The predictive value of the aggregate index of systemic inflammation for contrast-induced acute kidney injury in patients undergoing coranary angiography.

IF 2.1 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Acta cardiologica Pub Date : 2025-06-26 DOI:10.1080/00015385.2025.2524237

Tuba Unkun, Serdar Fidan, Sevim Türkday Derebey, Büsra Güvendi Sengör, Ahmet Karaduman, Gülümser Sevgin Halil, Gokhan Alıcı, Birol Özkan, Ali Karagöz, Süleyman Cagan Efe

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引用次数: 0

Abstract

Background: Contrast-induced acute kidney injury (CI-AKI) occurs as a result of the use of contrast media during coronary interventions and can lead to serious complications.

Aim: To investigate the predictive value of the pre-procedural aggregate index of systemic inflamation (AISI) for the development of CI-AKI in patients with chronic coronary artery disease suspicion who underwent coronary angiography (CAG) or percutaneous coronary intervention (PCI).

Methods: This retrospective cohort study conducted on 166 patients with chronic coronary artery disease suspicion who underwent CAG or PCI. The neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and AISI levels were calculated. The relationship between these parameters and the development of CI-AKI within 72 h after intervention was analysed.

Results: CI-AKI occurred in 25 patients (15.1%). Upon conducting a likelihood ratio test to compare full and reduced models, it was found that in the reduced model, variables such as NLR, SII and AISI were independently predictors of CI-AKI, The NLR model (Odds ratio (OR) =1.32, 95% CI [1.16-1.52]), SII model (OR =3.41, 95% CI [1.92-6.08]), and AISI model (OR =4.81, 95% CI [2.42-9.60]). An increase in AISI was linearly associated with CI-AKI and showed the highest prediction for CI-AKI.

Conclusion: These findings demonstrate that AISI is a significant independent predictor for CI-AKI in patients undergoing CAG or PCI.

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全身性炎症综合指数对冠状动脉造影患者造影剂急性肾损伤的预测价值。

背景：造影剂引起的急性肾损伤（CI-AKI）是冠状动脉介入治疗期间造影剂使用的结果，可导致严重的并发症。目的：探讨术前全身性炎症聚集指数（AISI）对疑似慢性冠状动脉疾病患者行冠状动脉造影（CAG）或经皮冠状动脉介入治疗（PCI）后发生CI-AKI的预测价值。方法：对166例疑似慢性冠状动脉疾病行CAG或PCI的患者进行回顾性队列研究。计算中性粒细胞与淋巴细胞比值（NLR）、全身免疫炎症指数（SII）和AISI水平。分析这些参数与干预后72 h内CI-AKI发生的关系。结果：CI-AKI 25例（15.1%）。通过似然比检验比较完整模型和简化模型，发现简化模型中NLR、SII和AISI等变量是CI- aki的独立预测因子，NLR模型（比值比(OR) =1.32, 95% CI[1.16-1.52]）、SII模型（OR =3.41, 95% CI[1.92-6.08]）和AISI模型（OR =4.81, 95% CI[2.42-9.60]）。AISI的增加与CI-AKI呈线性相关，并且对CI-AKI的预测最高。结论：这些发现表明，AISI是CAG或PCI患者CI-AKI的重要独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta cardiologica 医学-心血管系统

CiteScore

2.50

自引率

12.50%

发文量

115

审稿时长

2 months

期刊介绍： Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.