Acta cardiologicaPub Date : 2024-12-19DOI: 10.1080/00015385.2024.2443295
Özge Çakmak Karaaslan, Ekrem Şahan, Mustafa Karanfil, Ümit Güray
{"title":"Relationship between predictive factors and atrial high-rate episodes in heart failure with reduced ejection fraction patients with cardiac implantable electronic devices.","authors":"Özge Çakmak Karaaslan, Ekrem Şahan, Mustafa Karanfil, Ümit Güray","doi":"10.1080/00015385.2024.2443295","DOIUrl":"https://doi.org/10.1080/00015385.2024.2443295","url":null,"abstract":"<p><strong>Objective: </strong>Atrial high-rate episodes (AHRE) are atrial tachyarrhythmia episodes detected by implanted cardiac devices, characterised by an atrial rate exceeding 180-190 beats per minute. Recent studies have linked AHRE to the development of atrial fibrillation (AF) and increased stroke risk, especially when episodes last longer than 5-6 min. This study aimed to evaluate the relationship between predictive factors and the occurrence of AHRE in heart failure with reduced ejection fraction (HFrEF) patients with cardiac implantable electronic devices (CIEDs).</p><p><strong>Methods: </strong>This single-centre, retrospective study included a cohort of 155 consecutive HFrEF patients with CIEDs, but without a diagnosis of AF, enrolled between January 2023 and December 2023. Patients were stratified based on the presence of AHRE detected during device interrogation.</p><p><strong>Results: </strong>The average age of the patients was 54 ± 14 years, and 83.2% of the study population were male. Patients with AHRE had a reduced left ventricular ejection fraction (LVEF) (<i>p</i> = 0.026) and an increased left atrial diameter (<i>p</i> < 0.001) compared to the group without AHRE. Patients with AHRE had elevated levels of creatinine, uric acid, and TSH compared to those without AHRE (<i>p</i> = 0.006, <i>p</i> = 0.021, <i>p</i> = 0.009, respectively). In the univariable logistic regression analysis, LVEF (HR = 0.690, 95% CI = 0.610-0.913, <i>p</i> = 0.013), left atrial diameter (HR = 8.215, 95% CI = 1.557-43.34, <i>p</i> < 0.001), creatinine (HR = 7.369, 95% CI = 1.749-31.05, <i>p</i> = 0.006), uric acid (HR = 1.073, 95% CI = 1.062-1.196, <i>p</i> = 0.020), total cholesterol (HR = 0.989, 95% CI = 0.979-0.999, <i>p</i> = 0.031), and C-reactive protein levels (HR = 1.146, 95% CI = 1.002-1.131, <i>p</i> = 0.047) were identified as independent predictors of AHRE. In multivariable logistic regression analysis, left ventricular ejection fraction (HR = 0.890, 95% CI = 0.795-0.998, <i>p</i> = 0.046), left atrial diameter (HR = 8.215, 95% CI = 1.557-43.34, <i>p</i> < 0.001), and uric acid concentration (HR = 1.650, 95% CI = 1.063-2.561, <i>p</i> = 0.025) were identified as predictors of atrial high-rate events.</p><p><strong>Conclusion: </strong>LVEF, left atrial diameter, and uric acid level were found to be independent predictors of AHRE in patients with HFrEF. Identifying AHRE is crucial for risk stratification and guiding therapeutic decisions to improve patient outcome.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142852026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2024-12-16DOI: 10.1080/00015385.2024.2442800
Alexander E Berezin
{"title":"Deterioration of endothelial function as a risk factor for osteoporosis in patients with type 2 diabetes mellitus and MAFLD.","authors":"Alexander E Berezin","doi":"10.1080/00015385.2024.2442800","DOIUrl":"https://doi.org/10.1080/00015385.2024.2442800","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-3"},"PeriodicalIF":2.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2024-12-10DOI: 10.1080/00015385.2024.2436813
Peiyan Du, Jianxiang Jiang, Yurong Liu, Haihong Lv
{"title":"Correlation between vascular endothelial function and bone mineral density in type 2 diabetes mellitus patients with MAFLD.","authors":"Peiyan Du, Jianxiang Jiang, Yurong Liu, Haihong Lv","doi":"10.1080/00015385.2024.2436813","DOIUrl":"https://doi.org/10.1080/00015385.2024.2436813","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between vascular endothelial function and bone mineral density (BMD) in T2DM patients with metabolic dysfunction associated fatty liver (MAFLD) is still unclear. This study aims to analyse the correlation between vascular endothelial function and BMD or fracture risk in T2DM patients with MAFLD.</p><p><strong>Methods: </strong>A total of 872 T2DM patients aged ≥50 years were enrolled and divided into two groups according to the diagnostic criteria of MAFLD: MAFLD (+) and MAFLD (-). Flow-mediated dilation (FMD) was measured by high-resolution ultrasound to reflect vascular endothelial function. BMD was measured by dual-energy X-ray bone densitometry, and FRAX scores were calculated for 10-year hip fracture risk (HF<sup>1</sup>) and major osteoporotic fracture risk (MOF).</p><p><strong>Results: </strong>After multivariate adjustment, there was no significant correlation between FMD and BMD in MAFLD (-) group (<i>p</i> > 0.05). In MAFLD (+) and FMD < 4% group, FMD was positively correlated with WB, LS, and FN BMD, while FMD was negatively correlated with fracture risk and osteoporotic fracture history, and this correlation was only observed in female patients. However, FMD was not correlated with BMD and fracture risk and osteoporotic fracture history in 4%≤FMD ≤ 7% and FMD > 7% groups.</p><p><strong>Conclusions: </strong>The association of FMD with BMD in T2DM patients with MAFLD varies according to FMD level. The decrease of FMD is associated with reduced BMD and increased fracture risk in female patients with FMD < 4% group. FMD may be an influential factor for the occurrence and development of osteoporosis, and has some clinical value in early diagnosis of osteoporosis in T2DM patients with MAFLD.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2024-12-09DOI: 10.1080/00015385.2024.2436695
Maria Gabriela Matta, Rahul Lambert, Robert Park, Ian Agahari, Rowena Solayar
{"title":"Anomalous inferior vena cava unmasked 48 years later: a rare case of hypoxaemia in an adult with repaired atrial septal defect.","authors":"Maria Gabriela Matta, Rahul Lambert, Robert Park, Ian Agahari, Rowena Solayar","doi":"10.1080/00015385.2024.2436695","DOIUrl":"https://doi.org/10.1080/00015385.2024.2436695","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":2.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2024-12-09DOI: 10.1080/00015385.2024.2432590
Eman Mahmoud, Ereny Refaat Boshra Tadress, Khaled Ahmed El-Khashab, Ahmed Fathy Elkhateeb, Mohammed Gamal Mossa
{"title":"Accuracy of 2-dimensional speckle tracking echocardiography in diagnosis of coronary artery stenosis in stable angina pectoris.","authors":"Eman Mahmoud, Ereny Refaat Boshra Tadress, Khaled Ahmed El-Khashab, Ahmed Fathy Elkhateeb, Mohammed Gamal Mossa","doi":"10.1080/00015385.2024.2432590","DOIUrl":"https://doi.org/10.1080/00015385.2024.2432590","url":null,"abstract":"<p><strong>Background: </strong>It's difficult to detect the severity of coronary artery disease in the patients who have stable angina pectoris. Echocardiography is a well-validated non-invasive diagnostic tool for detecting myocardial ischaemia, but judging wall motion abnormalities is subjective. Conventional echocardiography can assess radial mechanics only, so it cannot assess the sensitive longitudinal mechanics. 2-Dimensional strain echocardiography is a recent tool that has the ability to solve these drawbacks.</p><p><strong>Aim of study: </strong>To detect the accuracy of 2D-STE in prediction of significant coronary artery stenosis in the patients with stable angina pectoris.</p><p><strong>Methods: </strong>This study included 70 patients who have stable angina pectoris. Conventional and 2D speckle tracking echocardiography were done to all patients then compared with the coronary angiography results. Patients were classified into three groups according to their coronary arteries affection; patients with normal Coronaries, non-obstructed lesion and patients with significant lesion.</p><p><strong>Results: </strong>Our study results show that the mean GLS was (-18.67 ± 0.93) in normal cases, and it was (-15.82 ± 1.11) in non-obstructed lesions but GLS was (-13.19 ± 1.7) in patients with significant CAD. And the best cut-off point of GLS was reported as (-17.35%) with a sensitivity of 97.6% and specificity of 93.3%. Also we found that SLS results in significant lesions of LAD, LCX, RCA territory was (-16.3%, -15.95%, -17.45%) with sensitivity and specificity (87.8%, 93.3%), (70.7%, 93.3%), (82.9%, 93.3%) respectively.</p><p><strong>Conclusion: </strong>Global longitudinal strain has a good diagnostic significance over visual evaluation during conventional echocardiogram in predicting significant stenosis of the coronary arteries in patients with stable coronary artery disease. Segmental Longitudinal strain is also a sensitive tool to detect the affected Coronary Territory.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}