Acta cardiologica最新文献

{"title":"Association between waist-to-height-haemoglobin A1c index and subclinical myocardial injury in individuals with and without hypertension.","authors":"Tala Tabrizi, Mohammad Sadra Kiani, Mobin Masoudimoghaddam, Shakiba Fardoost, Soroush Soraneh","doi":"10.1080/00015385.2026.2750006","DOIUrl":"https://doi.org/10.1080/00015385.2026.2750006","url":null,"abstract":"<p><strong>Aims: </strong>Recently, a novel metabolic indicator, the Waist-to-Height-Haemoglobin A1c (WHH) index, has been shown to be associated with diabetes risk. This study investigated the association of WHH with the Cardiac Infarction/Injury Score (CIIS) and the risk of subclinical myocardial injury (SC-MI), stratified by hypertension status.</p><p><strong>Methods: </strong>We conducted a cross-sectional analysis of 5,597 adults aged ≥40 years from the Third National Health and Nutrition Examination Survey who were free of CVD. The WHH index was calculated as waist circumference/height × HbA1c. SC-MI was defined as a CIIS ≥10 on a 12-lead electrocardiogram. Using weighted generalised linear and logistic regression models, we examined the associations of WHH with CIIS and SC-MI. Nonlinear relationships were assessed using restricted cubic spline (RCS) models.</p><p><strong>Results: </strong>The WHH index was not associated with SC-MI among adults without hypertension (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.73-1.24 per SD increase), but was positively associated among adults with hypertension (OR, 1.37; 95% CI, 1.08-1.72; <i>P</i>_interaction = 0.007). For the CIIS, each 1-SD higher WHH index was positively associated only among those with hypertension (β = 0.81; 95% CI, 0.12 to 1.63; <i>P</i>_interaction = 0.020). RCS analysis confirmed a linear relationship between WHH and SC-MI risk among individuals with hypertension.</p><p><strong>Conclusions: </strong>These findings demonstrate a significant association between the WHH index and subclinical myocardial injury, particularly among adults with hypertension.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-12"},"PeriodicalIF":4.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association is not mechanism: limitations in linking systemic inflammation to impaired right ventricular reserve in HFpEF.","authors":"Amna Faiz, Wazzuha Gulalai, Summaya Gul","doi":"10.1080/00015385.2026.2752313","DOIUrl":"https://doi.org/10.1080/00015385.2026.2752313","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-3"},"PeriodicalIF":4.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravascular imaging improves outcomes in left main PCI: insights from acute and chronic presentations.","authors":"Ana Sofia Nogueira Fernandes, Mónica Patrícia Silva Dias, Carla Rafaela Oliveira Ferreira, Filipe Xavier Silva Vilela, Catarina Quina Rodrigues, João Fernando Dos Santos Costa, Jorge Manuel Gomes Sousa Marques, Carlos Galvão de Oliveira Braga","doi":"10.1080/00015385.2026.2747420","DOIUrl":"https://doi.org/10.1080/00015385.2026.2747420","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous coronary intervention (PCI) has emerged as an established revascularization strategy for selected patients with left main coronary artery (LMCA) disease. However, data regarding outcomes in unselected real-world populations and the impact of intravascular imaging remain limited. We aimed to evaluate clinical outcomes following LMCA PCI according to clinical presentation and to assess the prognostic impact of intravascular imaging guidance.</p><p><strong>Methods: </strong>We conducted a retrospective single-centre study including consecutive patients undergoing LMCA PCI between 2019 and 2022. Patients were classified as having chronic (CCS) or acute coronary syndrome (ACS). Major adverse cardiac and cerebrovascular events (MACCE) were assessed during follow-up. Kaplan-Meier and Cox regression and stabilised inverse probability of treatment weighting (SIPTW) analyses were performed.</p><p><strong>Results: </strong>A total of 107 patients were included (19 CCS and 88 ACS; mean age 68.6 ± 11.3 years; 80.4% male). During a mean follow-up of 1121 ± 574 days, ACS patients experienced higher rates of MACCE (40.9% vs. 15.8%; <i>p</i> = 0.039) and all-cause mortality (29.5% vs. 5.3%; <i>p</i> = 0.027) compared with CCS patients. Intravascular imaging-guided PCI was associated with a significantly lower risk of MACCE in multivariable analysis (HR 0.32, 95% CI 0.14-0.75; <i>p</i> = 0.009). In a SIPTW-adjusted analysis, the association remained directionally favourable, although statistical significance was not maintained (HR 0.57, 95% CI 0.26-1.29; <i>p</i> = 0.178).</p><p><strong>Conclusions: </strong>Clinical presentation significantly influences outcomes after LMCA PCI, with worse long-term prognosis among ACS patients. Intravascular imaging-guided PCI was associated with lower rates of MACCE and remained directionally favourable after weighting analyses, supporting its role in optimising LMCA interventions.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-13"},"PeriodicalIF":4.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149219749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From SCORE-Belgium to SCORE2: impact of successive guideline updates on cardiovascular risk categorization.","authors":"Martin Benoit, Olivier Descamps, Elias Bentakhou, Fabian Demeure","doi":"10.1080/00015385.2026.2747548","DOIUrl":"https://doi.org/10.1080/00015385.2026.2747548","url":null,"abstract":"<p><p><b>Background:</b> Successive European guideline updates have modified the estimation and categorisation of cardiovascular risk. The transition from the Belgian SCORE calibration to SCORE2 in 2021, followed by revision of SCORE2 thresholds in 2025, may substantially alter clinical interpretation without changes in individual patient characteristics.<b>Methods:</b> Adults aged 40-69 years in primary prevention were retrospectively included from two Belgian centres. Both cohorts were pooled into a single analytical population. Cardiovascular risk was assessed using the HDL-corrected SCORE-Belgium model (2019), SCORE2 (2021), and the updated SCORE2 thresholds (2025), applied to identical baseline data. Low and moderate categories were harmonised. Reclassification was analysed descriptively.<b>Results:</b> Among 413 individuals, 84.3% were classified as low-moderate risk with SCORE-Belgium, 11.6% as high risk, and 4.1% as very high risk. With SCORE2 (2021), 58.8% were categorised as high risk and 7.3% as very high risk. Application of the 2025 thresholds reversed this distribution: 93.5% were classified as low-moderate risk, 6.5% as high risk, and none as very high risk. These variations affected largely the same individuals and occurred despite identical underlying risk estimates.<b>Conclusion:</b> Guideline updates markedly influence cardiovascular risk categorisation in primary prevention. The changes observed are predominantly attributable to the definitions of thresholds, rather than to differences in the underlying risk estimates. Risk categories should, therefore, be interpreted in the context of the specific assessment framework employed. In addition, supplementary methods for refining individual risk remain necessary.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-7"},"PeriodicalIF":4.0,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149214934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updated systematic review and meta-analysis comparing Myval versus Sapien 3 transcatheter heart valves in severe aortic stenosis: focus on early and one-year mortality.","authors":"Lin Yang, Guisong Yu, Mingchen Pan, Yandong Liu, Yuxi Zhu, Mengyu Zhang, Haigen Yu, Zhaohui Pei","doi":"10.1080/00015385.2026.2742689","DOIUrl":"https://doi.org/10.1080/00015385.2026.2742689","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter aortic valve implantation (TAVI) is a guideline-recommended treatment for severe aortic stenosis (AS). While the balloon-expandable Edwards Sapien 3 valve has long been the benchmark, the newer Myval valve has emerged as a potential alternative. Comparative data on mid-term survival, specifically one-year all-cause mortality, are lacking but crucial for clinical evaluation.</p><p><strong>Methods: </strong>This systematic review and meta-analysis synthesised direct comparative evidence on the Myval versus Sapien 3 valves in patients undergoing TAVI, searching PubMed, Embase, and Cochrane Central up to November 2025. The primary outcomes included all-cause mortality within 30 days and 1 year. Secondary outcomes were 30-day safety events and hemodynamic parameters.</p><p><strong>Results: </strong>Five studies (<i>n</i> = 2771) were included. The pooled analysis indicated no statistical difference in 30-day mortality (RR: 1.05, 95% CI: 0.53-2.07; <i>p</i> = 0.89; I²=0%) or in one-year all-cause mortality (RR: 0.93, 95% CI: 0.64-1.35; <i>p</i> = 0.70; I²=0%). Rates of stroke, major bleeding, pacemaker implantation, and other 30-day complications were also comparable (all <i>p</i> > 0.05). Hemodynamically, the Myval valve was superior at 30 days, with a lower mean gradient (MD: -2.37, 95% CI: -3.45 to -1.30; <i>p</i> < 0.0001) and larger effective orifice area (MD: 0.26, 95% CI: 0.17-0.35; <i>p</i> < 0.00001). Available one-year data from two randomised trials indicated this hemodynamic benefit was sustained.</p><p><strong>Conclusion: </strong>This updated meta-analysis demonstrates that the newer Myval valve offers comparable early safety and one-year survival to the established Sapien 3 valve, with superior and sustained hemodynamic performance. These findings support its role as a safe and effective alternative in the TAVI landscape.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-12"},"PeriodicalIF":4.0,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of a single high-concentration sodium bicarbonate bolus on contrast-induced nephropathy in STEMI patients undergoing Primary PCI: a prospective randomized study.","authors":"Basant Zahid, Ahmed Bendary, Mahmoud AbdelHay, Mona Hamadto","doi":"10.1080/00015385.2026.2747423","DOIUrl":"https://doi.org/10.1080/00015385.2026.2747423","url":null,"abstract":"<p><strong>Background: </strong>Contrast-induced nephropathy (CIN) remains an important complication following primary percutaneous coronary intervention (PPCI) in patients with ST-segment elevation myocardial infarction (STEMI). In emergency settings, preventive strategies must be rapid and compatible with timely reperfusion. This study evaluated whether a single preprocedural bolus of high-concentration sodium bicarbonate was associated with a lower incidence of CIN.</p><p><strong>Methods: </strong>In this prospective randomised study, 110 STEMI patients undergoing PPCI at two tertiary centres were enrolled. All patients received standard care, including isotonic saline hydration. Participants were assigned to saline hydration alone or saline plus a single intravenous bolus of 20 mEq of 8.4% sodium bicarbonate administered 5-10 min before contrast exposure. The primary endpoint was CIN within 48 ± 12 h, defined as an increase in serum creatinine ≥0.5 mg/dL or ≥25% from baseline.</p><p><strong>Results: </strong>Baseline characteristics were generally comparable, although baseline blood urea nitrogen was higher and estimated glomerular filtration rate lower in the control group. CIN occurred more frequently in controls than in the sodium bicarbonate group (16.4% vs. 1.8%; <i>p</i> = 0.008). Renal function trajectories also favoured sodium bicarbonate. However, sodium bicarbonate did not remain an independent predictor of CIN after multivariable adjustment (OR 0.061, 95% CI 0.003-1.205; <i>p</i> = 0.066).</p><p><strong>Conclusions: </strong>Sodium bicarbonate administration was associated with a lower unadjusted incidence of CIN. These findings should be considered hypothesis-generating and require confirmation in larger multicentre studies.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":4.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149163340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Celoria-Patton type a interrupted aortic arch with extensive collateral circulation in a 7-year-old girl.","authors":"Daoxiong Xiao, Binglin Lai","doi":"10.1080/00015385.2026.2747440","DOIUrl":"https://doi.org/10.1080/00015385.2026.2747440","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":4.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stanford type A aortic dissection in long-standing Langerhans cell histiocytosis: a possible association.","authors":"Daoxiong Xiao, Binglin Lai","doi":"10.1080/00015385.2026.2747424","DOIUrl":"https://doi.org/10.1080/00015385.2026.2747424","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":4.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time trend in hospitalisations for acute myocardial infarction among young adults in Brazil: 2015-2024.","authors":"Ana Clara Fernandes de Souza Santos, Simone Santos Souza, Rejane Santos Barreto, Emanuella Gomes Maia, Icaro J S Ribeiro","doi":"10.1080/00015385.2026.2742046","DOIUrl":"https://doi.org/10.1080/00015385.2026.2742046","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to analyse the temporal trend of hospitalisations due to AMI in young people in Brazil, from 2015 to 2024.</p><p><strong>Methods: </strong>This is an ecological time-series study (2015-2024), with data from the Hospital Information System, on hospitalisations due to AMI in young people, considering individuals aged between 10 and 29 years. The data were analysed using the Prais-Winsten method, with a significance level of 5%, where the temporal trend of the hospitalisations of AMI in young people was calculated.</p><p><strong>Results: </strong>10,100 AMI cases were reported, corresponding to an approximate hospitalisation rate of 1.56 cases per 100,000 inhabitants per year. From 2015 to 2024, hospitalisations for AMI among young people increased significantly (coefficient = 0.09), with the highest rises in the South (0.13) and Midwest (0.23) regions. Dividing the interval into two subperiods revealed that from 2015 to 2019, all coefficients were positive, but only the South region exhibited a statistically significant trend (coefficient = 0.07). In the next period, 2020-2024, Brazil showed an upward trend in AMI hospitalisations (coefficient = 0.15), with the Northeast (coefficient = 0.09), South (coefficient = 0.25), and Midwest (coefficient = 0.29) regions also demonstrating significant increases.</p><p><strong>Conclusion: </strong>The study indicates an upward trend in AMI in the young Brazilian population, reiterating the epidemiological transition, which points to the urgent need to reorient public health policies, focusing on early prevention, timely diagnosis and reducing social and racial inequalities that influence cardiovascular risk in young people.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":4.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe aortic stenosis with a calcifying fibrous tumour: a rare surgical challenge.","authors":"Gizem Yuksel, Duygu Genc Albayrak, Duygu Inan","doi":"10.1080/00015385.2026.2742044","DOIUrl":"https://doi.org/10.1080/00015385.2026.2742044","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-3"},"PeriodicalIF":4.0,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}