Acta dermato-venereologica最新文献_第2页

Skin Rash on Immunotherapy: When Trombicula Mimics a Cutaneous Immune-related Adverse Event. 皮肤皮疹免疫治疗：当恙螨模拟皮肤免疫相关的不良事件。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-08 DOI: 10.2340/actadv.v105.43467

Léa Frigout, Taha Tagmouti, Pierre Goineau, Anne Dompmartin, Jean Matthieu L'Orphelin

引用次数: 0

Comparison of Adjuvant and Salvage Therapy with Immune Checkpoint Inhibitors in Head and Neck Mucosal Melanoma Treated with Proton Beam Therapy: A Retrospective Cohort Study. 质子束治疗头颈部黏膜黑色素瘤的辅助和挽救治疗与免疫检查点抑制剂的比较：一项回顾性队列研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-08 DOI: 10.2340/actadv.v105.43602

Ken Horisaki, Shusuke Yoshikawa, Wataru Omata, Arata Tsutsumida, Yoshio Kiyohara

引用次数: 0

Potential Role of Ozenoxacin 1% Cream in the Topical Management of Hidradenitis Suppurativa: A Single-centre Experience (44 patients). 1%奥硝沙星乳膏局部治疗化脓性汗腺炎的潜在作用：单中心研究（44例）。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-03 DOI: 10.2340/actadv.v105.43629

Pablo Fernández-Crehuet, Delia Diaz-Ceca, F Javier Melgosa Ramos

引用次数: 0

Oral Manifestations of Bullous Systemic Lupus Erythematosus: A Systematic Review. 大疱性系统性红斑狼疮的口腔表现：系统综述。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-03 DOI: 10.2340/actadv.v105.43569

Gabrielle Keller Goff, Amy Xu

引用次数: 0

Bidirectional Risk Association Between Hidradenitis Suppurativa and Inflammatory Bowel Disease. 化脓性汗腺炎与炎症性肠病的双向风险关联

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-03 DOI: 10.2340/actadv.v105.43657

Louise Lönndahl, Maria Najeeb, Hassan Killasli, Lennart Emtestam, Ralf J Ludwig, Philip Curman

{"title":"Bidirectional Risk Association Between Hidradenitis Suppurativa and Inflammatory Bowel Disease.","authors":"Louise Lönndahl, Maria Najeeb, Hassan Killasli, Lennart Emtestam, Ralf J Ludwig, Philip Curman","doi":"10.2340/actadv.v105.43657","DOIUrl":"10.2340/actadv.v105.43657","url":null,"abstract":"Hidradenitis suppurativa is an inflammatory skin disease of the pilosebaceous unit encompassing painful, recurrent, and malodorous abscesses, inflammatory nodules, dermal sinus tracts, and cicatrices. Hidradenitis suppurativa has been linked to several comorbidities, including inflammatory bowel disease, though evidence is limited by small sample sizes and possible bidirectional associations remain uncertain. A large-scale, propensity-score matched retrospective cohort study was performed using the TriNetX platform to investigate bidirectional risks between hidradenitis suppurativa and inflammatory bowel disease. Data included over 200,000 hidradenitis suppurativa patients and 3.3 million inflammatory bowel disease patients. Hidradenitis suppurativa was associated with a 36% increased risk of developing any inflammatory bowel disease diagnosis within 5 years of diagnosis (hazard ratio [HR] 1.356, confidence interval [CI] 1.313-1.401), with the highest risk of Crohn's disease (HR 2.501, CI 2.209-2.832), followed by ulcerative colitis (UC) (HR 1.722, CI 1.536-1.930), and other/unspecified inflammatory bowel disease (HR 1.349, CI 1.306-1.394). Conversely, individuals with any inflammatory bowel disease diagnosis had a 31% increased risk of developing hidradenitis suppurativa (HR 1.313, CI 1.274-1.353), with Crohn's disease showing the strongest association (HR 2.441, CI 2.242-2.658), followed by UC (HR 1.493, CI 1.358-1.642). These findings highlight the bidirectional risk relationship between hidradenitis suppurativa and inflammatory bowel disease, demonstrating that the likelihood of developing either condition is significantly elevated in patients already diagnosed with the other.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43657"},"PeriodicalIF":3.5,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Field Cancerization Treatment with Tirbanibulin 1% Ointment: Results in Real-World Practice. 1%替巴布林软膏治疗现场癌变：现实世界实践的结果。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-01 DOI: 10.2340/actadv.v105.42927

Francisco Vílchez-Márquez, Daniel Muñoz-Barba, Alberto Soto-Moreno, Antonio Martínez-López, Salvador Arias-Santiago

引用次数: 0

Inhibitory Immune Checkpoints beyond Programmed Cell Death Ligand 1 in Merkel Cell Carcinoma: Abundant Expression of TIGIT Independent of the Presence of Merkel Cell Polyoma Virus. 梅克尔细胞癌中程序性细胞死亡配体1外的抑制免疫检查点：独立于梅克尔细胞多瘤病毒存在的TIGIT的丰富表达

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-01 DOI: 10.2340/actadv.v105.42882

Ferdinand Toberer, Julia K Winkler, Leroy Atienza Fernandez, Lea Adams, Alexander Brobeil, Marcell Tóth, Alexander H Enk, Jürgen C Becker, Anke Lonsdorf

{"title":"Inhibitory Immune Checkpoints beyond Programmed Cell Death Ligand 1 in Merkel Cell Carcinoma: Abundant Expression of TIGIT Independent of the Presence of Merkel Cell Polyoma Virus.","authors":"Ferdinand Toberer, Julia K Winkler, Leroy Atienza Fernandez, Lea Adams, Alexander Brobeil, Marcell Tóth, Alexander H Enk, Jürgen C Becker, Anke Lonsdorf","doi":"10.2340/actadv.v105.42882","DOIUrl":"10.2340/actadv.v105.42882","url":null,"abstract":"Merkel cell carcinoma is a rare, aggressive skin cancer in which Merkel cell polyoma virus (MCPyV) is frequently pathogenically involved. After failure of anti-programmed cell death protein 1/programmed cell death ligand 1 immunotherapy, therapeutic options for advanced disease are limited. The contribution of the coinhibitory checkpoint molecule T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), a regulator of exhausted CD8+ T cells, to the immunosuppressive Merkel cell carcinoma microenvironment is understudied. This study evaluated the immunohistochemical expression of tumour (Tumor Proportion Score, TPS) and infiltrating immune cells (Immune Cell Score, ICS) for programmed cell death ligand 1, TIGIT, its high-affinity receptor CD155, and CD8 in 21 primary Merkel cell carcinoma and 6 metastases. Unlike CD155, TIGIT was abundantly expressed by tumour and immune cells and independent of the MCPyV status, determined by RT-PCR. Programmed cell death ligand 1+ immune cells were significantly increased in TIGIT TPS-positive and MCPyV-positive primary MCC along with significant intercorrelations of programmed cell death ligand 1 and TIGIT immune cell expression and CD8+ infiltrates. Programmed cell death ligand 1 IC-positivity correlated with superior disease-specific survival. The data indicate that TIGIT may contribute to local immune dysfunction in Merkel cell carcinoma, beyond programmed cell death ligand 1 and independent of MCPyV, and provide a rationale to further explore TIGIT as a potential target for Merkel cell carcinoma immunotherapy.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42882"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235568/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Long-term Stability on Mental Health in Adults with Atopic Dermatitis: A Cohort Study with Unsupervised Cluster Analysis. 长期稳定性对成人特应性皮炎患者心理健康的影响：一项无监督聚类分析的队列研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-01 DOI: 10.2340/actadv.v105.43071

Lea K Nymand, Mia-Louise Nielsen, Maria Oberländer Christensen, Simon F Thomsen, Jacob P Thyssen, Alexander Egeberg

{"title":"Impact of Long-term Stability on Mental Health in Adults with Atopic Dermatitis: A Cohort Study with Unsupervised Cluster Analysis.","authors":"Lea K Nymand, Mia-Louise Nielsen, Maria Oberländer Christensen, Simon F Thomsen, Jacob P Thyssen, Alexander Egeberg","doi":"10.2340/actadv.v105.43071","DOIUrl":"10.2340/actadv.v105.43071","url":null,"abstract":"Atopic dermatitis (AD) is a heterogeneous disease characterized by unpredictable flares, potentially leading to impaired mental health. Adult patients with a dermatologist-verified AD diagnosis received after their 18th birthday were grouped according to patient-reported flare activity between 2018 and 2023. The k-means clustering algorithm was used in combination with dynamic time warping and barycenter averaging. Clusters were analysed according to current levels of anxiety and depression and severity across the 4 time points. The clustering method divided the 262 patients into 4 groups. Cluster 1 was characterized by a disease course with an average of < 6 annual flares, a median (interquartile range) anxiety and depression score of 3.0 (1.0-6.3), and 1.0 (0.0-4.0), respectively. Clusters 2 and 3 were characterized by annual flares ranging from 4 to 16 and anxiety scores of 6.0 (3.0-8.5) and 4.0 (2.0-7.0) and depression scores of 3.0 (1.0-6.0) and 2.0 (1.0-5.0), respectively. Cluster 4 was characterized by an unstable disease course with an average of ≥ 14 yearly flares, and anxiety and depression scores similar to cluster 2. Patients characterized by an unstable moderate disease course were more burdened compared with patients with a stable disease course (p = 0.03). This emphasizes the importance of long-term flare patterns in clinical decision-making.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv43071"},"PeriodicalIF":3.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12235569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chlamydia trachomatis Infections: A Rapid Decrease in Denmark from 2022 to 2024 is Driven by the Young Population. 沙眼衣原体感染：丹麦从2022年到2024年的快速下降是由年轻人口驱动的。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-01 DOI: 10.2340/actadv.v105.43603

Thomas Roland Pedersen, Kirsten Salado-Rasmussen, Steen Hoffmann, Maria Wessman, Jørgen Skov Jensen

引用次数: 0

Dupilumab Achieves Early Disease Control in Bullous Pemphigoid: A Case Series with TARC-based Biomarker Evaluation. Dupilumab实现大疱性类天疱疮的早期疾病控制：基于tarc的生物标志物评估的病例系列

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-07-01 DOI: 10.2340/actadv.v105.43999

Saori Takamura, Tomoo Fukuda

引用次数: 0