Acta dermato-venereologica最新文献_第2页

Increased use of Dermoscopy in Primary Healthcare Following the Implementation of Teledermatology in Southeast Sweden: A Retrospective Cohort Study of 2,137 Patients. 瑞典东南部实施远程皮肤病学后，基层医疗机构增加了皮肤镜的使用：一项针对 2,137 名患者的回顾性队列研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-13 DOI: 10.2340/actadv.v104.40890

Christofer Sahin, Mattias Carlsson, Fredrik Munir Ehrlington, Emanuela Micu, Magnus Falk

{"title":"Increased use of Dermoscopy in Primary Healthcare Following the Implementation of Teledermatology in Southeast Sweden: A Retrospective Cohort Study of 2,137 Patients.","authors":"Christofer Sahin, Mattias Carlsson, Fredrik Munir Ehrlington, Emanuela Micu, Magnus Falk","doi":"10.2340/actadv.v104.40890","DOIUrl":"10.2340/actadv.v104.40890","url":null,"abstract":"In the last 5 decades there has been a steady increase in skin cancer incidence globally. As patients wait for treatment before or after referral, the prognosis for those with melanoma worsens. Teledermatology was introduced to help reduce waiting times. The objective of this study was to investigate how the introduction of teledermatology affected management of skin tumours, from primary care physicians to dermatologists. A retrospective cohort study was performed 1 year before and 1 year after introduction of teledermatology in Östergötland County, Sweden. Patients were included from 3 primary healthcare centres by 3 independent observers. A total of 2,139 patients were included in the study. The 2 cohorts were well matched. At 2 of the 3 primary healthcare centres there was a significant increase in the use of dermoscopy, and almost 66% of all referrals were teledermatological in the year following its introduction. There was a trend towards higher diagnostic accuracy in the post-teledermatology cohort. No apparent effect on melanoma referral times was observed. The results of this study confirm previous findings showing the value of teledermatology as well as a novel finding of an increase in dermoscopy use in primary healthcare settings.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40890"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychiatric Comorbidities of Childhood-onset Atopic Dermatitis in Relation to Eczema Severity: A Register-based Study among 28,000 Subjects in Finland. 儿童期特应性皮炎的精神并发症与湿疹严重程度的关系：对芬兰 28,000 名受试者进行的登记研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-13 DOI: 10.2340/actadv.v104.40790

Amanda Blanco Sequeiros, Suvi-Päivikki Sinikumpu, Jari Jokelainen, Laura Huilaja

{"title":"Psychiatric Comorbidities of Childhood-onset Atopic Dermatitis in Relation to Eczema Severity: A Register-based Study among 28,000 Subjects in Finland.","authors":"Amanda Blanco Sequeiros, Suvi-Päivikki Sinikumpu, Jari Jokelainen, Laura Huilaja","doi":"10.2340/actadv.v104.40790","DOIUrl":"10.2340/actadv.v104.40790","url":null,"abstract":"Data on the severity of childhood-onset atopic dermatitis (AD) in relation to psychiatric comorbidities is scarce, even though AD predisposes to psychiatric comorbidities and the commonness of childhood-onset AD and its significance in disease progression are recognized. The purpose of this nationwide, register-based study of child patients diagnosed with AD in Finland between 1987 and 2017 was to determine how psychiatric comorbidities of AD patients differ depending on the disease severity of childhood-onset AD. AD severity was assessed by purchased AD treatment and risk of comorbidities was analyzed by the age of 18 and 30 years. The main finding of our study is that risk of several psychiatric disorders, i.e., depression, anxiety disorders and bipolar disorder, increased by the AD severity in childhood-onset AD already at young age. No difference was found for behavioral disorders, including hyperkinetic disorder, depending on AD severity. Childhood-onset AD is associated with different psychiatric comorbidities depending on AD severity, which supports the importance of mental health evaluation in AD patients.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40790"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intercellular, Linear Direct Immunofluorescence Staining Pattern of Sweat Glands and Hair Follicles may be Used as a Diagnostic Marker for Pemphigus Vulgaris in Cases where Epidermis is Missing. 在表皮缺失的病例中，汗腺和毛囊的细胞间线性直接免疫荧光染色模式可作为丘疹性荨麻疹的诊断标志。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-13 DOI: 10.2340/actadv.v104.40620

Orsolya N Horvath, Michaela Maurer, Vivian Wietzke, Victoria Fischer, Lars E French, Miklós Sárdy

{"title":"Intercellular, Linear Direct Immunofluorescence Staining Pattern of Sweat Glands and Hair Follicles may be Used as a Diagnostic Marker for Pemphigus Vulgaris in Cases where Epidermis is Missing.","authors":"Orsolya N Horvath, Michaela Maurer, Vivian Wietzke, Victoria Fischer, Lars E French, Miklós Sárdy","doi":"10.2340/actadv.v104.40620","DOIUrl":"10.2340/actadv.v104.40620","url":null,"abstract":"Due to its rarity, it takes months for patients to be correctly diagnosed with pemphigus vulgaris. This delay can be exacerbated by factors such as incorrect biopsy site selection. When the epidermis detaches from the dermis, evaluating fluorescence patterns is impossible. This monocentric, retrospective study aimed to assess the clinical significance of the honeycomb-like staining pattern of adnexal structures in patients with pemphigus vulgaris. The study was conducted in Munich, from 1 January 2012 to 31 December 2020. Forty-four biopsy samples for direct immunofluorescence microscopy from pemphigus patients along with 44 samples from control patients were included. The fluorescence intensity of adnexal structures did not differ significantly from that of the epidermis in pemphigus, except for hair follicles and sweat glands with C3 staining, where the epidermis showed stronger fluorescence. The sensitivity for the characteristic fluorescence pattern of at least 1 adnexal structure was 88.64% (n = 39/44, 95% CI 75.44% to 96.21%), with 100% specificity. The positive predictive value of adnexal fluorescence was 100%, and the negative predictive value was 89.8%. It was found that the honeycomb-like staining pattern of sweat glands, sweat gland ducts, and hair follicles is a highly specific marker for pemphigus vulgaris.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40620"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of Melanoma in Elderly Patients over 80 Years. 80 岁以上老年患者的黑色素瘤管理。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-13 DOI: 10.2340/actadv.v104.41029

Héloïse Jourdain, Justine Lavaud, Clémentine Descours, Emilie Auditeau, Philippe Bernard

{"title":"Management of Melanoma in Elderly Patients over 80 Years.","authors":"Héloïse Jourdain, Justine Lavaud, Clémentine Descours, Emilie Auditeau, Philippe Bernard","doi":"10.2340/actadv.v104.41029","DOIUrl":"10.2340/actadv.v104.41029","url":null,"abstract":"Melanoma is a malignant tumour with a poorer prognosis in stage III and IV patients. Development of effective therapies for the treatment of advanced melanoma has led to an improvement in survival. Furthermore, the French population is ageing, and treatment of melanoma in this population has several specific limitations. This descriptive, retrospective, single-centre study collected data on the diagnostic and therapeutic management of patients with melanoma of Breslow ≥ 1 mm or of unknown primary and metastatic spread, at Limoges University Hospital, between 2018 and 2022, and compared the results obtained between 2 groups: under 80 and over 80 years of age; 344 patients were included. The extension work-up was more frequently complete and the sentinel lymph node technique more frequently performed in patients under 80. Wide excision was more frequently in accordance with guidelines in patients over 80. Adjuvant or first-line metastatic treat-ment was more frequently instituted in patients under 80, but no difference was found as regards the second and third lines, the frequency of adverse events, and the reason for stopping treatment. Our study supports similar management of elderly and young subjects, given the safety profile and efficacy of treatments.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41029"},"PeriodicalIF":3.5,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Is the Use of the Extended (Meth)acrylate Series - Nails Justified? Characterization of Nail Acrylate Allergy in a Tertiary Medical Centre. 使用丙烯酸（甲基）酯扩展系列--指甲是否合理？一家三级医疗中心的丙烯酸甲酯过敏症特征。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-12 DOI: 10.2340/actadv.v104.41079

Joel Dascalu, Sophia Polansky, Ziad Khamaysi, Emily Avitan-Hersh, Mariela J Nevet

{"title":"Is the Use of the Extended (Meth)acrylate Series - Nails Justified? Characterization of Nail Acrylate Allergy in a Tertiary Medical Centre.","authors":"Joel Dascalu, Sophia Polansky, Ziad Khamaysi, Emily Avitan-Hersh, Mariela J Nevet","doi":"10.2340/actadv.v104.41079","DOIUrl":"10.2340/actadv.v104.41079","url":null,"abstract":"Methacrylate allergy is a common cause of allergic contact dermatitis, and its incidence has surged over the past decade. Consequently, the primary sensitizing agent, 2-hydroxyethyl methacrylate, was recently added to the European Baseline Series of contact allergens. This study aimed to assess the added value of testing for allergens included in the (Meth)Acrylate Series - Nails, in addition to 2-hydroxyethyl methacrylate, as well as to characterize patients who may benefit from more extensive testing. A retrospective analysis of medical records of patch-tested patients was conducted between June 2013 and July 2022. Among the 3,828 patients who underwent patch testing, 396 were tested with the (Meth)Acrylate Series - Nails; 153 (38.6%) of those patients tested positive for at least 1 acrylate. The most common hapten was 2-hydroxyethyl methacrylate (85.6%), followed by hydroxypropyl methacrylate (85.0%) and ethylene glycol dimethacrylate (80.4%). In our study, 22/153 patients (14.4%) would have been missed if tested only for 2-hydroxyethyl methacrylate. The analysis showed that including hydroxypropyl methacrylate and ethylene glycol dimethacrylate improved detection rate to 98%, rendering the use of the entire tray unnecessary in most cases.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41079"},"PeriodicalIF":3.5,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11571230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142611918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral Blood Mean Platelet Volume and the Ratio of Mean Platelet Volume to Platelet Count as Prognostic Biomarkers in Patients with Cutaneous Angiosarcoma of the Head and Neck: A Retrospective Cohort Study. 作为头颈部皮肤血管肉瘤患者预后生物标志物的外周血平均血小板体积和平均血小板体积与血小板计数之比：一项回顾性队列研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-07 DOI: 10.2340/actadv.v104.42227

Ken Horisaki, Tomoki Taki, Shoichiro Mori, Mao Okumura, Masashi Akiyama

引用次数: 0

Effect of betablockers on the course of Martorell hypertensive ulcers: a retrospective study. 贝特受体阻滞剂对马多雷尔高血压溃疡病程的影响：一项回顾性研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-07 DOI: 10.2340/actadv.v104.41087

Lucy Cleusix, Olesya Pavlova, Emmanuella Guenova, François Kuonen

{"title":"Effect of betablockers on the course of Martorell hypertensive ulcers: a retrospective study.","authors":"Lucy Cleusix, Olesya Pavlova, Emmanuella Guenova, François Kuonen","doi":"10.2340/actadv.v104.41087","DOIUrl":"10.2340/actadv.v104.41087","url":null,"abstract":"Martorell hypertensive ulcer (MHU) represents a painful, difficult-to-handle condition associated with peri-pheral, subcutaneous arteriolosclerosis caused by chronic hypertensive disease. Betablockers are effective for and widely used to treat hypertensive disease but are reported to exacerbate peripheral vasoconstriction. The effect of betablockers on pre-existing arteriolosclerosis and the course of MHU is, however, unknown. A retrospective study to assess the effect of betablockers on the course and response to treatment of MHU was conducted. Clinical and histopathological data were collected of patients treated for MHU at the authors' institution between 2014 and 2023 and a side-by-side comparison was performed of patients taking betablockers or not. Analysis focused on MHU severity at presentation, analgesic use, response to therapeutic intervention, and alterations of cutaneous arterioles. The study reports significantly larger ulcers and more frequent use of opioids in patients taking betablockers, while no significant difference was observed in terms of MHU response to treatment. Significantly increased luminal obstruction of peripheral cutaneous arterioles was found in patients taking beta-blockers. Based on these data, betablockers may have a negative effect on the course of MHU and should be carefully assessed in patients with MHU.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41087"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of 207 Studies Describing Validation Aspects of the Dermatology Life Quality Index. 对描述皮肤科生活质量指数验证方面的 207 项研究进行系统回顾。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-07 DOI: 10.2340/actadv.v104.41120

Jui Vyas, Jeffrey R Johns, Faraz M Ali, John R Ingram, Sam Salek, Andrew Y Finlay

{"title":"A Systematic Review of 207 Studies Describing Validation Aspects of the Dermatology Life Quality Index.","authors":"Jui Vyas, Jeffrey R Johns, Faraz M Ali, John R Ingram, Sam Salek, Andrew Y Finlay","doi":"10.2340/actadv.v104.41120","DOIUrl":"10.2340/actadv.v104.41120","url":null,"abstract":"This study systematically analysed peer-reviewed publications describing validation aspects of the Dermatology Life Quality Index (DLQI) and used Naicker's Critically Appraising for Antiracism Tool to assess risk of racial bias. Seven online databases were searched from 1994 until 2022 for articles containing DLQI validation data. Methodology followed PRISMA guidelines, the protocol was registered in PROSPERO, and articles reviewed independently by two assessors. Of 1,717 screened publications, 207 articles including 58,828 patients from > 49 different countries and 41 diseases met the inclusion criteria. The DLQI demonstrated strong test-retest reliability; 43 studies confirmed good internal consistency. Twelve studies were performed using anchors to assess change responsiveness with effect sizes from small to large, giving confidence that the DLQI responds appropriately to change. Forty-two studies tested known-groups validity, providing confidence in construct and use of the DLQI over many parameters, including disease severity, anxiety, depression, stigma, scarring, well-being, sexual function, disease location and duration. DLQI correlation was demonstrated with 119 Patient Reported Outcomes/Quality of Life measures in 207 studies. Only 15% of studies explicitly recruited minority ethnic participants; 3.9% stratified results by race/ethnicity. This review summarizes knowledge concerning DLQI validation, confirms many strengths of the DLQI and identifies areas for further validation.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41120"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Importance of Readability: A Guide to Understanding Alopecia Areata through Multilingual Online Resources. 可读性的重要性：通过多语言在线资源了解脱发症的指南》。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-07 DOI: 10.2340/actadv.v104.41046

Tomasz Skrzypczak, Anna Skrzypczak, Jacek C Szepietowski

{"title":"The Importance of Readability: A Guide to Understanding Alopecia Areata through Multilingual Online Resources.","authors":"Tomasz Skrzypczak, Anna Skrzypczak, Jacek C Szepietowski","doi":"10.2340/actadv.v104.41046","DOIUrl":"10.2340/actadv.v104.41046","url":null,"abstract":"Online resources play a vital role in patient education, yet the readability of alopecia areata-related materials remained understudied. A thorough analysis of online alopecia areata-related materials across 5 languages was conducted using Google search. Search terms \"alopecia areata\" and \"alopecia areata treatment\" were translated and queried, generating search result lists. The first 50 articles from each list were evaluated for suitability. The materials were categorized into 2 main groups: those focusing on alopecia areata itself and those addressing its treatment. Treatment materials were further divided into subgroups, including Janus kinase inhibitors and other treatment options. Readability was evaluated using the Lix score. The analysis included 251 articles in English, German, French, Italian, and Spanish. The overall mean Lix score was 52 ± 8, which classified them as very hard to comprehend. Articles on alopecia areata treatment had a mean Lix score of 55 ± 8, which was significantly higher (p < 0.001) than those on alopecia areata itself, 50 ± 8. alopecia areata-treatment articles dedicated to JAK inhibitors had an average Lix score of 57 ± 10 and it was significantly higher (p = 0.043) than those on other treatment, 53 ± 6. Online resources on alopecia areata and its treatments remained challenging to comprehend, particularly regarding JAK inhibitors. Improving clarity in patient education materials is crucial for informed decision-making and therapeutic relationships.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv41046"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High BRAF V600 Mutation Level Associated with Worse Outcome in Metastatic Melanoma Patients Receiving BRAF and MEK Inhibitors. 高 BRAF V600 基因突变水平与接受 BRAF 和 MEK 抑制剂治疗的转移性黑色素瘤患者的不良预后有关。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2024-11-07 DOI: 10.2340/actadv.v104.40913

Ariane Fizazi, Chris Serrand, Alexandre Evrard, Blanche Bergeret, Pierre-Emmanuel Stoebner, Myriam Marque

{"title":"High BRAF V600 Mutation Level Associated with Worse Outcome in Metastatic Melanoma Patients Receiving BRAF and MEK Inhibitors.","authors":"Ariane Fizazi, Chris Serrand, Alexandre Evrard, Blanche Bergeret, Pierre-Emmanuel Stoebner, Myriam Marque","doi":"10.2340/actadv.v104.40913","DOIUrl":"10.2340/actadv.v104.40913","url":null,"abstract":"The prognostic value of BRAF V600 mutation level on clinical outcomes in patients with BRAF V600-mutated metastatic melanoma treated with BRAF and MEK inhibitors remains uncertain. The association was retrospectively analysed between BRAF V600 mutation level (defined as the ratio of the quantification of the BRAF V600 allele to the percentage of tumoral cells in the sample analysed) and progression-free and overall survival (PFS and OS, respectively) and 3-month response rate in a cohort of 58 patients with metastatic melanoma who harboured BRAF V600E/K mutations and received dual targeted-therapy BRAF/MEK inhibitors. The BRAF mutation level cut-off determined by the area under the receiver operating characteristic curve after internal validation by bootstrap methods was 0.44. Risk of poor PFS and OS was associated with BRAF V600 mutation level > 0.44 on multivariate analysis (p = 0.02 and p = 0.02, respectively) after adjusting for major confounding factors (age, sex, lactate dehydrogenase level, brain metastasis, and treatment line). No association was found between BRAF mutation level and 3-month response rate. Our study shows that high BRAF V600 mutation level in melanoma tissue was associated with poor prognosis in patients with metastatic melanoma treated with BRAF and MEK inhibitors.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40913"},"PeriodicalIF":3.5,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558860/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0