Acta cardiologica最新文献

{"title":"Tumour necrosis factor alpha-inducing protein 3 (TNFAIP3) can independently predict coronary heart disease (CHD).","authors":"Anyi Wang, Mengmeng Ren, Han Sun, Zan Xie, Tongxin An, Hua Wang, Chunxiao Wang, Lin Zhong","doi":"10.1080/00015385.2025.2548160","DOIUrl":"https://doi.org/10.1080/00015385.2025.2548160","url":null,"abstract":"<p><strong>Background: </strong>Multiple indicators of inflammation are significantly associated with coronary heart disease (CHD). Tumour necrosis factor alpha-inducible protein 3 (TNFAIP3) is an anti-inflammatory protein that inhibits inflammatory responses. However, the relationship between TNFAIP3 and CHD is currently unknown.</p><p><strong>Methods: </strong>This study included 236 patients. They were divided into the CHD group (<i>n</i> = 162) and the control group (<i>n</i> = 74) according to whether at least one coronary artery was >50% stenosed by coronary angiography or computed tomography angiography (CTA). All patients in the CHD group presented with acute coronary syndromes. TNFAIP3 levels were measured using enzyme-linked adsorbent assay (ELISA). Propensity score matching was performed using a 1:1 ratio, and 56 pairs of patients were identified. The association between TNFAIP3 and the risk of developing CHD was analysed by one-way and multivariate logistic regression.</p><p><strong>Results: </strong>Before and after propensity score matching, TNFAIP3 levels were significantly lower in CHD patients than in controls. TNFAIP3 was negatively correlated with CHD. Logistic regression model showed that TNFAIP3 was an independent factor for CHD.ROC curves showed an AUC of 0.957 (0.916, 0.998), a sensitivity of 0.964, a specificity of 0.929, a Youden index 0.893, TNFAIP3 showed a good predictive effect on the development of CHD.</p><p><strong>Conclusions: </strong>Patients with CHD had decreased levels of TNFAIP3, and TNFAIP3 was an independent predictor of CHD. These findings suggest that TNFAIP3 levels can be tested clinically to provide a reference for the diagnosis of CHD.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-6"},"PeriodicalIF":2.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is the optimal site for cardiac pacing in children?","authors":"Thierry Bové","doi":"10.1080/00015385.2025.2554390","DOIUrl":"https://doi.org/10.1080/00015385.2025.2554390","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":2.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of coronary ischaemia associated with aortic valve disease: outcome of treatment modalities.","authors":"Ivo Deblier, Karl Dossche, Anthony Vanermen, Wilhelm Mistiaen","doi":"10.1080/00015385.2024.2431760","DOIUrl":"https://doi.org/10.1080/00015385.2024.2431760","url":null,"abstract":"<p><p>Aortic valve disease is often associated with coronary ischaemic heart disease (CIHD). Surgical aortic valve replacement (SAVR) can be combined with CABG, but its outcome is still a matter for debate, especially when there is postoperative residual ischaemia. Demographic, comorbid, operative variables and postoperative outcome were investigated in patients who underwent SAVR for their distribution across patients with and without CABG. Patients who underwent an associated CABG were more of male gender (970/1520 vs. 481/1018, <i>p</i> < 0.001), octogenarians (440/1520 vs. 241/1018, <i>p</i> = 0.003), needed more urgent surgery (266/1335 vs. 148/913, <i>p</i> = 0.026), but had less prior CABG (110/1518 vs.101/1018, <i>p</i> = 0.017) or SAVR (24/1517 vs. 46/1018, <i>p</i> < 0.001). They also had more cardiopulmonary bypass times > 120 min (705/1255 vs. 102/865, <i>p</i> < 0.001). There was also a higher need for blood transfusion (239/902 vs. 82/614, <i>p</i> < 0.001), prolonged mechanical ventilation (405/900 vs. 184/614, <i>p</i> < 0.001), prolonged stay on the ICU (417/1119 vs. 196/752, <i>p</i> < 0.001) and more postoperative adverse events, including 30-day mortality (93/1520 vs. 44/1018, <i>p</i> = 0.050). Need for urgent SAVR was the dominant predictor, common for both surgical groups. Residual ischaemia was also a predictor for mortality in the CABG group. The association of CABG reduced the 60-month survival rate from 79.9 ± 1.3% to 76.7 ± 0.1% (<i>p</i> = 0.006). The effect of residual ischaemia on survival was stronger (77.2 ± 1.3% versus 67.5 ± 3.7%, <i>p</i> = 0.002). Age above 80 was the dominant predictor for both groups. Need for urgent SAVR had become less important. Residual ischaemia had a clear effect on survival, but was not identified as an independent predictor. The effect of need for urgent SAVR on the outcome suggests that an adequate treatment should not be postponed. In patients with concomitant coronary artery disease, residual ischaemia should be avoided if technically possible.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-11"},"PeriodicalIF":2.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabry disease in women: still hidden or overlooked diagnosis?","authors":"V Reskovic Luksic, D Petkovic Ramadza, J Separovic Hanzevacki","doi":"10.1080/00015385.2025.2554393","DOIUrl":"https://doi.org/10.1080/00015385.2025.2554393","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-3"},"PeriodicalIF":2.5,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of HALP score on long-term clinical outcomes in patients with coronary bifurcation lesion undergoing 2-stent strategy.","authors":"Hicaz Zencirkıran Ağuş, Serkan Kahraman, Sezgin Atmaca, İrem Türkmen, Mehmet Çiçek, Erhan Melikoğlu, Hasan Şahin, Abidin Emre Tırnaksız, Doğukan Salduz, Yusuf Karadağ, Mehmet Altunova, Ali Kemal Kalkan, Mehmet Ertürk","doi":"10.1080/00015385.2025.2554397","DOIUrl":"https://doi.org/10.1080/00015385.2025.2554397","url":null,"abstract":"<p><strong>Objectives: </strong>Percutaneous coronary interventions (PCI) of coronary bifurcation lesions (CBL) are challenging lesions. Recently haemoglobin, albumin, lymphocyte, platelet index (HALP), has been used to determine the prognosis of many diseases and gives valuable information about the patient's nutritional status and systemic inflammation. Our study aimed to assess the impact of HALP on long-term major advers cardiac events (MACE) for patients undergoing true coronary bifurcation stenting (CBS) procedure.</p><p><strong>Methods: </strong>A total of 773 patients who underwent percutaneous coronary intervention for true non-left main CBL were retrospectively enrolled. The primary clinical endpoint was MACE defıned as the occurence of target lesion revascularization (TLR), target vessel myocardial infarction (TVMI) or cardiac mortality. Secondary endpoint was stent thrombosis (ST). According to the best cut-off value of HALP score of 31.891, the study samples were divided into two groups.</p><p><strong>Results: </strong>HALP score was negatively associated with the risk of MACE. Compared with patients whose HALP scores were >31.891, those who had HALP scores <31.891 seemed to have a high risk of MACE. In multivariate regression analysis HALP and CRP were determined as independent predictors of MACE. Kaplan-Meier survival curve analysis showed that the higher HALP group had a significantly better event-free survival regarding the occurrence of MACE, TVMI, TLR and cardiac mortality.</p><p><strong>Conclusion: </strong>Our study's findings indicate that, HALP score was a significant independent predictor of long-term majör advers cardiovascular events in patients undergoing coronary artery bifurcation stenting procedure.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of transcatheter aortic valve implantation on retinal hemodynamics: a Doppler imaging study.","authors":"Ayşe İrem Demirtola, Mehmet Akif Erdöl, Anar Mammadli, Özlem Ünal, Ali İpek, Çağrı Yayla, Ahmet Göktuğ Ertem, Adnan Burak Akçay","doi":"10.1080/00015385.2025.2554404","DOIUrl":"https://doi.org/10.1080/00015385.2025.2554404","url":null,"abstract":"<p><strong>Objectives: </strong>After transcatheter aortic valve implantation (TAVI), various hemodynamic alterations occur due to increased cardiac output, which may influence retinal blood flow. This study aimed to evaluate the impact of TAVI on retinal artery dynamics by measuring Doppler parameters before and after the procedure.</p><p><strong>Methods: </strong>In this prospective, single-centre study, patients scheduled for TAVI were evaluated using retinal Doppler within one week before TAVI, on the first postoperative day, and at one month post-procedure. The resistive index (RI) and pulsatility index (PI) measured retinal artery dynamics.</p><p><strong>Results: </strong>The analysis included 50 patients undergoing TAVI. Significant changes in the right and left ophthalmic artery RI and PI (ROAPI, ROARI, LOAPI, and LOARI) and left central retinal artery RI and PI (LCRRI and LCRPI) were noted from pre-TAVI to the first postoperative day: ROAPI (1.71-1.90, <i>p</i> = 0.033), ROARI (0.82-0.90, <i>p</i> = 0.045), LOAPI (1.75-2.05, <i>p</i> = 0.042), LOARI (0.81-0.85, <i>p</i> = 0.040), LCRPI (1.50-1.57, <i>p</i> = 0.025), and LCRRI (0.76 to 0.79, <i>p</i> = 0.005). No significant differences were observed between preoperative and one-month postoperative values. Correlation analysis revealed significant associations between the mean aortic gradient and LOAPI (<i>r</i> = 0.447, <i>p</i> = 0.010) as well as LOARI (<i>r</i> = 0.383, <i>p</i> = 0.030).</p><p><strong>Conclusion: </strong>Increased resistive indices on the first postoperative day suggest a transient autoregulatory response to altered hemodynamics after TAVI, possibly linked to chronic hypoperfusion from aortic stenosis. This study provides insights into ocular hemodynamic changes in the context of TAVI.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.5,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of chronic kidney disease on the association of high ankle-brachial index with cardiovascular mortality and all-cause mortality.","authors":"Huan Jin, Tianbo Wang","doi":"10.1080/00015385.2025.2538405","DOIUrl":"10.1080/00015385.2025.2538405","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the impact of chronic kidney disease (CKD) on the association of ankle-brachial index (ABI) with long-term cardiovascular and all-cause mortality.</p><p><strong>Methods: </strong>This cohort study utilised the data from the National Health and Nutrition Examination Survey (NHANES), with mortality follow-up tracked through the National Death Index until December 31, 2019. CKD was defined by an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m² and/or a urinary albumin-to-creatinine ratio (UACR) ≥30 mg/g. ABI categories were defined as ≤0.9 (low), 0.9-1.4 (normal), and >1.4 (high). Cox proportional hazards models were employed to evaluate the association of ABI with long-term cardiovascular and all-cause mortality in individuals with or without CKD.</p><p><strong>Results: </strong>A total of 6,318 individuals were included, with 1,311 (20.8%) having CKD. The median follow-up duration was 203 (IQR: 183-223) months. After adjustments, compared to those with normal ABI, high ABI was associated with increased cardiovascular and all-cause mortality in individuals with CKD (hazard ratio [HR] 3.64, 95% CI 1.30-10.23 for cardiovascular mortality; HR 2.10, 95% CI 1.14-3.89 for all-cause mortality) but not in those without CKD. Low ABI was associated with an increased risk of cardiovascular and all-cause mortality in both CKD (HR 1.95, 95% CI 1.31-2.92 and HR 1.49, 95% CI 1.13-1.97, respectively) and non-CKD individuals (HR 1.90, 95% CI 1.27-2.82 and HR 1.60, 95% CI 1.32-1.94, respectively).</p><p><strong>Conclusions: </strong>High ABI was associated with increased cardiovascular and all-cause mortality in patients with CKD, but not in those without CKD.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"736-744"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the relationship between TIMI frame count, Tp-E interval duration and Tp-E/QT ratio in patients with ST elevation myocardial infarction.","authors":"Murat Erdem Alp, Mustafa Feridun Koşar, Ece Çelebi Coşkun","doi":"10.1080/00015385.2025.2553958","DOIUrl":"https://doi.org/10.1080/00015385.2025.2553958","url":null,"abstract":"<p><strong>Background: </strong>TIMI (Thrombolysis In Myocardial Infarction) frame count is a quantitative method that objectively assesses slow coronary blood flow. In our study, corrected TIMI frame count and non-invasive parameters such as Tp-e interval and Tp-e/QT ratio were investigated after revascularization in patients with ST Elevation Myocardial Infarction (STEMI).</p><p><strong>Methods: </strong>Patients who were admitted to our hospital with a preliminary diagnosis of STEMI between January 2020 and July 2020 were included in our study. From coronary angiography views, post-procedure corrected TIMI frame counts were measured. Pre and post-procedure Tp-e interval and Tp-e/QT ratios from ECGs were recorded. The patients were divided into 2 groups based on the corrected TIMI frame count of 27. TP-e interval and Tp-e/QT ratios between these two groups were examined.</p><p><strong>Results: </strong>When the changes in corrected TIMI frame counts and Tp-e interval time were compared, an inverse correlation was found between the changes in Tp-e interval time and corrected TIMI frame count <b>(<i>r</i>= -0.349; <i>p</i> = 0.001)</b>. Similarly, an inverse correlation was observed in the change in the Tp-e/QT ratio <b>(<i>r</i>= -0.343; <i>p</i> = 0.002)</b>. Patients were divided into 2 groups based on the corrected TIMI frame count (upper limit value of 27). There was a significant difference between the two groups in terms of Tp-e interval <b>(<i>p</i> = 0.003; <i>p</i> < 0.01)</b> and Tp-e/QT ratios (<i>p</i> = 0.023; <i>p</i> < 0.05) measured in the 90th minute ECGs after revascularization.</p><p><strong>Conclusions: </strong>Coronary antegrade blood flow can be demonstrated invasively by the non-invasive parameters TP-e interval and Tpe/QT ratio instead of corrected TIMI frame count.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-6"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Volume challenge in women with congenital heart disease during reproductive age and pregnancy outcomes.","authors":"Kaat Verhenne, Pieter De Meester, Geert Schuurmans, Philip Moons, Els Troost, Alexander Van De Bruaene, Werner Budts","doi":"10.1080/00015385.2025.2480939","DOIUrl":"10.1080/00015385.2025.2480939","url":null,"abstract":"<p><strong>Background: </strong>Thanks to medical improvements in the care for patients with congenital heart disease (CHD), women with CHD reach reproductive age. Pregnancy is not without risk due to the cardiovascular changes that occur. University Hospitals Leuven use a standardised protocol, including a catheterisation and volume challenge, to assess these women before pregnancy. This protocol has never been evaluated.</p><p><strong>Objective: </strong>The primary aim was to evaluate this volume challenge protocol. The second objective was to investigate whether hemodynamic data obtained during cardiac catheterisation were associated with maternal and/or neonatal outcome.</p><p><strong>Methods: </strong>A single-centre, retrospective study was conducted. Primarily, changes in catheterisation measurements were evaluated. Second, correlation statistics investigated associations between catheterisation data and outcome.</p><p><strong>Results: </strong>Twenty-five women, with nine different CHDs were eligible for inclusion and underwent a catheterisation with volume challenge. Significant changes in pre- and post-volume challenge measurements were observed in the mean averaged systemic venous pressure (ASVP) (<i>p</i> < 0.001), diastolic and mean pulmonary artery pressures (<i>p</i> < 0.001), and the pulmonary capillary wedge pressure (<i>p</i> < 0.001). A negative correlation was observed between the pre-test ASVP and the neonatal gestational age at delivery (<i>p</i> = 0.002). Another negative correlation was found between the post-test cardiac index (CI) and gestational age at delivery (<i>p</i> = 0.049) and birthweight (<i>p</i> = 0.018).</p><p><strong>Conclusion: </strong>The results suggest that higher ASVP is associated with lower gestational age at delivery. Remarkably, higher CI was related with lower gestational age and birthweight. However, our data do not support that a systematic volume challenge in women with CHD can be considered as a reliable prediction test.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"695-702"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on: AC-2025-00245R2. Impact of chronic kidney disease on the association of high ankle brachial index with cardiovascular mortality and all-cause mortality.","authors":"François Jouret, Justine Huart","doi":"10.1080/00015385.2025.2544369","DOIUrl":"10.1080/00015385.2025.2544369","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"764-765"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}