Acta dermato-venereologica最新文献

{"title":"Psychological Resilience and Quality of Life in Mycosis Fungoides Patients: A BIO-MUSE Study.","authors":"Angelica Johansson, Katarina Velickovic, Emma Belfrage, Kristina Drott, Per Johnsson, Sara Ek","doi":"10.2340/actadv.v106.adv-2025-0211","DOIUrl":"10.2340/actadv.v106.adv-2025-0211","url":null,"abstract":"<p><p>Cutaneous T-cell lymphoma is a chronic disease with a highly heterogeneous and unpre-dictable clinical course, and the impact on psychological resilience is still unknown. The primary aim was to investigate psychological resilience in cutaneous T-cell lymphoma patients over time and to relate it to dermatology-related quality of life (QoL) metrics. Psychological investigations were evaluated in 45 patients with mycosis fungoides included in the BIO-MUSE study. Psychological resilience was assessed using the Connor-Davidson Resilience Scale (CD-RISC), and dermatology-associated QoL was assessed with the Dermatology Life Quality Index (DLQI) and numeric rating scales for itch and sleep disorders. The resilience of the mycosis fungoides patients was further compared to a Swedish general population cohort comprising more than 2,500 individuals. This study demonstrates that mycosis fungoides patients in the BIO-MUSE cohort, where 39 of 45 cases had early-stage disease, exhibit a high and stable resilience over 1 year of the disease. The CD-RISC score is higher than in a Swedish general population cohort and in a subgroup of that cohort with psoriasis or eczema. Furthermore, the DLQI was consistently low, indicating a higher QoL in the BIO-MUSE cohort than in published data for similar patient populations.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cross-sectional Study on Quality of Life in EB: Validation of the Italian QOLEB and Assessment in Italian Patients.","authors":"Giovanna Zambruno, Tonia Samela, Andrea Diociaiuti, Gudrun Salamon, Sophie Strobl, Cinzia Pilo, Damiano Abeni, Renata Linertová, Dedee F Murrell, May El Hachem","doi":"10.2340/actadv.v106.adv-2026-0543","DOIUrl":"10.2340/actadv.v106.adv-2026-0543","url":null,"abstract":"<p><p>Inherited epidermolysis bullosa comprises a heterogeneous group of skin fragility diseases, presenting with a range of manifestations and complications that profoundly affect quality of life (QoL). A disease-specific instrument, Quality of Life in EB (QOLEB), has been developed to assess the impact of epidermolysis bullosa signs and symptoms on QoL. The aim of this cross sectional study, conducted as part of a European project - BUR-EB, was to test the psychometric properties of the Italian version of the QOLEB and to assess QoL in Italian epidermolysis bullosa patients. Demographic, clinical, and QOLEB data of 56 Italian patients aged ≥11 years participating in the BUR-EB online survey were analysed. Principal component analysis showed excellent internal consistency of Italian QOLEB, and high convergent validity with the generic questionnaire EQ-5D. About 40% of patients reported severe to very severe disease burden, and a strong correlation was observed between disease severity and QOLEB scores. Independent variables associated with worse QoL were pain, chronic wounds, wheelchair use and patient organization membership. Our study confirms the good psychometric properties of the Italian QOLEB. In addition to depicting the major impact of epidermolysis bullosa on QoL, it identifies pain, chronic wounds and functional disability as major targets for therapeutic interventions.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reported Penicillin Allergy Affects the Length of Hospital Stay in Patients with Erysipelas.","authors":"Atlas Shahmoradi, Julian Kögel, Naomi Scheithe, Florian Hitzenbichler, Sigrid Karrer, Konstantin Drexler","doi":"10.2340/actadv.v106.adv-2026-0572","DOIUrl":"10.2340/actadv.v106.adv-2026-0572","url":null,"abstract":"<p><p>Patients with a reported penicillin allergy are often treated with less effective antibiotics. This study examined the impact of anamnestic penicillin allergy on the length of hospital stay in patients with erysipelas, a condition for which penicillin is considered the first-line therapy and addresses the question: Does anamnestic penicillin allergy directly affect the length of hospital stay in patients with erysipelas? This retrospective analysis included patients who were admitted to the University Medical Center Regensburg for the treatment of erysipelas. The data analysed were sex, age at diagnosis, body temperature at admission, C-reactive protein, leucocyte count, procalcitonin, length of hospital stay, Charlson Comorbidity Index and antibiotic therapy. Patients were divided into 2 groups: with and without the label anamnestic penicillin allergy. Multiple regression analysis showed that patients with anamnestic penicillin allergy stayed 1.83 days longer in hospital than patients without anamnestic penicillin allergy (mean length of stay 12.17±7.01 days for patients with anamnestic penicillin allergy compared to 10.34±4.80 days for patients without anamnestic penicillin allergy, as determined by a t-test p=0.046). According to our data, anamnestic penicillin allergy is associated with prolonged hospital stay. Therefore, delabelling of penicillin allergy should be widely implemented.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148343763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinctive Reactivity to the C-terminal Epitope of BP180 Characterizes Immune Checkpoint Inhibitor-associated Bullous Pemphigoid, and an ELISA Based on the BP180 Ectodomain Enables Prompt Diagnosis in a Subset of Patients.","authors":"Anna Pira, Martina Merli, Feliciana Mariotti, Marco Andreani, Angelo Valerio Marzano, Clara De Simone, Rosa Falcone, Giuseppe Testa, Mariarosa Battarra, Maurizio Romagnuolo, Pietro Sollena, Federica De Galitiis, Emiliano Antiga, Roberto Maglie, Dario Didona, Jo Linda Maria Sinagra, Marzia Caproni, Michael Hertl, Emanuele Cozzani, Pamela Vezzoli, Laura Calabrese, Giovanni Paolino, Sofia Verkhovskaia, Luca Fania, Giulia Gasparini, Anna Rita Giampetruzzi, Biagio Didona, Pietro Quaglino, Giovanni Di Zenzo","doi":"10.2340/actadv.v106.adv-2026-0336","DOIUrl":"10.2340/actadv.v106.adv-2026-0336","url":null,"abstract":"<p><p>Growing evidence has linked bullous pemphigoid (BP) to immune checkpoint inhibitor (ICI) therapy in cancer treatment. However, the immunological features of ICI-associated BP (ICI-BP) are not yet fully elucidated. In order to characterize the humoral response in ICI BP patients and investigate whether their epitope profile differs from idiopathic BP (IBP), 53 ICI-BP patients were enrolled, immunologically characterized and compared with 59 IBP patients. ICI-BP had a distinctive IgG humoral profile, with reduced reactivity toward BP230 and recognition of multiple BP180 epitopes beyond the immunodominant extracellular noncollagenous 16A domain (NC16A). Specifically, reactivity to BP180 ectodomain was present in 94% of ICI-BP and 78% of IBP (p=0.044). Moreover, BP180 C-terminal epitope was more frequently targeted in ICI-BP than IBP (72% vs 41%, p=0.002). Notably, the combined use of an in-house BP180 ectodomain ELISA and the commercial BP180 test increased diagnostic sensitivity from 83% to 100%. Enhanced IgG reactivity toward nonimmunodominant epitopes, and especially C-terminal epitope recognition, characterize the humoral immune response in ICI-BP. Our data suggest that combining NC16A and fulllength BP180 ectodomain ELISAs may help reduce diagnostic delay in ICI-BP patients, in whom a timely diagnosis is crucial to appropriately manage the disease and ultimately avoid discontinuation of cancer therapy.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13314586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Painful Occipital Nodules in a Child Returning from South America: A Quiz.","authors":"Ilaria Salvi, Marco Del Monte, Sara Naim, Angelica Pisati, Gianmaria Viglizzo","doi":"10.2340/actadv.v106.adv-2026-0557","DOIUrl":"10.2340/actadv.v106.adv-2026-0557","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13314584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and Responsiveness of the Rosacea Area and Severity Index in a Chinese Cohort: A Comparative Study with the Investigator's Global Assessment.","authors":"Yukun Wang, Hongjie Luo, Deyu Song, Xinjin Liu, Yuanting Wang, Yingying Dai, Xucheng Zhou, Hui Li, Xian Jiang","doi":"10.2340/actadv.v106.adv-2026-0599","DOIUrl":"10.2340/actadv.v106.adv-2026-0599","url":null,"abstract":"<p><p>The Rosacea Area and Severity Index (RASI) is a recently developed tool for assessing rosacea severity, but its validation has so far been limited, requiring further independent evaluation. This study aimed to comprehensively assess the reliability, validity and responsiveness of the RASI in a Chinese cohort. Six trained observers independently evaluated standardized photographs of 230 Chinese patients with rosacea using both the RASI and the Investigator's Global Assessment (IGA). Round 1 assessment was used to determine interobserver reliability and convergent validity, while a subgroup of 60 patients was reassessed to evaluate intraobserver reliability and responsiveness (Round 2). In this subgroup, baseline and 1-month follow-up photographs were rescored after 3 months by the same observers. Results showed moderateto-strong correlations between RASI and IGA at baseline, supporting validity. Interobserver reliability was high for both RASI and IGA overall scores, with intraclass correlation coefficients of 0.923 and 0.935. Intraobserver reliability showed no significant deviation (p>0.05). For responsiveness, RASI demonstrated a higher standardized response mean than IGA (0.43 vs 0.37) with a similar effect size. Additionally, RASI detected statistically significant changes (p<0.001) in patients classified as \"stable\" by IGA. Overall, RASI showed robust reliability, validity and superior responsiveness.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13316856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspects of Adverse Effects of Cosmetic Products: An Invited Narrative Review.","authors":"James Yu, Peter C Schalock","doi":"10.2340/actadv.v106.adv-2026-0340","DOIUrl":"10.2340/actadv.v106.adv-2026-0340","url":null,"abstract":"<p><p>The use of cosmetic products is ubiquitous around the world. This article reviews the medical literature documenting adverse effects associated with cosmetic product use. An extensive, nonexhaustive literature search was conducted using the PubMed database. Studies reporting adverse effects from cosmetic products were included, encompassing case reports, case series, clinical trials and epidemiological studies. Contact dermatitis is the most common adverse effect associated with cosmetic use, affecting approximately 1-5% of the general population. Additional effects, including respiratory sensitization, photosensitization, workplace exposures and issues specific to pregnancy/lactation, are discussed. The clinical significance of these effects remains poorly understood, particularly regarding long-term exposure and cumulative health impacts. Cosmetic usage can result in a spectrum of adverse effects that represent significant clinical and public health concerns.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mycosis Fungoides with Concurrent Squamous Cell Carcinoma in a Young Patient: A Rare Case.","authors":"Jianv Wang, Wei Chen, Tingting Wang, Lin Wang","doi":"10.2340/actadv.v106.adv-2025-0062","DOIUrl":"10.2340/actadv.v106.adv-2025-0062","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reported Pregnancy Outcomes after Biologic Therapy Exposure in Hidradenitis Suppurativa: A Systematic Review of Published Cases.","authors":"Verónica Sánchez-García, Eva De-Miguel-Balsa, José-Manuel Ramos-Rincón, Isabel Belinchón-Romero","doi":"10.2340/actadv.v106.adv-2026-0501","DOIUrl":"10.2340/actadv.v106.adv-2026-0501","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neisseria gonorrhoeae in Six University Hospital STI Clinics in Sweden - Distribution, Antimicrobial Resistance and Treatment.","authors":"Sinja Kristiansen, Annika Johnsson, Christian Steczkó Nilsson, Elisabet Nylander, Karin Sanner, Miryam Spångerud, Petra Tunbäck, Arne Wikström","doi":"10.2340/actadv.v106.adv-2025-0250","DOIUrl":"10.2340/actadv.v106.adv-2025-0250","url":null,"abstract":"<p><p>Gonorrhoea is a sexually transmitted infection caused by Neisseria gonorrhoeae with an increasing incidence and a widespread antimicrobial resistance. The aim was to investigate the case burden, distribution of infection site, management and antibiotic resistance in N. gonorrhoeae cases in 6 university hospitals in Sweden. Diagnosis of N. gonorrhoeae was made by nucleic acid amplification tests (NAAT). Included were 1,060 cases with 27.3% women, 72.4% men and 4 transgender persons, constituting around one third of all 3,356 N. gonorrhoeae cases in Sweden 2022. The NAAT test for N. gonorrhoeae from urine was positive in 51.7% (428/828), 40.4% (428/1,060) among the total included population, from vagina/cervix in 87.9% (246/280), 23.2% (246/1,060) in the total population and from rectum in 66.1% (353/534), 33.3% (353/1,060) among all included cases, with 78.9% (277/351) positive rectal samples in men and 21.1% (74/351) in women (p<0.001), the majority being among men having sex with men (76.5%). Antimicrobial resistance was most common against ciprofloxacin, seen in 43.7% (463/1,060) and second most common against azithromycin, in 9.4% (150/1,060). The study elucidates the complexity of handling gonococcal infections regarding relevant test methods, infections in several locations and the problem with antibiotic resistance.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"106 ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13294295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148315138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}