Acta dermato-venereologica最新文献

{"title":"Objectively Measured Photoaging and Skin Cancer in Organ Transplant Recipients.","authors":"Stine R Wiegell, Peter A Philipsen, Susanne K Kjær, Jay F Nash, Peter Bjerring, Merete Hædersdal","doi":"10.2340/actadv.v106.adv-2026-0417","DOIUrl":"10.2340/actadv.v106.adv-2026-0417","url":null,"abstract":"<p><p>Solid organ transplant recipients (SOTRs) have an increased risk of keratinocyte skin cancer (KC) due to lifelong immunosuppression. Photoaging, reflecting cumulative ultraviolet (UV) exposure, may serve as a biomarker of KC risk. This study characterized objective photoaging features in SOTRs and their association with age, photodamage, photoaging phenotype, actinic keratoses (AKs) and KC history. In 251 SOTRs, VISIA imaging showed significant age-related increases in photoaging features; median red- feature scores reflecting erythema and telangiectasia were 44 AU (arbitrary units) in patients >60 vs 22 AU in those <60. Higher clinical photodamage severity corresponded to higher VISIA scores, especially red- features and visible- spots. The atrophic photoaging phenotype, observed in 60 % of patients, showed higher red- features (40 AU) than the hypertrophic type (27 AU). Patients with AKs had elevated UV- spots and red- features. A history of KC (32 % of participants) was associated with older age, longer time since transplantation, fairer skin type, more severe photodamage, higher VISIA scores, especially red- features (45 AU vs 29 AU) and greater pigmentation on sun-exposed sites. Objective imaging identified photoaging features associated with cumulative UV damage. Further studies should evaluate their predictive value for KC development to improve individualized risk stratification and surveillance strategies in this high-risk population.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13625172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Eruptive Facial Tumours in a 72-year-old Man Receiving Pembrolizumab: A Quiz.","authors":"Charlotte Desjonqueres, Baptiste Sourty, Hervé Maillard","doi":"10.2340/actadv.v106.adv-2026-0500","DOIUrl":"https://doi.org/10.2340/actadv.v106.adv-2026-0500","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of Best Evidence for Wound Management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.","authors":"Shuzhen Kong, Haoru Niu, Simeng Cui, Yuxuan Kong, Yingnan Zhai, Jianqiao Ye, Yuanjie Zhang, Haoyang Hong, Jiahui Tian, Yirui Zhou, Bin Peng, Baibing Mi, Songmei Geng","doi":"10.2340/actadv.v106.adv-2026-0511","DOIUrl":"10.2340/actadv.v106.adv-2026-0511","url":null,"abstract":"<p><p>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threate-ning mucocutaneous reactions characterized by extensive epidermal detachment and systemic complications. Wound management is central to survival and long-term outcomes, yet standardiz-ed care pathways remain controversial and in-consistently implemented. This study aimed to systematically synthesize the best available evidence on wound management for patients with SJS/TEN to support clinical decision-making and optimize clinical outcomes. A comprehensive search of major international and Chinese databases and authoritative websites was conducted from January 2010 to May 2025 to collect relevant clinical decisions, guidelines, expert consensus, systematic reviews, and evidence summaries. Two reviewers independently screened and evaluated the literature, and then extracted and summarized evidence using the JBI grading system. A total of 14 high-quality publications met the inclusion criteria, yielding 28 pieces of best evidence across seven7 domains: wound assessment, conservative management, surgical approach, dressing selection, pain management, infection prevention and surveillance, and hospital setting. Among them, 11 recommendations were graded as strong and 17 as weak. This evidence-based synthesis provides practical guidance for wound management in SJS/TEN and supports the development of standardized care protocols to promote epithelial recovery, reduce complications, and improve quality of life.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Minocycline-induced DIHS/DRESS with Predominant Pulmonary Involvement.","authors":"Eriko Oiwa, Mayu Kanamoto, Hikari Sakamoto, Ibuki Uchino, Shunsuke Takahagi","doi":"10.2340/actadv.v106.adv-2026-0829","DOIUrl":"10.2340/actadv.v106.adv-2026-0829","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linear Atrophoderma of Moulin with Telangiectatic Erythema: An Atypical Presentation.","authors":"Shiwen Guo, Yanjing Chen, Lin Wang","doi":"10.2340/actadv.v106.adv-2026-0951","DOIUrl":"10.2340/actadv.v106.adv-2026-0951","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three Progressive Upper Trunk Nodules: A Quiz.","authors":"Sophie Reiser, Kai-Philipp Linse","doi":"10.2340/actadv.v106.adv-2025-0161","DOIUrl":"10.2340/actadv.v106.adv-2025-0161","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13617985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149068915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Systemic Immunomodulating Drugs and Management Practices in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis among Dermatologists in the Philippines: A Cross-sectional Survey Study.","authors":"Ivan Arni Preclaro, Michaela Tabalon-Morales, Ma Corazon Iniego-Rodas, Lian Jamisola","doi":"10.2340/actadv.v106.adv-2026-0499","DOIUrl":"10.2340/actadv.v106.adv-2026-0499","url":null,"abstract":"<p><p>Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are rare, life-threatening cutaneous adverse drug reactions with potential morbidity and mortality. Despite increasing use of systemic immunomodulatory therapies, consensus regarding optimal medical management remains lacking, particularly in resource-limited settings. We evaluated management practices and treatment preferences for SJS/TEN among board-certified dermatologists in the Philippines using a clinical vignette-based (CV) survey approach.</p><p><strong>Methods: </strong>A cross-sectional online survey was conducted among Philippine board-certified dermatologists from January to June 2025. The survey assessed res-pondent characteristics, clinical experience with SJS/TEN, management practices, referral patterns, and treatment preferences across six6 standardized CVs. Ordinal data were analysed using weighted scores, Friedman tests, and Kendall's coefficient of concordance to assess inter-physician agreement..</p><p><strong>Results: </strong>There were forty-eight48 dermatologists participated. Most respondents reported prior SJS/TEN experience and inpatient clinical exposure. Corticosteroids were the most commonly used systemic therapy (85.4%), while 35.4 % reported managing selected cases with supportive care alone. Significant differences in treatment rankings were observed across all six6 vignettes (all p<0.001). Agreement was large for CV1 (W=0.516), moderate for CV2-5 (W=0.398-0.465), and small for CV6 (W=0.236). Corticosteroids and IVIG consistently ranked highest, while other immunosuppressants showed scenario-dependent variability.</p><p><strong>Conclusions: </strong>The use of systemic immunosuppressants remains to be preferred in SJS/TEN treatment. However, treatment practices among Filipino dermatologists demonstrate substantial heterogeneity especially in complex cases. These findings highlight the need for stratified treatment frameworks and persistent uncertainty in SJS/TEN management.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic Diagnosis of Actinic Keratosis: A Systematic Review.","authors":"Younes Kazbennaou, Marie Boileau, Cyril Maire, Nadira Delhem, Anne-Sophie Dewalle, Laurent Mortier","doi":"10.2340/actadv.v106.adv-2026-0949","DOIUrl":"10.2340/actadv.v106.adv-2026-0949","url":null,"abstract":"<p><p>Actinic keratosis (AK) is a precancerous condition typically diagnosed by hyperkeratotic papules. The concept of field cancerization suggests subclinical lesions surround visible actinic keratoses. Photodynamic diagnosis (PDD)is a non-invasive imaging modality that can im-prove actinic keratosis diagnosis and treatment assessment. This systematic review describes current evidence regarding photodynamic diagnosis modalities for actinic keratosis. We searched MEDLINE and Embase through 28 February, 2025. Data synthesis was descriptive due to methodological heterogeneity across studies. Thirty-seven studies were included. Methyl aminolevulinate(MAL) and aminolevulinic acid (ALA)were used in 54% and 51% of studies, respectively. Incubation times ranged from 20 to 1080 min, 70 % of studies followed a 3 -h protocol. Most excitation sources (89%) emitted light within the 400-410 nm range, often via clinical-grade systems (54%). Imaging hardware varied: 54 % used integrated clinical systems, 30 % used independent cameras. Fluorescence quantification was described in 62 % of studies, and 54 % used specialized analysis software. Patient positioning was rarely reported (8%). This review highlights significant methodological heterogeneity in actinic keratosis photodynamic diagnosis, particularly in photosensitizer protocols and imaging systems. While clinical-grade systems provide standardization, low-cost alternatives enhance accessibility. However, lack of procedural consistency limits comparability. Future efforts should focus on advancing standardized protocols to support broader clinical validation and adoption.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thymoma-associated Multiorgan Autoimmunity Presenting as Severe Psoriasiform Keratotic Erythroderma 35 Years after Thymoma Diagnosis.","authors":"Kazuki Higuchi, Mika Watanabe, Sho Katayama, Takamasa Ito, Hideyuki Ujiie","doi":"10.2340/actadv.v106.adv-2026-0814","DOIUrl":"10.2340/actadv.v106.adv-2026-0814","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13596028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity and Risk of Autoimmune Bullous Skin Diseases: A Prospective Cohort Study.","authors":"Shuai Ju, Guowei Zhou, Changmin Liu, Fangfang Li, Qingyu Hong, Wanyao Liu, Hong Liu, Jia Guo","doi":"10.2340/actadv.v106.adv-2026-0705","DOIUrl":"10.2340/actadv.v106.adv-2026-0705","url":null,"abstract":"<p><p>Physical activity has been linked to immunee regulation in several autoimmune diseases, but its association with autoimmune bullous skin diseases (AIBD), mainly pemphigus and pemphigoid, has not been adequately evaluated. We examined the association between regular physical activity and incident AIBD in 476,057 UK Biobank participants. Multivariable-adjusted Cox models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) for AIBD risk according to habitual physical activity. We also assessed joint associations with polygenic risk and performed mediation analysis. During a median follow-up of 15.21 years, 272 incident AIBD cases were documented, including 61 pemphigus and 211 pemphigoid cases. Physically active participants had a 31% lower risk of AIBD than inactive participants (adjusted HR 0.69, 95% CI 0.54-0.88). Similar associations were observed for pemphigus (HR 0.53) and pemphigoid (HR 0.72). Individuals with high genetic risk who were physically inactive had a higher risk than physically active individuals with low genetic risk (HR 2.12, 95% CI 1.47-3.07). In an exploratory mediation analysis, BMI accounted for 8.86 % of the association. These findings suggest that regular physical activity is associated with a lower risk of AIBD after adjustment for genetic susceptibility and other risk factors.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13595829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}