{"title":"The association between peak tricuspid regurgitation velocity and 1-year heart failure readmission in hospitalised patients with heart failure with preserved ejection fraction.","authors":"Tianbo Wang, Xiaohan Liu, Yue Zhang, Chenli Fang, Junbo Xu","doi":"10.1080/00015385.2024.2421638","DOIUrl":"10.1080/00015385.2024.2421638","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the association between peak tricuspid regurgitation velocity (TRV) and 1-year heart failure (HF) readmission in hospitalised patients with HF with preserved ejection fraction (HFpEF) because the impact of peak TRV on the short-term prognosis of these patients has been unclear.</p><p><strong>Methods: </strong>From January 2020 to December 2021, 513 hospitalised HFpEF patients age ≥ 60 years with 1-year follow-up were included in this study. Peak TRV was classified as normal (≤ 2.8 m/s) and high (> 2.8 m/s) value according to pulmonary hypertension probability.</p><p><strong>Results: </strong>Approximately 68.23% of HFpEF patients had a high peak TRV value. In the final adjusted Cox regression model, peak TRV was still independently associated with HF readmission (HR: 1.74, 95% CI: 1.19-2.55, <i>p</i> = 0.004). Furthermore, patients with high peak TRV were also associated with an increased risk of HF readmission (HR: 2.30, 95% CI: 1.31-4.04, <i>p</i> = 0.004), compared to those with normal peak TRV. After inverse probability of weighting, the risk of HF readmission in patients with high peak TRV was 2.53 (95% CI: 1.35-4.75, <i>p</i> = 0.004) compared to those with normal peak TRV. Additionally, Subgroup analysis revealed very elderly patients, male, and patients with hypertension had a significantly worse prognosis.</p><p><strong>Conclusion: </strong>Peak TRV is independently associated with HF readmission in hospitalised HFpEF patients. High peak TRV has a higher risk of HF readmission in patients age ≥ 80 years, male and patients with hypertension, indicating that special attention should be paid to these patients.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"217-224"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-05-01Epub Date: 2024-08-29DOI: 10.1080/00015385.2024.2396757
Cian Murray, James Mannion, Mark Wilkinson
{"title":"Severe tricuspid regurgitation and right heart failure secondary to carcinoid heart disease.","authors":"Cian Murray, James Mannion, Mark Wilkinson","doi":"10.1080/00015385.2024.2396757","DOIUrl":"10.1080/00015385.2024.2396757","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"304-305"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-05-01Epub Date: 2025-03-31DOI: 10.1080/00015385.2025.2480961
Li Lin, Wanhua Chen, Hang Chen, Jianwen Liu, Kanghui Chen, Lianglong Chen, Liangwan Chen, Zhaoyang Chen
{"title":"Complete heart block after occlusion and repair for perimembranous ventricular septal defect.","authors":"Li Lin, Wanhua Chen, Hang Chen, Jianwen Liu, Kanghui Chen, Lianglong Chen, Liangwan Chen, Zhaoyang Chen","doi":"10.1080/00015385.2025.2480961","DOIUrl":"10.1080/00015385.2025.2480961","url":null,"abstract":"<p><strong>Background: </strong>Complete atrioventricular conduction block (CAVB) is a major complication of the repair and occlusion of perimembranous ventricular septal defects (pmVSDs).</p><p><strong>Objective: </strong>This study aimed to analyse the incidence and risk factors of CAVB after occlusion and repair of pmVSD.</p><p><strong>Methods: </strong>We reviewed patients with pmVSDs who underwent occlusion and repair between January 2010 and January 2022. Permanent CAVB was defined as a CAVB requiring permanent pacemaker implantation or occluder extraction.</p><p><strong>Results: </strong>Of 2436 patients who underwent pmVSD repair, 7 (0.3%) developed permanent CAVB. In all, 16 (0.7%) of the 2200 patients in the device group developed permanent CAVBs. All permanent CAVBs in the repair group occurred during hospital stay. In contrast, eight (50%) permanent CAVBs in the device group occurred over 1 month. A large pmVSD size (odds ratio [OR], 1.575; 95% confidence interval [CI], 1.260-1.970, <i>p</i> < 0.001) and device/defect ratio (OR, 2.608; 95% CI, 1.587-4.287, <i>p</i> < 0.001) were independent risk factors for permanent CAVB after surgical repair and device occlusion, respectively. Multivariate regression showed that device occlusion versus surgical repair was associated with a significantly higher risk of permanent CAVBs (OR, 4.675; 95% CI, 1.586-13.780, <i>p</i> = 0.005).</p><p><strong>Conclusion: </strong>The incidence rates of permanent CAVB after device occlusion and surgical repair were 0.7% and 0.3%, respectively. Large VSD size and device/defect ratio were independently associated with permanent CAVB after surgical repair and device occlusion, respectively. Compared with surgical repair, device occlusion was associated with a significantly higher risk of permanent CAVB after pmVSD closure.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"266-273"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Left atrial strain as a surrogate parameter for successful percutaneous ballon mitral valvotomy?","authors":"Bhagwati Prasad Pant, Rohit Walse, Harikrishnan Sivadasapillai, Sanjay Ganapathi, Ajitkumar Valaparambil","doi":"10.1080/00015385.2025.2484506","DOIUrl":"10.1080/00015385.2025.2484506","url":null,"abstract":"<p><strong>Background: </strong>Severe mitral stenosis (MS) leads to morphological and functional changes in the left atrium (LA) causing dysfunction. Relieving mitral obstruction improves the LA mechanics and structural remodelling. However, this is not taken as a measure of successful Ballon Mitral Valvotomy (BMV) in clinical practice.</p><p><strong>Methods: </strong>We studied the relationship between LA strain and severe MS and the short-term effect of BMV on LA mechanics in a prospective observational single-centre study.</p><p><strong>Results: </strong>Peak atrial longitudinal strain (PALS) was impaired in patients (<i>n</i> = 40) with severe MS and improved 24 h following BMV (11.93 ± 3.29% vs 14.96 ± 3.59%, <i>p</i> < 0.001). There was a significant decrease in transmitral gradient (12.0 ± 4 mmHg vs 3.2 ± 1.6 mmHg, <i>p</i> < 0.001) and systolic pulmonary artery pressure (sPAP) (42.0 ± 8 mmHg vs 40.0 ± 4.8 mmHg, <i>p</i> < 0.001) after the procedure. Mitral valve area (1.03 ± 0.27 cm<sup>2</sup> vs 1.81 ± 0.31 cm<sup>2</sup>, <i>p</i> < 0.001) significantly increased after the procedure. Peak atrial longitudinal strain failed to predict the success of the procedure as (AUC: 0.53; 95% CI, 0.32-0.75, <i>p</i> = 0.791). A cut-off value of 11.42% demonstrated a sensitivity of 64.7% and specificity of 66.7%. (<i>R</i> = 0.33; 95% CI 0.09, 0.6, <i>p</i> = 0.038).</p><p><strong>Conclusion: </strong>Peak atrial longitudinal strain shows a significant improvement following a successful BMV. This increase in values reflects an improvement in clinical status and function class in follow-up. While PALS offers promise, it has limitations. Therefore, it seems reasonable to consider PALS as a supportive indicator alongside established markers like MV area and pressure gradient for assessing procedural success.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"274-282"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-05-01Epub Date: 2025-03-31DOI: 10.1080/00015385.2025.2484848
Xingyuan Zhao, Nan Hu, Liying Wang, Zongling Xia
{"title":"Vericiguat versus sacubitril/valsartan for the treatment of heart failure with reduced ejection fraction in China: a cost-utility analysis.","authors":"Xingyuan Zhao, Nan Hu, Liying Wang, Zongling Xia","doi":"10.1080/00015385.2025.2484848","DOIUrl":"10.1080/00015385.2025.2484848","url":null,"abstract":"<p><strong>Background: </strong>PARADIGM-HF and VICTORIA studies have shown that treatment with sacubitril/valsartan or vericiguat could reduce cardiovascular mortality and hospitalisation in the patients with heart failure (HF) with reduced ejection fraction (HFrEF). However, the cost-utility analysis of adding sacubitril/valsartan or vericiguat to the standard treatment of heart failure in Chinese patients with HFrEF was still unclear.</p><p><strong>Methods: </strong>Based on the Chinese healthcare system, a multi-state Markov model has been established for the cost-utility analysis and compared with the results of VICTORIA study subgroups and relevant local data in China. This model simulated the direct medical costs and quality-adjusted life years (QALYs) of HFrEF patients over a period of 20 years, in which these patients were treated with the standard treatment of heart failure and either adding sacubitril/valsartan or vericiguat. Moreover, incremental cost-utility ratio (ICUR) and incremental net monetary benefit (INMB) were also analysed and the robustness of the results was verified by using sensitivity analysis.</p><p><strong>Results: </strong>In the base case study, according to the Chinese HFrEF patients, the total costs for the sacubitril/valsartan group and the vericiguat group were 4,237.42 USD and 4,618.59 USD, respectively, and the total utility was 3.62 and 3.48 QALYs, respectively. The ICUR was -2,611.68 USD/QALY, and the INMB was -5,772.32 USD. The sensitivity analysis indicated that the results were robust. The results of scenario analysis and base-case analysis were basically consistent.</p><p><strong>Conclusions: </strong>On the standard treatment of heart failure, adding sacubitril/valsartan alone was more cost-effective than adding vericiguat alone for the treatment of HFrEF.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"283-291"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}