Causal correlation between gut microbiota and stable angina pectoris: a two-sample Mendelian randomisation study.

Abstract

Background: Patients with stable angina pectoris (SAP) are usually accompanied by gut microbiota (GM) imbalance, but whether this is a causal association is yet unclear.

Methods: The present study used the summary data of the open genome-wide association study (GWAS) to conduct two-sample Mendelian randomisation (MR) to test the causal association between GM and SAP. Finally, functional maps and annotations from GWASs were used to determine the biological functions of the genes.

Results: MR analysis found that Ruminococcus 2 was significantly positively associated with the risk of SAP. For every unit increase in Ruminococcus 2, the relative risk of SAP increased by 22.3% (p = 4.55E - 04, Bonferroni p = 6.82E - 03). Firmicutes, Odoribacter, Actinomyces, Veillonellaceae, Eisenbergiella, and Ruminococcus gauvreauii groups may be positively related to the risk of SAP, while Proteobacteria, Methanobacteriaceae, Euryarchaeota, Verrucomicrobia, Ruminiclostridium 9, and Anaerofilum may be negatively associated with the risk of SAP. Nonetheless, the specific role of SNPs gene enrichment analysis results needs further investigation.

Conclusions: The findings of this study suggest a causal relationship between GM and SAP. The discovery of GM and its gene biological functions may offer insights for preventing and treating SAP.