Acta dermato-venereologica最新文献_第10页

Chronic Pain and Pain Tolerance in Psoriasis: A Cross-sectional Study of Three Population-based Cohorts in the Netherlands and Norway. 银屑病的慢性疼痛和疼痛耐受性：荷兰和挪威三个基于人群的横断面研究。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-06-01 DOI: 10.2340/actadv.v106.adv-2026-0510

Juliette Bollemeijer, Christian Page, Isabel Klein, Kjersti Danielsen, Anne-Sofie Furberg, Marita Jenssen, Ólöf Steingrimsdottir, Audun Stubhaug, Lieke Kuiper, Joyce Van Meurs, Tamar Nijsten, Christopher Nielsen, Luba Pardo

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Commentary on "Prevalence of Central Sensitization in Notalgia Paresthetica Patients and Its Association with Vertebral Degeneration: A Cross-sectional Study". 对“感觉异常Notalgia患者中枢性致敏的患病率及其与椎体退变的关系：一项横断面研究”的评论。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-06-01 DOI: 10.2340/actadv.v106.adv-2026-0391

Shiloh Plaut

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Psoriasis Triggers and Disease Activity: Analysis of Survey Data from the PSODEEP1 Study. 银屑病诱因和疾病活动：来自PSODEEP1研究的调查数据分析

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-06-01 DOI: 10.2340/actadv.v106.adv-2025-0167

Albert Duvetorp, Juul van den Reek, Juni Wikström, Magnus Blom Petersen, Wenning Zheng, Josefin Lysell, Lone Skov, Fernando Valenzuela, Beatrice Dyring-Andersen, Liv Eidsmo

{"title":"Psoriasis Triggers and Disease Activity: Analysis of Survey Data from the PSODEEP1 Study.","authors":"Albert Duvetorp, Juul van den Reek, Juni Wikström, Magnus Blom Petersen, Wenning Zheng, Josefin Lysell, Lone Skov, Fernando Valenzuela, Beatrice Dyring-Andersen, Liv Eidsmo","doi":"10.2340/actadv.v106.adv-2025-0167","DOIUrl":"10.2340/actadv.v106.adv-2025-0167","url":null,"abstract":"Numerous patients with psoriasis will associate disease triggers to changes in disease activity over time. Modern treatments induce remission, but relapse is common if the treatment is stopped. Exploring patients' first-hand experiences is a key starting point to identify triggers that may influence disease relapse. A cross-sectional digital questionnaire was distributed to 2716 individuals with psoriasis in Chile, Denmark, Sweden, and the Netherlands. 71% of participants reported psoriatic disease triggers. Triggers were classified into 24 subgroups dominated by stress (55.3%), infections (17.7%) and alcohol (10.8%). The majority (65%) of the participants experienced seasonal variation in disease activity, and approximately half reported fluctuating disease activity with periods of flare-ups. The self-reported trigger prevalence varied by gender, disease manifestation (skin psoriasis and/or psoriatic arthritis), and country of residence. The female participants more often reported stress and infections as triggers. Alcohol consumption is more often reported as a trigger in males. Chileans more often reported stress and less frequently reported infections as triggers. Insights into patient-reported disease variations and triggers can be used to aid patient-physician conversations and patient phenotyping during routine clinical practice. Trigger assessment and management could potentially contribute to patient counselling and motivate lifestyle changes.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148136536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The Candle Spot: An Unreported Sign of SULT2B1-nEDD. 蜡烛斑：SULT2B1-nEDD未报告的迹象。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-06-01 DOI: 10.2340/actadv.v106.adv-2025-0264

Sarah Milesi, Christine Chiaverini, Laura Chêne, Nathalie Jonca, Juliette Mazereeuw-Hautier

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Increased Mortality in Patients with Bullous Pemphigoid: A Nationwide Population-based Cohort Study of 5,738 Patients in Sweden. 大疱性类天疱疮患者死亡率增加：瑞典5738例全国人群队列研究

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-05-28 DOI: 10.2340/actadv.v106.44309

Zeyad Albadri, Henrike Häbel, Kristofer Thorslund, Carina Grönhagen, Oliver Seifert

{"title":"Increased Mortality in Patients with Bullous Pemphigoid: A Nationwide Population-based Cohort Study of 5,738 Patients in Sweden.","authors":"Zeyad Albadri, Henrike Häbel, Kristofer Thorslund, Carina Grönhagen, Oliver Seifert","doi":"10.2340/actadv.v106.44309","DOIUrl":"10.2340/actadv.v106.44309","url":null,"abstract":"Bullous pemphigoid (BP) is the most common autoimmune blistering disease and has been linked to increased mortality, although previous studies have generally relied on small populations and no data have been available specifically for the Swedish population. This study aimed to evaluate the 1- and 10-year mortality rates and all-cause mortality in Swedish patients with BP compared with the general population. Using the National Patient Register, we conducted a retrospective cohort study and identified all BP cases in Sweden from 1 January 2005, to 31 December 2016. Age, sex, and county of residence matched controls without BP were drawn from the general population, and mortality data were obtained from the Swedish Cause of Death Register. In total, 5,738 patients with BP and 17,167 controls were included. BP patients had a significantly higher all-cause mortality (HR 2.15, 95% CI 2.06-2.24) than controls, with 1- and 10-year mortality rates of 21.2% and 80.2%, respectively. Cardiovascular diseases accounted for the largest proportion of deaths (25.3%). Notably, improved survival was observed among BP patients treated with methotrexate (MTX), prednisolone, and potent topical corticosteroids (HR 0.76, 95% CI 0.69-0.83). To our knowledge, this is the first nationwide Swedish study on BP mortality and one of the largest to date, confirming a significantly increased mortality risk in BP patients, particularly due to cardiovascular causes, while also suggesting that combined MTX, prednisolone, and potent topical steroid treatment may improve survival outcomes.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":"adv44309"},"PeriodicalIF":3.8,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13224781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymorphic Skin Rash and Fatigue in a Patient with Diabetes Mellitus: A Quiz. 糖尿病患者的多态皮疹和疲劳：一个测验。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-05-27 DOI: 10.2340/actadv.v106.adv-2026-0637

Kaan Yilmaz, Manuel Winkler, Blerina Misiraj, Karlotta Lammers, Cyrill Géraud

引用次数: 0

Magnified Dermoscopy Allows Better Differentiation between Dermal Nevi and Basal Cell Carcinoma. 放大皮肤镜可以更好地区分真皮痣和基底细胞癌。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-05-27 DOI: 10.2340/actadv.v106.adv-2026-0506

Joanna Pogorzelska-Dyrbuś, Maria Teresa Fernández-Figueras, Jacek C Szepietowski

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A Real-world Meta-analysis Study of Disease Severity in European Patients Who Received Baricitinib for Atopic Dermatitis: Data from BioDay, SCRATCH and TREATgermany. 接受Baricitinib治疗特应性皮炎的欧洲患者疾病严重程度的真实meta分析研究：来自BioDay、SCRATCH和TREATgermany的数据

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-05-27 DOI: 10.2340/actadv.v106.adv-2025-0231

Celeste Boesjes, Marjolein de Bruin-Weller, Nicolaas P A Zuithoff, Said El Bouhaddani, Inge Haeck, Marijke Kamsteeg, Marie-Louise Schuttelaar, Luca Le Treust, Nick Denholm, Ahmet Akkoc, Simon F Thomsen, Ida Vittrup, Thomas Birkner, Luise Heinrich, Jochen Schmitt, Stephan Weidinger, Thomas Werfel

{"title":"A Real-world Meta-analysis Study of Disease Severity in European Patients Who Received Baricitinib for Atopic Dermatitis: Data from BioDay, SCRATCH and TREATgermany.","authors":"Celeste Boesjes, Marjolein de Bruin-Weller, Nicolaas P A Zuithoff, Said El Bouhaddani, Inge Haeck, Marijke Kamsteeg, Marie-Louise Schuttelaar, Luca Le Treust, Nick Denholm, Ahmet Akkoc, Simon F Thomsen, Ida Vittrup, Thomas Birkner, Luise Heinrich, Jochen Schmitt, Stephan Weidinger, Thomas Werfel","doi":"10.2340/actadv.v106.adv-2025-0231","DOIUrl":"10.2340/actadv.v106.adv-2025-0231","url":null,"abstract":"Clinical trials have demonstrated the effectiveness of baricitinib, an oral selective Janus kinase 1/2 inhibitor, for patients with moderate-severe atopic dermatitis, but data from real-world practice are limited. This non-interventional cohort study evaluated clinician- and patient-reported disease severity over 16 weeks using 3 national atopic dermatitis registries: BioDay (Netherlands), SCRATCH (Denmark) and TREATgermany (Germany). Absolute scores for Eczema Area and Severity Index (EASI) and itch Numerical Rating Scale (Itch-NRS) were assessed at baseline and follow-up (Week 13/16) for each registry and for the overall pooled cohort. Descriptive analyses, generalized linear mixed modelling and meta-analysis approaches were applied to complete-case and multiply-imputed datasets. In total, 264 patients (89 BioDay, 117 SCRATCH, 58 TREATgermany) were included. Results showed improvements in EASI, with 58%, 68% and 62% achieving EASI≤7 at Week 13/16 in BioDay, SCRATCH and TREATgermany, respectively. In the pooled cohort, the proportion was 62% (95% CI: 50-73%). The pooled mean EASI change was -7.8 [14.4,-1.1]. Effectiveness was generally observed in both biologic-naïve and -experienced patients. Notable heterogeneity was observed, particularly for Itch-NRS, with the proportion achieving NRS≤4 ranging from 20% (BioDay) to 71% (TREATgermany). These real-world findings support the effectiveness of baricitinib while also highlighting variability in patient outcomes.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13216443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A Case of Nonpedal Subcorneal Haematoma Mimicking Melanoma. 非足部角膜下血肿模拟黑色素瘤1例。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-05-27 DOI: 10.2340/actadv.v106.adv-2026-0641

Mengya Shang, Haiyang He, Weihua Pan, Chao Zhang

引用次数: 0

Hidradenitis Suppurativa Changes Major Life Decisions of Affected Patients: A Cross-sectional Study. 化脓性汗腺炎改变患者的主要生活决定：一项横断面研究。

IF 3.8 4区医学

Acta dermato-venereologica Pub Date : 2026-05-27 DOI: 10.2340/actadv.v106.adv-2026-0427

Marta Szepietowska, Piotr K Krajewski, Przemyslaw Pacan, Anna Wojas-Pelc, Lukasz Matusiak, Andrzej K Jaworek

{"title":"Hidradenitis Suppurativa Changes Major Life Decisions of Affected Patients: A Cross-sectional Study.","authors":"Marta Szepietowska, Piotr K Krajewski, Przemyslaw Pacan, Anna Wojas-Pelc, Lukasz Matusiak, Andrzej K Jaworek","doi":"10.2340/actadv.v106.adv-2026-0427","DOIUrl":"10.2340/actadv.v106.adv-2026-0427","url":null,"abstract":"Hidradenitis suppurativa (HS) is a chronic inflammatory disease associated with substantial physical and psychosocial burden. Its long-term impact on major life-changing decisions (MLCD) remains poorly investigated. This cross-sectional study included 123 adult HS patients assessed using the validated Major Life-Changing Decision Profile (MLCDP). Disease severity was evaluated with Hurley staging and IHS4. Quality of life (DLQI, HiSQOL), disease acceptance (AIS), and psychiatric symptoms (PHQ-9, GAD-7) were also assessed. Overall, 87.887.8% of patients reported at least one affected MLCD, with a mean of 6.2±65.2 decisions per patient. The mean MLCDP total score was 20.1±1720.91 points, without sex differences. The most frequently affected areas concerned lifestyle habits, physical activity, and intimate relationships. Patients with Hurley stage III demonstrated significantly higher MLCDP scores compared with stages I and II. MLCDP correlated with IHS4 (r=r0.218), pain intensity (r=r0.256), DLQI (r=r0.401), HiSQOL (r=r0.507), PHQ-9 (r=r0.354), and GAD-7 (r=r0.315) (all p<p0.05). A strong inverse correlation was observed with illness acceptance (r = -0.584, p<p0.001). HS substantially influences key life decisions, particularly in patients with advanced disease and reduced psychological adaptation.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13216440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148040618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0