Acta cardiologica最新文献

{"title":"Navi-gating through tortuous anatomy.","authors":"Nikolaos Pyrpyris, Kyriakos Dimitriadis, Konstantinos Aznaouridis, Konstantinos Tsioufis","doi":"10.1080/00015385.2025.2500890","DOIUrl":"10.1080/00015385.2025.2500890","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"523-524"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in cardiovascular care from risk assessment to intervention.","authors":"Patrizio Lancellotti, Mathieu Lempereur","doi":"10.1080/00015385.2025.2521184","DOIUrl":"10.1080/00015385.2025.2521184","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"435-439"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of lipid lowering therapy intensification in very high risk patients with dyslipidaemia eligible for PCSK9 monoclonal antibodies: 1-year outcomes of the PERI-DYS study.","authors":"Klaus G Parhofer, David Pittrow, Andreas L Birkenfeld, Uwe Fraass, Bernd Hohenstein, Carsten Siegert, Jens Klotsche, Elisabeth Steinhagen-Thiessen, Stefan Dexl, Volker J J Schettler, Ulrich Laufs","doi":"10.1080/00015385.2025.2490381","DOIUrl":"10.1080/00015385.2025.2490381","url":null,"abstract":"<p><strong>Purpose: </strong>The PERI-DYS study evaluates patients at very high cardiovascular (CV) risk, including those who receive PCSK9 monoclonal antibodies (PCSK9-mAb) and those who are eligible for PCSK9-mAb but do not receive them.</p><p><strong>Methods: </strong>This is a prospective observational registry at 70 sites in Germany, categorising patients by PCSK9-mAb treatment status at baseline. LDL cholesterol (LDL-C) changes and factors influencing lipid-lowering therapy (LLT) intensification were assessed after one year. Identifier: ClinicalTrials.gov NCT03110432.</p><p><strong>Results: </strong>Among 1565 patients, LDL-C levels decreased from 91.0 mg/dL at baseline to 73.5 mg/dL at 6 months and 71.5 mg/dL at 12 months. A total of 33.1% achieved the LDL-C goal (<55 mg/dL) according to EAS/ESC dyslipidaemia guidelines, with achievement rates ranging from 16.3% in those without PCSK9-mAb and statins to 50.5% in those on combined PCSK9-mAb, statins, and/or ezetimibe. Lipid intensity changed in 22.3% of patients, with 14.8% experiencing intensification and 9.3% reduction. Significant predictors of LLT intensification included younger age (odds ratio (OR) for 60+ years 0.73), no baseline ezetimibe (OR 0.43), LDL-C > 100 mg/dL (OR 3.90), and statin intolerance (OR 0.68).</p><p><strong>Conclusions: </strong>Despite eligibility for PCSK9-mAb treatment and management by specialised physicians, most patients did not reach the LDL-C target, and LLT intensification was rare. This suggests an underutilisation of available treatments, highlighting a gap in the management of high CV risk patients.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"475-486"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of obesity traits and uric acid levels with cardiovascular disease in Punjabi patients from Faisalabad, Pakistan.","authors":"Muhammad Umer Ghori, Muhammad Shareef Masoud, Muhammad Shafique, Misbah Hussain, Fazli Rabbi Awan","doi":"10.1080/00015385.2025.2490369","DOIUrl":"10.1080/00015385.2025.2490369","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular diseases (CVDs) are one of the significant public health concerns worldwide. Understanding the relationship between Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip Ratio (WHR) and uric acid levels are important in assessing cardiovascular risk. This study aimed to investigate the associations of BMI, WHR, WC and several biochemical parameters including uric acid levels with cardiovascular disease in patients from Faisalabad, Pakistan.</p><p><strong>Methods: </strong>This is a Retrospective Observational Study. A total of 403 cardiovascular patients were enrolled. Anthropometric measurements including BMI, WC and WHR were recorded. Serum samples were used to measure various biochemical parameters. SPSS ver. 21 was used to perform statistical analyses.</p><p><strong>Results: </strong>Results showed that BMI (29%↑), waist circumference (7%↑) and hip circumference (8%↑) were higher in obese CVD patients as compared to non-obese CVD patients. Additionally, uric acid levels were high (11%↑) in male CVD patients as compared to female CVD patients while total cholesterol (8%↑) and triglycerides (20%↑) levels were higher in female CVD patients as compared to male CVD patients. Pearson correlation and Linear regression analysis confirmed that uric acid was associated with total cholesterol, triglycerides, alanine transaminase, creatinine and urea levels (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>This study confirms the associations between BMI, WC, WHR, uric acid levels and multiple biochemical parameters with health status in cardiovascular patients from Faisalabad, Pakistan.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"465-474"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing predictive accuracy of the 13-item Acute Coronary Syndrome checklist: a novel approach to improving risk assessment and diagnosis.","authors":"Mohammad Sahebkar, Najme Lagzian, Mohammad Reza Armat, Sarina Ramtin, Seyyedeh Samaneh Tabaee, Abdolghader Assarroudi","doi":"10.1080/00015385.2025.2480958","DOIUrl":"10.1080/00015385.2025.2480958","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the discriminatory capacity of the 13-Item ACS checklist and improve the accuracy of ACS diagnosis through the application of weighted regression analysis.</p><p><strong>Materials and methods: </strong>This predictive correlation study enrolled 300 patients admitted to Emergency Department between February 2021 and January 2022. The ACS checklist was administered upon initial triage, followed by patient tracking over a one-month hospitalisation period, capturing ACS diagnoses. Data analysis employed STATA 17 and MEDCALC 20.0.13 software.</p><p><strong>Results: </strong>Findings indicated that patients with sweating and shortness of breath symptoms had a heightened likelihood of true ACS diagnosis by 14% and 11%, respectively, compared to those without ACS (<i>p</i> = 0.005 and 0.019). Conversely, palpitations were associated with a 20% decreased likelihood of authentic ACS diagnosis (<i>p</i> < 0.001). Integration of significant regression coefficients - palpitation severity (-21), sweating severity (13.7), and shortness of breath severity (11) demonstrated significant discriminatory enhancements in the checklists. The weighted 13-item ACS checklist surpassed the unweighted version's performance, yielding superior discriminatory power for ACS diagnosis (<i>p</i> < 0.001 and <i>p</i> = 0.089). The weighted checklist elevated the AUC score from 55% to 70%.</p><p><strong>Conclusions: </strong>Incorporating weighted factors - shortness of breath severity, sweating severity, and palpitations severity - into the checklist notably enhanced ACS identification. However, it's important to note that this tool, while showing promise, is not intended to serve as a standalone diagnostic tool for ACS. Instead, this tool has the potential to enhance risk assessment and aid in clinical decision-making.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"440-446"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uric acid and cardiovascular risk in context: reflections on a regional study.","authors":"Ramazan Aslan, İsa Ardahanlı","doi":"10.1080/00015385.2025.2500891","DOIUrl":"10.1080/00015385.2025.2500891","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"532-533"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the heart eat along? A two years lifestyle intervention in shift workers.","authors":"Christine Binder-Mendl, Thorsten Schwerte, Wolfgang Marktl","doi":"10.1080/00015385.2025.2484847","DOIUrl":"10.1080/00015385.2025.2484847","url":null,"abstract":"<p><strong>Background: </strong>The present study investigates whether it is possible to reduce heart rate by nutritional information and lifestyle modification.</p><p><strong>Methods: </strong>In this exploratory study 18 male rotating shift workers (39.7 ± 7.5 y) were randomly divided into two groups by using the urn model. At the beginning of the study, all subjects wore a heart rate sensor for 24 hours during a night shift. This recording was repeated after 1 year, when groups switched, and at the end of the study. Participants received nutritional information every other month for 1 year. The nutritional counseling was provided by a dietician/nutritionist and only contained information about healthy eating. By using the food diaries, nutritional errors were uncovered and could easily be corrected. Subjects were also encouraged to incorporate more endurance and resistance training into their daily routines.</p><p><strong>Results: </strong>After the intervention, heart rate in group A decreased during the day from 75 ± 6.3 beats per minute (bpm) before to 73 ± 7.5 bpm afterward and during the night from 72 ± 9.8 bpm before to 70 ± 9.5 bpm afterward. In group B heart rate increased during the day from 72 ± 9.1 bpm before to 76 ± 7.2 bpm afterward and decreased at night from 69 ± 10.0 bpm before to 66 ± 11.2 bpm afterward. All values were highly significant (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Motivation to adopt a better lifestyle in terms of healthy eating and daily exercise could be a cost-effective contribution to heart health among rotating shift workers. However, the individually adapted interventions need to occur more frequently.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"447-455"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between inflammatory factors and major adverse cardiovascular events in atherosclerosis coronary artery ectasia: a prospective, cohort study.","authors":"Yu Luo, Xiaolin Li, Yaling Liu, Xiaodong Wang","doi":"10.1080/00015385.2025.2515306","DOIUrl":"10.1080/00015385.2025.2515306","url":null,"abstract":"<p><strong>Background: </strong>To investigate the relationship among high sensitive C reactive protein (hs-CRP), interleukin (IL)-6, tumour necrosis factor (TNF)-α, matrix metalloproteinase (MMP)-9, growth differentiation factor (GDF)-15, corrected thrombolysis in myocardial infarction (TIMI) frame count and major adverse cardiovascular events (MACEs) in atherosclerosis coronary artery ectasia (CAE).</p><p><strong>Materials and methods: </strong>One hundred and sixty-five CAE patients were included. All candidates were divided into symptomatic (107) and asymptomatic (58). Serum hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 were detected. Coronary artery blood flow velocity was evaluated by corrected TIMI frame count (CTFC). The relationship among inflammatory marker levels, CTFC, and clinical symptoms was analysed. The MACEs were recorded during a 2-year follow-up.</p><p><strong>Results: </strong>Symptomatic atherosclerosis CAE manifested male gender, more hypertension, dyslipidemia and smoking than asymptomatic compartments. These patients demonstrated higher serum levels of hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 than those of asymptomatic compartments (<i>p</i> < 0.05, respectively). The CTFC in symptomatic atherosclerosis CAE was lower than that of asymptomatic ones (<i>p</i> < 0.05, respectively). More MACEs occurred in symptomatic than in asymptomatic atherosclerosis CAE during the 2-year follow-up (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>Male gender, hypertension, dyslipidemia and smoking are more frequent in symptomatic atherosclerosis CAE. Hs-CRP, IL-6, TNF-α, MMP-9 and GDF-15 have a positive correlation with symptoms and CTFC in atherosclerosis CAE and are predictors of MACEs during 2-year follow-up.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"506-513"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long extracranial vertebral artery fenestration.","authors":"Damandeep Singh, Niraj Nirmal Pandey, Aprateem Mukherjee, Nitish Naik","doi":"10.1080/00015385.2025.2510013","DOIUrl":"10.1080/00015385.2025.2510013","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"525-526"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum and dietary fatty acids and their relationship to vascular inflammation and carotid intima-media thickness: implications for cardiovascular risk in patients with arterial hypertension.","authors":"Georgina N Marchiori, María E Paqualini, David Flores, María F Triquell, María J Moreira-Espinoza, Aldo R Eynard, Mirta A Valentich, María D Defagó","doi":"10.1080/00015385.2025.2493978","DOIUrl":"10.1080/00015385.2025.2493978","url":null,"abstract":"<p><strong>Background: </strong>Pathogenic mechanisms involved in arterial hypertension (HT) promote the atherosclerosis development. Fatty acids (FAs) could modulate these processes. We investigated the association between dietary and serum FAs and early atherosclerosis development and their correlation with serum vascular inflammation markers in HT.</p><p><strong>Methods: </strong>96 patients were included. Dietary information was collected through a validated food frequency questionnaire. Serum FAs were detected by gas chromatography. High-sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6) and fibrinogen serum were determined by immunoturbidimetry, enzyme immunoassay and Clauss method, respectively. Carotid intima media-thickness (cIMT) was determined by ultrasound. Multivariate linear regression models were applied.</p><p><strong>Results: </strong>Patients showed an adverse health profile, with high caloric intake (3113 ± 1477 kcal/day), LDL cholesterol (126.0 ± 35.1 mg/dL), and overweight (BMI 31.1 ± 5.5 kg/t2), and also an inflam-matory process, characterised by higher hs-CRP (3.9 ± 2.7 mg/L) and fibrinogen (433.4 ± 84.6 mg/dL) concentrations. We found significant inverse correlations between dietary monounsaturated FAs (MUFAs), serum omega-3 polyunsaturated FAs (n-3 PUFAs), and hs-CRP (<i>β</i> = -3.59, [95% CI -6.87 to -0.32], <i>p</i> = 0.03 and <i>β</i> = -0.70, [95% CI -1.42-0.01], <i>p</i> = 0.05, respectively), significant positive associations between dietary MUFAs, serum saturated FAs (SFAs) and cIMT (<i>β</i> = 81.96, [95% CI 33.42-130.50], <i>p</i> = 0.002 and <i>β</i> = 36.71, [95% CI 6.34-67.08], <i>p</i> = 0.02, respectively), and significant inverse correlations between serum omega-6 polyunsaturated FAs (n-6 PUFAs) and cIMT (<i>β</i> = -91.44, [95% CI -168.01 to -14.88], <i>p</i> = 0.02 and <i>β</i> = -41.01, [95% CI -70.73-11.28], <i>p</i> = 0.01).</p><p><strong>Conclusions: </strong>Serum n-3 PUFAs modulate hs-CRP levels, while n-6 PUFAs suggest antiatherosclerotic properties in HT. The ambiguous impact of MUFAs requires comprehensive research.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"498-505"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}