"10.2340/actadv.v105.43119","DOIUrl":"10.2340/actadv.v105.43119","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43119"},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971838/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katharine Hopkins, Annarita Antelmi, Jakob Dahlin, Karin Olsson, Cecilia Svedman, Jacqueline Åstrand, Peter Olsson, Magnus Bruze
{"title":"Clinical Relevance of Contact Allergy to Gold Sodium Thiosulphate in Fibromyalgia.","authors":"Katharine Hopkins, Annarita Antelmi, Jakob Dahlin, Karin Olsson, Cecilia Svedman, Jacqueline Åstrand, Peter Olsson, Magnus Bruze","doi":"10.2340/actadv.v105.42463","DOIUrl":"10.2340/actadv.v105.42463","url":null,"abstract":"<p><p>Fibromyalgia is a chronic syndrome characterized by pain, fatigue, and cognitive disturbances. The increased prevalence of contact allergy to gold in individuals with fibromyalgia when compared with the general population has previously been described. Gold contact allergy can manifest as a systemic contact dermatitis, with cutaneous and extracutaneous manifestations presenting upon systemic administration of gold. This study aimed to establish whether gold allergy is of significance in the fibromyalgia population. Prior to patch testing with the Swedish baseline series and an extended dental series, 119 females with fibromyalgia answered questionnaires including details of past medical history, dental history, and previous cutaneous and mucous membrane intolerance to metals. Prevalence of allergy to gold sodium thiosulphate (2.0% and 5.0%) was 33.6% (40 individuals). There was a statistically significant overrepresentation of gold allergy among individuals who experienced cutaneous symptoms upon direct contact with gold (p = 0.010). Contact allergy to gold was more frequent among patients with oral symptoms (p = 0.024). This study demonstrates concordance between reported cutaneous symptomatology related to gold exposure and gold allergy in the fibromyalgia population. Whether individuals with oral symptoms and gold allergy have objective oral clinical findings and relevant gold exposure is the focus of ongoing study.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42463"},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rina Obata, Mika Yamanaka-Takaichi, Hisayoshi Imanishi, Tomoko Oshimo, Daisuke Tsuruta
{"title":"Generalized Pustular Psoriasis with Breast Cancer Successfully Treated with Spesolimab Causing Neutrophilia: A Case Report.","authors":"Rina Obata, Mika Yamanaka-Takaichi, Hisayoshi Imanishi, Tomoko Oshimo, Daisuke Tsuruta","doi":"10.2340/actadv.v105.42368","DOIUrl":"10.2340/actadv.v105.42368","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42368"},"PeriodicalIF":3.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recurrent Neutrophilic Dermatosis of the Face Successfully Treated with Potassium Iodide.","authors":"Masakazu Kakurai, Atsushi Oda, Yoshihiro Moriyama","doi":"10.2340/actadv.v105.42065","DOIUrl":"10.2340/actadv.v105.42065","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42065"},"PeriodicalIF":3.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}