Acta cardiologica最新文献

{"title":"The relationship between inflammatory factors and major adverse cardiovascular events in atherosclerosis coronary artery ectasia: a prospective, cohort study.","authors":"Yu Luo, Xiaolin Li, Yaling Liu, Xiaodong Wang","doi":"10.1080/00015385.2025.2515306","DOIUrl":"10.1080/00015385.2025.2515306","url":null,"abstract":"<p><strong>Background: </strong>To investigate the relationship among high sensitive C reactive protein (hs-CRP), interleukin (IL)-6, tumour necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-9, growth differentiation factor (GDF)-15, corrected thrombolysis in myocardial infarction (TIMI) frame count and major adverse cardiovascular events (MACEs) in atherosclerosis coronary artery ectasia (CAE).</p><p><strong>Materials and methods: </strong>One hundred and sixty-five CAE patients were included. All candidates were divided into symptomatic (107) and asymptomatic (58). Serum hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 were detected. Coronary artery blood flow velocity was evaluated by corrected TIMI frame count (CTFC). The relationship among inflammatory marker levels, CTFC, and clinical symptoms was analysed. The MACEs were recorded during a 2-year follow-up.</p><p><strong>Results: </strong>Symptomatic atherosclerosis CAE manifested male gender, more hypertension, dyslipidemia and smoking than asymptomatic compartments. These patients demonstrated higher serum levels of hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 than those of asymptomatic compartments (<i>p</i> < 0.05, respectively). The CTFC in symptomatic atherosclerosis CAE was lower than that of asymptomatic ones (<i>p</i> < 0.05, respectively). More MACEs occurred in symptomatic than in asymptomatic atherosclerosis CAE during the 2-year follow-up (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>Male gender, hypertension, dyslipidemia and smoking are more frequent in symptomatic atherosclerosis CAE. Hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 have a positive correlation with symptoms and CTFC in atherosclerosis CAE and are predictors of MACEs during 2-year follow-up.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"506-513"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long extracranial vertebral artery fenestration.","authors":"Damandeep Singh, Niraj Nirmal Pandey, Aprateem Mukherjee, Nitish Naik","doi":"10.1080/00015385.2025.2510013","DOIUrl":"10.1080/00015385.2025.2510013","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"525-526"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum and dietary fatty acids and their relationship to vascular inflammation and carotid intima-media thickness: implications for cardiovascular risk in patients with arterial hypertension.","authors":"Georgina N Marchiori, María E Paqualini, David Flores, María F Triquell, María J Moreira-Espinoza, Aldo R Eynard, Mirta A Valentich, María D Defagó","doi":"10.1080/00015385.2025.2493978","DOIUrl":"10.1080/00015385.2025.2493978","url":null,"abstract":"<p><strong>Background: </strong>Pathogenic mechanisms involved in arterial hypertension (HT) promote the atherosclerosis development. Fatty acids (FAs) could modulate these processes. We investigated the association between dietary and serum FAs and early atherosclerosis development and their correlation with serum vascular inflammation markers in HT.</p><p><strong>Methods: </strong>96 patients were included. Dietary information was collected through a validated food frequency questionnaire. Serum FAs were detected by gas chromatography. High-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6) and fibrinogen serum were determined by immunoturbidimetry, enzyme immunoassay and Clauss method, respectively. Carotid intima media-thickness (cIMT) was determined by ultrasound. Multivariate linear regression models were applied.</p><p><strong>Results: </strong>Patients showed an adverse health profile, with high caloric intake (3113 ± 1477 kcal/day), LDL cholesterol (126.0 ± 35.1 mg/dL), and overweight (BMI 31.1 ± 5.5 kg/t2), and also an inflam-matory process, characterised by higher hs-CRP (3.9 ± 2.7 mg/L) and fibrinogen (433.4 ± 84.6 mg/dL) concentrations. We found significant inverse correlations between dietary monounsaturated FAs (MUFAs), serum omega-3 polyunsaturated FAs (n-3 PUFAs), and hs-CRP (<i>β</i> = -3.59, [95% CI -6.87 to -0.32], <i>p</i> = 0.03 and <i>β</i> = -0.70, [95% CI -1.42-0.01], <i>p</i> = 0.05, respectively), significant positive associations between dietary MUFAs, serum saturated FAs (SFAs) and cIMT (<i>β</i> = 81.96, [95% CI 33.42-130.50], <i>p</i> = 0.002 and <i>β</i> = 36.71, [95% CI 6.34-67.08], <i>p</i> = 0.02, respectively), and significant inverse correlations between serum omega-6 polyunsaturated FAs (n-6 PUFAs) and cIMT (<i>β</i> = -91.44, [95% CI -168.01 to -14.88], <i>p</i> = 0.02 and <i>β</i> = -41.01, [95% CI -70.73-11.28], <i>p</i> = 0.01).</p><p><strong>Conclusions: </strong>Serum n-3 PUFAs modulate hs-CRP levels, while n-6 PUFAs suggest antiatherosclerotic properties in HT. The ambiguous impact of MUFAs requires comprehensive research.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"498-505"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical correlation of blood pressure recovery ratio following exercise testing and SYNTAX score in patients with stable coronary artery disease: its implications for CAD severity assessment.","authors":"Özkan Bekler, Onur Kaypaklı, Asım Enhoş, Oğuz Akkuş, Alparslan Kurtul","doi":"10.1080/00015385.2025.2524241","DOIUrl":"https://doi.org/10.1080/00015385.2025.2524241","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure response during exercise testing provides valuable prognostic information. This study examined the association between blood pressure recovery ratio (BPRR) and SYNTAX score (SS) in patients with stable coronary artery disease (CAD). .</p><p><strong>Methods: </strong>A total of 98 patients (mean age 57.3 ± 7.3 years) with ≥50% lesion in ≥1 coronary artery who underwent coronary angiography after an exercise test were included. Patients were classified into low SS (≤22) and intermediate-high SS (>22) groups. BPRR was calculated as the ratio of third-minute to peak exercise systolic blood pressure (SBP).</p><p><strong>Results: </strong>BPRR was significantly higher in the intermediate-high SS group (0.96 ± 0.05) than in the low SS group (0.87 ± 0.06) (<i>p</i> < 0.001). It showed a positive correlation with SS, E/e' ratio, and left atrial volume, and a negative correlation with LVEF. In multivariate analysis, BPRR (OR: 1.446, <i>p</i> < 0.001) and LVEF (OR: 0.802, <i>p</i> = 0.005) were independent predictors of intermediate-high SS. Each 0.01 unit increase in BPRR increased risk by 44.6%. ROC analysis identified a BPRR cut-off of 0.928 (AUC = 0.892).</p><p><strong>Conclusions: </strong>BPRR, a simple and accessible parameter from exercise testing, is independently associated with CAD severity. It may enhance the non-invasive prediction of intermediate to high SS.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of the aggregate index of systemic inflammation for contrast-induced acute kidney injury in patients undergoing coranary angiography.","authors":"Tuba Unkun, Serdar Fidan, Sevim Türkday Derebey, Büsra Güvendi Sengör, Ahmet Karaduman, Gülümser Sevgin Halil, Gokhan Alıcı, Birol Özkan, Ali Karagöz, Süleyman Cagan Efe","doi":"10.1080/00015385.2025.2524237","DOIUrl":"https://doi.org/10.1080/00015385.2025.2524237","url":null,"abstract":"<p><strong>Background: </strong>Contrast-induced acute kidney injury (CI-AKI) occurs as a result of the use of contrast media during coronary interventions and can lead to serious complications.</p><p><strong>Aim: </strong>To investigate the predictive value of the pre-procedural aggregate index of systemic inflamation (AISI) for the development of CI-AKI in patients with chronic coronary artery disease suspicion who underwent coronary angiography (CAG) or percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>This retrospective cohort study conducted on 166 patients with chronic coronary artery disease suspicion who underwent CAG or PCI. The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and AISI levels were calculated. The relationship between these parameters and the development of CI-AKI within 72 h after intervention was analysed.</p><p><strong>Results: </strong>CI-AKI occurred in 25 patients (15.1%). Upon conducting a likelihood ratio test to compare full and reduced models, it was found that in the reduced model, variables such as NLR, SII and AISI were independently predictors of CI-AKI, The NLR model (Odds ratio (OR) =1.32, 95% CI [1.16-1.52]), SII model (OR =3.41, 95% CI [1.92-6.08]), and AISI model (OR =4.81, 95% CI [2.42-9.60]). An increase in AISI was linearly associated with CI-AKI and showed the highest prediction for CI-AKI.</p><p><strong>Conclusion: </strong>These findings demonstrate that AISI is a significant independent predictor for CI-AKI in patients undergoing CAG or PCI.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary computed tomography angiography enables detection of coronary-right ventricular fistula missed by selective coronary angiography: a case report.","authors":"Shuyi Hu, Jiatian Yi, Hua Yan, Dan Song, Handong Zhu","doi":"10.1080/00015385.2025.2520030","DOIUrl":"https://doi.org/10.1080/00015385.2025.2520030","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-3"},"PeriodicalIF":2.1,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NLR/inflammasome pathway in cardiovascular disorders: from pathogenesis to potential therapies.","authors":"Behnaz Hammami, Nasrin Zare, Ali Sohrabi, Maryam Alimohammady, Mohammad Sabet Eghlidi, Nastaran Naderi","doi":"10.1080/00015385.2025.2515322","DOIUrl":"https://doi.org/10.1080/00015385.2025.2515322","url":null,"abstract":"<p><p>The inflammasome is a multimeric protein complex that plays an essential role in the innate immune response by triggering the cleavage and activation of the proinflammatory cytokines interleukins (IL)-1β and IL-18. The dysregulation of NLRs and subsequent inflammasome activation has emerged under various pathologic conditions that contribute to the progression of heart failure, including pressure overload, acute or chronic overactivation of the sympathetic system, myocardial infarction, and diabetic cardiomyopathy. Our study unfolds by examining the pivotal role of the NLRP3 inflammasome in cardiac inflammation and fibrosis, exploring the intricate signalling pathways, including NLRs, involved in the initiation and progression of heart failure. Insights from preclinical and clinical studies indicate the use of potential therapeutic strategies targeting NLRs and the inflammasome to mitigate adverse cardiac outcomes. This review aims to consolidate existing knowledge, pinpoint gaps in our understanding, and propose directions for future research. This study may elucidate the function of NLRs/inflammasomes in heart failure and establishes a foundation for subsequent research focused on developing targeted therapeutics to alleviate inflammatory pathways associated with heart failure.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-25"},"PeriodicalIF":2.1,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Torsemide vs. furosemide in congestive heart failure: a systematic-review and meta-analysis on mortality and rehospitalization.","authors":"Nino Gudushauri, Edgar Theodore Polintan, Irakli Lemonjava, Rajiv Hans Menghrajani, Pia Gabrielle Alfonso, Samir Shah, Zurab Azmaiparashvili, Kevin Bryan Lo, Janani Rangaswami","doi":"10.1080/00015385.2025.2460406","DOIUrl":"10.1080/00015385.2025.2460406","url":null,"abstract":"<p><strong>Background: </strong>Current guidelines suggest the use of loop diuretics as the preferred agent for decongestion in patients with heart failure. However, there is no clear evidence as to superiority of one loop diuretic over the other. The understanding of pharmacokinetic and pharmacodynamic superiority of torsemide over furosemide has generated the hypothesis that these features could result in better clinical outcomes.</p><p><strong>Objectives: </strong>To determine whether the use of torsemide is associated with reduced risk for mortality and rehospitalizations in comparison to furosemide among patients with heart failure.</p><p><strong>Methods: </strong>The study involves a comprehensive search of literature from PubMed, Cochrane CENTRAL, and ClinicalTrials.gov of clinical trials addressing the use of torsemide vs. furosemide in patients with heart failure. Pooled risk ratios (RR) were used to measure association for all outcomes with inverse-variance weighting and random effects model.</p><p><strong>Results: </strong>The literature search included 188 studies that were screened individually. A total of 24 studies were identified out of which 12 were excluded. The pooled risk ratio (RR) revealed all-cause mortality of 0.98 [0.87 to 1.10] with 0% heterogeneity, all cause rehospitalization of 0.95 [0.88 to 1.02] with 5% heterogeneity, and heart failure rehospitalization of 0.85 [0.52 to 1.38] with 55% heterogeneity.</p><p><strong>Conclusion: </strong>Considering the evidence from pooled randomised trials, the use of torsemide compared to furosemide did not result in statistically significant differences in all-cause mortality or rehospitalization rates.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"351-357"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A late presentation of congenital heart defect: sinus venosus ASD with PAPVR.","authors":"Maria Gabriela Matta, Nicholas Seton, Brad Hefford, Selvanayagam Niranjan, Ian Agahari, Rowena Solayar, Sylvio Carvalho Junior Provenzano","doi":"10.1080/00015385.2025.2459452","DOIUrl":"10.1080/00015385.2025.2459452","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"412-414"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of an interpretable machine learning method to predict the risk of death during hospitalization in patients with acute myocardial infarction combined with diabetes mellitus.","authors":"Zhijun Bu, Siyu Bai, Chan Yang, Guanhang Lu, Enze Lei, Youzhu Su, Zhaoge Han, Muyan Liu, Jingge Li, Linyan Wang, Jianping Liu, Yao Chen, Zhaolan Liu","doi":"10.1080/00015385.2025.2481662","DOIUrl":"10.1080/00015385.2025.2481662","url":null,"abstract":"<p><strong>Background: </strong>Predicting the prognosis of patients with acute myocardial infarction (AMI) combined with diabetes mellitus (DM) is crucial due to high in-hospital mortality rates. This study aims to develop and validate a mortality risk prediction model for these patients by interpretable machine learning (ML) methods.</p><p><strong>Methods: </strong>Data were sourced from the Medical Information Mart for Intensive Care IV (MIMIC-IV, version 2.2). Predictors were selected by Least absolute shrinkage and selection operator (LASSO) regression and checked for multicollinearity with Spearman's correlation. Patients were randomly assigned to training and validation sets in an 8:2 ratio. Seven ML algorithms were used to construct models in the training set. Model performance was evaluated in the validation set using metrics such as area under the curve (AUC) with 95% confidence interval (CI), calibration curves, precision, recall, F1 score, accuracy, negative predictive value (NPV), and positive predictive value (PPV). The significance of differences in predictive performance among models was assessed utilising the permutation test, and 10-fold cross-validation further validated the model's performance. SHapley Additive exPlanations (SHAP) and Local Interpretable Model-agnostic Explanations (LIME) were applied to interpret the models.</p><p><strong>Results: </strong>The study included 2,828 patients with AMI combined with DM. Nineteen predictors were identified through LASSO regression and Spearman's correlation. The Random Forest (RF) model was demonstrated the best performance, with an AUC of 0.823 (95% CI: 0.774-0.872), high precision (0.867), accuracy (0.873), and PPV (0.867). The RF model showed significant differences (<i>p</i> < 0.05) compared to the K-Nearest Neighbours and Decision Tree models. Calibration curves indicated that the RF model's predicted risk aligned well with actual outcomes. 10-fold cross-validation confirmed the superior performance of RF model, with an average AUC of 0.828 (95% CI: 0.800-0.842). Significant Variables in RF model indicated that the top eight significant predictors were urine output, maximum anion gap, maximum urea nitrogen, age, minimum pH, maximum international normalised ratio (INR), mean respiratory rate, and mean systolic blood pressure.</p><p><strong>Conclusion: </strong>This study demonstrates the potential of ML methods, particularly the RF model, in predicting in-hospital mortality risk for AMI patients with DM. The SHAP and LIME methods enhance the interpretability of ML models.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"358-375"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}