Xue-Min Wang, Ye-Qiang Liu, Bin Li, Ming Li, Yan Peng, Wen-Cheng Jiang
{"title":"Single-system Langerhans Cell Histiocytosis with Skin Ulcers as the Initial Presentation.","authors":"Xue-Min Wang, Ye-Qiang Liu, Bin Li, Ming Li, Yan Peng, Wen-Cheng Jiang","doi":"10.2340/actadv.v104.40193","DOIUrl":"10.2340/actadv.v104.40193","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40193"},"PeriodicalIF":3.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Circadian Rhythm of Itching among 241 Adults with Atopic Dermatitis: A Cross-sectional Study.","authors":"Xiaoxue Sang, Jianyun Lu, Lina Tan, Jinrong Zeng, Dan Wang, Aiyuan Guo, Siyuan Tang, Qian Zeng, Wei Liu, Lihua Gao","doi":"10.2340/actadv.v104.35427","DOIUrl":"10.2340/actadv.v104.35427","url":null,"abstract":"<p><p>The pattern of itching in patients with atopic dermatitis has not been systematically studied. Therefore, this study aimed to assess the pattern of itching in adults with atopic dermatitis using questionnaires to assess for a circadian rhythm of itching in participating patients at a single institution (n = 241). A self-report questionnaire was used to assess circadian rhythm and intensity of itching in patients. In addition, the patients' disease severity (Eczema Area and Severity Index [EASI]) and quality of life (Dermatology Life Quality Index [DLQI]) were assessed. Itching occurred most frequently (74.69%) and with the greatest severity (62.66%) between 20:00 and 00:00, and the least number of patients (25.31%) experienced itching between 04:00 and 08:00. The DLQI and EASI scores both correlated with the average and maximum itch intensity (r = 0.582, r = 0.533, respectively; r = 0.539, r = 0.517, respectively; p < 0.001). The DLQI and EASI scores were associated with average itch intensity (B = 0.179, B = 0.204, respectively; 95% CI: 0.112 to 0.246, 95% CI: 0.096 to 0.313, respectively; p < 0.001), and the EASI score was associated with males and family history (B = 0.285, B = 0.287, respectively; 95% CI: 0.094 to 0.476, 95% CI: 0.096 to 0.478, respectively; p = 0.003). Adult patients with atopic dermatitis exhibited a circadian rhythm of itching; these study results could positively impact treatment approaches.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv35427"},"PeriodicalIF":3.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wolfgang G Philipp-Dormston, Lasse R Braathen, Colin A Morton, Merete Haedersdal, Yolanda Gilaberte, Nicole Basset-Seguin, Elena Sotiriou, Stine Regin Wiegell, Piergiacomo Calzavara-Pinton, Thomas Dirschka, Hans Christian Wulf, Günther Hofbauer, Rolf Markus Szeimies
{"title":"A European Consensus on the Consistent Use of the Term \"Keratinocyte Cancer\".","authors":"Wolfgang G Philipp-Dormston, Lasse R Braathen, Colin A Morton, Merete Haedersdal, Yolanda Gilaberte, Nicole Basset-Seguin, Elena Sotiriou, Stine Regin Wiegell, Piergiacomo Calzavara-Pinton, Thomas Dirschka, Hans Christian Wulf, Günther Hofbauer, Rolf Markus Szeimies","doi":"10.2340/actadv.v104.40601","DOIUrl":"10.2340/actadv.v104.40601","url":null,"abstract":"<p><p>Keratinocyte-derived skin cancers comprise basal cell carcinoma, squamous cell carcinoma, its precursor actinic keratosis, and Bowen's disease. Historically, this group of neoplasms has been subsumed under the term non-melanoma skin cancer. However, the term non-melanoma skin cancer can be misleading and lacks precision. Therefore, more precise and reasonable terminology, valuing the relevance of keratinocyte-derived cancer, appears pertinent to meet its clinical and scientific significance. A group of experienced dermato-oncologists initiated a consensus approach to promote the use of the term \"keratinocyte cancer\" instead of \"non-melanoma skin cancer\" when referring to carcinomas and their precursors that are derived from keratinocytes. The vote among members of the consensus group indicated unanimous agreement on the consistent use of the term \"keratinocyte cancer\" instead of \"non-melanoma skin cancer\". International delegates also voted in favour of the revised terminology. The more precise and, by means of etiopathogenesis, correct term \"keratinocyte cancer\" should be consistently used for malignancies originated from keratinocytes. This is expected to have a positive impact on patient-physician communication and gives better justice to this important group of keratinocyte-derived cancers.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40601"},"PeriodicalIF":3.5,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olivier Maillard, Clotilde Fera, Elisa Joly, Kevin Diallo, Patrick Mavingui, Yves-Marie Diarra, Yatrika Koumar, André Cabié, Antoine Bertolotti
{"title":"Mucocutaneous Manifestations in Patients with Dengue Fever: From the EPIDENGUE Cohort on Reunion Island.","authors":"Olivier Maillard, Clotilde Fera, Elisa Joly, Kevin Diallo, Patrick Mavingui, Yves-Marie Diarra, Yatrika Koumar, André Cabié, Antoine Bertolotti","doi":"10.2340/actadv.v104.40334","DOIUrl":"10.2340/actadv.v104.40334","url":null,"abstract":"<p><p>Nearly 4 billion people live in a dengue risk area worldwide. The prevalence of dengue-related mucocutaneous manifestations and their association with severe dengue differ across studies. The aim of the study was to describe the characteristics of patients with dengue-related mucocutaneous manifestations and to investigate those were associated with severe dengue. A retrospective study was conducted in 2019 among patients with a positive RT-PCR for dengue at the University Hospital of Reunion, which has been experiencing a re-emergence of dengue since 2018. Of 847 patients with confirmed dengue, 283 (33.4%) developed mucocutaneous manifestations. Only manifestations of dehydration such as glossitis, dysgeusia, or conjunctivitis were associated with severe dengue, unlike pruritus and rash, in bivariate analysis but not in multivariate analysis. The rash and pruritus of dengue appear to be accompanied by a pronounced flu-like syndrome in younger people without comorbidity or severity, although careful examination of mucous membranes would better identify signs of dehydration and thus cases likely to worsen.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40334"},"PeriodicalIF":3.5,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Filippos Giannopoulos, Martin Gillstedt, Sofia Lindskogen, John Paoli, Sam Polesie
{"title":"Performance of a Machine Learning Algorithm on Lesions with a High Preoperative Suspicion of Invasive Melanoma.","authors":"Filippos Giannopoulos, Martin Gillstedt, Sofia Lindskogen, John Paoli, Sam Polesie","doi":"10.2340/actadv.v104.40023","DOIUrl":"10.2340/actadv.v104.40023","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40023"},"PeriodicalIF":3.5,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262359/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multiple Papules and Nodules Over the Body with Diffuse Thickening of the Facial Skin: A Quiz.","authors":"Aravind Reddy, Yash Buccha, Rohan Manoj, Namratha Puttur, Kshitiz Lakhey","doi":"10.2340/actadv.v104.40206","DOIUrl":"10.2340/actadv.v104.40206","url":null,"abstract":"","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40206"},"PeriodicalIF":3.5,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11262363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141615629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Teresa Fernandez-Figueras, Noelia Perez-Muñoz, Luis Puig, Rodolfo Posada-Caez, Rosa Ballester Victoria, Martha Henriquez, Eva Musulen
{"title":"Predictors of Local Invasion in Infiltrative Basal Cell Carcinoma: Tumour Budding Outperforms the WHO Subtyping.","authors":"Maria Teresa Fernandez-Figueras, Noelia Perez-Muñoz, Luis Puig, Rodolfo Posada-Caez, Rosa Ballester Victoria, Martha Henriquez, Eva Musulen","doi":"10.2340/actadv.v104.40172","DOIUrl":"10.2340/actadv.v104.40172","url":null,"abstract":"<p><p>Tumour budding (TB) correlates with increased local invasion in various neoplasms. Certain basal cell carcinomas (BCCs) exhibit local aggressiveness. Detecting adverse prognostic factors in partial biopsies could aid in identifying cases with heightened local risk. The absolute number of TB (≤ 3 tumour cells) in excision specimens of 271 infiltrative BCCs (0: absent; 1: 1-2 foci; 2: ≥ 3 foci; 3: ≥ 10 foci), the histopathological subtype and depth of infiltration, perineural invasion, and other histological features were evaluated. A significant correlation was found between TB and both depth of infiltration (rho 0.445, p < 0.001) and perineural invasion (p = 0.009). In the multivariate analysis of depth and perineural invasion (multiple regression, stepwise), TB was identified as a significant covariate together with diameter, inflammation, and perineural invasion for the former, and depth for the latter. Conversely, no correlation existed between the WHO histological subtypes (infiltrating, sclerosing, and micronodular), and depth of infiltration or perineural invasion. This study demonstrates the value of TB as a biomarker for local invasiveness in BCC. In routine practice, a count of ≥ 3 TB foci in lesions incompletely excised or with narrow tumour-free surgical margins would be a straightforward and reproducible method to guide BCC treatment.</p>","PeriodicalId":6944,"journal":{"name":"Acta dermato-venereologica","volume":"104 ","pages":"adv40172"},"PeriodicalIF":3.5,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11247513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141490480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}