Acta cardiologica最新文献

{"title":"Case report: Pompe disease.","authors":"Shuyi Hu, Hua Yan, Yanli Long, Handong Zhu","doi":"10.1080/00015385.2025.2476886","DOIUrl":"10.1080/00015385.2025.2476886","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"418-421"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The intriguing relationships between atrial fibrillation and heart failure: insights from cardiac implantable electronic devices.","authors":"Davide Antonio Mei, Matteo Martella, Giuseppe Boriani","doi":"10.1080/00015385.2025.2469001","DOIUrl":"10.1080/00015385.2025.2469001","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"429-431"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Off-label use of Occlutech^® Atrial Flow Regulator Device for re-direction blood flow at anomaly of systemic venous return.","authors":"Musa Öztürk, İlker Ertuğrul, Hayrettin Hakan Aykan, Tevfik Karagöz, Alpay Çeliker","doi":"10.1080/00015385.2025.2468999","DOIUrl":"10.1080/00015385.2025.2468999","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"415-417"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ratio of red blood cell distribution width to albumin: a predictive biomarker of In-hospital mortality in heart failure patients.","authors":"Jingyi Lin, Lin Zhang, Shuaishuai Deng, Boxuan Feng, Li Liu, Guanwei Fan","doi":"10.1080/00015385.2025.2491151","DOIUrl":"10.1080/00015385.2025.2491151","url":null,"abstract":"<p><strong>Background: </strong>The ratio of red blood cell distribution width (RDW) to albumin (ALB), known as RAR, functions as an innovative indicator related to prognosis. However, whether RAR can predict the in-hospital mortality (IHM) for heart failure (HF) patients remains ambiguous.</p><p><strong>Methods: </strong>This study included HF patients derived from the Medical Information Mart for Intensive Care III (MIMIC-III) and IV (MIMIC-IV) databases. To examine the association between RAR and IHM, multiple Logistic regression models were conducted, complemented by subgroup analyses. Additionally, to ascertain the optimal threshold for RAR, restricted cubic spline (RCS) regressions were applied.</p><p><strong>Results: </strong>In the MIMIC-III (<i>n</i> = 9,413) and MIMIC-IV (<i>n</i> = 18,685) HF cohorts, the incidence of IHM was observed in 1,639 (17.41%) and 1,175 (6.29%) participants. Following adjustment for various covariates, RAR was shown to correlate with IHM (OR, 1.45 [95% CI, 1.08-1.39]). The areas under the curves for RAR were 0.683 (MIMIC-III) and 0.710 (MIMIC-IV), indicating superior predictive value than RDW and ALB. In subgroup analysis, younger HF patients with diabetes and without atrial fibrillation or anaemia showed higher ORs than older patients without diabetes or atrial fibrillation and those with anaemia, respectively. RCS indicated the OR for RAR was non-linear with IHM, and the optimal threshold for RAR prediction was between 4.5 and 5.</p><p><strong>Conclusion: </strong>An elevated RAR correlates with an increased risk of IHM in HF patients. Given that RAR can be readily derived from routine laboratory tests, it holds potential as a novel biomarker for identifying high-risk HF patients.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"376-386"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aortic thrombosis presenting as acute hypertensive pulmonary edema: a diagnostic challenge.","authors":"Wannes Heylen, Matthias De Boulle, Joeri Voet","doi":"10.1080/00015385.2025.2490380","DOIUrl":"10.1080/00015385.2025.2490380","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"422-424"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing risk stratification in heart failure: integrating hemodynamic, biochemical, and computational markers.","authors":"Patrizio Lancellotti, Arnaud Ancion","doi":"10.1080/00015385.2025.2513762","DOIUrl":"https://doi.org/10.1080/00015385.2025.2513762","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":"80 4","pages":"329-333"},"PeriodicalIF":2.1,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When closure isn't closure: postoperative dehiscence of surgically ligated left atrial appendage.","authors":"Maria Gabriela Matta, Dipesh Raniga, Bradley Hefford, Ahmed Reza","doi":"10.1080/00015385.2025.2510015","DOIUrl":"https://doi.org/10.1080/00015385.2025.2510015","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical impact of pulmonary artery pulsatility index in patients with atrial fibrillation and heart failure.","authors":"Yuta Ozaki, Yusuke Uemura, Toru Kondo, Shingo Kazama, Shogo Yamaguchi, Takashi Okajima, Takayuki Mitsuda, Shinji Ishikawa, Kenji Takemoto, Takahiro Okumura, Toyoaki Murohara, Masato Watarai","doi":"10.1080/00015385.2025.2510705","DOIUrl":"https://doi.org/10.1080/00015385.2025.2510705","url":null,"abstract":"<p><strong>Background: </strong>Both atrial fibrillation (AF) and right ventricular dysfunction (RVD) are prognostic factors in patients with heart failure (HF). However, the association between AF and RVD in patients with HF is not fully understood. The pulmonary artery pulsatility index (PAPi), obtained <i>via</i> right heart catheterisation, is a hemodynamic index of the right ventricular function. We investigated the clinical impact of PAPi in patients with HF and concomitant AF.</p><p><strong>Methods: </strong>This was a single-center, retrospective cohort study involving consecutive patients who underwent right heart catheterisation for HF between January 2016 and December 2018. Patients with acute decompensated phase of HF were excluded. The primary endpoint was a composite of all-cause death or hospitalisation due to HF.</p><p><strong>Results: </strong>A total of 347 patients with compensated HF were enrolled. The median follow-up duration was 3.2 years. Patients with AF had lower PAPi levels compared to those without AF. Multiple regression analysis revealed that AF was independently associated with reduced PAPi levels (partial regression coefficient -0.116, 95% confidence intervals [CIs] - 0.174 to -0.058; <i>p</i> < 0.001). Multivariate Cox regression analysis further revealed that low PAPi was an independent predictor of the incidence of the primary endpoint in patients with HF and AF (HR 1.861, 95% CIs 1.076-3.219, <i>p</i> = 0.026).</p><p><strong>Conclusion: </strong>AF was associated with reduced PAPi levels in patients with HF. Low PAPi independently predicted the prognosis of patients with AF and HF. Measuring PAPi provides useful information for the management of patients with HF and concomitant AF.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International survey of cardiac device clinic staff determining patient-perceived challenges with remote monitoring.","authors":"Bert Vandenberk, Neal Ferrick, Elaine Y Wan, Sanjiv M Narayan, Aileen M Ferrick, Satish R Raj","doi":"10.1080/00015385.2025.2510704","DOIUrl":"https://doi.org/10.1080/00015385.2025.2510704","url":null,"abstract":"<p><strong>Background: </strong>Regular interaction with patients with cardiac implantable electronic devices (CIEDs) provides CIED clinic personnel with unique insights into patient-related barriers and challenges to remote monitoring (RM) implementation.</p><p><strong>Methods: </strong>Using a global network, an international survey was administered to CIED clinic personnel. Qualitative questions gathered information on perceived challenges with patient connectivity and patient-level barriers associated with RM implementation.</p><p><strong>Results: </strong>A total of 339 responses from 302 unique centres were included in the analysis. Respondents most often were cardiac electrophysiologists (57.8%), followed by nurses (17.1%) and nurse practitioners (7.7%). Most respondents (84.7%) reported at least one challenge in daily RM management. The biggest challenge was the increasing data volume and data variability (38.3%), followed by staff shortage (33.8%), difficulties with billing for technical activities (20.2%), and insufficient RM reimbursement (16.0%). Patient connectivity was identified as a major barrier by 72.7% of respondents. The main concerns were patient literacy (80.8%), followed by a lack of patient understanding of RM importance (65.8%), the lack of required bandwidth or technology to support RM (49.6%), and the cost to the patient (47.9%). Subgroup analyses showed that patient connectivity was often identified as a major barrier by non-MD CIED clinic staff, respondents working in office-based CIED clinics, and respondents from clinics with a per-patient payment reimbursement model.</p><p><strong>Conclusions: </strong>There are many patient-related barriers identified by non-MD CIED clinic staff. Dedicated strategies to optimise the utilisation and adherence of RM of patients with CIEDs are urgently needed to improve clinical outcomes.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circular RNA profiling reveals an abundant circPTK2 that contributes everolimus-induced endothelial cell dysfunction via regulating miR-1-5p/ACVR2B/StarD13 axis.","authors":"Yixin Zhao, Jiangrong Wang, Xiaomeng Jia, Hao Li, Pengju Zhu, Cong Wang, Qingbin Zhang, Yinglong Hou, Weizong Wang","doi":"10.1080/00015385.2025.2510706","DOIUrl":"https://doi.org/10.1080/00015385.2025.2510706","url":null,"abstract":"<p><strong>Background: </strong>mTOR inhibitors released from drug-eluting stents (DESs) play a critical role in the pathogenesis of in-stent neoatherosclerosis (ISNA), contributing to the development of late in-stent restenosis (ISR). Circular RNAs (circRNAs) are emerging as key regulators in various pathophysiological processes, but their involvement in ISNA remains unclear.</p><p><strong>Methods: </strong>The expression pattern of circRNAs in human umbilical vein endothelial cells (HUVECs) treated with everolimus (EVL) was analysed using RNA sequencing. The expression levels of circRNAs, miR-1-5p, and the downstream targets ACVR2B/StarD13 were measured by quantitative real-time PCR. The effects of circPTK2 on cell proliferation, migration, apoptosis, and permeability in EVL-treated endothelial cells were assessed using cell counting kit-8, scratch, Annexin-V FITC and PI double-staining, and transwell assays. Bioinformatics analysis and dual luciferase assay were used to identify the interaction between circPTK2 and miR-1-5p. The association between circPTK2, miR-1-5p, and ACVR2B/StarD13 was further evaluated by functional rescue experiments.</p><p><strong>Results: </strong>CircPTK2 was significantly upregulated in EVL-treated HUVECs. Knockdown of circPTK2 reversed the EVL-induced suppression of cell viability and migration, reduced apoptosis, and alleviated endothelial barrier leakage. Conversely, circPTK2 overexpression produced the opposite effects. Mechanistically, circPTK2 acted as a sponge for miR-1-5p, leading to increased expression of its target genes ACVR2B and StarD13. Silencing ACVR2B or StarD13 partially attenuated the exacerbating effects of miR-1-5p inhibition on EVL-induced endothelial dysfunction. Moreover, inflammatory conditions affected the expressions of circPTK2, miR-1-5p, and ACVR2B/StarD13.</p><p><strong>Conclusions: </strong>CircPTK2 regulates EVL-induced endothelial dysfunction via the miR-1-5p/ACVR2B/StarD13 axis, providing novel insights for the treatment of late ISR after DES implantation.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-17"},"PeriodicalIF":2.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}