Assessing the prognostic significance of platelet-to-lymphocyte ratio (PLR) for coronary artery lesions in Kawasaki disease.

IF 2.1 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2025-02-27 DOI:10.1080/00015385.2025.2471656
Tiantuo Huang, Qi Peng, Yue Cao, Xiaochen Fan
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引用次数: 0

Abstract

Objective: We aimed to examine the correlation between the platelet-to-lymphocyte ratio (PLR) and coronary artery lesions (CALs) in individuals diagnosed with Kawasaki disease (KD) and to evaluate its prognostic significance.

Methods: Our study entailed a detailed retrospective examination and analysis of clinical records for patients diagnosed with KD at the First Affiliated Hospital of Anhui Medical University from January 2017 to January 2023. In our methodological approach, we applied various statistical techniques - including univariate analyses, binary logistic regression, and receiver operating characteristic (ROC) curve analysis - to meticulously assess the relationship between the PLR and the incidence of CALs in this patient cohort. Our objective was to elucidate potential predictive markers for CALs development in KD patients, thereby contributing valuable insights into the prognosis and management of this condition.

Results: In the conducted research, a total of 364 patients were analysed, among which 63 individuals (17.3%) exhibited CALs upon admission. Through the application of binary logistic regression analysis, our findings underscored PLR as a statistically significant predictor for the presence of CALs. Furthermore, the ROC curve analysis demonstrated an AUC (area under the curve) value of 0.707 (95%CI 0.641-0.772, p < .001) for the prognostic capacity of PLR concerning CALs.

Conclusions: The outcomes of our investigation indicate that PLR acts as a significant risk indicator for CALs. Such insights pave the way for improved risk stratification and potentially guide therapeutic decision-making in patients with KD.

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来源期刊
Acta cardiologica
Acta cardiologica 医学-心血管系统
CiteScore
2.50
自引率
12.50%
发文量
115
审稿时长
2 months
期刊介绍: Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.
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