Acta cardiologica最新文献

{"title":"Effect of dapagliflozin on the no-reflow phenomenon in patients with acute myocardial infarction and type II diabetes mellitus.","authors":"Alaa Quisi, Nur Selin Nacar Quisi, Gökhan Alıcı, İdil Donma, Abdullah Yıldırım, Ömer Genç","doi":"10.1080/00015385.2025.2500892","DOIUrl":"10.1080/00015385.2025.2500892","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the effect of dapagliflozin on the no-reflow phenomenon in patients with type II diabetes mellitus (T2DM) and acute myocardial infarction (AMI) who underwent percutaneous coronary intervention (PCI).</p><p><strong>Methods: </strong>This single-center, observational cohort study included a total of 829 consecutive T2DM patients who were diagnosed with AMI and underwent PCI within 24 h of the onset of symptoms. Only patients using dapagliflozin (10 mg per day) for more than one year were considered as patients using dapagliflozin. The no-reflow phenomenon was defined as inadequate myocardial perfusion within a segment of the coronary circulation without angiographic evidence of mechanical vessel obstruction, dissection, or residual stenosis after PCI.</p><p><strong>Results: </strong>Four hundred and thirty-four patients were diagnosed with ST-segment elevation myocardial infarction (STEMI), and 395 patients were diagnosed with non-ST-segment elevation myocardial infarction (NSTEMI). Forward conditional logistic regression analysis demonstrated that the estimated glomerular filtration rate (OR = 0.940, 95% CI: 0.900 to 0.982, <i>p</i> = 0.006), SYNTAX score I (OR = 1.338, 95% CI: 1.179 to 1.520, <i>p</i> < 0.001), and dapagliflozin use (OR = 0.030, 95% CI: 0.004 to 0.228, <i>p</i> = 0.001) were independent predictors of the no-reflow phenomenon in STEMI. However, dapagliflozin use (OR = 0.112, 95% CI: 0.013 to 0.933, <i>p</i> = 0.043) was the only independent predictor of the no-reflow phenomenon in NSTEMI.</p><p><strong>Conclusion: </strong>Lower rates of the no-reflow phenomenon were observed in T2DM patients taking dapagliflozin, diagnosed with AMI, and underwent PCI. However, this finding requires further investigation.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"394-402"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between predictive factors and atrial high-rate episodes in heart failure with reduced ejection fraction patients with cardiac implantable electronic devices.","authors":"Özge Çakmak Karaaslan, Ekrem Şahan, Mustafa Karanfil, Ümit Güray","doi":"10.1080/00015385.2024.2443295","DOIUrl":"10.1080/00015385.2024.2443295","url":null,"abstract":"<p><strong>Objective: </strong>Atrial high-rate episodes (AHRE) are atrial tachyarrhythmia episodes detected by implanted cardiac devices, characterised by an atrial rate exceeding 180-190 beats per minute. Recent studies have linked AHRE to the development of atrial fibrillation (AF) and increased stroke risk, especially when episodes last longer than 5-6 min. This study aimed to evaluate the relationship between predictive factors and the occurrence of AHRE in heart failure with reduced ejection fraction (HFrEF) patients with cardiac implantable electronic devices (CIEDs).</p><p><strong>Methods: </strong>This single-centre, retrospective study included a cohort of 155 consecutive HFrEF patients with CIEDs, but without a diagnosis of AF, enrolled between January 2023 and December 2023. Patients were stratified based on the presence of AHRE detected during device interrogation.</p><p><strong>Results: </strong>The average age of the patients was 54 ± 14 years, and 83.2% of the study population were male. Patients with AHRE had a reduced left ventricular ejection fraction (LVEF) (<i>p</i> = 0.026) and an increased left atrial diameter (<i>p</i> < 0.001) compared to the group without AHRE. Patients with AHRE had elevated levels of creatinine, uric acid, and TSH compared to those without AHRE (<i>p</i> = 0.006, <i>p</i> = 0.021, <i>p</i> = 0.009, respectively). In the univariable logistic regression analysis, LVEF (HR = 0.690, 95% CI = 0.610-0.913, <i>p</i> = 0.013), left atrial diameter (HR = 8.215, 95% CI = 1.557-43.34, <i>p</i> < 0.001), creatinine (HR = 7.369, 95% CI = 1.749-31.05, <i>p</i> = 0.006), uric acid (HR = 1.073, 95% CI = 1.062-1.196, <i>p</i> = 0.020), total cholesterol (HR = 0.989, 95% CI = 0.979-0.999, <i>p</i> = 0.031), and C-reactive protein levels (HR = 1.146, 95% CI = 1.002-1.131, <i>p</i> = 0.047) were identified as independent predictors of AHRE. In multivariable logistic regression analysis, left ventricular ejection fraction (HR = 0.890, 95% CI = 0.795-0.998, <i>p</i> = 0.046), left atrial diameter (HR = 8.215, 95% CI = 1.557-43.34, <i>p</i> < 0.001), and uric acid concentration (HR = 1.650, 95% CI = 1.063-2.561, <i>p</i> = 0.025) were identified as predictors of atrial high-rate events.</p><p><strong>Conclusion: </strong>LVEF, left atrial diameter, and uric acid level were found to be independent predictors of AHRE in patients with HFrEF. Identifying AHRE is crucial for risk stratification and guiding therapeutic decisions to improve patient outcome.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"334-341"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting heart failure mortality using the Danish Comorbidity Index for Acute Myocardial Infarction (DANCAMI).","authors":"Usama Sikandar, Kasper Bonnesen, Uffe Heide-Jørgensen, Morten Schmidt","doi":"10.1080/00015385.2025.2452131","DOIUrl":"10.1080/00015385.2025.2452131","url":null,"abstract":"<p><strong>Background: </strong>Patients with congestive heart failure (HF) are often burdened with comorbidities that increase mortality. Comorbidity indices provide a standardised method to measure comorbidity burden and predict prognosis. We aimed to investigate whether the Danish Comorbidity Index for Acute Myocardial Infarction (DANCAMI) can discriminate mortality in patients with HF.</p><p><strong>Methods: </strong>We conducted a population-based cohort study of all adult Danish patients with first-time HF during 1995-2020 (<i>N</i> = 311,628). We used logistic regression to calculate the area under the receiver operating characteristic curve (AUC) for cardiovascular and all-cause mortality within 30 days, 1 year, and 10 years of diagnosis. The AUCs were computed for a model including age and sex (baseline) and models also including the DANCAMI, the Charlson Comorbidity Index (CCI), or the Elixhauser Comorbidity Index (ECI).</p><p><strong>Results: </strong>For all-cause mortality, the AUCs were higher for the DANCAMI than for the baseline model (30-day: 0.688 vs. 0.662; 1-year: 0.715 vs. 0.680; 10-year: 0.840 vs. 0.810). For cardiovascular mortality, the AUCs were comparable between the DANCAMI and the baseline model (30-day: 0.683 vs. 0.676; 1-year: 0.690 vs. 0.684; 10-year: 0.659 vs. 0.658). For both 30-day, 1-year, and 10-year all-cause and cardiovascular mortality, the AUCs for the CCI and the ECI were comparable to those for the DANCAMI.</p><p><strong>Conclusions: </strong>Adding the DANCAMI to a model including patient age and sex improved discrimination of short and long-term all-cause mortality but not of cardiovascular mortality.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"342-350"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary artery pulsatility index as a prognostic marker in heart failure with preserved ejection fraction.","authors":"Muhammad Osama, Safiyyah Ubaid, Ubaid Ullah, Maryam Ubaid","doi":"10.1080/00015385.2024.2412372","DOIUrl":"10.1080/00015385.2024.2412372","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"425-426"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed ventricular septal rupture post paediatric blunt chest trauma.","authors":"Ping Hu, Wang Jie, Xiao-Jing Ma","doi":"10.1080/00015385.2024.2374093","DOIUrl":"10.1080/00015385.2024.2374093","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"403-404"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of the FIB-4 index in ST-elevation myocardial infarction patients: from admission to follow-up.","authors":"Ayşe İrem Demirtola, Anar Mammadli, Gökhan Çiçek","doi":"10.1080/00015385.2025.2493977","DOIUrl":"10.1080/00015385.2025.2493977","url":null,"abstract":"<p><strong>Background: </strong>ST-elevation myocardial infarction (STEMI) remains a leading cause of global mortality despite advancements in primary percutaneous coronary intervention (PCI). The fibrosis-4 (FIB-4) index, a non-invasive marker of liver fibrosis, has been associated with cardiovascular outcomes. However, its predictive value for in-hospital and post-discharge all-cause mortality in STEMI patients undergoing PCI remains uncertain. This study aimed to evaluate the prognostic utility of the FIB-4 index in this high-risk population.</p><p><strong>Methods: </strong>This retrospective study analysed 2186 STEMI patients who underwent PCI. Patients were categorised into three groups based on FIB-4 tertiles: Group 1 (FIB-4 < 4.52), group 2 (4.52 ≤ FIB-4 < 6.07), and group 3 (FIB-4 ≥ 6.07). Logistic regression assessed predictors of in-hospital mortality, while Kaplan-Meier's survival analysis and Cox proportional hazards models were used to evaluate post-discharge mortality.</p><p><strong>Results: </strong>In-hospital mortality was significantly higher in group 3 (4.3%) compared to group 2 and group 1 (<i>p</i> = .016). The FIB-4 index was an independent predictor of in-hospital mortality (OR: 1.105, 95% CI: 1.011-1.207, <i>p</i> = .028), alongside Killip class ≥ II, diabetes mellitus and reduced eGFR < 76.8 mL/min. During a median follow-up of 21 months post-discharge, all-cause mortality occurred in 8% of patients (<i>n</i> = 178), with rates highest in group 3 (10%, <i>n</i> = 74) compared to group 2 and group 1 (<i>p</i> = .002). Kaplan-Meier's survival analysis demonstrated significantly lower cumulative survival in group 3 (log-rank test, <i>p</i> = .003). Multivariable Cox analysis confirmed an increased post-discharge mortality risk in group 3 (HR: 1.862, 95% CI: 1.254-2.764, <i>p</i> = .002) compared to group 1.</p><p><strong>Conclusions: </strong>The FIB-4 index independently predicts in-hospital and post-discharge all-cause mortality in STEMI patients undergoing PCI. Its integration into clinical practice could improve risk stratification and patient management.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"387-393"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A left atrial spindle cell sarcoma mimicking a myxoma.","authors":"Xuemei Yang, Yanhong Luo","doi":"10.1080/00015385.2024.2406682","DOIUrl":"10.1080/00015385.2024.2406682","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"405-406"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right heart and heart failure with preserved ejection fraction: the dark side of the moon.","authors":"Bülent Özlek, Süleyman Barutçu","doi":"10.1080/00015385.2025.2460402","DOIUrl":"10.1080/00015385.2025.2460402","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"427-428"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous origin of posterior descending artery from the first septal perforating branch on cardiac computed tomography.","authors":"Shu Yoshihara, Taku Yaegashi, Masaki Matsunaga, Masaaki Naito","doi":"10.1080/00015385.2024.2403284","DOIUrl":"10.1080/00015385.2024.2403284","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"407-409"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the evidence base: constructive feedback on the comparative effectiveness of torsemide and furosemide in heart failure.","authors":"Ramazan Aslan, Murat Özmen, Faik Özel, Erhan Arıkan, İsa Ardahanlı","doi":"10.1080/00015385.2025.2476890","DOIUrl":"10.1080/00015385.2025.2476890","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"432-433"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}