Journal of Bone and Mineral Research最新文献

{"title":"New Insights into DXA for Predicting Hip Fracture.","authors":"Tony M Keaveny","doi":"10.1093/jbmr/zjaf101","DOIUrl":"https://doi.org/10.1093/jbmr/zjaf101","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parity and lactation cause transient bone loss but are not risk factors for osteoporosis later in life.","authors":"Christopher S Kovacs","doi":"10.1093/jbmr/zjaf095","DOIUrl":"https://doi.org/10.1093/jbmr/zjaf095","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burosumab: What can it do in children and adult patients with X-linked hypophosphatemia?","authors":"Seiji Fukumoto","doi":"10.1093/jbmr/zjaf097","DOIUrl":"https://doi.org/10.1093/jbmr/zjaf097","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invisible seams: dorsal and ventral elements of long bones are formed by distinct cells.","authors":"Federico La Manna, Matthew B Greenblatt","doi":"10.1093/jbmr/zjaf096","DOIUrl":"https://doi.org/10.1093/jbmr/zjaf096","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144648089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D-DXA reveals significant effects of burosumab on trabecular and cortical skeletal envelopes in symptomatic adults with X-linked Hypophosphatemia.","authors":"Rucha Patki, Thomas Carpenter, Keerti Murari, Stephen Parziale, Yanhong Deng, Ludovic Humbert, Mirella Lopez Picazo, Karl Insogna","doi":"10.1093/jbmr/zjaf092","DOIUrl":"https://doi.org/10.1093/jbmr/zjaf092","url":null,"abstract":"<p><p>Fractures and pseudofractures cause considerable morbidity in adults with X-linked Hypophosphatemia (XLH). They frequently occur in cortically-enriched bones of the lower extremities. Burosumab, a neutralizing antibody to FGF23, heals fractures in adults with XLH, presumably by healing osteomalacia. Histomorphometry has documented healing of osteomalacia in trabecular bone. The effects of burosumab on cortical bone have not been reported. Therefore, 3D-DXA measurements of the proximal femur were used to examine the impact of 1 yr of burosumab therapy on cortical and trabecular bone in symptomatic adults with XLH. Twenty volunteers from the registration trial for burosumab were separately consented for this study. DXA scans of the hip were obtained before and 6, 12 and 18-24 mo (mo.) after drug therapy (1 mg/kg every 4 wk). 3D-DXA analyses were performed using 3D-Shaper software (3D-Shaper Medical). Changes in femoral neck (FN) areal BMD (aBMD), total hip (TH) aBMD, TH trabecular volumetric BMD (vBMD), FN trabecular vBMD, TH cortical surface BMD (sBMD), FN cortical sBMD, and FN cross-sectional moment of inertia (CSMI) were analyzed. Both TH and FN trabecular vBMD showed significant increases over the course of therapy (13.6% and 14.1% respectively at the end of treatment compared to baseline; p < .0001 for each). Fractures and pseudofractures often occur in the cortically-enriched FN in XLH. Burosumab induced a significant increase in FN cortical sBMD between 6 and 12 mo. (p < .05) and between 6 and 18-24 mo. of drug treatment (p < .05). The FN CSMI, an indicator of FN strength, also significantly increased at 12 and 18-24 mo. when compared to baseline; p < .05 and p < .01 respectively. These data demonstrate that burosumab increases both cortical and trabecular bone in the hip a site of frequent fracture in XLH.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144615596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type 1 and 2 diabetes mellitus: comprehensive fracture risk relationships in UK Biobank.","authors":"Elizabeth M Curtis, Rebecca J Moon, Stefania D'Angelo, Zahra Raisi-Estabragh, Cyrus Cooper, Nicholas C Harvey","doi":"10.1093/jbmr/zjaf094","DOIUrl":"https://doi.org/10.1093/jbmr/zjaf094","url":null,"abstract":"<p><p>We aimed to investigate associations between diabetes mellitus and incident fracture, stratified by diabetes type (1 or 2), disease duration and microvascular complications of diabetes. This prospective cohort analysis used data from the UK Biobank, a large population-based cohort of participants recruited 2006-2010 at age 40-69 yr. The exposure was type 1 or type 2 diabetes at baseline, with the outcome of first incident osteoporotic fracture. Poisson regression was used to calculate incidence rate ratios (IRRs) for osteoporotic fracture to investigate prospective relationships between diabetes type 1 or 2 and fracture risk independent of traditional clinical risk factors, estimated bone mineral density by heel ultrasound (eBMD), adiposity, and C-reactive protein. The role of diabetic microvascular complications and associations between diabetes duration and fracture risk were studied. There were 498 949 participants (271 882 women, mean age 56 yr; 227 067 men, 57 yr). In fully adjusted models, type 1 and 2 diabetes were associated with increased fracture risk [type 1; IRR: 2.93 (95%CI:2.37,3.62); type 2: 1.25 (1.14,1.38)], similar by sex. The magnitude of risk associated with type 2 diabetes increased with duration of disease. Increasing number of microvascular complications was associated with greater fracture risk [any vs no complications, IRR 2.03 (1.57,2.62)]. Diabetes is associated with increased risk of fracture (magnitude of effect greater in type 1 than type 2 diabetes). Associations were partly independent of traditional risk factors, adiposity, eBMD and CRP. Type 2 diabetes disease duration and the presence of microvascular complications in both types were dose-dependent risk factors for fracture.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estrogen Loss Activates Memory T-Cells to Compromise Bone Integrity Through Distinct Cortical Compartments in Mice.","authors":"Di Wu, Anna Cline-Smith, Daniel Goering, Aarushi Choudhary, Deborah Veis, Rajeev Aurora","doi":"10.1093/jbmr/zjaf089","DOIUrl":"https://doi.org/10.1093/jbmr/zjaf089","url":null,"abstract":"<p><p>Fragility fractures are a significant cause of morbidity and mortality in postmenopausal women. Menopause leads to a significant decline in bone mass and quality, with over half of women sustaining fragility fractures without reaching the osteoporotic threshold (T-score < -2.5), underscoring the pivotal role of bone quality in fracture risk. Previous studies have shown that estrogen (E₂) deficiency following ovariectomy (OVX) in mice activates memory T-cells (TM) to produce TNFα and IL-17A, resulting in trabecular bone loss. This study extends these findings to cortical bone, revealing that under habitual load osteoclasts are predominantly localized on the posterior endosteal surface. Post-OVX, mice exhibited enlarged lacunae indicative of osteocytic osteolysis and reduced dendrite density in osteocytes (Ocy) adjacent to T-cells, with these effects being more pronounced on the posterior side where osteoclast-T-cell interactions are heightened. Additionally, osteoblast (OB) function analysis revealed that while bone formation at the mid-diaphysis remained unchanged, the collagen matrix became more disorganized, particularly in the posterior cortical compartment. Importantly, OVX increased bone fragility without altering cortical thickness or mineral density. These detrimental changes were absent in OVX mice lacking TNFα and IL-17A expression in TM cells (IL15RAΔT), suggesting that these cytokines specifically impair the osteolineage (Ocy and OB), compromising bone quality in ways undetectable by μCT. Our findings reveal a novel mechanism where T-cell-mediated inflammation reduced cortical bone quality by targeting the osteolineage, leading to disrupted matrix organization and Ocy dendrite density. Clinically, these results highlight the potential of targeting T-cell responses to maintain bone quality and strength in estrogen-deficient states. Additionally, estrogen loss adversely affects endosteal bone quality in distinct cortical compartments without impacting bone mass, a deficit that may remain undetected by DXA scans.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femoral neck width is associated with unique trajectories of age-related hip structural changes and fracture risk within populations of adult women and men.","authors":"Karl J Jepsen, Todd L Bredbenner, Carrie A Karvonen-Gutierrez, Aleda M Leis, Michelle M Hood, Sioban D Harlow, John Randolph, Gregory A Clines, Steffenie Merillat, Michael R Elliott, Jane A Cauley, Gail A Greendale, Arun S Karlamangla, Katherine W Peters, Stephanie L Harrison, Li-Yung Lui, Peggy M Cawthon, Eric Orwoll","doi":"10.1093/jbmr/zjaf090","DOIUrl":"https://doi.org/10.1093/jbmr/zjaf090","url":null,"abstract":"<p><strong>Background: </strong>Osteoporosis management relies heavily on areal bone mineral density (aBMD) to identify women and men with reduced bone strength. We tested the hypothesis that baseline femoral neck (FN) external size is associated with different bone-loss and area-gain trajectories that are not reflected in aBMD-decline but that have different biomechanical implications.</p><p><strong>Methods: </strong>We analyzed data from four longitudinal studies with repeated hip dual-energy X-ray absorptiometry (DXA) scans of women and men over 10-15 yr of follow-up. Changes in FN bone mineral content (BMC), area, and aBMD were compared across height-adjusted baseline FN area tertiles using linear models. Fracture risk differences across the tertiles were tested using Cox proportional-hazard models.</p><p><strong>Results: </strong>Women and men with smaller baseline FN area had smaller BMC-declines and greater area-increases over 10-15 yr compared to those with larger FN area who had twice the annual BMC-declines but much smaller area-increases. In general, these structural changes were not reflected in aBMD-changes for either sex. The likelihood of fracturing a hip was 2.5 times greater for women and 2.4-4.2 times greater for men in the larger FN area tertile compared to those in the smaller FN area tertile.</p><p><strong>Discussion: </strong>Unique patterns of age-related structural changes with different biomechanical implications were identified within populations of women and men. These results challenge the general assumption that age-related structural changes are homogenous within a population and question whether aBMD-declines reflect strength-declines consistently among women and men. How these unique patterns of structural change affect the response of women and men to osteoporosis interventions remain to be determined.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"You are what you breathe? Metabolites may begin to explain the link between air pollution and bone damage.","authors":"Stefaan W Verbruggen","doi":"10.1093/jbmr/zjaf070","DOIUrl":"10.1093/jbmr/zjaf070","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"825-826"},"PeriodicalIF":5.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of Concern: Comparative cardiovascular safety of romosozumab versus bisphosphonates in Japanese patients with osteoporosis: a new-user, active comparator design with instrumental variable analyses.","authors":"","doi":"10.1093/jbmr/zjaf074","DOIUrl":"10.1093/jbmr/zjaf074","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"906"},"PeriodicalIF":5.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}