Acta cardiologica最新文献

{"title":"Regional differences in survival after ICD implantation.","authors":"Sebastian Ingelaere, Ruben Hoffmann, Jean-Benoit le Polain de Waroux, Ivan Blankoff, Georges H Mairesse, Johan Vijgen, Yves Vandekerckhove, Bert Vandenberk, Rik Willems","doi":"10.1080/00015385.2024.2443296","DOIUrl":"10.1080/00015385.2024.2443296","url":null,"abstract":"<p><strong>Background: </strong>The implantable cardioverter-defibrillator (ICD) remains the cornerstone in the prevention of sudden cardiac death. Cost-effectiveness depends on survival after implantation. In Belgium there are unexplained major differences in 3-year mortality after ICD implantation. Centre volume and socio-economic differences might affect survival after implantation.</p><p><strong>Methods: </strong>In total, 9647 patients underwent a first ICD implantation between February 2010 and 2016 in Belgium and were retrospectively compared for demographics, 30-day and 3-year mortality. Chi-squared and Mann-Whitney U tests were used to determine differences across centre volume.</p><p><strong>Results: </strong>Low-volume centres treated patients with different characteristics and implanted more patients with ischaemic heart disease (50.2 vs 47.9%, <i>p</i> = 0.002), in primary prevention (66.7 vs 62.0%, <i>p</i> < 0.001) and with overall more comorbidities. Kaplan-Meier survival analysis showed a significant higher 3-year mortality in low-volume centres (16.3 vs 11.4%, <i>p</i> < 0.001). After adjudication with a multivariable Cox model, centre volume remained an independent predictor of 3-year mortality (low volume HR 1.300 [95% CI 1.124-1.504]. However similar 30-day mortality (0.6% in low vs 0.5% in high volume centres, <i>p</i> = 0.393) suggests that implantation related determinants alone are insufficient to explain the long-term survival difference. Socio-economic factors like regional average income (wealth) and overall survival (health) also were associated with the survival difference between low- and high-volume centres.</p><p><strong>Conclusions: </strong>There exist large survival differences after ICD implantation between implanting centres in Belgium that cannot only be explained by a volume-outcome effect. Centres size and characteristics are inhomogeneous and vary according to different socio-economic variables. Some of these variables are also significantly associated with survival and warrant further investigation.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"124-134"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualising rare coronary anatomy: critical insights from multimodal imaging in RCA atresia.","authors":"Jie Wang, Ping Hu, Hong Yan, Huan Yuan, Xiao-Jing Ma","doi":"10.1080/00015385.2025.2450955","DOIUrl":"10.1080/00015385.2025.2450955","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"195-197"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional intercoronary communication: a rare coronary anomaly.","authors":"L Caverenne, F Demeure","doi":"10.1080/00015385.2024.2436807","DOIUrl":"10.1080/00015385.2024.2436807","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"188-189"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'The role of the triglyceride-glucose index in assessing coronary artery disease risk in diabetes mellitus'.","authors":"Muhammad Osama, Safiyyah Ubaid, Raheel Ahmed, Maryam Ubaid","doi":"10.1080/00015385.2024.2432588","DOIUrl":"10.1080/00015385.2024.2432588","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"201-202"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of TGF-β1/Smad3 signalling pathway in renal tubulointerstitial fibrosis and renal damage in elderly rats with isolated systolic hypertension induced by increased pulse pressure.","authors":"Lu Li, Guiling Xia, Lei Lei, Qiong Hu, Xueying Wei, Mengbi Cui, Qiaoling Tang, Donghua Yang, Anju Zhao","doi":"10.1080/00015385.2024.2445339","DOIUrl":"10.1080/00015385.2024.2445339","url":null,"abstract":"<p><strong>Objective: </strong>Elevated systolic blood pressure and increased pulse pressure are closely associated with renal damage; however, the exact mechanism remains unclear. Therefore, we investigated the effects of increased pulse pressure on tubulointerstitial fibrosis and renal damage in elderly rats with isolated systolic hypertension (ISH). Additionally, the role of renal tubular epithelial-mesenchymal transition (EMT) and its upstream signalling pathways were elucidated.</p><p><strong>Methods: </strong>Ten-month-old male rats were randomly divided into control and ISH groups, with seven rats in each group administered warfarin and vitamin K1 for 6 weeks. Blood pressure, renal function, mean blood flow in the common iliac artery, and diastolic vessel diameter were assessed, and the rat kidney medulla was collected for histological, genetic, and protein level analysis.</p><p><strong>Results: </strong>Increased pulse pressure, abnormal renal function, and increased shear stress were detected in rats with ISH. Histology assessments revealed fibrosis in the interstitium of ISH rats. Epithelial marker E-cadherin protein expression was decreased, while the protein expression of interstitial markers α-SMA and Vimentin was increased, and transforming growth factor (TGF)-β1/Smad3 signalling was upregulated in the kidney tissue of ISH rats.</p><p><strong>Conclusions: </strong>Increased pulse pressure in elderly rats with ISH caused an increase in shear stress. These effects led to the development of EMT and the activation of its upstream TGF-β1/Smad3 signalling pathway, ultimately leading to renal tubular interstitial fibrosis causing renal injury.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"135-147"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142942455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive value of inflammatory indices for one year outcome of primary percutaneous coronary intervention on saphenous vein graft in post-coronary artery bypass grafting patients.","authors":"MohammadHossein MozafaryBazargany, Niloofar Gholami, Amir Azimi, Mohsen Maadani, Sara Adimi, Armina Zamani Kia, Ehsan Khalilipur","doi":"10.1080/00015385.2024.2413221","DOIUrl":"10.1080/00015385.2024.2413221","url":null,"abstract":"<p><strong>Background: </strong>This study aims to evaluate the prognostic value of the inflammatory indices i.e. Platelet Lymphocyte Ratio (PLR), Neutrophil Lymphocyte Ratio (NLR), and Systemic Immune Inflammation Index (SII) as potential predictors of Major Adverse Cardiovascular Event (MACE) in patients undergoing Primary Percutaneous Coronary Intervention (PPCI) on Saphenous Vein Graft (SVG) with a history of Coronary Artery Bypass Graft (CABG).</p><p><strong>Methods: </strong>This retrospective study evaluated 74 patients who underwent PPCI on SVG at a tertiary centre between 2015-2023. Patients were divided based on experiencing MACE within one year. Baseline characteristics and inflammatory markers were compared between groups. Logistic regression identified predictors of MACE.</p><p><strong>Results: </strong>Of these 78, 74 completed the one-year follow-up and were included in the analysis. MACE occurred in 24 patients. We divided patients into two groups based on the occurrence of MACE. The MACE group had a significantly higher pre-procedural PLR compared to others (Mean difference [95%CI]: 22.24 [1.39, 42.23], p-value: 0.0346), while pre-procedural NLR, and SII, and post-procedural PLR, NLR, and SII were comparable between groups. Left Ventricular Ejection Fraction (LVEF) and pre-procedural PLR were predictors of one-year MACE; however, with low odds ratios (Odds Ratio [95%CI]: 0.91 [0.86, 0.96], 1.02 [1.00, 1.03], respectively). Only LVEF was an independent predictor of MACE. LVEF yielded a better discriminatory power than pre-procedural PLR. Pre-procedural PLR > 104.18 yielded a 70% sensitivity at 54% specificity for one-year MACE.</p><p><strong>Conclusion: </strong>Pre-procedural PLR and LVEF might be a predictor of one-year MACE following PPCI on SVG in post-CABG patients.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"109-114"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Access to implantable cardioverter defibrillator therapy within and across countries: the barriers still persist.","authors":"Jacopo Francesco Imberti, Alberto Fisce, Giuseppe Boriani","doi":"10.1080/00015385.2025.2469000","DOIUrl":"10.1080/00015385.2025.2469000","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"206-208"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant abdominal aortic aneurysm.","authors":"Sam Mirzaee, Andrei-Dumitru Margulescu","doi":"10.1080/00015385.2025.2467004","DOIUrl":"10.1080/00015385.2025.2467004","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"200"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of myocardial ischaemia: the importance of novel tools.","authors":"Flavio Giuseppe Biccirè","doi":"10.1080/00015385.2025.2453791","DOIUrl":"10.1080/00015385.2025.2453791","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"203-205"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142998292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic yields of ambulatory blood pressure measurements in haemodialysis patients: a 6-year longitudinal study.","authors":"J Huart, P Vanderweckene, L Seidel, C Bovy, P Delanaye, B Dubois, S Grosch, P Xhignesse, A Saint-Remy, J-M Krzesinski, F Jouret","doi":"10.1080/00015385.2024.2436811","DOIUrl":"10.1080/00015385.2024.2436811","url":null,"abstract":"<p><strong>Background: </strong>Blood pressure (BP) control in haemodialysis (HD) patients is essential. Peri-dialytic BP levels do not accurately diagnose hypertension or predict the cardiovascular (CV) mortality.</p><p><strong>Methods: </strong>In this study, we recruited 43 adult patients who had been on chronic HD for ≥3 months. Seven-day home BP monitoring (HBPM) (values of Day1 discarded) and 44-h interdialytic ambulatory BP monitoring (iABPM) were performed. Pre- and post-dialysis BP levels were measured during the 6 dialysis sessions prior to iABPM. A 6-year follow-up was carried out to assess all-cause and CV mortality.</p><p><strong>Results: </strong>In patients considered as normotensive in pre-dialysis (<i>n</i> = 17), masked hypertension was found in 24% and 29% on the basis of iABPM and HBPM, respectively. Conversely, among hypertensive patients in pre-dialysis (<i>n</i> = 26), 'white-coat' hypertension was noted in 23% either by iABPM or HBPM. After a 6-year follow-up, 25 patients were deceased including 6 patients from CV causes. Day-time systolic BP measured by iABPM was associated with all-cause mortality in an adjusted model for age and gender (<i>p</i> = 0.045).</p><p><strong>Conclusion: </strong>In chronic HD patients, 44-h iABPM and 6-day HBPM show a reliable concordance and help to re-classify ∼25% of cases miscategorised based on pre-dialysis measurements. Day-time systolic BP levels using iABPM were significantly associated with 6-year all-cause mortality.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"115-123"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}