Acta cardiologica最新文献

{"title":"The relationship between inflammatory factors and major adverse cardiovascular events in atherosclerosis coronary artery ectasia: a prospective, cohort study.","authors":"Yu Luo, Xiaolin Li, Yaling Liu, Xiaodong Wang","doi":"10.1080/00015385.2025.2515306","DOIUrl":"https://doi.org/10.1080/00015385.2025.2515306","url":null,"abstract":"<p><strong>Background: </strong>To investigate the relationship among high sensitive C reactive protein (hs-CRP), interleukin (IL)-6, tumour necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-9, growth differentiation factor (GDF)-15, corrected thrombolysis in myocardial infarction (TIMI) frame count and major adverse cardiovascular events (MACEs) in atherosclerosis coronary artery ectasia (CAE).</p><p><strong>Materials and methods: </strong>One hundred and sixty-five CAE patients were included. All candidates were divided into symptomatic (107) and asymptomatic (58). Serum hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 were detected. Coronary artery blood flow velocity was evaluated by corrected TIMI frame count (CTFC). The relationship among inflammatory marker levels, CTFC, and clinical symptoms was analysed. The MACEs were recorded during a 2-year follow-up.</p><p><strong>Results: </strong>Symptomatic atherosclerosis CAE manifested male gender, more hypertension, dyslipidemia and smoking than asymptomatic compartments. These patients demonstrated higher serum levels of hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 than those of asymptomatic compartments (<i>p</i> < 0.05, respectively). The CTFC in symptomatic atherosclerosis CAE was lower than that of asymptomatic ones (<i>p</i> < 0.05, respectively). More MACEs occurred in symptomatic than in asymptomatic atherosclerosis CAE during the 2-year follow-up (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>Male gender, hypertension, dyslipidemia and smoking are more frequent in symptomatic atherosclerosis CAE. Hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 have a positive correlation with symptoms and CTFC in atherosclerosis CAE and are predictors of MACEs during 2-year follow-up.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac arrest in a young female: the potentially fatal synergy of selective serotonin reuptake inhibitors and recreational marijuana use.","authors":"Cristian Castillo-Rodriguez, Jesus Davalos, Douglas Andre Salguero-Lopez, Sameh Girgis","doi":"10.1080/00015385.2025.2500889","DOIUrl":"https://doi.org/10.1080/00015385.2025.2500889","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":2.1,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aetiology, clinical characteristics, and risk factors influencing mortality in patients with infective endocarditis: a retrospective study.","authors":"Özkan Vural, Özcan Yılmaz, Ömer Gedikli, Alperen Taş","doi":"10.1080/00015385.2025.2511519","DOIUrl":"https://doi.org/10.1080/00015385.2025.2511519","url":null,"abstract":"<p><strong>Introduction: </strong>Infective endocarditis is defined as an infection of the endothelial surfaces in the heart (valves and endocardium), prosthetic heart valves, and intracardiac devices (such as pacemaker leads and ventricular assist devices). Due to diagnostic challenges, determining the true incidence of infective endocarditis is difficult. Despite advancements in diagnosis and treatment, incidence and mortality rates have not decreased. In this study, we evaluated the clinical and laboratory parameters of patients with infective endocarditis followed in our hospital between 2005 and 2018 and assessed their relationship with in-hospital and one-year mortality.</p><p><strong>Methods: </strong>This study retrospectively analysed 145 patients aged ≥18 years who were diagnosed with infective endocarditis and followed in our hospital between 2005 and 2018. Data were analysed using IBM SPSS V23. Statistical analyses included the Shapiro-Wilk test, T-test, Mann-Whitney U test, and Chi-square test.</p><p><strong>Results: </strong>The average age of the patients was 53 (18-86), and 52.4% (<i>n</i> = 76) were male. In 34% (<i>n</i> = 37) of our patients, the predisposing factor for infective endocarditis was rheumatic valve disease. In-hospital mortality was 31.7%, and one-year mortality was 40.6%. A statistically significant difference in in-hospital mortality was found between combination therapy (23%) and medical therapy (40.8%). Mitral valve involvement was the most common, occurring in 48.3% of patients. Staphylococci were the most frequently isolated microorganisms in blood cultures (41.4%). Heart failure was the most common complication and was associated with the highest mortality rate (23.4%). NYHA was an independent predictor of in-hospital mortality.</p><p><strong>Conclusion: </strong>In our study, surgical intervention, i.e. combination therapy, applied after two weeks of antibiotic treatment, was found to be more effective. Early combination therapy may be life-saving.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When closure isn't closure: postoperative dehiscence of surgically ligated left atrial appendage.","authors":"Maria Gabriela Matta, Dipesh Raniga, Bradley Hefford, Ahmed Reza","doi":"10.1080/00015385.2025.2510015","DOIUrl":"https://doi.org/10.1080/00015385.2025.2510015","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of pulmonary artery pulsatility index in patients with atrial fibrillation and heart failure.","authors":"Yuta Ozaki, Yusuke Uemura, Toru Kondo, Shingo Kazama, Shogo Yamaguchi, Takashi Okajima, Takayuki Mitsuda, Shinji Ishikawa, Kenji Takemoto, Takahiro Okumura, Toyoaki Murohara, Masato Watarai","doi":"10.1080/00015385.2025.2510705","DOIUrl":"https://doi.org/10.1080/00015385.2025.2510705","url":null,"abstract":"<p><strong>Background: </strong>Both atrial fibrillation (AF) and right ventricular dysfunction (RVD) are prognostic factors in patients with heart failure (HF). However, the association between AF and RVD in patients with HF is not fully understood. The pulmonary artery pulsatility index (PAPi), obtained <i>via</i> right heart catheterisation, is a hemodynamic index of the right ventricular function. We investigated the clinical impact of PAPi in patients with HF and concomitant AF.</p><p><strong>Methods: </strong>This was a single-center, retrospective cohort study involving consecutive patients who underwent right heart catheterisation for HF between January 2016 and December 2018. Patients with acute decompensated phase of HF were excluded. The primary endpoint was a composite of all-cause death or hospitalisation due to HF.</p><p><strong>Results: </strong>A total of 347 patients with compensated HF were enrolled. The median follow-up duration was 3.2 years. Patients with AF had lower PAPi levels compared to those without AF. Multiple regression analysis revealed that AF was independently associated with reduced PAPi levels (partial regression coefficient -0.116, 95% confidence intervals [CIs] - 0.174 to -0.058; <i>p</i> < 0.001). Multivariate Cox regression analysis further revealed that low PAPi was an independent predictor of the incidence of the primary endpoint in patients with HF and AF (HR 1.861, 95% CIs 1.076-3.219, <i>p</i> = 0.026).</p><p><strong>Conclusion: </strong>AF was associated with reduced PAPi levels in patients with HF. Low PAPi independently predicted the prognosis of patients with AF and HF. Measuring PAPi provides useful information for the management of patients with HF and concomitant AF.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International survey of cardiac device clinic staff determining patient-perceived challenges with remote monitoring.","authors":"Bert Vandenberk, Neal Ferrick, Elaine Y Wan, Sanjiv M Narayan, Aileen M Ferrick, Satish R Raj","doi":"10.1080/00015385.2025.2510704","DOIUrl":"https://doi.org/10.1080/00015385.2025.2510704","url":null,"abstract":"<p><strong>Background: </strong>Regular interaction with patients with cardiac implantable electronic devices (CIEDs) provides CIED clinic personnel with unique insights into patient-related barriers and challenges to remote monitoring (RM) implementation.</p><p><strong>Methods: </strong>Using a global network, an international survey was administered to CIED clinic personnel. Qualitative questions gathered information on perceived challenges with patient connectivity and patient-level barriers associated with RM implementation.</p><p><strong>Results: </strong>A total of 339 responses from 302 unique centres were included in the analysis. Respondents most often were cardiac electrophysiologists (57.8%), followed by nurses (17.1%) and nurse practitioners (7.7%). Most respondents (84.7%) reported at least one challenge in daily RM management. The biggest challenge was the increasing data volume and data variability (38.3%), followed by staff shortage (33.8%), difficulties with billing for technical activities (20.2%), and insufficient RM reimbursement (16.0%). Patient connectivity was identified as a major barrier by 72.7% of respondents. The main concerns were patient literacy (80.8%), followed by a lack of patient understanding of RM importance (65.8%), the lack of required bandwidth or technology to support RM (49.6%), and the cost to the patient (47.9%). Subgroup analyses showed that patient connectivity was often identified as a major barrier by non-MD CIED clinic staff, respondents working in office-based CIED clinics, and respondents from clinics with a per-patient payment reimbursement model.</p><p><strong>Conclusions: </strong>There are many patient-related barriers identified by non-MD CIED clinic staff. Dedicated strategies to optimise the utilisation and adherence of RM of patients with CIEDs are urgently needed to improve clinical outcomes.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular RNA profiling reveals an abundant circPTK2 that contributes everolimus-induced endothelial cell dysfunction via regulating miR-1-5p/ACVR2B/StarD13 axis.","authors":"Yixin Zhao, Jiangrong Wang, Xiaomeng Jia, Hao Li, Pengju Zhu, Cong Wang, Qingbin Zhang, Yinglong Hou, Weizong Wang","doi":"10.1080/00015385.2025.2510706","DOIUrl":"https://doi.org/10.1080/00015385.2025.2510706","url":null,"abstract":"<p><strong>Background: </strong>mTOR inhibitors released from drug-eluting stents (DESs) play a critical role in the pathogenesis of in-stent neoatherosclerosis (ISNA), contributing to the development of late in-stent restenosis (ISR). Circular RNAs (circRNAs) are emerging as key regulators in various pathophysiological processes, but their involvement in ISNA remains unclear.</p><p><strong>Methods: </strong>The expression pattern of circRNAs in human umbilical vein endothelial cells (HUVECs) treated with everolimus (EVL) was analysed using RNA sequencing. The expression levels of circRNAs, miR-1-5p, and the downstream targets ACVR2B/StarD13 were measured by quantitative real-time PCR. The effects of circPTK2 on cell proliferation, migration, apoptosis, and permeability in EVL-treated endothelial cells were assessed using cell counting kit-8, scratch, Annexin-V FITC and PI double-staining, and transwell assays. Bioinformatics analysis and dual luciferase assay were used to identify the interaction between circPTK2 and miR-1-5p. The association between circPTK2, miR-1-5p, and ACVR2B/StarD13 was further evaluated by functional rescue experiments.</p><p><strong>Results: </strong>CircPTK2 was significantly upregulated in EVL-treated HUVECs. Knockdown of circPTK2 reversed the EVL-induced suppression of cell viability and migration, reduced apoptosis, and alleviated endothelial barrier leakage. Conversely, circPTK2 overexpression produced the opposite effects. Mechanistically, circPTK2 acted as a sponge for miR-1-5p, leading to increased expression of its target genes ACVR2B and StarD13. Silencing ACVR2B or StarD13 partially attenuated the exacerbating effects of miR-1-5p inhibition on EVL-induced endothelial dysfunction. Moreover, inflammatory conditions affected the expressions of circPTK2, miR-1-5p, and ACVR2B/StarD13.</p><p><strong>Conclusions: </strong>CircPTK2 regulates EVL-induced endothelial dysfunction via the miR-1-5p/ACVR2B/StarD13 axis, providing novel insights for the treatment of late ISR after DES implantation.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-17"},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long extracranial vertebral artery fenestration.","authors":"Damandeep Singh, Niraj Nirmal Pandey, Aprateem Mukherjee, Nitish Naik","doi":"10.1080/00015385.2025.2510013","DOIUrl":"https://doi.org/10.1080/00015385.2025.2510013","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The protective role of dapagliflozin on the noreflow phenomenon in type 2 diabetic patients with acute coronary syndrome undergoing percutaneous coronary intervention.","authors":"Cemal Köseoğlu, Ali Çoner, Can Ramazan Öncel","doi":"10.1080/00015385.2025.2511523","DOIUrl":"10.1080/00015385.2025.2511523","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-3"},"PeriodicalIF":2.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of 2021 ESC Guidelines on cardiac pacing and cardiac resynchronisation therapy, on cardiovascular disease prevention, on the management of valvular heart disease and of heart failure.","authors":"George H Mairesse, Johan De Sutter, Patrizio Lancellotti, Michel De Pauw, Marc J Claeys","doi":"10.1080/00015385.2025.2506338","DOIUrl":"https://doi.org/10.1080/00015385.2025.2506338","url":null,"abstract":"<p><p>During the ESC congress in September 2021, the new ESC guidelines were presented and are available on the ESC website. The new guidelines describes management recommendations on following cardiovascular domains : cardiac pacing and cardiac resynchronization therapy, cardiovascular prevention, valvular heart disease and heart failure. The present document gives a summary of these guidelines and highlights the most important recommendations and changes in the management of these diseases. It will help to increase awareness about the new guidelines and may stimulate to consult the full document for specific items. Ultimately, the authors hope that this document will enhance implementation of new ESC guidelines in daily clinical practice.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144140970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}