Acta cardiologicaPub Date : 2025-04-14DOI: 10.1080/00015385.2025.2484855
Qi Qi, Xinyu Wu, Xinyu Cui, Quanle Han, Jie Yu, Jie Deng, Xuechao Zhang, Yue Jiang, Nan Wang, Shouling Wu, Kangbo Li
{"title":"Triglyceride/high-density lipoprotein cholesterol ratio associates major adverse cardiac and cerebrovascular events: a 13-year prospective cohort study.","authors":"Qi Qi, Xinyu Wu, Xinyu Cui, Quanle Han, Jie Yu, Jie Deng, Xuechao Zhang, Yue Jiang, Nan Wang, Shouling Wu, Kangbo Li","doi":"10.1080/00015385.2025.2484855","DOIUrl":"https://doi.org/10.1080/00015385.2025.2484855","url":null,"abstract":"<p><strong>Background: </strong>Few studies have been conducted to investigate the association between the triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratio and major adverse cardiac and cerebrovascular events (MACCEs) in a predominantly male cohort from China.</p><p><strong>Methods: </strong>A prospective cohort study was conducted on a total 95,837 individuals (males account for 79.67) extracted from the Kailuan study. All individuals were grouped according to the TG/HDL-C ratio quartile. The endpoints of this study were composite MACCEs and its subtypes [non-fatal myocardial (MI), non-fatal stroke and all-cause mortality]. The Kaplan-Meier method was employed to illustrate the cumulative incidence curve. The incidence rate was reported as per 1000 person-years. To explore the impact of varying quartiles of the TG/HDL-C ratio on the risk of MACCEs, Cox proportional hazard regression analysis was conducted. Furthermore, multivariate adjusted spline regression models were applied to examine the relationship between the TG/HDL-C ratio and the risk of MACCEs.</p><p><strong>Results: </strong>A total of 18,430 cases of composite MACCEs occurred during a 13.97-year follow-up. In brief, 1762 cases of MI, 6653 cases of stroke, and 12,524 cases of all-cause mortality were reported, respectively. The cumulative incidence and incidence rate of composite MACCEs, MI, and stroke increased with increment in the TG/HDL-C ratio (<i>p</i> < 0.001). In comparison to quartile 1, the hazard ratios of quartile 4 for composite MACCEs, MI, stroke, and all-cause mortality were 1.13 (95% CI 1.07-1.19), 1.55 (95% CI 1.30-1.84), 1.21 (95% CI 1.12-1.31), and 1.12 (95% CI 1.05-1.20), respectively. Multivariate adjusted spline regression models showed a nonlinear relationship between baseline TG/HDL-C ratio and risk of composite MACCEs (<i>p</i> for non-linearity < 0.01), MI (<i>p</i> for non-linearity < 0.01), stroke (<i>p</i> for non-linearity < 0.01), and all-cause mortality (<i>p</i> for non-linearity = 0.029).</p><p><strong>Conclusions: </strong>The TG/HDL-C ratio is significantly associated with an increased risk of MACCEs in a predominantly male cohort from northern China.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-04-14DOI: 10.1080/00015385.2025.2490369
Muhammad Umer Ghori, Muhammad Shareef Masoud, Muhammad Shafique, Misbah Hussain, Fazli Rabbi Awan
{"title":"Association of obesity traits and uric acid levels with cardiovascular disease in Punjabi patients from Faisalabad, Pakistan.","authors":"Muhammad Umer Ghori, Muhammad Shareef Masoud, Muhammad Shafique, Misbah Hussain, Fazli Rabbi Awan","doi":"10.1080/00015385.2025.2490369","DOIUrl":"https://doi.org/10.1080/00015385.2025.2490369","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases (CVDs) are one of the significant public health concerns worldwide. Understanding the relationship between Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip Ratio (WHR) and uric acid levels are important in assessing cardiovascular risk. This study aimed to investigate the associations of BMI, WHR, WC and several biochemical parameters including uric acid levels with cardiovascular disease in patients from Faisalabad, Pakistan.</p><p><strong>Methods: </strong>This is a Retrospective Observational Study. A total of 403 cardiovascular patients were enrolled. Anthropometric measurements including BMI, WC and WHR were recorded. Serum samples were used to measure various biochemical parameters. SPSS ver. 21 was used to perform statistical analyses.</p><p><strong>Results: </strong>Results showed that BMI (29%↑), waist circumference (7%↑) and hip circumference (8%↑) were higher in obese CVD patients as compared to non-obese CVD patients. Additionally, uric acid levels were high (11%↑) in male CVD patients as compared to female CVD patients while total cholesterol (8%↑) and triglycerides (20%↑) levels were higher in female CVD patients as compared to male CVD patients. Pearson correlation and Linear regression analysis confirmed that uric acid was associated with total cholesterol, triglycerides, alanine transaminase, creatinine and urea levels (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>This study confirms the associations between BMI, WC, WHR, uric acid levels and multiple biochemical parameters with health status in cardiovascular patients from Faisalabad, Pakistan.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-04-11DOI: 10.1080/00015385.2025.2491148
İsa Ardahanlı, Ramazan Aslan, Murat Özmen
{"title":"Congenital heart disease and volume loading: a critical evaluation of current predictive value.","authors":"İsa Ardahanlı, Ramazan Aslan, Murat Özmen","doi":"10.1080/00015385.2025.2491148","DOIUrl":"https://doi.org/10.1080/00015385.2025.2491148","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":2.1,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-04-08DOI: 10.1080/00015385.2025.2490382
Yue Jiang, Lingyan Zhang, Zhaoyang Liu, Lei Wang
{"title":"The value of handheld ultrasound in point-of-care or at home EF prediction.","authors":"Yue Jiang, Lingyan Zhang, Zhaoyang Liu, Lei Wang","doi":"10.1080/00015385.2025.2490382","DOIUrl":"10.1080/00015385.2025.2490382","url":null,"abstract":"<p><p>In this paper, AI-enabled handheld ultrasound is used in point-of-care or at home, and evaluate the accuracy of it for left ventricular ejection fraction (LVEF) evaluation. It provides a simple, convenient, and practical tool for the patients with heart disease, especially those with heart failure. The AI model used for this AI-enabled handheld ultrasound is a machine learning model trained with tens of thousands of ultrasound four-chamber cardiograms. The LVEF evaluation accuracy of the AI model was compared by the experts performing ultrasound four-chamber cardiogram detection in 100 patients on high-end ultrasound in the hospital. In the 100 clinical trials, the sensitivity, specificity, and accuracy of the AI model were 91%, 95%, and 98%, respectively. Then 10 cases were used to compare the LVEF results of hospital tests with the predicted results of the AI model. The difference between the two is less than 10%. Finally, over the course of one month, the AI-enabled handheld ultrasound was employed to conduct regular evaluations of left LVEF for point-of-care purposes on a group of 10 patients diagnosed with heart failure. The LVEF evaluation accuracy of AI-enabled handheld ultrasound is more than 96%, which was higher than that of experts in high-end ultrasound in hospitals. The easy-to-use AI-enabled handheld ultrasound can evaluate the LVEF in the point of care or at home and get the same accuracy as the high-end ultrasound equipment in the hospital. It may play an important role in monitoring cardiac function at home for the ambulatory heart failure patients.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-7"},"PeriodicalIF":2.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-04-01Epub Date: 2025-02-27DOI: 10.1080/00015385.2025.2471656
Tiantuo Huang, Qi Peng, Yue Cao, Xiaochen Fan
{"title":"Assessing the prognostic significance of platelet-to-lymphocyte ratio (PLR) for coronary artery lesions in Kawasaki disease.","authors":"Tiantuo Huang, Qi Peng, Yue Cao, Xiaochen Fan","doi":"10.1080/00015385.2025.2471656","DOIUrl":"10.1080/00015385.2025.2471656","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to examine the correlation between the platelet-to-lymphocyte ratio (PLR) and coronary artery lesions (CALs) in individuals diagnosed with Kawasaki disease (KD) and to evaluate its prognostic significance.</p><p><strong>Methods: </strong>Our study entailed a detailed retrospective examination and analysis of clinical records for patients diagnosed with KD at the First Affiliated Hospital of Anhui Medical University from January 2017 to January 2023. In our methodological approach, we applied various statistical techniques - including univariate analyses, binary logistic regression, and receiver operating characteristic (ROC) curve analysis - to meticulously assess the relationship between the PLR and the incidence of CALs in this patient cohort. Our objective was to elucidate potential predictive markers for CALs development in KD patients, thereby contributing valuable insights into the prognosis and management of this condition.</p><p><strong>Results: </strong>In the conducted research, a total of 364 patients were analysed, among which 63 individuals (17.3%) exhibited CALs upon admission. Through the application of binary logistic regression analysis, our findings underscored PLR as a statistically significant predictor for the presence of CALs. Furthermore, the ROC curve analysis demonstrated an AUC (area under the curve) value of 0.707 (95%CI 0.641-0.772, <i>p</i> < .001) for the prognostic capacity of PLR concerning CALs.</p><p><strong>Conclusions: </strong>The outcomes of our investigation indicate that PLR acts as a significant risk indicator for CALs. Such insights pave the way for improved risk stratification and potentially guide therapeutic decision-making in patients with KD.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"181-187"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-04-01Epub Date: 2025-02-14DOI: 10.1080/00015385.2025.2460404
Juan Zhang, Jing Jiang, Jieqiong Zhao, Kangli Chen, Pingnian Yuan, Yang Wang, Huan Zhang
{"title":"Association between cardiometabolic index and myocardial Infarction: based on NHANES database.","authors":"Juan Zhang, Jing Jiang, Jieqiong Zhao, Kangli Chen, Pingnian Yuan, Yang Wang, Huan Zhang","doi":"10.1080/00015385.2025.2460404","DOIUrl":"10.1080/00015385.2025.2460404","url":null,"abstract":"<p><strong>Background: </strong>The cardiometabolic index (CMI) combines abdominal obesity and abnormal blood lipid indices, representing a good predictive indicator of risk in cardiovascular diseases (CVDs). However, the association between CMI and myocardial infarction (MI) is not clear.</p><p><strong>Objective: </strong>The present project was designed to explore the linkage between CMI and MI.</p><p><strong>Methods: </strong>Data from the National Health and Nutrition Examination Survey (NHANES) 2005-2018 were employed in this project, with CMI as the independent variable and MI as the dependent variable. Weighted logistic regression was applied in the association analysis between CMI and MI. Restricted cubic spline (RCS), subgroup analysis, and interaction tests were employed to elucidate the non-linear relationship and stability of CMI and MI's link. Moreover, to verify the robustness of the results, sensitivity analysis was conducted, with the MI status of subjects taking lipid-lowering drugs as the outcome variable.</p><p><strong>Results: </strong>A total of 13,923 participants were gathered in this project, with 605 cases of MI, accounting for 3.5%. In the weighted logistic regression model, a positive linkage was observed between CMI and the risk of MI (OR: 1.41, 95% CI: 1.18-1.68, <i>p</i> < 0.001). The RCS curves indicated a linear relationship between CMI and MI (<i>P</i>-non-linear = 0.146). Subgroup analysis manifested that CMI was positively linked with MI risk in males, individuals with BMI > 30kg/m<sup>2</sup>, and alcohol drinkers (<i>p</i> < 0.05). In addition, the interaction results demonstrated that there was no heterogeneity in the association between CMI and MI risk in the subgroups (<i>p</i> > 0.05). The sensitivity analysis showed that after adjusting for all confounding factors in the model, there was still a significant positive correlation (<i>p</i> < 0.01) between CMI and MI in the population taking lipid-lowering drugs.</p><p><strong>Conclusion: </strong>There is a significant positive linkage of CMI with MI risk, which is particularly significant in males, those with a BMI greater than 30 kg/m<sup>2</sup>, and those who have drinking habits. Even after considering the impact of lipid-lowering drug therapy, the positive correlation between CMI and MI remains robust, supporting CMI as a promising tool for assessing MI risk and guiding clinical prevention. Further research is required to probe into the application of CMI in different populations and its role in the prevention of CVDs.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"163-172"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-04-01Epub Date: 2025-01-15DOI: 10.1080/00015385.2025.2452020
Ericka Arrazola Lopez, João Vagner Cavalari, Kamila Grandolfi, Diego Giulliano Destro Christofaro, Andreo Fernando Aguiar, Sergio Marques Borghi, Juliano Casonatto
{"title":"Exploring the immediate effects of aerobic exercise on nocturnal blood pressure dip in medication-controlled hypertensive individuals: a randomised controlled trial.","authors":"Ericka Arrazola Lopez, João Vagner Cavalari, Kamila Grandolfi, Diego Giulliano Destro Christofaro, Andreo Fernando Aguiar, Sergio Marques Borghi, Juliano Casonatto","doi":"10.1080/00015385.2025.2452020","DOIUrl":"10.1080/00015385.2025.2452020","url":null,"abstract":"<p><strong>Background: </strong>Nocturnal blood pressure dipping is crucial for cardiovascular health, but the effect of exercise on this phenomenon is not well understood. This study aims to investigate how a single session of aerobic exercise impacts nocturnal blood pressure dipping in individuals with hypertension who are on medication.</p><p><strong>Methods: </strong>Twenty hypertensive adults (67 ± 16 years) participated in a randomised, parallel-group clinical trial. They were randomly assigned to either an exercise or control group. Resting blood pressure was measured after a 20-minute period of comfortable seating in a calm environment. The exercise group performed 40 min of treadmill running/walking at an intensity of 60-70% of their reserve heart rate. The control group remained seated for an equivalent period with reading allowed. Ambulatory blood pressure monitoring was used to measure blood pressure over 24 h. Nocturnal dip was calculated by comparing the mean wakefulness and sleep blood pressure values.</p><p><strong>Results: </strong>No significant differences were observed between the exercise and control groups in systolic and diastolic blood pressure values at rest, during wakefulness, sleep, or over 24 h. The absolute nocturnal dip also showed no significant differences between the groups for systolic blood pressure (MD = 3.00 [95% CI: -4.77 to 10.77] <i>p</i> = 0.428) or diastolic blood pressure (MD = 4.60 [95% CI: -2.81 to 12.00] <i>p</i> = 0.208). Similarly, the relative nocturnal dip (percentage) did not differ significantly for systolic blood pressure (MD = 0.029 [95% CI: -0.039 to 0.837] <i>p</i> = 0.465) or diastolic blood pressure (MD = 0.047 [95% CI: -0.036 to 0.132] <i>p</i> = 0.250).</p><p><strong>Conclusions: </strong>A single session of aerobic exercise does not impact the nocturnal dip in systolic and diastolic blood pressure in medication-controlled hypertensive individuals.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"156-162"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}