Journal of Bone and Mineral Research最新文献

{"title":"From imaging to insight: biomechanical CT for fracture risk prediction.","authors":"Shengzhi Luan, Elise F Morgan","doi":"10.1093/jbmr/zjag040","DOIUrl":"10.1093/jbmr/zjag040","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"461-462"},"PeriodicalIF":5.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural crest-specific disruption of Evc2 provides an animal model to study the temporomandibular joint development and homeostasis in response to jaw loading.","authors":"Rafael Correia Cavalcante, Honghao Zhang, Felicia Miranda, Susannah C Midla, Veronique M Lefebvre, Peter X Ma, Lucia H S Cevidanes, Yuji Mishina","doi":"10.1093/jbmr/zjaf140","DOIUrl":"10.1093/jbmr/zjaf140","url":null,"abstract":"<p><p>The temporomandibular joint (TMJ), essential for jaw movements, is susceptible to osteoarthritis, impacting a significant portion of the population. This study introduces an innovative genetic mouse model to explore TMJ development, maintenance, and interactions with the mechanical environment. We exploited Evc2/Limbin conditional KO (Evc2 cKO) mice, specifically targeting neural crest cell-derived tissues (Wnt1Cre), to observe TMJ development. Disruption of Evc2 in neural crest cells contributed to morphological changes in the TMJ growth plate cartilage layers, predisposing the joint components to defects. Condyle defective regions presented a unique environment composed of cartilage, bone, stem cells, and an augmented polymorphic layer. Our findings further revealed that the Evc2 cKO mice presented TMJ components degeneration clinically like those observed in human TMJ-osteoarthritis (OA). Mandible condyle gene expression analysis showed augmented expression of general inflammatory and OA markers. Supplying the mice with regular chow worsens the phenotype, but soft chow fed partially rescued both condyle morphology and intra-articular space. The data suggest that changes in the loading environment critically affect the integrity and functionality of the TMJ, with direct implications for its preservation and disease management.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"537-550"},"PeriodicalIF":5.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12861122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solving chewy problems and a pain in the jaw: a novel mouse model for jaw joint malfunction.","authors":"Andre J van Wijnen, Yasaman Daneshian","doi":"10.1093/jbmr/zjaf157","DOIUrl":"10.1093/jbmr/zjaf157","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"465-466"},"PeriodicalIF":5.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145407641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Countering bone loss and marrow fat expansion in the race to Mars.","authors":"Quentin A Meslier, Mary L Bouxsein, Erica L Scheller","doi":"10.1093/jbmr/zjaf170","DOIUrl":"10.1093/jbmr/zjaf170","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"463-464"},"PeriodicalIF":5.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145538266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved prediction of hip fracture using multi-faceted biomechanical computed tomography.","authors":"Tony M Keaveny, Annette L Adams, Eric S Orwoll, Sundeep Khosla, Michael R McClung, Mary L Bouxsein, Shireen Fatemi, Bryce A Besler, David C Lee, David L Kopperdahl","doi":"10.1093/jbmr/zjaf139","DOIUrl":"10.1093/jbmr/zjaf139","url":null,"abstract":"<p><p>With the goal of preventing more hip fractures, a next generation of the VirtuOst Biomechanical Computed Tomography (BCT) test was developed that integrates measurements from a clinical CT scan related to fall risk, impact force, and femoral strength, the three main determinants of hip fracture. Here, we introduce the test and validate it against BMD and FRAX. Our source population from a large healthcare system comprised of 341364 patients (≥65 yr) with an abdominal-pelvic CT during care. Using data from 3035 patients (1790 with hip fracture), we developed a \"BCT Risk Score\" (range: 0-100) having input risk factors of age, femoral strength, ratio of trabecular/cortical BMD, muscle area, intramuscular fat, FN volume, hip width, and posterior fat thickness. In a geographically distinct set of 2124 patients (1293 with hip fracture), we then compared the BCT Risk Score against a DXA-equivalent hip BMD T-score (lowest hip value, measured from the CT scan by VirtuOst) and FRAX hip fracture risk (with BMD but without parental fracture history) for predicting a first incident hip fracture within 5 yr. For the women, the c-statistic for predicting fracture was higher for BCT (0.89, 95% CI: 0.87-0.90) than for BMD (0.81, 0.79-0.84) or FRAX (0.85, 0.83-0.87). Using binary thresholds to identify high-risk patients, sensitivity for BCT (Risk Score ≥ 75) was higher than for BMD (T-score ≤ -2.5) and FRAX (hip risk ≥ 3.0%): 81.4% vs 47.8% vs 75.9%, respectively; positive predictive values confirmed comparable high-risk status (BCT 13.6% vs BMD 15.3% vs FRAX 12.7%). Similar trends were observed for the men, 2-yr outcomes, and identifying very-high-risk patients. We conclude that, compared to both BMD and FRAX, the integrative BCT test better predicted hip fracture and its high sensitivity should improve fracture prevention.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"507-520"},"PeriodicalIF":5.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and pitfalls in diagnosing and managing severe gestational hypercalcemia.","authors":"Charlotte Dewdney, Stephanie Penswick, Carolyn Chiswick, Mary E M Porteous, Scott D Mackenzie","doi":"10.1093/jbmr/zjaf203","DOIUrl":"10.1093/jbmr/zjaf203","url":null,"abstract":"<p><p>A 38-yr-old primigravida presented at 30 + 2 wk gestation with pregnancy-induced hypertension and was found to have severe hypercalcemia (adjusted calcium 3.19 mmol/L). Intravenous fluid therapy produced only transient improvement, and recurrent hypercalcemia required repeated inpatient management. PTH was suppressed, while both 25(OH)D₃ and 1,25(OH)₂D₃ (calcitriol) were elevated. Imaging and laboratory investigations revealed no evidence of malignancy or granulomatous disease. Delivery by elective cesarean section was undertaken at 35 wk gestation. The neonate developed transient hypocalcemia with suppressed PTH, requiring brief i.v. calcium supplementation. Maternal hypercalcemia persisted postpartum, and renal imaging revealed nephrolithiasis and nephrocalcinosis. Serum calcium remained elevated during lactation but normalized after weaning. Extended vitamin D metabolite profiling showed an increased 25(OH)D₃:24,25(OH)₂D₃ ratio, and genetic analysis confirmed compound heterozygous pathogenic variants in CYP24A1, encoding vitamin D 24-hydroxylase, the enzyme responsible for calcitriol degradation. The findings established a diagnosis of gestational hypercalcemia due to CYP24A1 deficiency. Normal pregnancy is associated with physiological rises in calcitriol, reduced PTH, and hypercalciuria, features that can mimic or mask this disorder. This case illustrates the diagnostic challenges of recognizing CYP24A1 deficiency in pregnancy.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"492-496"},"PeriodicalIF":5.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145909655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent administration of teriparatide and denosumab: attenuation of bone accrual?","authors":"Jacques P Brown","doi":"10.1093/jbmr/zjag023","DOIUrl":"10.1093/jbmr/zjag023","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"459-460"},"PeriodicalIF":5.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fine-tuning the growth plate by miRNA.","authors":"Noriaki Ono","doi":"10.1093/jbmr/zjaf191","DOIUrl":"10.1093/jbmr/zjaf191","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"467-468"},"PeriodicalIF":5.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145740265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: A novel brachydactyly type E syndrome caused by variants in helix 8 of the PTH1R.","authors":"","doi":"10.1093/jbmr/zjag026","DOIUrl":"10.1093/jbmr/zjag026","url":null,"abstract":"","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"581"},"PeriodicalIF":5.9,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147363461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Markers and regulators of osteoblast and osteoclast activity in children with X-linked hypophosphatemia treated with burosumab.","authors":"Ineke Böckmann, Maren Leifheit-Nestler, Mirko Rehberg, Giuseppina Spartà, Katrina Evers, Karl Peter Schlingmann, Markus J Kemper, Annette Richter-Unruh, Dorothee Schmidt, Olaf Hiort, Karina Grohmann-Held, Carmen Schröder, Ute Derichs, Clemens Freiberg, Marcus Weitz, Desiree Dunstheimer, Elmar Schmid, Ulrike John-Kroegel, Oliver Metzing, Sabine Heger, Norbert Jorch, Hagen Staude, Ludwig Patzer, Elke Wühl, Carl-Joachim Partsch, Angela Hübner, Michaela Marx, Christof Land, Norbert Albers, Jens Banzer, Inka Baus, Frauke Wilkening, Kristina Möller, Verena Wagner, Gabriele Krauch, Michaela Gessner, Alexandra Goischke, Miroslav Zivicnjak, Dirk Schnabel, Dieter Haffner","doi":"10.1093/jbmr/zjag071","DOIUrl":"https://doi.org/10.1093/jbmr/zjag071","url":null,"abstract":"<p><p>Burosumab is effective for treatment of rickets in children with X-linked hypophosphatemia (XLH). The effects of burosumab on markers and regulators of osteoblast and osteoclast acitivity are largely unknown. In this cross-sectional observational study, we investigated 7 key markers and regulators of osteoblast and osteoclast activity in 107 burosumab-treated children with XLH. We calculated z-scores for bone-specific alkaline phosphatase (BAP), procollagen-1-N-terminal propeptide (P1NP), carboxy-terminal telopeptide of type 1 collagen (CTX), tartrate-resistant acid phosphatase type 5b (TRAP5b), soluble receptor activator of NF-κB ligand (sRANKL), osteoprotegerin (OPG), and sclerostin. The median age at investigation and duration of burosumab treatment were 10.7 and 2.2 yr, respectively, with 18.7% of patients on primary burosumab treatment and 81.3% with prior treatment with phosphate and active vitamin D. Height and body mass index improved by approx. 0.3 z-score from baseline with burosumab treatment, and serum phosphate, 1,25-dihydroxyvitamin D, and alkaline phosphatase improved by 2 z-scores (each p < .01 versus prior burosunab), but phosphate (-1.8 z-score) and calcium (-0.65 z-score) remained reduced (each p < .001 versus age and sex specific reference values). The z-scores for osteoblast (BAP, P1NP) and osteoclast (CTX, TRAP5b) activity markers and for the osteoblast suppressor sclerostin were increased (each p < .001). Standardized sRANKL was reduced (p < .05), while the RANKL inhibitor OPG was increased resulting in a reduced sRANKL/OPG ratio (each p < .001). Multivariate analysis revealed significant associations between serum sclerostin and serum phosphate (negative), serum calcium and vitamin D sufficiency (positive), and primary burosumab treatment with BAP (negative). In this real-world setting, pediatric XLH patients receiving burosumab treatment showed persisting mild hypophosphatemia and increased markers of osteoblast and osteoclast acitivity despite negative counter-regulation of osteoblasts by sclerostin and osteoclasts by OPG/RANKL. Our data suggest a more pronounced normalization osteoblast activity when children are primarily treated with burosumab and underscore the need for adequate vitamin D supplementation.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":""},"PeriodicalIF":5.9,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}