Acta cardiologicaPub Date : 2025-05-01Epub Date: 2025-03-31DOI: 10.1080/00015385.2025.2480961
Li Lin, Wanhua Chen, Hang Chen, Jianwen Liu, Kanghui Chen, Lianglong Chen, Liangwan Chen, Zhaoyang Chen
{"title":"Complete heart block after occlusion and repair for perimembranous ventricular septal defect.","authors":"Li Lin, Wanhua Chen, Hang Chen, Jianwen Liu, Kanghui Chen, Lianglong Chen, Liangwan Chen, Zhaoyang Chen","doi":"10.1080/00015385.2025.2480961","DOIUrl":"10.1080/00015385.2025.2480961","url":null,"abstract":"<p><strong>Background: </strong>Complete atrioventricular conduction block (CAVB) is a major complication of the repair and occlusion of perimembranous ventricular septal defects (pmVSDs).</p><p><strong>Objective: </strong>This study aimed to analyse the incidence and risk factors of CAVB after occlusion and repair of pmVSD.</p><p><strong>Methods: </strong>We reviewed patients with pmVSDs who underwent occlusion and repair between January 2010 and January 2022. Permanent CAVB was defined as a CAVB requiring permanent pacemaker implantation or occluder extraction.</p><p><strong>Results: </strong>Of 2436 patients who underwent pmVSD repair, 7 (0.3%) developed permanent CAVB. In all, 16 (0.7%) of the 2200 patients in the device group developed permanent CAVBs. All permanent CAVBs in the repair group occurred during hospital stay. In contrast, eight (50%) permanent CAVBs in the device group occurred over 1 month. A large pmVSD size (odds ratio [OR], 1.575; 95% confidence interval [CI], 1.260-1.970, <i>p</i> < 0.001) and device/defect ratio (OR, 2.608; 95% CI, 1.587-4.287, <i>p</i> < 0.001) were independent risk factors for permanent CAVB after surgical repair and device occlusion, respectively. Multivariate regression showed that device occlusion versus surgical repair was associated with a significantly higher risk of permanent CAVBs (OR, 4.675; 95% CI, 1.586-13.780, <i>p</i> = 0.005).</p><p><strong>Conclusion: </strong>The incidence rates of permanent CAVB after device occlusion and surgical repair were 0.7% and 0.3%, respectively. Large VSD size and device/defect ratio were independently associated with permanent CAVB after surgical repair and device occlusion, respectively. Compared with surgical repair, device occlusion was associated with a significantly higher risk of permanent CAVB after pmVSD closure.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"266-273"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Left atrial strain as a surrogate parameter for successful percutaneous ballon mitral valvotomy?","authors":"Bhagwati Prasad Pant, Rohit Walse, Harikrishnan Sivadasapillai, Sanjay Ganapathi, Ajitkumar Valaparambil","doi":"10.1080/00015385.2025.2484506","DOIUrl":"10.1080/00015385.2025.2484506","url":null,"abstract":"<p><strong>Background: </strong>Severe mitral stenosis (MS) leads to morphological and functional changes in the left atrium (LA) causing dysfunction. Relieving mitral obstruction improves the LA mechanics and structural remodelling. However, this is not taken as a measure of successful Ballon Mitral Valvotomy (BMV) in clinical practice.</p><p><strong>Methods: </strong>We studied the relationship between LA strain and severe MS and the short-term effect of BMV on LA mechanics in a prospective observational single-centre study.</p><p><strong>Results: </strong>Peak atrial longitudinal strain (PALS) was impaired in patients (<i>n</i> = 40) with severe MS and improved 24 h following BMV (11.93 ± 3.29% vs 14.96 ± 3.59%, <i>p</i> < 0.001). There was a significant decrease in transmitral gradient (12.0 ± 4 mmHg vs 3.2 ± 1.6 mmHg, <i>p</i> < 0.001) and systolic pulmonary artery pressure (sPAP) (42.0 ± 8 mmHg vs 40.0 ± 4.8 mmHg, <i>p</i> < 0.001) after the procedure. Mitral valve area (1.03 ± 0.27 cm<sup>2</sup> vs 1.81 ± 0.31 cm<sup>2</sup>, <i>p</i> < 0.001) significantly increased after the procedure. Peak atrial longitudinal strain failed to predict the success of the procedure as (AUC: 0.53; 95% CI, 0.32-0.75, <i>p</i> = 0.791). A cut-off value of 11.42% demonstrated a sensitivity of 64.7% and specificity of 66.7%. (<i>R</i> = 0.33; 95% CI 0.09, 0.6, <i>p</i> = 0.038).</p><p><strong>Conclusion: </strong>Peak atrial longitudinal strain shows a significant improvement following a successful BMV. This increase in values reflects an improvement in clinical status and function class in follow-up. While PALS offers promise, it has limitations. Therefore, it seems reasonable to consider PALS as a supportive indicator alongside established markers like MV area and pressure gradient for assessing procedural success.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"274-282"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-05-01Epub Date: 2025-03-31DOI: 10.1080/00015385.2025.2484848
Xingyuan Zhao, Nan Hu, Liying Wang, Zongling Xia
{"title":"Vericiguat versus sacubitril/valsartan for the treatment of heart failure with reduced ejection fraction in China: a cost-utility analysis.","authors":"Xingyuan Zhao, Nan Hu, Liying Wang, Zongling Xia","doi":"10.1080/00015385.2025.2484848","DOIUrl":"10.1080/00015385.2025.2484848","url":null,"abstract":"<p><strong>Background: </strong>PARADIGM-HF and VICTORIA studies have shown that treatment with sacubitril/valsartan or vericiguat could reduce cardiovascular mortality and hospitalisation in the patients with heart failure (HF) with reduced ejection fraction (HFrEF). However, the cost-utility analysis of adding sacubitril/valsartan or vericiguat to the standard treatment of heart failure in Chinese patients with HFrEF was still unclear.</p><p><strong>Methods: </strong>Based on the Chinese healthcare system, a multi-state Markov model has been established for the cost-utility analysis and compared with the results of VICTORIA study subgroups and relevant local data in China. This model simulated the direct medical costs and quality-adjusted life years (QALYs) of HFrEF patients over a period of 20 years, in which these patients were treated with the standard treatment of heart failure and either adding sacubitril/valsartan or vericiguat. Moreover, incremental cost-utility ratio (ICUR) and incremental net monetary benefit (INMB) were also analysed and the robustness of the results was verified by using sensitivity analysis.</p><p><strong>Results: </strong>In the base case study, according to the Chinese HFrEF patients, the total costs for the sacubitril/valsartan group and the vericiguat group were 4,237.42 USD and 4,618.59 USD, respectively, and the total utility was 3.62 and 3.48 QALYs, respectively. The ICUR was -2,611.68 USD/QALY, and the INMB was -5,772.32 USD. The sensitivity analysis indicated that the results were robust. The results of scenario analysis and base-case analysis were basically consistent.</p><p><strong>Conclusions: </strong>On the standard treatment of heart failure, adding sacubitril/valsartan alone was more cost-effective than adding vericiguat alone for the treatment of HFrEF.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"283-291"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-05-01Epub Date: 2025-04-15DOI: 10.1080/00015385.2025.2491150
Mehmet Altunova, Ali Evsen, Hicaz Zencirkiran Agus, Samet Sevinc, Serpil Ozturk, Erhan Melikoglu, Gamze Babur Guler
{"title":"Predicting in-hospital mortality in infective endocarditis: insights from the Naples prognostic score.","authors":"Mehmet Altunova, Ali Evsen, Hicaz Zencirkiran Agus, Samet Sevinc, Serpil Ozturk, Erhan Melikoglu, Gamze Babur Guler","doi":"10.1080/00015385.2025.2491150","DOIUrl":"https://doi.org/10.1080/00015385.2025.2491150","url":null,"abstract":"<p><strong>Background: </strong>Infective Endocarditis (IE) is a severe and potentially life-threatening infection of the heart valves, necessitating a comprehensive understanding of factors influencing patient outcomes.</p><p><strong>Objective: </strong>The study aims to investigate the relationship between NPS and in-hospital mortality in patients diagnosed with Infective Endocarditis (IE).</p><p><strong>Methods: </strong>A total of 153 IE patients were included in the study, with 32 (20,9%) experiencing in-hospital mortality. Patients were categorised into survivors and non-survivors, and detailed clinical and demographic characteristics were recorded. The final endpoint of the study was determined as in-hospital mortality. Regression analyses were conducted to identify the independent variables, and Kaplan-Meier estimates were created to determine survival outcomes, using a significance level of <i>p</i> < 0.05 for all statistical analyses.</p><p><strong>Results: </strong>The non-survivor group exhibited a significantly higher NPS compared to the survivor group (28 (87.5) vs. 56 (46.3); <i>p</i> < 0.001). ROC curve analysis, utilising NPS, the neutrophil-to-lymphocyte ratio (NLR), the lymphocyte-to-monocyte ratio (LMR), albumin, and total cholesterol values, identified NPS as the most robust parameter, with an area under the curve of 0.704 (95% CI: 0.612-0.797; <i>p</i> < 0.001). Multivariate regression analysis revealed Septic shock (<i>p</i> = 0.001), NPS (<i>p</i> = 0.004), and Age (<i>p</i> = 0.012) as independent determinants of in-hospital mortality in IE patients.</p><p><strong>Conclusions: </strong>This study demonstrated a strong correlation between NPS and mortality in IE. This novel score, as it reflects both the level of inflammation and nutrition, can be used to predict the prognosis in IE.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":"80 3","pages":"292-301"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-05-01Epub Date: 2025-01-15DOI: 10.1080/00015385.2025.2452125
Lorenzo Caratti di Lanzacco, Mourad Boudouft, Caroline Lepièce, Damien Badot, Antoine de Meester de Ravestein
{"title":"Post-transseptal puncture re-entrant atrial tachycardia mimicking typical flutter.","authors":"Lorenzo Caratti di Lanzacco, Mourad Boudouft, Caroline Lepièce, Damien Badot, Antoine de Meester de Ravestein","doi":"10.1080/00015385.2025.2452125","DOIUrl":"10.1080/00015385.2025.2452125","url":null,"abstract":"<p><p>This case report discusses the management of a 75-year-old man who developed an unusual type of atypical atrial flutter following a previous pulmonary vein isolation for paroxysmal atrial fibrillation. Despite a second attempt to re-isolate the pulmonary veins and performing cavotricuspid isthmus ablation (which was suspected to be part of the arrythmia circuit), the flutter continued and was converted to sinus rhythm through electrical cardioversion. A few weeks later, the patient's atrial tachycardia relapsed. Initial ablation attempts at the coronary sinus ostium were unsuccessful due to incomplete assessment of the circuit, leading to another transseptal approach. Activation mapping identified a macroreentrant circuit around the site of the first transseptal puncture, which was successfully ablated. This report highlights the risk of macroreentrant atrial tachycardias developing at transseptal puncture sites and the difficulty of diagnosing 'pseudotypical' flutters, which may appear to originate from the cavotricuspid isthmus but are in fact passively activated. The report emphasises that electrophysiologists should be aware of these factors in similar cases, especially with the growing number of left atrial procedures requiring transseptal access.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"213-216"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-04-30DOI: 10.1080/00015385.2025.2496852
Hayrettin Hakan Aykan, Ali Dinç Bozat, Tevfik Karagöz
{"title":"Hidden risk behind the septum: late presentation of coronary compression following transcatheter atrial septal defect closure in a child.","authors":"Hayrettin Hakan Aykan, Ali Dinç Bozat, Tevfik Karagöz","doi":"10.1080/00015385.2025.2496852","DOIUrl":"https://doi.org/10.1080/00015385.2025.2496852","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-3"},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acta cardiologicaPub Date : 2025-04-29DOI: 10.1080/00015385.2025.2496851
Ilyass Zekhnini, Sohaib Mansour, Thomas Nguyen
{"title":"Use of the octaspline multielectrode catheter in a patient with a mechanical mitral valve.","authors":"Ilyass Zekhnini, Sohaib Mansour, Thomas Nguyen","doi":"10.1080/00015385.2025.2496851","DOIUrl":"https://doi.org/10.1080/00015385.2025.2496851","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":2.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}