Taking a closer look at matrix vesicle biogenesis.

IF 5.9 1区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Charlotte Clews, Scott Dillon, Fabio Nudelman, Colin Farquharson, Louise A Stephen
{"title":"Taking a closer look at matrix vesicle biogenesis.","authors":"Charlotte Clews, Scott Dillon, Fabio Nudelman, Colin Farquharson, Louise A Stephen","doi":"10.1093/jbmr/zjaf076","DOIUrl":null,"url":null,"abstract":"<p><p>Matrix vesicles (MVs) are crucial components in the development of a healthy mineralized skeleton. They are also the key elements leading to the pathological calcification of vasculature; however, we know surprisingly little about them. First characterized over 55 yr ago, MVs are small membrane bound extracellular vesicles (EVs) that provide an environment for the concentration of calcium and phosphate. This makes MVs the first step in producing calcium phosphate, leading to the nucleation of HA mineral within the extracellular matrix, the key process in biomineralization. In this review, we discuss the literature on MV biogenesis and explore their components in the context of EVs and exosomes. We consider MVs in light of the Minimal Information for Studies of Extracellular Vesicles (MISEV2023). In doing so, we identify striking parallels in the biogenesis, contents, and roles of MVs and exosomes, opening opportunities for new avenues of research and understanding. We also explore the debate around whether MVs really contain HA, and propose emerging technologies, particularly in the field of imaging, to improve our understanding of MVs and galvanize research in the area over the coming years. By taking a closer look at MV biogenesis, we will be able to make use of the emerging technologies around EVs more widely, with the aim of fully understanding these vital vesicles and harnessing their potential therapeutic benefits.</p>","PeriodicalId":185,"journal":{"name":"Journal of Bone and Mineral Research","volume":" ","pages":"931-945"},"PeriodicalIF":5.9000,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12308673/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Bone and Mineral Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/jbmr/zjaf076","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

Abstract

Matrix vesicles (MVs) are crucial components in the development of a healthy mineralized skeleton. They are also the key elements leading to the pathological calcification of vasculature; however, we know surprisingly little about them. First characterized over 55 yr ago, MVs are small membrane bound extracellular vesicles (EVs) that provide an environment for the concentration of calcium and phosphate. This makes MVs the first step in producing calcium phosphate, leading to the nucleation of HA mineral within the extracellular matrix, the key process in biomineralization. In this review, we discuss the literature on MV biogenesis and explore their components in the context of EVs and exosomes. We consider MVs in light of the Minimal Information for Studies of Extracellular Vesicles (MISEV2023). In doing so, we identify striking parallels in the biogenesis, contents, and roles of MVs and exosomes, opening opportunities for new avenues of research and understanding. We also explore the debate around whether MVs really contain HA, and propose emerging technologies, particularly in the field of imaging, to improve our understanding of MVs and galvanize research in the area over the coming years. By taking a closer look at MV biogenesis, we will be able to make use of the emerging technologies around EVs more widely, with the aim of fully understanding these vital vesicles and harnessing their potential therapeutic benefits.

Abstract Image

Abstract Image

Abstract Image

仔细观察基质囊泡的生物发生。
基质囊泡(MVs)是健康矿化骨骼发育的重要组成部分。它们也是导致血管病理性钙化的关键因素;然而,令人惊讶的是,我们对它们知之甚少。mv是一种小的膜结合细胞外囊泡,它为钙和磷酸盐的浓度提供了一个环境,在55年前首次被发现。这使得mv成为生产磷酸钙的第一步,导致细胞外基质内HA矿物成核,这是生物矿化的关键过程。在本文中,我们讨论了在细胞外囊泡(EVs)和外泌体的背景下关于MV生物发生的文献,并探讨了它们的成分。我们根据细胞外囊泡研究的最小信息(MISEV2023)来考虑mv。在此过程中,我们发现了mv和外泌体在生物发生、内容和作用方面的惊人相似之处,为研究和理解的新途径开辟了机会。我们还探讨了关于mv是否真的含有HA的争论,并提出了新兴技术,特别是在成像领域,以提高我们对mv的理解,并在未来几年激发该领域的研究。通过对MV生物发生机制的深入研究,我们将能够更广泛地利用围绕电动汽车的新兴技术,以充分了解这些重要的囊泡并利用其潜在的治疗效益。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Bone and Mineral Research
Journal of Bone and Mineral Research 医学-内分泌学与代谢
CiteScore
11.30
自引率
6.50%
发文量
257
审稿时长
2 months
期刊介绍: The Journal of Bone and Mineral Research (JBMR) publishes highly impactful original manuscripts, reviews, and special articles on basic, translational and clinical investigations relevant to the musculoskeletal system and mineral metabolism. Specifically, the journal is interested in original research on the biology and physiology of skeletal tissues, interdisciplinary research spanning the musculoskeletal and other systems, including but not limited to immunology, hematology, energy metabolism, cancer biology, and neurology, and systems biology topics using large scale “-omics” approaches. The journal welcomes clinical research on the pathophysiology, treatment and prevention of osteoporosis and fractures, as well as sarcopenia, disorders of bone and mineral metabolism, and rare or genetically determined bone diseases.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信