European Journal of Heart Failure最新文献

{"title":"Malnutrition and outcomes in patients with tricuspid regurgitation undergoing transcatheter tricuspid valve repair","authors":"Matteo Pagnesi, Marianna Adamo, Lukas Stolz, Edoardo Pancaldi, Karl-Patrik Kresoja, Jennifer von Stein, Vera Fortmeier, Benedikt Koell, Wolfgang Rottbauer, Mohammad Kassar, Bjoern Goebel, Paolo Denti, Paul Achouh, Tienush Rassaf, Manuel Barreiro-Perez, Peter Boekstegers, Andreas Rück, Monika Zdanyte, Flavien Vincent, Philipp Schlegel, Ralph-Stephan von Bardeleben, Mirjam G. Wild, Christian Besler, Stephanie Brunner, Stefan Toggweiler, Julia Grapsa, Tiffany Patterson, Holger Thiele, Tobias Kister, Giuseppe Tarantini, Giulia Masiero, Marco De Carlo, Alessandro Sticchi, Mathias H. Konstandin, Eric Van Belle, Tobias Geisler, Rodrigo Estévez-Loureiro, Peter Luedike, Nicole Karam, Francesco Maisano, Philipp Lauten, Fabien Praz, Mirjam Kessler, Daniel Kalbacher, Volker Rudolph, Christos Iliadis, Philipp Lurz, Jörg Hausleiter, Marco Metra","doi":"10.1002/ejhf.3623","DOIUrl":"https://doi.org/10.1002/ejhf.3623","url":null,"abstract":"The impact of malnutrition in patients with tricuspid regurgitation (TR) undergoing tricuspid transcatheter edge-to-edge repair (T-TEER) is not well established. We evaluated the impact of malnutrition among patients with symptomatic TR undergoing T-TEER.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"12 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low blood pressure and the effect of empagliflozin in acute heart failure: An EMPULSE analysis","authors":"João Pedro Ferreira, Francisco Vasques-Nóvoa, Christiane E. Angermann, Jan Biegus, Sean P. Collins, Mikhail Kosiborod, Michael E. Nassif, Mitchell A. Psotka, Jasper Tromp, Robert J. Mentz, Piotr Ponikowski, John R. Teerlink, Adriaan A. Voors","doi":"10.1002/ejhf.3626","DOIUrl":"https://doi.org/10.1002/ejhf.3626","url":null,"abstract":"Empagliflozin improves outcomes in acute heart failure (AHF). Patients with AHF and low blood pressure (BP) have poor prognosis. Whether empagliflozin is effective and safe in patients with AHF and low BP is currently unknown. The aim of this study was to assess the efficacy and safety of empagliflozin (vs. placebo) in patients with low BP – either systolic BP (SBP) <110 mmHg or diastolic BP (DBP) <70 mmHg – at randomization.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"89 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143463041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics, determinants, and prognostic impact of severe tricuspid regurgitation in patients with atrial functional mitral regurgitation: Insights from the REVEAL-AFMR registry.","authors":"Tomohiro Kaneko, Azusa Murata, Masashi Amano, Yukio Sato, Yohei Ohno, Masaru Obokata, Kimi Sato, Taiji Okada, Wataru Fujita, Kojiro Morita, Tomoko Machino-Ohtsuka, Yukio Abe, Tohru Minamino, Nobuyuki Kagiyama","doi":"10.1002/ejhf.3624","DOIUrl":"https://doi.org/10.1002/ejhf.3624","url":null,"abstract":"<p><strong>Aims: </strong>Tricuspid regurgitation (TR) is often seen in patients with atrial functional mitral regurgitation (AFMR). The aim of this study was to investigate the characteristics, determinants, and prognostic impact of severe TR coexisting with AFMR.</p><p><strong>Methods and results: </strong>In 26 facilities in Japan, patients with significant AFMR defined with moderate or severe functional mitral regurgitation with dilated left atrium and preserved left ventricular function were enrolled. The primary endpoint was a composite of heart failure hospitalization and all-cause mortality. The secondary endpoint was all-cause mortality. In 792 patients with AFMR (mean age 77 ± 9 years, 55% female), the prevalence of severe TR was 14.9% (n = 118) overall, and 34.6% in severe AFMR. Patients with severe TR were older, mostly with atrial fibrillation, and had more severe heart failure symptoms and more advanced left atrial and right heart remodelling than those with non-severe TR. Age >75 years, permanent atrial fibrillation, chronic obstructive pulmonary disease, and higher right atrial pressure appeared as independent determinants of severe TR. Severe TR was associated with both the primary and secondary endpoints after adjusted for covariates including the severity of AFMR (adjusted hazard ratio 1.65 [95% confidence interval 1.09-2.47], p = 0.017 and 1.80 [1.06-3.06], p = 0.029 for the primary and secondary endpoints, respectively). Atrial and ventricular functional TR accounted for 41% and 59% of significant TR. Despite more advanced right heart remodelling in ventricular TR, these groups showed similar prognosis.</p><p><strong>Conclusions: </strong>Severe TR coexisting with AFMR was common and was associated with increased event rates. Further study is warranted to establish therapeutic strategies.</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal muscle and subcutaneous fat quantity as prognostic indicators in cardiac amyloidosis.","authors":"Joshua Longinow, Saeid Mirzai, Po-Hao Chen, Mazen Hanna, W H Wilson Tang","doi":"10.1002/ejhf.3622","DOIUrl":"https://doi.org/10.1002/ejhf.3622","url":null,"abstract":"<p><strong>Aims: </strong>Disease-related changes in body composition are associated with worse outcomes in chronic heart failure. In cardiac amyloidosis (CA), the prognostic value of direct body composition measures is understudied.</p><p><strong>Methods and results: </strong>We identified 160 consecutive patients with CA (transthyretin [ATTR] or light chain [AL]) diagnosed between 2001 and 2021 who had chest computed tomography within 1 year before diagnosis. Skeletal muscle index (SMI), intermuscular adipose tissue percentage (IMAT%), and subcutaneous adipose tissue index (SATI) were quantified at the twelfth vertebral level and analysed continuously, in sex-stratified tertiles, and with derived outcome-based cutoffs. In a comprehensive model including IMAT% and SATI, only SMI independently predicted 10-year mortality (hazard ratio 0.69 per standard deviation increase, 95% confidence interval 0.52-0.91, p = 0.010). In tertile analyses, low SMI was associated with 2 to 2.5 times higher 1-year, 5-year, and 10-year mortality versus high SMI. Medium IMAT% and SATI showed approximately 1.9 times higher 5-year and 10-year mortality versus high tertiles. These associations were more pronounced in ATTR-CA, with low SATI also predicting higher mortality. AL-CA showed fewer significant associations. Interaction testing by CA type was not significant. Outcome-based SMI cutoffs of 23.5 cm²/m² (males) and 27.8 cm²/m² (females) for 10-year mortality were derived but need validation.</p><p><strong>Conclusion: </strong>Lower SMI was associated with increased mortality risk in patients with CA, particularly ATTR-CA. The relationship between SATI and mortality was more nuanced: in the overall cohort, medium SATI was associated with higher mortality risk, while in patients with ATTR-CA, lower SATI predicted higher mortality risk.</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":16.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of finerenone across the stages of heart failure: From prevention to treatment","authors":"Jan Biegus, Alberto Palazzuoli, Stephen J. Greene","doi":"10.1002/ejhf.3606","DOIUrl":"https://doi.org/10.1002/ejhf.3606","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"64 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to ‘Concerns regarding the study on circulating GDF‐15 levels and diastolic dysfunction’","authors":"Luca Monzo, Nicolas Girerd","doi":"10.1002/ejhf.3621","DOIUrl":"https://doi.org/10.1002/ejhf.3621","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"10 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concerns regarding the study on circulating GDF-15 levels and diastolic dysfunction. Letter regarding the article ‘Circulating growth differentiation factor-15 levels are associated with early echocardiographic signs of diastolic dysfunction impairment in the STANISLAS cohort: A 20-year follow-up study’","authors":"Lei Shi","doi":"10.1002/ejhf.3620","DOIUrl":"https://doi.org/10.1002/ejhf.3620","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"9 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline characteristics of contemporary trial participants with heart failure and reduced ejection fraction: The VICTOR trial","authors":"Clara I. Saldarriaga, Faiez Zannad, Ciaran J. McMullan, Aiwen Xing, Davis Gates, Kevin J. Anstrom, Marc P. Bonaca, Stefano Corda, Justin A. Ezekowitz, Carolyn S.P. Lam, Eldrin F. Lewis, JoAnn Lindenfeld, Robert J. Mentz, Christopher O'Connor, Mahesh Patel, Piotr Ponikowski, Yogesh N.V. Reddy, Giuseppe M.C. Rosano, Michele Senni, James Udelson, Adriaan A. Voors, Javed Butler","doi":"10.1002/ejhf.3598","DOIUrl":"https://doi.org/10.1002/ejhf.3598","url":null,"abstract":"AimsTo describe the baseline characteristics of the participants in the VICTOR (Vericiguat Global Study in Patients with Chronic Heart Failure; NCT05093933) trial and compare them to recent trials in patients with heart failure and reduced ejection fraction (HFrEF).Methods and resultsBaseline characteristics were evaluated in 6105 patients randomized to vericiguat or placebo. The mean age of the participants was 67 ± 11 years, 23.6% were women, 64.4% were White, and 10.7% were self‐identified Black. Overall, 29.1% of participants were enrolled in Latin and South America, 27.8% and 18.5% in Eastern and Western Europe, 14.0% in Asia‐Pacific and 10.6% in North America. The mean left ventricular ejection fraction was 30 ± 7% and 79% had New York Heart Association class II symptoms. Mean estimated glomerular filtration rate was 70.9 ± 24.0 ml/min/1.73 m<jats:sup>2</jats:sup>. Median N‐terminal pro‐B‐type natriuretic peptide level was 1476 (970–2495) pg/ml and 47.5% of participants had no prior hospitalization for heart failure. Baseline therapy included 94.4% beta‐blockers, 94.3% renin–angiotensin system modulation (including 56.0% on an angiotensin receptor–neprilysin inhibitor), 77.7% mineralocorticoid receptor antagonists, 59.1% sodium–glucose cotransporter 2 inhibitors, and 32.9% implantable cardioverter‐defibrillators. Overall characteristics were relatively similar to other recent HFrEF trials but the VICTOR trial enrolled a higher proportion of participants receiving contemporary drug and device therapy.ConclusionThe VICTOR trial enrolled the most optimally treated population in a phase III heart failure trial. These features will facilitate assessment of the benefit of vericiguat and elucidate the outcomes of patients on up‐to‐date medical therapy.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"41 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The win ratio for trials for heart failure: academic desperation or investigator decadence?","authors":"Milton Packer, Javed Butler","doi":"10.1002/ejhf.3608","DOIUrl":"https://doi.org/10.1002/ejhf.3608","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"3 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143426934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ perfusion pressure predicts outcomes in cardiogenic shock patients","authors":"Pier Paolo Bocchino, Simone Frea, Alice Sacco, Maurizio Bertaina, Federico Pappalardo, Guido Tavazzi, Nuccia Morici, Filippo Angelini, Laura Garatti, Martina Briani, Carlotta Sorini Dini, Luca Villanova, Guglielmo Gallone, Amelia Ravera, Letizia Bertoldi, Anna Corsini, Giulia Maj, Luciano Potena, Rita Camporotondo, Costanza Natalia Julia Colombo, Andrea Montisci, Fabrizio Oliva, Mario Iannaccone, Nicoletta D'Ettore, Serafina Valente, Matteo Pagnesi, Marco Metra, Marco Marini, Gaetano Maria De Ferrari","doi":"10.1002/ejhf.3627","DOIUrl":"https://doi.org/10.1002/ejhf.3627","url":null,"abstract":"The diagnosis of cardiogenic shock (CS) relies upon signs and/or symptoms of end-organ hypoperfusion. The combination of hypoperfusion and systemic congestion identifies patients at particularly high risk. This study evaluated organ perfusion pressure (OPP), calculated as mean arterial pressure minus invasive central venous pressure, as a predictor of outcomes in CS.","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":"1 1","pages":""},"PeriodicalIF":18.2,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}