Acta cardiologica最新文献

{"title":"Beneficial effects of doxycycline on atrial electrical remodelling in a rat model of atrial fibrillation.","authors":"Kai Zhang, Zuowang Ma, Yu Yang, Guangping Li","doi":"10.1080/00015385.2025.2500888","DOIUrl":"https://doi.org/10.1080/00015385.2025.2500888","url":null,"abstract":"<p><strong>Background: </strong>Previous studies showed that doxycycline (Dox) can attenuate chronic intermittent hypoxia (CIH)-induced atrial fibrosis in rats. On this basis, we further investigated the effects of Dox on CIH-induced atrial electrical remodelling.</p><p><strong>Methods: </strong>Rats were randomised into 3 groups: Control group, CIH group, and CIH with Dox treatment (CIH-D) group (<i>n</i> = 30). CIH and CIH-D rats were subjected to CIH 8 h/d for 6 weeks. After collecting the basic parameters of the rats, atrial fibrillation (AF) inducibility, conduction inhomogeneity, and epicardial conduction velocity were examined by <i>in vitro</i> cardiac electrophysiology experiments. The expression levels of ion channel subunits in the atrium were detected by Western blotting. Whole-cell patch clamp experiments were used to recorded action potential (AP), I_Ca-L, I_to, and the kinetic parameters.</p><p><strong>Results: </strong>Compared to the Control rats, CIH rats showed increased AF inducibility, conduction inhomogeneity, and expression levels of p-RyR2, p-CaMKII, K_v11.1, K_ir2.3, K_Ca3.1, whereas the epicardial conduction velocity, I_Ca-L, I_to, and expression levels of Ca_v1.2, K_v1.5, K_v4.3 were decreased. Dox-treatment significantly improved the expression levels of K_v1.5, K_v4.3 and K_ir2.3 in CIH-D rats.</p><p><strong>Conclusion: </strong>CIH caused atrial electrical remodelling in our rats, which was improved by Dox treatment. These changes indicated the potential effects of Dox in AF.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accessory mitral valve tissue causing left ventricular outflow obstruction.","authors":"Damandeep Singh, Vineeta Ojha, Niraj Nirmal Pandey, Suad Akhtar, Aprateem Mukherjee, Sanjeev Kumar, Sivasubramanian Ramakrishnan","doi":"10.1080/00015385.2024.2424481","DOIUrl":"10.1080/00015385.2024.2424481","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"308-310"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142602115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The scalpel's dilemma: weighing the mortality risk of combined surgical aortic valve replacement and coronary artery bypass grafting.","authors":"Astrid Declercq, Vincent Floré, Nico Van de Veire","doi":"10.1080/00015385.2025.2476887","DOIUrl":"10.1080/00015385.2025.2476887","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"326-327"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial myopathy in rheumatic mitral stenosis; three-dimensional and speckle tracking echocardiography study.","authors":"Hoda Abdelgawad, Darius Dufatanye, Mahmoud Shehata, Ingy Waheed, Noha Hesham, Judy Rizk, Rasha Abayazeed, Moustafa Dawood, Mohamed Ayman Abdel-Hay, Amr Zaki","doi":"10.1080/00015385.2025.2457180","DOIUrl":"10.1080/00015385.2025.2457180","url":null,"abstract":"<p><strong>Background: </strong>In developing countries, rheumatic mitral valve stenosis (MS) is still a problem and its progression leads to left atrial (LA) damage. Due to the complexity of the LA geometry, currently used techniques like antero-posterior dimension (LAD) and 2D echo derived LA volume (LAV) have several limitations that are corrected by 3D derived LA volumes in addition to functional evaluation.</p><p><strong>Purpose: </strong>To assess the LA functions using 2D speckle tracking echocardiography and 3D transthoracic echocardiography in patients with clinically significant MS in comparison to normal healthy subjects.</p><p><strong>Results: </strong>Fifty patients and 50 healthy controls were studied. Patients' mean age was 40.2 ± 8.8 years, the majority were female 45(81.8%). 3D indexed LA maximum (LAVmaxI) and minimum (LAVminI) volumes were significantly higher in MS than in the control group, whereas 3D LA EF was significantly lower in MS than in the control group (p 0.001). LA strain reservoir, conduit, and contraction parameters were significantly lower in the MS group than in the control group (<i>p</i> = 0.001). However, only 3D LAEF, 2D LASr, 2D LAScd, and 2D LASct showed a correlation with the mitral valve area with a <i>p</i> < 0.05, but 3D LAVmaxI and 3D LAVminI did not. Additionally, in the comparison of severe and very severe mitral stenosis subgroups, 3D LAVmaxI and 3D LAVminI did not show any statistically significant differences between the two groups, although 3D LAEF, 2D LASr, 2D LAScd, and 3D LASct showed significant difference between the two groups (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Left atrial functional and structural remodelling has been highlighted in patients with significant rheumatic MS. However, left atrial functional assessment by 3D echocardiography and 2D speckle tracking echocardiography correlate better with mitral valve area than conventional LA size measurements. Whether the functional assessment of the LA has an additive predictive value with regards to patient outcome needs to be interrogated.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"225-236"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143027505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary perspectives in cardiovascular medicine: imaging, interventions, and prognostic strategies.","authors":"Patrizio Lancellotti","doi":"10.1080/00015385.2025.2496029","DOIUrl":"https://doi.org/10.1080/00015385.2025.2496029","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":"80 3","pages":"209-212"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the 'Life's Essential 8' with FeNO and all-cause mortality: a population-based study in U.S. adults.","authors":"Kai Li, Jie Feng, Leilei Han, Yanqing Wu","doi":"10.1080/00015385.2025.2480960","DOIUrl":"10.1080/00015385.2025.2480960","url":null,"abstract":"<p><strong>Background: </strong>The 'Life's Essential 8' (LE8), a recent framework introduced by the American Heart Association (AHA), refines and expands the concept of wellness, with a particular emphasis on promoting cardiovascular health. The fractional exhaled nitric oxide (FeNO) score, a non-invasive and easily obtainable biomarker, offers a convenient method for evaluating respiratory conditions such as asthma. While both LE8 and FeNO represent emerging and widely recognised indicators of health, research exploring their interrelationship remains limited. This study aims to examine the associations between LE8, FeNO, and all-cause mortality.</p><p><strong>Methods: </strong>A total of 14,293 eligible participants, aged ≥18 years, were enrolled from the National Health and Nutrition Examination Survey (NHANES) database spanning 2007-2012. This observational cohort study integrated baseline NHANES data with mortality records from the U.S. National Death Index through 2021. To assess the association between LE8 and FeNO, we employed multiple linear regression models, both with and without adjustments for demographic factors and health-related practices. Additionally, these data were utilised to explore the relationships between various health determinants and all-cause mortality.</p><p><strong>Results: </strong>In this observational analysis, we found that an increase in the LE8 score was positively associated with elevated FeNO levels, a marker implicated in immune responses to respiratory diseases. Furthermore, higher LE8 scores were inversely associated with survival risk in the population, suggesting a potential protective effect on survival in the studied population.</p><p><strong>Conclusions: </strong>Our findings suggest that primary and tertiary prevention efforts to promote cardiovascular health should be strengthened, especially those targeting unhealthy factors and behaviours to improve cardiorespiratory fitness and reduce survival risk.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"245-253"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"René Gerónimo Favaloro (1923-2000): the challenging dream of a heart surgeon.","authors":"Hernan Gonzalo Valdes-Socin, Vincent Tchana-Sato","doi":"10.1080/00015385.2024.2448866","DOIUrl":"10.1080/00015385.2024.2448866","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"319-321"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac 'quartet': a rare case of quadricuspid aortic valve combined with ascending aortic aneurysm.","authors":"Mengqi Tang, Juan Xia, Yafeng He, Yanling Xue, Zifan Wu, Xiaojing Ma","doi":"10.1080/00015385.2025.2484859","DOIUrl":"10.1080/00015385.2025.2484859","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"313-314"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prostaglandin G/H synthase 1 promotes thrombosis in atrial fibrillation through modulation of platelet activation, macrophage infiltration, inflammation, and autophagy inhibition.","authors":"Hao Bai, Guiyang Xi, Yangyang Cheng","doi":"10.1080/00015385.2025.2467009","DOIUrl":"10.1080/00015385.2025.2467009","url":null,"abstract":"<p><strong>Background: </strong>Prostaglandin G/H synthase 1 (PTGS1) is known to regulate platelet function and inflammation. However, its role in atrial fibrillation (AF)-related thrombosis is not well understood. This study investigates the role of PTGS1 in AF-associated thrombus formation and its underlying mechanisms.</p><p><strong>Methods: </strong>Left atrial appendage (LAA) tissues were collected from 48 patients undergoing valve replacement surgery, divided into three groups: sinus rhythm (SR), AF with thrombus [AF (+) T (+)], and AF without thrombus [AF (+) T (-)]. PTGS1 expression, platelet activation markers (MPA, sCD40L, and d-dimer), macrophage phenotypes (M1 and M2), inflammatory cytokines (IL-1β, TNF-α, IL-6), and autophagy-related proteins (LC3II and p62) were assessed. Furthermore, the effect of PTGS1 manipulation on autophagy in endocardial endothelial cells (EECs) was examined using cell transfection experiments.</p><p><strong>Results: </strong>PTGS1 expression was significantly higher in LAA tissues of AF (+) T (+) patients compared to AF (+) T (-) and SR groups. It was positively correlated with reduced LAA emptying velocity (LAAEV), higher CHA2DS2-VASc scores, and elevated platelet activation markers (MPA, sCD40L, and d-dimer). Data also showed increased M1 macrophage infiltration and higher pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) in AF (+) T (+) patients, with PTGS1 expression strongly linked to these markers. Furthermore, PTGS1 overexpression inhibited autophagy in EECs by decreasing LC3II/LC3I ratio and increasing p62 levels, while PTGS1 knockdown promoted autophagy, protecting against endothelial dysfunction.</p><p><strong>Conclusions: </strong>PTGS1 is overexpressed in AF patients with thrombosis and may play an important role in promoting thrombus formation through enhanced platelet activation, inflammation, and inhibition of autophagy.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"254-265"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female sex as risk factor for undertreatment: need for a paradigm shift in the care of atrial fibrillation and ischaemic disease.","authors":"Bernadette Corica, Davide Antonio Mei, Giuseppe Boriani","doi":"10.1080/00015385.2025.2453790","DOIUrl":"10.1080/00015385.2025.2453790","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"317-318"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}