European Journal of Heart Failure最新文献

{"title":"Ventricular arrhythmia-heart failure interaction and mortality in ICD recipients after myocardial infarction.","authors":"Mathieu Echivard, Jean-Marc Sellal, John J V McMurray, Chloé Ziliox, Luca Monzo, Zohra Lamiral, Kévin Duarte, Christian De Chillou, Guillaume Baudry, Nicolas Girerd","doi":"10.1093/ejhf/xuag312","DOIUrl":"https://doi.org/10.1093/ejhf/xuag312","url":null,"abstract":"<p><strong>Aims: </strong>Ventricular arrhythmia (VA) and heart failure (HF) frequently coexist in patients with ischaemic left ventricular (LV) dysfunction. Whether VA and HF events are bidirectionally associated remains unclear. We investigated their bidirectional relationship and associations with mortality.</p><p><strong>Methods: </strong>We analysed 1014 patients from the multicentre WICD-MI study. All received a wearable cardioverter-defibrillator after acute myocardial infarction (MI) and subsequently underwent implantable cardioverter-defibrillator (ICD) implantation, with persistent LV ejection fraction ≤35%. Associations between ICD-treated VA, HF-events (HF hospitalization, heart transplantation, or LV assist device implantation), and all-cause mortality were assessed using time-dependent Cox models.</p><p><strong>Results: </strong>Over a median follow-up of 2.6 years post-ICD implantation, VA was independently associated with an increased risk of HF events [aHR = 3.50 (1.66-7.38), P = .001], while HF events similarly preceded subsequent VA [aHR = 2.96 (1.59-5.50), P = .0008]. Both were independently associated with all-cause mortality, with a numerically higher aHR for HF events [aHR = 7.96 (4.71-13.47), P < .0001] than for VA [aHR = 4.43 (2.35-8.36), P < .0001]. Sensitivity analyses suggested that the VA-HF association was strongest for shock-treated arrhythmias. In exploratory analyses, VA was strongly associated with subsequent HF events in subcutaneous ICD recipients [aHR = 15.08 (4.62-49.22), P < .0001] but not in transvenous ICD recipients (P for interaction = .0002).</p><p><strong>Conclusion: </strong>In ICD recipients with persistent LV dysfunction following MI, VA and HF events are bidirectionally associated and independently associated with mortality. The VA-HF association was strongest for shock-treated arrhythmias. These findings highlight the potential value of integrated HF and VA management.</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149339999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of empagliflozin in heart failure with preserved ejection fraction according to the presence of echocardiographic features of diastolic dysfunction in the EMPEROR-Preserved trial.","authors":"Andrew J Stewart Coats, Javed Butler, Hendrik Zimmet, Faiez Zannad, Michael Böhm, Vijay K Chopra, Subodh Verma, Matias Nordaby, Tomoko Iwata, Egon Pfarr, Cordula Zeller, Piotr Ponikowski, Stefan D Anker","doi":"10.1093/ejhf/xuag327","DOIUrl":"https://doi.org/10.1093/ejhf/xuag327","url":null,"abstract":"<p><strong>Aims: </strong>To define the impact of diastolic dysfunction (DD) on the response to empagliflozin treatment in patients with heart failure with preserved ejection fraction.</p><p><strong>Methods and results: </strong>Diastolic dysfunction was defined by left atrial volume index ≥34 ml/m2, the ratio of early diastolic mitral inflow velocity to early diastolic mitral annular tissue velocity (E/e) ≥ 13 or left ventricular mass index >115 (males) or >95 (females). We created three categories of increasing DD (0, 1, or ≥2 DD criteria at baseline) to describe the effect of DD on response to empagliflozin therapy and adverse effects. Of 5988 patients in the EMPEROR-Preserved trial, 3766 (63%) had no documented baseline DD, 1619 (27%) had one, and 603 (10%) had two or more measures. Baseline DD was associated with sex, race, ethnicity, and region and was more common with lower heart rate, DBP, body weight, and eGFR. Despite baseline DD not being significantly associated with the primary endpoint of hospitalization for heart failure or cardiovascular death within the placebo group, a progressive treatment effect across the three DD categories was seen (trend test P-value .0014), with estimated hazard ratios of empagliflozin vs placebo of 0.91 (none present), 0.64 (1 present), and 0.49 (≥2). A significant treatment-by-subgroup trend test was also observed for the total number of hospitalizations for heart failure. Both Kansas City Cardiomyopathy Questionnaire Clinical Summary Score improvement at week 52 and safety profile were consistent across DD categories.</p><p><strong>Conclusion: </strong>Baseline detection of echocardiographic DD predicted improved clinical response to empagliflozin in a graded fashion, but the reasons cannot be reliably determined from this analysis.</p>","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: The effect of vericiguat on sudden cardiac death: insights from the VICTOR trial.","authors":"","doi":"10.1093/ejhf/xuag333","DOIUrl":"https://doi.org/10.1093/ejhf/xuag333","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DPP3-positive circulatory shock: from targetable ICU endotype to Horizon Europe precision-therapy trial.","authors":"Mahir Karakas, Karolina Ziolkowska, Olga Kovalenko, Serhiy Zemskov, Anna V Blagaia, Tanja Zeller, Anja M Boos","doi":"10.1093/ejhf/xuag328","DOIUrl":"https://doi.org/10.1093/ejhf/xuag328","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":""},"PeriodicalIF":10.3,"publicationDate":"2026-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149293510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter regarding the article 'Modification of the association between age and mortality in heart failure by frailty status'.","authors":"Shankar Biswas, Yashasvi Srivastava, Venkateswarlu Chintagumpala","doi":"10.1093/ejhf/xuag164","DOIUrl":"10.1093/ejhf/xuag164","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":"844-845"},"PeriodicalIF":10.3,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to letter regarding the article 'Modification of the association between age and mortality in heart failure by frailty status'.","authors":"Caroline Hartwell Garred, Mariam Elmegaard, Lars Køber, Morten Schou","doi":"10.1093/ejhf/xuag173","DOIUrl":"10.1093/ejhf/xuag173","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":"846"},"PeriodicalIF":10.3,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147961598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast recovery in infarct-related cardiogenic shock: can we identify the patient who does not need mechanical support?","authors":"Binyamin Ben Avraham, Oliviana Geavlete, Tuvia Ben Gal","doi":"10.1093/ejhf/xuag205","DOIUrl":"10.1093/ejhf/xuag205","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":"750-752"},"PeriodicalIF":10.3,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148576382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Ziltivekimab in heart failure with preserved and mildly reduced ejection fraction: rationale and design of the ATHENA and HERMES trials.","authors":"","doi":"10.1093/ejhf/xuag248","DOIUrl":"10.1093/ejhf/xuag248","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":"852-853"},"PeriodicalIF":10.3,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148862909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The hidden economic burden of potentially inappropriate prescribing in HFrEF: translating clinical risk into system-level impact.","authors":"Seif El Hadidi","doi":"10.1093/ejhf/xuag183","DOIUrl":"10.1093/ejhf/xuag183","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":"847-848"},"PeriodicalIF":10.3,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148051549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Catheter ablation in end-stage heart failure with atrial fibrillation: an hierarchical endpoint analysis of the CASTLE-HTx trial.","authors":"","doi":"10.1093/ejhf/xuag246","DOIUrl":"10.1093/ejhf/xuag246","url":null,"abstract":"","PeriodicalId":164,"journal":{"name":"European Journal of Heart Failure","volume":" ","pages":"851"},"PeriodicalIF":10.3,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}