Acta cardiologica最新文献

{"title":"Impact of chronic kidney disease on the association of high ankle-brachial index with cardiovascular mortality and all-cause mortality.","authors":"Huan Jin, Tianbo Wang","doi":"10.1080/00015385.2025.2538405","DOIUrl":"10.1080/00015385.2025.2538405","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the impact of chronic kidney disease (CKD) on the association of ankle-brachial index (ABI) with long-term cardiovascular and all-cause mortality.</p><p><strong>Methods: </strong>This cohort study utilised the data from the National Health and Nutrition Examination Survey (NHANES), with mortality follow-up tracked through the National Death Index until December 31, 2019. CKD was defined by an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m² and/or a urinary albumin-to-creatinine ratio (UACR) ≥30 mg/g. ABI categories were defined as ≤0.9 (low), 0.9-1.4 (normal), and >1.4 (high). Cox proportional hazards models were employed to evaluate the association of ABI with long-term cardiovascular and all-cause mortality in individuals with or without CKD.</p><p><strong>Results: </strong>A total of 6,318 individuals were included, with 1,311 (20.8%) having CKD. The median follow-up duration was 203 (IQR: 183-223) months. After adjustments, compared to those with normal ABI, high ABI was associated with increased cardiovascular and all-cause mortality in individuals with CKD (hazard ratio [HR] 3.64, 95% CI 1.30-10.23 for cardiovascular mortality; HR 2.10, 95% CI 1.14-3.89 for all-cause mortality) but not in those without CKD. Low ABI was associated with an increased risk of cardiovascular and all-cause mortality in both CKD (HR 1.95, 95% CI 1.31-2.92 and HR 1.49, 95% CI 1.13-1.97, respectively) and non-CKD individuals (HR 1.90, 95% CI 1.27-2.82 and HR 1.60, 95% CI 1.32-1.94, respectively).</p><p><strong>Conclusions: </strong>High ABI was associated with increased cardiovascular and all-cause mortality in patients with CKD, but not in those without CKD.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"736-744"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between TIMI frame count, Tp-E interval duration and Tp-E/QT ratio in patients with ST elevation myocardial infarction.","authors":"Murat Erdem Alp, Mustafa Feridun Koşar, Ece Çelebi Coşkun","doi":"10.1080/00015385.2025.2553958","DOIUrl":"https://doi.org/10.1080/00015385.2025.2553958","url":null,"abstract":"<p><strong>Background: </strong>TIMI (Thrombolysis In Myocardial Infarction) frame count is a quantitative method that objectively assesses slow coronary blood flow. In our study, corrected TIMI frame count and non-invasive parameters such as Tp-e interval and Tp-e/QT ratio were investigated after revascularization in patients with ST Elevation Myocardial Infarction (STEMI).</p><p><strong>Methods: </strong>Patients who were admitted to our hospital with a preliminary diagnosis of STEMI between January 2020 and July 2020 were included in our study. From coronary angiography views, post-procedure corrected TIMI frame counts were measured. Pre and post-procedure Tp-e interval and Tp-e/QT ratios from ECGs were recorded. The patients were divided into 2 groups based on the corrected TIMI frame count of 27. TP-e interval and Tp-e/QT ratios between these two groups were examined.</p><p><strong>Results: </strong>When the changes in corrected TIMI frame counts and Tp-e interval time were compared, an inverse correlation was found between the changes in Tp-e interval time and corrected TIMI frame count <b>(<i>r</i>= -0.349; <i>p</i> = 0.001)</b>. Similarly, an inverse correlation was observed in the change in the Tp-e/QT ratio <b>(<i>r</i>= -0.343; <i>p</i> = 0.002)</b>. Patients were divided into 2 groups based on the corrected TIMI frame count (upper limit value of 27). There was a significant difference between the two groups in terms of Tp-e interval <b>(<i>p</i> = 0.003; <i>p</i> < 0.01)</b> and Tp-e/QT ratios (<i>p</i> = 0.023; <i>p</i> < 0.05) measured in the 90th minute ECGs after revascularization.</p><p><strong>Conclusions: </strong>Coronary antegrade blood flow can be demonstrated invasively by the non-invasive parameters TP-e interval and Tpe/QT ratio instead of corrected TIMI frame count.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-6"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volume challenge in women with congenital heart disease during reproductive age and pregnancy outcomes.","authors":"Kaat Verhenne, Pieter De Meester, Geert Schuurmans, Philip Moons, Els Troost, Alexander Van De Bruaene, Werner Budts","doi":"10.1080/00015385.2025.2480939","DOIUrl":"10.1080/00015385.2025.2480939","url":null,"abstract":"<p><strong>Background: </strong>Thanks to medical improvements in the care for patients with congenital heart disease (CHD), women with CHD reach reproductive age. Pregnancy is not without risk due to the cardiovascular changes that occur. University Hospitals Leuven use a standardised protocol, including a catheterisation and volume challenge, to assess these women before pregnancy. This protocol has never been evaluated.</p><p><strong>Objective: </strong>The primary aim was to evaluate this volume challenge protocol. The second objective was to investigate whether hemodynamic data obtained during cardiac catheterisation were associated with maternal and/or neonatal outcome.</p><p><strong>Methods: </strong>A single-centre, retrospective study was conducted. Primarily, changes in catheterisation measurements were evaluated. Second, correlation statistics investigated associations between catheterisation data and outcome.</p><p><strong>Results: </strong>Twenty-five women, with nine different CHDs were eligible for inclusion and underwent a catheterisation with volume challenge. Significant changes in pre- and post-volume challenge measurements were observed in the mean averaged systemic venous pressure (ASVP) (<i>p</i> < 0.001), diastolic and mean pulmonary artery pressures (<i>p</i> < 0.001), and the pulmonary capillary wedge pressure (<i>p</i> < 0.001). A negative correlation was observed between the pre-test ASVP and the neonatal gestational age at delivery (<i>p</i> = 0.002). Another negative correlation was found between the post-test cardiac index (CI) and gestational age at delivery (<i>p</i> = 0.049) and birthweight (<i>p</i> = 0.018).</p><p><strong>Conclusion: </strong>The results suggest that higher ASVP is associated with lower gestational age at delivery. Remarkably, higher CI was related with lower gestational age and birthweight. However, our data do not support that a systematic volume challenge in women with CHD can be considered as a reliable prediction test.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"695-702"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on: AC-2025-00245R2. Impact of chronic kidney disease on the association of high ankle brachial index with cardiovascular mortality and all-cause mortality.","authors":"François Jouret, Justine Huart","doi":"10.1080/00015385.2025.2544369","DOIUrl":"10.1080/00015385.2025.2544369","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"764-765"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Careful cardiovascular risk assessment and management is essential in patients receiving bevacizumab.","authors":"Thibault Bourgeois, Wouter Snoeck, Karl Dujardin","doi":"10.1080/00015385.2025.2530286","DOIUrl":"10.1080/00015385.2025.2530286","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"749-752"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144599080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on 'Effect of dapagliflozin on the no-reflow phenomenon in patients with acute myocardial infarction and type iI diabetes mellitus'.","authors":"Cedric Davidsen","doi":"10.1080/00015385.2025.2524238","DOIUrl":"10.1080/00015385.2025.2524238","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"762-763"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How important is the risk of medical malpractice litigations against cardiologists in Belgium?","authors":"Nathalie Meyten, Tom G Moreels","doi":"10.1080/00015385.2025.2516943","DOIUrl":"10.1080/00015385.2025.2516943","url":null,"abstract":"<p><strong>Background: </strong>Medical malpractice litigations represent an increasing reality for clinical physicians. No malpractice claims data are available on cardiologists in Belgium.</p><p><strong>Aim: </strong>We calculated the number of malpractice claims against cardiologists in Belgium based on the annual reports of the Fund for Medical Accidents (FMA).</p><p><strong>Methods: </strong>FMA annual reports are available online in the public domain from 2012 onwards, and they were reviewed focussing on Cardiology.</p><p><strong>Results: </strong>A total of 6884 applications for malpractice litigations were filed through the FMA, resulting in a final decision for 3185 health providers between 2014 and 2023. In this 10 year period, claims were filed against 73 cardiologists, ranking them in the top 15 specialities at risk for malpractice litigations. There are currently 1237 practicing cardiologists in Belgium, indicating that the cumulative 10 year risk of malpractice litigation through the FMA alone is 6%. This is lower than expected based on data in the literature, showing that missed diagnosis (myocardial infarction) and complications of interventional cardiology procedures represent the most common types of malpractice litigations against cardiologists. Compared to Gastroenterology, another interventional speciality within the field of Internal Medicine, Belgian cardiologists seem less prone to malpractice litigations. A total of 92 claims were filed through the FMA on a total of 777 practicing gastroenterologists (12%; <i>p</i> < 0.001 Chi-square).</p><p><strong>Conclusions: </strong>Based on the FMA annual reports, Belgian cardiologists face only a moderate risk of malpractice litigations reaching 6% over a 10 year time period, as compared to 12% cumulative risk of gastroenterologists.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"703-708"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"About a \"false-positive\" case of elevated troponin levels: differential diagnosis.","authors":"Tana Berisha, Adriana Postolache, Laura Vrancken, François Jouret, Patrizio Lancellotti, Caroline Le Goff","doi":"10.1080/00015385.2025.2462438","DOIUrl":"10.1080/00015385.2025.2462438","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"753-755"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left ventricular compression from giant emphysematous bulla.","authors":"Jean Philippe Henry, Maria-Luiza Luchian, Laurence Gabriel, Julien Higny, Olivier Xhaët, Benoit Robaye, Alin-Mihail Telbis, Fabian Demeure, Antoine Guedes, Martin Benoit","doi":"10.1080/00015385.2025.2450954","DOIUrl":"10.1080/00015385.2025.2450954","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"745-746"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empagliflozin in heart failure with preserved ejection fraction: from randomized trials to real-world evidence.","authors":"Sebastiaan Dhont, Amrit Singh, Bram Swinnen, Kwinten Vandebergen, Vince Smolders, Evelyne Meekers, Wilfried Mullens, Pieter Martens, Philippe B Bertrand","doi":"10.1080/00015385.2025.2538386","DOIUrl":"10.1080/00015385.2025.2538386","url":null,"abstract":"<p><strong>Background: </strong>The EMPEROR-Preserved clinical trial established empagliflozin as an effective therapy in heart failure with preserved ejection fraction (HFpEF), yet real-world validation in elderly, comorbid populations remain limited. We aimed to evaluate the clinical profile, tolerability, and outcomes of empagliflozin in a large Belgian HFpEF cohort.</p><p><strong>Methods: </strong>This retrospective, single-centre observational study of consecutive HFpEF patients (LVEF >50%) initiated on empagliflozin (10 mg daily) between April 2023 and April 2024. Baseline characteristics, clinical parameters, laboratory values, and outcomes were collected from electronic health records.</p><p><strong>Results: </strong>Of 798 screened patients, 577 were included (median age 82 years, 58% female). Atrial fibrillation (67%) and hypertension (78%) were highly prevalent. Empagliflozin use was associated with significant improvements in NYHA functional class (NYHA II: 56% to 77%, <i>p</i> < 0.001) and reduction in peripheral oedema (26% to 9%, <i>p</i> < 0.001). Modest reductions were observed in systolic blood pressure (131 to 130 mmHg, <i>p</i> = 0.017), heart rate (71 to 68 bpm, <i>p</i> = 0.004), body weight (76 to 75 kg, <i>p</i> < 0.001), and BMI (27.7 to 27.2 kg/m², <i>p</i> < 0.001). Haemoglobin levels increased (<i>p</i> = 0.002), while renal function declined modestly without clinical sequelae. Treatment discontinuation occurred in 2.8% of patients, mainly due to genitourinary infections. During a median follow-up period of 16 months, the all-cause mortality rate was 6.9%.</p><p><strong>Conclusion: </strong>In real-world elderly and comorbid HFpEF population, empagliflozin was well tolerated and associated with improvements in congestion and functional status, supporting the external validity of randomised trial findings.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"730-735"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144797936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}