Acta dermato-venereologica最新文献_第10页

An 81-year-old Woman with a 1-year-old Blue Pigmented Patch on the Right Upper Back: A Quiz. 一位81岁的妇女，右上背部有一年前的蓝色色素斑块：一个小测验。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-08 DOI: 10.2340/actadv.v105.42915

Jin Young Lee, Jun Young Kim

引用次数: 0

Type 2 Diabetes Impacts the Efficacy of Syphilis Treatment and is a Risk Factor for Late Syphilis: A Retrospective Cohort Study. 2型糖尿病影响梅毒治疗效果，是晚期梅毒的危险因素：一项回顾性队列研究

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-08 DOI: 10.2340/actadv.v105.42210

Yijie Tang, Mengxiao Wu, Wenwen Xu, Jiajie Yu, Dandan Yang, Jiaqin Zhang, Lingyun Shen, Qinghui Xie, Qingqiong Luo

引用次数: 0

Real-world Effectiveness and Safety of Janus Kinase Inhibitors in Alopecia Areata: A Retrospective Cohort Study of 72 Patients. Janus激酶抑制剂治疗斑秃的有效性和安全性：一项72例患者的回顾性队列研究。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-07 DOI: 10.2340/actadv.v105.42990

Sophie C Van Helmond, Mathias Willaert, Viet-Hoa Nguyen, Tamar Nijsten, Rick Waalboer-Spuij, DirkJan Hijnen

{"title":"Real-world Effectiveness and Safety of Janus Kinase Inhibitors in Alopecia Areata: A Retrospective Cohort Study of 72 Patients.","authors":"Sophie C Van Helmond, Mathias Willaert, Viet-Hoa Nguyen, Tamar Nijsten, Rick Waalboer-Spuij, DirkJan Hijnen","doi":"10.2340/actadv.v105.42990","DOIUrl":"10.2340/actadv.v105.42990","url":null,"abstract":"Alopecia areata (AA) is an autoimmune hair loss disorder characterized by sudden hair shedding due to immune dysregulation involving the Janus Kinase - Signal Transducer and Activator of Transcription (JAK-STAT) pathway. JAK inhibitors (JAKi) have demonstrated efficacy in clinical trials, but data from real-world settings remain scarce. This retrospective, single-centre cohort study evaluated the real-world effectiveness and safety of JAKi (abrocitinib, baricitinib, ritlecitinib, upadacitinib, and tofacitinib) in 72 patients treated between December 2017 and February 2024. Patients had a mean age of 34 years and a mean disease duration of 8 years. At time points 3, 6, 9, 12, and 18 months substantial regrowth was observed in 18 (25%), 28 (38.9%), 25 (34.7%), 22 (30.6%), and 19 (26.4%) patients respectively. Over a median follow-up of 16 months, 61% achieved substantial regrowth at a median time of 7 months. At 3, 6, 9, and 12 months, the cumulative regrowth rates were 11.1%, 40.2%, 55.6%, and 59.7%, respectively. Among non-responders who switched medications, 75% achieved substantial regrowth. Two serious adverse events occurred (sickle cell crisis and renal failure with pre-existing dysfunction). The findings indicate that JAKi are effective and safe for AA treatment in real-world settings. Further prospective studies are necessary to optimize treatment guidelines.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42990"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgery or Non-invasive Treatment for Superficial Basal Cell Carcinoma: Does a Patient Decision Aid Help to Make a Personalized Treatment Decision? 浅表基底细胞癌的手术或非侵入性治疗：患者的决定是否有助于做出个性化的治疗决定？

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-07 DOI: 10.2340/actadv.v105.41914

Lieke C J Van Delft, Myrthe M G Moermans, Brigitte A B Essers, Patty J Nelemans, Klara Mosterd, Marieke E C Van Winden, Satish F K Lubeek, Nicole W J Kelleners-Smeets

{"title":"Surgery or Non-invasive Treatment for Superficial Basal Cell Carcinoma: Does a Patient Decision Aid Help to Make a Personalized Treatment Decision?","authors":"Lieke C J Van Delft, Myrthe M G Moermans, Brigitte A B Essers, Patty J Nelemans, Klara Mosterd, Marieke E C Van Winden, Satish F K Lubeek, Nicole W J Kelleners-Smeets","doi":"10.2340/actadv.v105.41914","DOIUrl":"10.2340/actadv.v105.41914","url":null,"abstract":"Patients with a superficial basal cell carcinoma can be treated surgically or non-invasively, all with specific (dis)advantages. An investigation was undertaken into whether the preference for surgery or non-invasive treatment of a superficial basal cell carcinoma differs between patients who used a patient decision aid and a control group. Secondly, whether patients were satisfied with their decision post-treatment was investigated. A prospective observational study was performed comparing patients with a superficial basal cell carcinoma who used a patient decision aid (patient decision aid group) with a control group. The primary outcome was the proportion of patients that chose non-invasive treatment. A secondary outcome was the mean score of \"effective decision-making\" on the Decisional Conflict Scale 3 months post-treatment. In the patient decision aid group, 48.6% (52/109) seemed to prefer non-invasive treatment vs 40.8% (42/103) in the control group (p = 0.255); the result was not significant. Three months post-treatment, the adjusted between-group mean difference in \"effective decision-making\" was -4.10 (p = 0.082) favouring the patient decision aid group (effect size 0.3). To conclude, patients who used a patient decision aid seemed to choose non-invasive therapy over surgery slightly more often but the result was not significant.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv41914"},"PeriodicalIF":3.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11995428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Polymyxin B Induced Transverse Melanonychia Affecting All 20 Nails. 多粘菌素B致横断性黑甲病1例。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-07 DOI: 10.2340/actadv.v105.43353

Fatmanur Hacınecipoğlu, Gülten Ütebey, Bahriye Nur Dinçer, Selda Pelin Kartal

引用次数: 0

Distinct Impact of Phosphodiesterade-4 (PDE4) Inhibition in Two Pre-clinical Psoriasis Models. 磷酸二酯-4 （PDE4）抑制对两种临床前银屑病模型的不同影响

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-07 DOI: 10.2340/actadv.v105.41972

Sören Dräger, Thorge Mester, Hermann Tenor, Ralf J Ludwig, Katja Bieber

引用次数: 0

Topical Steroid Withdrawal: The Challenging Transition from Patient Self-Diagnosis on Social Media to Medical Science and Care. 局部类固醇戒断：从患者在社交媒体上的自我诊断到医学科学和护理的挑战性转变。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-03 DOI: 10.2340/actadv.v105.43455

Alain Taieb

引用次数: 0

Radiotherapy-induced Angiosarcoma Mimicking Merkel Cell Carcinoma Metastases. 放射治疗诱导的血管肉瘤模拟默克尔细胞癌转移。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-03 DOI: 10.2340/actadv.v105.42509

Franziska Anna Wenz, Anna-Maria Forster, Beda Muehleisen, Alina Miriam Mueller

引用次数: 0

Papuloerythroderma of Ofuji Associated with Elevated Varicella-zoster Virus Complement-fixing Antibody Titers Following BNT162b2 mRNA COVID-19 Vaccination. 接种BNT162b2 mRNA COVID-19疫苗后，小富士丘疹红皮病与水痘-带状疱疹病毒补体固定抗体滴度升高相关

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-02 DOI: 10.2340/actadv.v105.42546

Masahiro Oka

引用次数: 0

Chronic Hand Eczema, Real World, and Patient Centricity: A Narrative Review. 慢性手湿疹，真实世界，和病人为中心：叙述回顾。

IF 3.5 4区医学

Acta dermato-venereologica Pub Date : 2025-04-02 DOI: 10.2340/actadv.v105.42596

Sonja Molin, Emma Guttman-Yassky, Jacob P Thyssen, Anthony Bewley

{"title":"Chronic Hand Eczema, Real World, and Patient Centricity: A Narrative Review.","authors":"Sonja Molin, Emma Guttman-Yassky, Jacob P Thyssen, Anthony Bewley","doi":"10.2340/actadv.v105.42596","DOIUrl":"10.2340/actadv.v105.42596","url":null,"abstract":"Chronic hand eczema is a multifactorial, fluctuating, inflammatory skin disease of the hands and wrists, defined as hand eczema that persists for at least 3 months or recurs at least twice within 1 year. Chronic hand eczema is heterogeneous in nature with different clinical manifestations. This chronic condition can significantly impact daily activities and health-related quality of life for patients, including notable physical, psychosocial, occupational, and socioeconomic burdens. However, awareness of the disease and the patient experience remains poor. This review aims to improve understanding of chronic hand eczema in the context of its underlying pathogenesis, clinical subtypes and presentation, and risk factors. Additionally, an overview of the patient experience of the disease, including health-related quality of life and socioeconomic implications, is provided. Improved understanding of chronic hand eczema will support optimal patient care by empowering healthcare providers to more quickly and correctly diagnose this disease with high unmet treatment needs and subsequently offer appropriate holistic care.","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"105 ","pages":"adv42596"},"PeriodicalIF":3.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977413/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143762644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0