Acta cardiologica最新文献_第10页

Predictive utility of residual SYNTAX score for clinical outcomes after successful primary percutaneous coronary intervention. 经皮冠状动脉介入治疗成功后，残留 SYNTAX 评分对临床结果的预测作用。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-08-19 DOI: 10.1080/00015385.2024.2392327

Ahmad Samir, Mai Elshinawi, Hesham Yehia, Azza Farrag

{"title":"Predictive utility of residual SYNTAX score for clinical outcomes after successful primary percutaneous coronary intervention.","authors":"Ahmad Samir, Mai Elshinawi, Hesham Yehia, Azza Farrag","doi":"10.1080/00015385.2024.2392327","DOIUrl":"10.1080/00015385.2024.2392327","url":null,"abstract":"Background: In patients presenting with ST-segment elevation myocardial infarction (STEMI), the prevalence of having concomitant severe non-culprit lesion(s) is ≥40%. While timely primary PCI (pPCI) for the culprit lesion is the standard practice, management of the non-culprit lesions remains unsettled.Results: This prospective multi-center observational study recruited 492 acute STEMI patients who underwent successful pPCI for the culprit lesion. Culprit-only versus complementary non-culprit lesion(s) PCI (either immediate or staged during the same hospital stay) was according to the operator's discretion. Clinical, echocardiographic, and angiographic data were collected and tabulated. The residual SYNTAX score (rSS) was completed by the time of discharge considering the residual lesions after all in-hospital revascularization procedures. Through a minimum follow-up of 12 months, older age, presentation with heart failure Killip class ≥ II, lower estimated glomerular filtration rate (eGFR) on admission, lower left ventricular ejection fraction (LVEF), and higher rSS by discharge were significantly associated with recurrent MACE. In multivariate regression analysis, Killip class ≥ II, LVEF, and rSS were found to be independent predictors for recurrent MACE. In the Receiver Operating Characteristics curve, an rSS of >8 had a sensitivity of 70.1%, and specificity of 75.3% to predict 1-year MACE.Conclusions: Residual syntax score proved to be an independent predictor for recurrent MACE through the subsequent year post STEMI. Patients with rSS >8 seem to be at the highest risk for adverse events and are likely to be the most deserving for completing revascularization to reduce the disease burden.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"761-767"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing renal function as a predictor of adverse outcomes in diabetic patients undergoing percutaneous coronary intervention. 评估肾功能对接受经皮冠状动脉介入治疗的糖尿病患者不良预后的预测作用。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-10-08 DOI: 10.1080/00015385.2024.2410603

Farima Sadat Mousavi, Babak Bagheri, Rozita Jalalian, Maryam Nabati, Amir Moradi, Fatemeh Mousavi, Erfan Ghadirzadeh

{"title":"Assessing renal function as a predictor of adverse outcomes in diabetic patients undergoing percutaneous coronary intervention.","authors":"Farima Sadat Mousavi, Babak Bagheri, Rozita Jalalian, Maryam Nabati, Amir Moradi, Fatemeh Mousavi, Erfan Ghadirzadeh","doi":"10.1080/00015385.2024.2410603","DOIUrl":"10.1080/00015385.2024.2410603","url":null,"abstract":"Background: Cardiovascular diseases remain a leading cause of global mortality, particularly among diabetic patients undergoing percutaneous coronary intervention (PCI). Chronic kidney disease (CKD) poses an additional risk in this population. Yet, its specific impact on major adverse cardiovascular events (MACEs), mortality, and triple vessel disease (TVD) post-PCI remains a topic of debate, specifically in patients with type 2 diabetes mellitus (T2DM).Objective: This study aimed to examine the impact of renal function on MACE, mortality, and TVD among diabetic patients undergoing PCI.Methods: Diabetic patients undergoing PCI were analysed for renal function and outcomes. Participants were stratified by glomerular filtration rate (GFR). Logistic regression and receiver operating characteristic (ROC) analysis assessed associations and predictive capabilities.Results: A total of 505 patients enrolled in the study. A significant difference was observed regarding age, creatinine levels, and number of culprit vessels between diabetics with and without CKD. Severe CKD was associated with higher odds of 1-month mortality (OR: 15.694, p value <.001), 1-month MACE (OR: 7.734, p value <.001), and TVD (OR: 3.740, p value <.001). Patients with severe CKD also had significantly higher odds of 6-months mortality (OR: 12.192, p value <.001) and 6-months MACE (OR: 3.848, p value: .001). Moreover, GFR showed significant predictive accuracy for mortality at one- and six-months follow-up (AUC: 0.77 and 0.71, respectively).Conclusions: Renal dysfunction, particularly severe CKD, significantly elevates risks of MACE, mortality, and TVD. Strategies to optimise renal function and tailor cardiovascular management could mitigate adverse outcomes in this high-risk population.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"824-832"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grüntzig's coronary angioplasty, revisited, modified and improved. 格伦茨格冠状动脉血管成形术的再认识、改进和改良。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-08-15 DOI: 10.1080/00015385.2024.2391140

Pitt O Lim

引用次数: 0

Mid-aortic syndrome in a 5-year-old girl: multimodal imaging approaches and treatment and successful external anatomic bypass surgery. 一名 5 岁女孩的主动脉中段综合征：多模态成像方法和治疗以及成功的外部解剖搭桥手术。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-08-21 DOI: 10.1080/00015385.2024.2392316

Juan Xu, Xiaojing Ma, Renhui Cai, Chaoqun Yan

引用次数: 0

The relationship between the new inflammatory markers and disease severity in patients with acute coronary syndrome. 急性冠状动脉综合征患者的新炎症标志物与疾病严重程度之间的关系。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-09-17 DOI: 10.1080/00015385.2024.2403933

Gonul Seyda Seydel, Inayet Gunturk, Hasan Akkaya, Ertugrul Emre Gunturk

{"title":"The relationship between the new inflammatory markers and disease severity in patients with acute coronary syndrome.","authors":"Gonul Seyda Seydel, Inayet Gunturk, Hasan Akkaya, Ertugrul Emre Gunturk","doi":"10.1080/00015385.2024.2403933","DOIUrl":"10.1080/00015385.2024.2403933","url":null,"abstract":"Background: Inflammation plays a crucial role in the progression of acute coronary syndrome.Aims: The aim of this study was to investigate the relationship between the SYNTAX score and new inflammatory markers including albumin-globulin ratio (AGR), C-reactive protein-to-albumin ratio (CAR), fibrinogen-to-albumin ratio (FAR), neutrophil-to-albumin ratio (NAR), and neutrophil percentage-to-albumin ratio (NPAR) in STEMI and NSTEMI patients.Methods: The study involved 53 STEMI and 64 NSTEMI patients, and each patient group was evaluated separately. Multivariate linear regression analysis was utilised to identify independent risk factors associated with SYNTAX scores.Results: Out of the 64 NSTEMI patients, 42 had low SYNTAX score (65.6%), and 22 had high SYNTAX score (34.4%). Patients with high SYNTAX scores had significantly higher levels of age, glucose, fibrinogen, monocyte, and FAR, and lower levels of albumin and total protein. We found that FAR and monocyte levels were independent predictors of the high SYNTAX score. The study also determined that the cut-off value for FAR as 9.99, with a sensitivity of 81% and a specificity of 73% for predicting high SYNTAX score in NSTEMI patients. Out of the 53 STEMI patients, 42 had low SYNTAX score (79.2%), and 11 had high SYNTAX score (20.8%). Patients with high SYNTAX scores exhibited significantly higher total cholesterol, LDL, and glucose levels, and lower albumin and total protein levels.Conclusions: The FAR level is significantly linked with the high SYNTAX score and can be a useful marker for predicting the severity of disease in NSTEMI patients.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"778-786"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circulating miR-133a-3p and miR-451a as potential biomarkers for diagnosis of coronary artery disease. 循环 miR-133a-3p 和 miR-451a 作为诊断冠状动脉疾病的潜在生物标记物。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-10-07 DOI: 10.1080/00015385.2024.2410599

Rathinavel Andiappan, Ramajayam Govindan, Thirunavukkarasu Ramasamy, Maheshkumar Poomarimuthu

{"title":"Circulating miR-133a-3p and miR-451a as potential biomarkers for diagnosis of coronary artery disease.","authors":"Rathinavel Andiappan, Ramajayam Govindan, Thirunavukkarasu Ramasamy, Maheshkumar Poomarimuthu","doi":"10.1080/00015385.2024.2410599","DOIUrl":"10.1080/00015385.2024.2410599","url":null,"abstract":"Background: Coronary artery disease (CAD) remains the leading cause of mortality and morbidity around the world. Despite significant progress in the diagnosis and treatment of cardiovascular diseases, still there is a clinical need to identify novel biomarkers for early diagnosis and treatment of CAD. The aim of the study is to investigate circulating miRNAs in CAD patients to identify potential biomarkers for early detection and therapeutic management of CAD.Methods: We assessed the expression of different candidate miRNAs (miR-21-5p, miR-133a-3p, miR-221-3p, miR-451a and miR-584-5p) in plasma from 50 CAD patients and 50 controls by qRT-PCR analysis.Results: The expression levels of miR-133a-3p (fold change (FC): 28.05, p < 0.0001), miR-451a (FC: 27.47, p < 0.0001), miR-584-5p (FC: 7.89, p < 0.0001), miR-21-5p (FC: 5.35, p < 0.0001) and miR-221-3p (FC: 5.03, p < 0.0001) were significantly up-regulated in CAD patients compared to controls. Receiver operating characteristic curve analysis showed that miR-133a-3p and miR-451a were powerful biomarkers for detecting CAD.Conclusions: Our results suggested that miR-21-5p, miR-133a-3p, miR-221-3p, miR-451a and miR-584-5p may serve as independent biomarkers for CAD. Further, the combination of miR-133a-3p and miR-451a could be used as a specific signature in CAD diagnosis.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"813-823"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare coronary anomaly: left anterior descending coronary artery to right ventricular fistula. 罕见的冠状动脉畸形：左冠状动脉前降支至右心室瘘。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-08-01 DOI: 10.1080/00015385.2024.2380842

Li Zhu, Zhenzhen Xiao, Leizhi Ku, Ping Hu, Xiaojing Ma

引用次数: 0

The association between the single-nucleotide polymorphism of site rs1333040 in region 9p21 and the risk of coronary heart disease in Chinese population. 中国人群 9p21 区段 rs1333040 位点的单核苷酸多态性与冠心病风险的关系

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-08-15 DOI: 10.1080/00015385.2024.2391132

Chen-Hui Zhao

{"title":"The association between the single-nucleotide polymorphism of site rs1333040 in region 9p21 and the risk of coronary heart disease in Chinese population.","authors":"Chen-Hui Zhao","doi":"10.1080/00015385.2024.2391132","DOIUrl":"10.1080/00015385.2024.2391132","url":null,"abstract":"Background: Rs1333040 is the single-nucleotide polymorphisms (SNP) related with coronary heart disease (CHD). The aim of the present study is to examine the association between rs1333040 polymorphism genotypes and CHD and to further explore the molecular mechanism in Chinese population.Methods: A case-control study was used in this study, including 500 CHD patients and 500 control subjects. CHD patients and controls were distinguished by coronary angiography. Genotypes of rs1333040 were determined on the Agena MassARRAY system. Statistical analysis was conducted by SPSS (Ver 16.0) and plink (Ver. 1.07, Shaun Purcell).Results: Fisher's exact test by plink indicated a significant difference in the allele distribution between cases and controls, the allele T may be associated with a higher risk of CHD (p = 0.012, odds ratio (OR) = 1.258). The serum levels of low-density lipoprotein cholesterol (LDL-C) (p = 0.029) and Gensini score (p = 0.008) distributed differently in patients with various alleles. In the recessive model, the levels of high-density lipoprotein (HDL) and apolipoprotein A (ApoA) were higher in the TC + CC genotype than in the TT genotype. The TC + TT genotype was found to be risk factors against CHD in a dominant model (OR = 1.278, p = 0.014). The TC + TT genotype along with multiple risk factors significantly positively correlated with the risk of CHD.Conclusions: The present study investigates the association between the rs1333040 polymorphism genotypes and CHD. The T allele of rs1333040 is the susceptibility site of CHD. The interaction between SNP and various risk factors plays an important role in the development of CHD.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"751-760"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141981399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRPC5-mediated NLRP3 inflammasome activation contributes to myocardial cell pyroptosis in chronic intermittent hypoxia rats. TRPC5介导的NLRP3炎症小体活化导致慢性间歇性缺氧大鼠心肌细胞脓毒症。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-10-08 DOI: 10.1080/00015385.2024.2408137

Yu Li, Sharezhati Yishajiang, Yulan Chen, Gulinazi Tulahong, Wen Wen, Mengmeng Wang, Zhiqiang Li

{"title":"TRPC5-mediated NLRP3 inflammasome activation contributes to myocardial cell pyroptosis in chronic intermittent hypoxia rats.","authors":"Yu Li, Sharezhati Yishajiang, Yulan Chen, Gulinazi Tulahong, Wen Wen, Mengmeng Wang, Zhiqiang Li","doi":"10.1080/00015385.2024.2408137","DOIUrl":"10.1080/00015385.2024.2408137","url":null,"abstract":"Background: Chronic intermittent hypoxia (CIH) is the primary cause of myocardial inflammation in obstructive sleep apnea-hypopnea syndrome (OSAHS). Pyroptosis is a newly discovered form of programmed cell death accompanying inflammatory reactions. Our previous study showed that TRPC5 is upregulated in the myocardial injury of CIH rats. The present study aimed to explore the role of TRPC5 in CIH-induced myocardial cell pyroptosis.Methods: A model of CIH in OSA rats was established. SD rats were randomly divided into control group(8rats) and OSA group(8rats). Scanning electron microscope(SEM) was performed on left ventricular tissues slides. Western blot were used to detect the expression levels of pyroptosis-related factors and TRPC5 and its downstream proteins in myocardia tissue.Results: The pyroptosis of myocardial cells by SEM revealed damaged cell membrane integrity of OSA group rats, with fibrous tissue attached to the cell membrane surface, and vesicular protrusions and pyroptotic bodies were observed. Compared to the control group, the expression of pyroptosis-related proteins, such as caspase1, pro-IL-1β, IL-1β, IL-18, GSDMD, and GSDMD-N was upregulated in the OSA group (p < 0.05). Compared to the control group, the expression of TRPC5, NLPR3, p-CaMKIIβ + δ+γ, and HDAC4 was higher in the OSA group (p < 0.05).Conclusions: These findings indicated that the pyroptosis response increases in CIH-induced myocardial injury, and the mechanism that TRPC5 is upregulated, promoting the expression of NLRP3 and inflammasome formation through CaMKII phosphorylation and HDAC4 cytoplasmic translocation. This might be a potential target for the treatment of OSA-induced myocardial injury.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"796-804"},"PeriodicalIF":2.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142387221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aorta-right atrial tunnel with anomalous circumflex artery origin. 主动脉-右心房隧道伴有异常的环状动脉起源。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2024-09-01 Epub Date: 2024-07-04 DOI: 10.1080/00015385.2024.2375050

Dlm Wang-Ying, Ming-Bin Deng, Xiao-Jun Xie

引用次数: 0