Acta cardiologica最新文献_第2页

'The role of the triglyceride-glucose index in assessing coronary artery disease risk in diabetes mellitus'. 甘油三酯-葡萄糖指数在评估糖尿病患者冠心病风险中的作用"。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2024-11-26 DOI: 10.1080/00015385.2024.2432588

Muhammad Osama, Safiyyah Ubaid, Raheel Ahmed, Maryam Ubaid

引用次数: 0

Role of TGF-β1/Smad3 signalling pathway in renal tubulointerstitial fibrosis and renal damage in elderly rats with isolated systolic hypertension induced by increased pulse pressure. TGF-β1/Smad3信号通路在脉压升高引起的老年孤立性收缩期高血压大鼠肾小管间质纤维化和肾损害中的作用

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2025-01-09 DOI: 10.1080/00015385.2024.2445339

Lu Li, Guiling Xia, Lei Lei, Qiong Hu, Xueying Wei, Mengbi Cui, Qiaoling Tang, Donghua Yang, Anju Zhao

{"title":"Role of TGF-β1/Smad3 signalling pathway in renal tubulointerstitial fibrosis and renal damage in elderly rats with isolated systolic hypertension induced by increased pulse pressure.","authors":"Lu Li, Guiling Xia, Lei Lei, Qiong Hu, Xueying Wei, Mengbi Cui, Qiaoling Tang, Donghua Yang, Anju Zhao","doi":"10.1080/00015385.2024.2445339","DOIUrl":"10.1080/00015385.2024.2445339","url":null,"abstract":"Objective: Elevated systolic blood pressure and increased pulse pressure are closely associated with renal damage; however, the exact mechanism remains unclear. Therefore, we investigated the effects of increased pulse pressure on tubulointerstitial fibrosis and renal damage in elderly rats with isolated systolic hypertension (ISH). Additionally, the role of renal tubular epithelial-mesenchymal transition (EMT) and its upstream signalling pathways were elucidated.Methods: Ten-month-old male rats were randomly divided into control and ISH groups, with seven rats in each group administered warfarin and vitamin K1 for 6 weeks. Blood pressure, renal function, mean blood flow in the common iliac artery, and diastolic vessel diameter were assessed, and the rat kidney medulla was collected for histological, genetic, and protein level analysis.Results: Increased pulse pressure, abnormal renal function, and increased shear stress were detected in rats with ISH. Histology assessments revealed fibrosis in the interstitium of ISH rats. Epithelial marker E-cadherin protein expression was decreased, while the protein expression of interstitial markers α-SMA and Vimentin was increased, and transforming growth factor (TGF)-β1/Smad3 signalling was upregulated in the kidney tissue of ISH rats.Conclusions: Increased pulse pressure in elderly rats with ISH caused an increase in shear stress. These effects led to the development of EMT and the activation of its upstream TGF-β1/Smad3 signalling pathway, ultimately leading to renal tubular interstitial fibrosis causing renal injury.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"135-147"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive value of inflammatory indices for one year outcome of primary percutaneous coronary intervention on saphenous vein graft in post-coronary artery bypass grafting patients. 炎症指标对冠状动脉搭桥术后隐静脉移植患者经皮冠状动脉介入治疗1年预后的预测价值。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2025-01-16 DOI: 10.1080/00015385.2024.2413221

MohammadHossein MozafaryBazargany, Niloofar Gholami, Amir Azimi, Mohsen Maadani, Sara Adimi, Armina Zamani Kia, Ehsan Khalilipur

{"title":"Predictive value of inflammatory indices for one year outcome of primary percutaneous coronary intervention on saphenous vein graft in post-coronary artery bypass grafting patients.","authors":"MohammadHossein MozafaryBazargany, Niloofar Gholami, Amir Azimi, Mohsen Maadani, Sara Adimi, Armina Zamani Kia, Ehsan Khalilipur","doi":"10.1080/00015385.2024.2413221","DOIUrl":"10.1080/00015385.2024.2413221","url":null,"abstract":"Background: This study aims to evaluate the prognostic value of the inflammatory indices i.e. Platelet Lymphocyte Ratio (PLR), Neutrophil Lymphocyte Ratio (NLR), and Systemic Immune Inflammation Index (SII) as potential predictors of Major Adverse Cardiovascular Event (MACE) in patients undergoing Primary Percutaneous Coronary Intervention (PPCI) on Saphenous Vein Graft (SVG) with a history of Coronary Artery Bypass Graft (CABG).Methods: This retrospective study evaluated 74 patients who underwent PPCI on SVG at a tertiary centre between 2015-2023. Patients were divided based on experiencing MACE within one year. Baseline characteristics and inflammatory markers were compared between groups. Logistic regression identified predictors of MACE.Results: Of these 78, 74 completed the one-year follow-up and were included in the analysis. MACE occurred in 24 patients. We divided patients into two groups based on the occurrence of MACE. The MACE group had a significantly higher pre-procedural PLR compared to others (Mean difference [95%CI]: 22.24 [1.39, 42.23], p-value: 0.0346), while pre-procedural NLR, and SII, and post-procedural PLR, NLR, and SII were comparable between groups. Left Ventricular Ejection Fraction (LVEF) and pre-procedural PLR were predictors of one-year MACE; however, with low odds ratios (Odds Ratio [95%CI]: 0.91 [0.86, 0.96], 1.02 [1.00, 1.03], respectively). Only LVEF was an independent predictor of MACE. LVEF yielded a better discriminatory power than pre-procedural PLR. Pre-procedural PLR > 104.18 yielded a 70% sensitivity at 54% specificity for one-year MACE.Conclusion: Pre-procedural PLR and LVEF might be a predictor of one-year MACE following PPCI on SVG in post-CABG patients.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"109-114"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Giant abdominal aortic aneurysm.

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2025-02-21 DOI: 10.1080/00015385.2025.2467004

Sam Mirzaee, Andrei-Dumitru Margulescu

引用次数: 0

Access to implantable cardioverter defibrillator therapy within and across countries: the barriers still persist.

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2025-03-03 DOI: 10.1080/00015385.2025.2469000

Jacopo Francesco Imberti, Alberto Fisce, Giuseppe Boriani

引用次数: 0

Diagnostic and prognostic yields of ambulatory blood pressure measurements in haemodialysis patients: a 6-year longitudinal study. 血液透析患者动态血压测量的诊断和预后：一项为期6年的纵向研究。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2024-12-07 DOI: 10.1080/00015385.2024.2436811

J Huart, P Vanderweckene, L Seidel, C Bovy, P Delanaye, B Dubois, S Grosch, P Xhignesse, A Saint-Remy, J-M Krzesinski, F Jouret

{"title":"Diagnostic and prognostic yields of ambulatory blood pressure measurements in haemodialysis patients: a 6-year longitudinal study.","authors":"J Huart, P Vanderweckene, L Seidel, C Bovy, P Delanaye, B Dubois, S Grosch, P Xhignesse, A Saint-Remy, J-M Krzesinski, F Jouret","doi":"10.1080/00015385.2024.2436811","DOIUrl":"10.1080/00015385.2024.2436811","url":null,"abstract":"Background: Blood pressure (BP) control in haemodialysis (HD) patients is essential. Peri-dialytic BP levels do not accurately diagnose hypertension or predict the cardiovascular (CV) mortality.Methods: In this study, we recruited 43 adult patients who had been on chronic HD for ≥3 months. Seven-day home BP monitoring (HBPM) (values of Day1 discarded) and 44-h interdialytic ambulatory BP monitoring (iABPM) were performed. Pre- and post-dialysis BP levels were measured during the 6 dialysis sessions prior to iABPM. A 6-year follow-up was carried out to assess all-cause and CV mortality.Results: In patients considered as normotensive in pre-dialysis (n = 17), masked hypertension was found in 24% and 29% on the basis of iABPM and HBPM, respectively. Conversely, among hypertensive patients in pre-dialysis (n = 26), 'white-coat' hypertension was noted in 23% either by iABPM or HBPM. After a 6-year follow-up, 25 patients were deceased including 6 patients from CV causes. Day-time systolic BP measured by iABPM was associated with all-cause mortality in an adjusted model for age and gender (p = 0.045).Conclusion: In chronic HD patients, 44-h iABPM and 6-day HBPM show a reliable concordance and help to re-classify ∼25% of cases miscategorised based on pre-dialysis measurements. Day-time systolic BP levels using iABPM were significantly associated with 6-year all-cause mortality.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"115-123"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of myocardial ischaemia: the importance of novel tools. 心肌缺血检测：新工具的重要性。

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2025-01-18 DOI: 10.1080/00015385.2025.2453791

Flavio Giuseppe Biccirè

引用次数: 0

Office white-coat effect tail and long-term cardiovascular risks in 60-year follow-up of the European cohorts of the Seven Countries Study.

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2025-02-20 DOI: 10.1080/00015385.2025.2467006

Xavier Humbert, Andry Rabiaza, Anthony Kafatos, Paolo Piras, Hanna Tolonen, Paolo-Emilio Puddu

{"title":"Office white-coat effect tail and long-term cardiovascular risks in 60-year follow-up of the European cohorts of the Seven Countries Study.","authors":"Xavier Humbert, Andry Rabiaza, Anthony Kafatos, Paolo Piras, Hanna Tolonen, Paolo-Emilio Puddu","doi":"10.1080/00015385.2025.2467006","DOIUrl":"10.1080/00015385.2025.2467006","url":null,"abstract":"Aim: The aim of this study was to determine whether the office white-coat effect tail (OWCET), defined as decreasing of SBP ≥10 mmHg in multiple office systolic blood pressure measures, predicts major long-term fatal events in the nearly extinct European cohorts of the Seven Country Study (ECSCS).Material and methods: In the present analysis, 4,937 men (49 ± 5 years) were included. All-cause mortality and specific mortalities [cardiovascular mortality (CVD) including stroke, coronary heart disease (CHD) death as well as heart disease of uncertain aetiology (HDUE)] were considered using Cox models. Also non-CVD deaths were studied by Fine-Gray competing risk analysis.Results: At inclusion, subjects with OWCET were significantly more hypertensive. After 60-year follow-up, OWCET was not associated with risk of both CVD [aHR: 0.95 (95% CI: 0.82-1.03), p = 0.5] and all-cause death [aHR: 0.92 (95% CI: 0.82-1.03), p = 0.16] independently of traditional risk factors (age, SBP, BMI, total cholesterol and cigarettes) in ECSCS. Same results were found for Northern and Southern Europe cohorts of ECSCS concerning CVD death [aHR: 0.98 (95% CI: 0.76-1.26), p = 0.85 and aHR: 0.95 (95% CI: 0.74-1.20), p = 0.66] and all-cause death, respectively [aHR: 0.90 (95% CI: 0.75-1.07), p = 0.23 and aHR: 0.93 (95% CI: 0.79-1.09), p = 0.38].Conclusions: In a general population of men, OWCET is not associated to CVD or non-CVD and all-cause mortality and consequently cannot improve stratification of long-term CVD risks in ECSCS.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"173-180"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myocardial work in ischaemic heart disease.

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI: 10.1080/00015385.2025.2457179

María Elena Sánchez, Mercedes Panno, Mateo Giordano, Anabel Gafni

引用次数: 0

Unusual late presentation of symptomatic type II popliteal artery entrapment syndrome in a 62 years adult.

IF 2.1 4区医学

Acta cardiologica Pub Date : 2025-03-29 DOI: 10.1080/00015385.2025.2484861

Gourav Saini, Resham Singh, Renu Yadav, Priyanka Singh

引用次数: 0