Serum and dietary fatty acids and their relationship to vascular inflammation and carotid intima-media thickness: implications for cardiovascular risk in patients with arterial hypertension.

IF 2.1 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Acta cardiologica Pub Date : 2025-04-25 DOI:10.1080/00015385.2025.2493978

Georgina N Marchiori, María E Paqualini, David Flores, María F Triquell, María J Moreira-Espinoza, Aldo R Eynard, Mirta A Valentich, María D Defagó

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引用次数: 0

Abstract

Background: Pathogenic mechanisms involved in arterial hypertension (HT) promote the atherosclerosis development. Fatty acids (FAs) could modulate these processes. We investigated the association between dietary and serum FAs and early atherosclerosis development and their correlation with serum vascular inflammation markers in HT.

Methods: 96 patients were included. Dietary information was collected through a validated food frequency questionnaire. Serum FAs were detected by gas chromatography. High-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6) and fibrinogen serum were determined by immunoturbidimetry, enzyme immunoassay and Clauss method, respectively. Carotid intima media-thickness (cIMT) was determined by ultrasound. Multivariate linear regression models were applied.

Results: Patients showed an adverse health profile, with high caloric intake (3113 ± 1477 kcal/day), LDL cholesterol (126.0 ± 35.1 mg/dL), and overweight (BMI 31.1 ± 5.5 kg/t2), and also an inflam-matory process, characterised by higher hs-CRP (3.9 ± 2.7 mg/L) and fibrinogen (433.4 ± 84.6 mg/dL) concentrations. We found significant inverse correlations between dietary monounsaturated FAs (MUFAs), serum omega-3 polyunsaturated FAs (n-3 PUFAs), and hs-CRP (β = -3.59, [95% CI -6.87 to -0.32], p = 0.03 and β = -0.70, [95% CI -1.42-0.01], p = 0.05, respectively), significant positive associations between dietary MUFAs, serum saturated FAs (SFAs) and cIMT (β = 81.96, [95% CI 33.42-130.50], p = 0.002 and β = 36.71, [95% CI 6.34-67.08], p = 0.02, respectively), and significant inverse correlations between serum omega-6 polyunsaturated FAs (n-6 PUFAs) and cIMT (β = -91.44, [95% CI -168.01 to -14.88], p = 0.02 and β = -41.01, [95% CI -70.73-11.28], p = 0.01).

Conclusions: Serum n-3 PUFAs modulate hs-CRP levels, while n-6 PUFAs suggest antiatherosclerotic properties in HT. The ambiguous impact of MUFAs requires comprehensive research.

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血清和膳食脂肪酸及其与血管炎症和颈动脉内膜-中膜厚度的关系：对动脉高血压患者心血管风险的影响

背景：动脉高血压（HT）的发病机制参与了动脉粥样硬化的发展。脂肪酸（FAs）可以调节这些过程。我们研究了饮食和血清FAs与早期动脉粥样硬化发展的关系，以及它们与HT血清血管炎症标志物的关系。方法：96例患者。通过有效的食物频率问卷收集饮食信息。气相色谱法检测血清FAs。分别采用免疫比浊法、酶免疫法和Clauss法测定血清高敏c反应蛋白（hs-CRP）、白细胞介素6 （IL-6）和纤维蛋白原。超声检测颈动脉内膜中膜厚度（cIMT）。采用多元线性回归模型。结果：患者表现出不良的健康状况，高热量摄入（3113±1477 kcal/天），低密度脂蛋白胆固醇（126.0±35.1 mg/dL），超重（BMI 31.1±5.5 kg/t2），以及炎症过程，其特征是hs-CRP（3.9±2.7 mg/L）和纤维蛋白原（433.4±84.6 mg/dL）浓度较高。我们发现饮食之间存在着显著的负相关关系不饱和FAs (MUFAs),血清ω- 3多不饱和FAs (n - 3欧),和hs-CRP(β= -3.59,95%可信区间-6.87到-0.32,p = 0.03,β= -0.70 (95% CI -1.42 - -0.01), p = 0.05),饮食MUFAs之间显著正关联,血清饱和FAs(美国)和测量(β= 81.96 (95% CI 33.42 - -130.50), p = 0.002,β= 36.71 (95% CI 6.34 - -67.08), p = 0.02),血清omega-6多不饱和脂肪酸（n-6 PUFAs）与cIMT呈显著负相关（β = -91.44, [95% CI -168.01 ~ -14.88], p = 0.02; β = -41.01, [95% CI -70.73 ~ 11.28], p = 0.01）。结论：血清n-3 PUFAs调节hs-CRP水平，而n-6 PUFAs提示HT的抗动脉粥样硬化特性。mufa的模糊影响需要全面的研究。

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来源期刊

Acta cardiologica 医学-心血管系统

CiteScore

2.50

自引率

12.50%

发文量

115

审稿时长

2 months

期刊介绍： Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.