Acta cardiologica最新文献_第4页

Metformin ameliorates blunted cardioprotective response of ischemic postconditioning in rats subjected to high fat diet. 二甲双胍改善高脂饮食大鼠缺血后适应的钝化心脏保护反应。

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-12 DOI: 10.1080/00015385.2025.2538399

Satnam Singh, Kuldeep Kumar, Ayush Kandpal, Harlokesh Narayan Yadav, Leonid Maslov, Amteshwar Singh Jaggi, Nirmal Singh

{"title":"Metformin ameliorates blunted cardioprotective response of ischemic postconditioning in rats subjected to high fat diet.","authors":"Satnam Singh, Kuldeep Kumar, Ayush Kandpal, Harlokesh Narayan Yadav, Leonid Maslov, Amteshwar Singh Jaggi, Nirmal Singh","doi":"10.1080/00015385.2025.2538399","DOIUrl":"https://doi.org/10.1080/00015385.2025.2538399","url":null,"abstract":"Background: Cardioprotective response of ischaemic postconditioning (iPoCo) is blunted in conditions of vascular endothelial dysfunction (ED) associated with hypercholesterolaemia, diabetes, hypertension, etc.Objective: The current study investigates the effect of metformin on the blunted cardioprotective response of iPoCo in rats subjected to high fat diet (HFD).Methodology: Wistar rats were subjected to HFD for 56 days. Myocardial ischaemia-reperfusion (I/R) injury was induced by subjecting the heart to global ischaemia of 30 min followed by reperfusion of 120 min after mounting on Langendorff Power Lab apparatus. iPoCo consisting of 6 alternative cycles of ischaemia and reperfusion of 10 sec each, was given after the global ischaemia at the onset of reperfusion. Metformin (25 µM and 50 µM) treatment was given after the global ischaemia just before reperfusion. Myocardial injury was assessed by estimation of infarct size, specific biomarkers of myocardial injury, oxidative stress, inflammation and hemodynamic index.Results: HFD animal showed significant rise in serum total cholesterol and nitrate levels reflecting hypercholesterolaemia and ED. I/R produced significant myocardial damage indicated by an increase in infarct size, specific biomarkers (LDH, CK-MB, cTn I), oxidative stress- inflammatory parameters (heart Nrf-2, TBARS, TNF-α and decreased GSH and catalase levels) and altered hemodynamic index. iPoCo significantly alleviated I/R induced myocardial injury with respect to above parameters in normal rats but failed to produce such an effect in HFD rats. Treatment of metformin (25 µM and 50 µM) not only mimicked the cardioprotective effect of iPoCo in normal rats but also restored the lost effect of iPoCo in HFD rats.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-19"},"PeriodicalIF":2.5,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of purified eicosapentaenoic acid versus mixed eicosapentaenoic/docosahexaenoic acid pharmacotherapies on coronary plaque volume: network meta-analysis of prospective coronary imaging trials. 纯化二十碳五烯酸与混合二十碳五烯酸药物治疗对冠状动脉斑块体积的影响：前瞻性冠状动脉影像学试验的网络荟萃分析

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-12 DOI: 10.1080/00015385.2025.2538404

John P Sheppard, Suvasini Lakshmanan, Leonard Palatnic, Suraj Dahal, Sion K Roy, Deepak L Bhatt, Matthew J Budoff, John R Nelson

{"title":"Effects of purified eicosapentaenoic acid versus mixed eicosapentaenoic/docosahexaenoic acid pharmacotherapies on coronary plaque volume: network meta-analysis of prospective coronary imaging trials.","authors":"John P Sheppard, Suvasini Lakshmanan, Leonard Palatnic, Suraj Dahal, Sion K Roy, Deepak L Bhatt, Matthew J Budoff, John R Nelson","doi":"10.1080/00015385.2025.2538404","DOIUrl":"https://doi.org/10.1080/00015385.2025.2538404","url":null,"abstract":"Background: Reduced cardiovascular event risk is observed with eicosapentaenoic acid (EPA), but EPA mixed with docosahexaenoic acid (EPA/DHA) does not show consistent benefit. Comparative effects of EPA versus EPA/DHA on coronary plaque remain unclear.Methods: We systematically reviewed trials measuring coronary plaque volume in patients randomised to statin + EPA or statin + EPA/DHA therapy compared to statin monotherapy, and used network meta-analysis to compare percent change in total and lipid coronary plaque volumes on these treatments.Results: Among 553 articles, ten trials comprising 860 patients met inclusion criteria. Among statin, statin + EPA, and statin + EPA/DHA respectively, random effects analysis yielded changes of +1.9% [-3.4%, +7.2%], -10.0% [-17.5%, -2.5%], and -3.3% [-14.2%, +7.5%] in total plaque volume and +1.3% [-4.7%, +7.4%], -21.5% [-32.1%, -10.8%], and -6.1% [-18.9%, +6.7%] in lipid volume. Compared with statin, statin + EPA achieved greater percent reduction in coronary plaque volumes (total volume: SMD = 0.60, p < 0.0001; lipid volume: SMD = 1.1, p = 0.0017) but statin + EPA/DHA showed no difference (total volume: SMD = 0.19, p = 0.19; lipid volume: SMD = 0.43, p = 0.38).Conclusions: EPA but not EPA/DHA is associated with reductions in coronary plaque burden when given as adjunct to statins in patients with coronary artery disease.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-13"},"PeriodicalIF":2.5,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodality imaging diagnosis and therapy of type I persistent truncus arteriosus. I型持续性动脉干的多模态影像学诊断与治疗。

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-07 DOI: 10.1080/00015385.2025.2538403

Leizhi Ku, Yuhang Wang, Zheng Liu, Xiaojing Ma

引用次数: 0

Evaluating IVUS-guided PCI in acute myocardial infarction: a comparative meta-analysis with angiography guidance. 评估ivus引导的急性心肌梗死PCI：与血管造影指导的比较荟萃分析。

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-06 DOI: 10.1080/00015385.2025.2529133

Hongjuan Fang, Ting Wang, Lina Zhang, Dongxu Qi, Xia Peng, Ying Chang

{"title":"Evaluating IVUS-guided PCI in acute myocardial infarction: a comparative meta-analysis with angiography guidance.","authors":"Hongjuan Fang, Ting Wang, Lina Zhang, Dongxu Qi, Xia Peng, Ying Chang","doi":"10.1080/00015385.2025.2529133","DOIUrl":"https://doi.org/10.1080/00015385.2025.2529133","url":null,"abstract":"Background: Intravascular ultrasound (IVUS) guidance shows benefits in various PCI settings; however, its impact in acute myocardial infarction (AMI) patients is not fully understood. This study aims to systematically review and meta-analyse the outcomes of IVUS-guided versus angiography-guided PCI in AMI.Methods: A comprehensive search across PubMed, Cochrane Library, Embase, Web of Science, and CNKI identified studies comparing IVUS- and angiography-guided PCI in AMI patients. Primary outcomes were all-cause mortality, major adverse cardiac events (MACE), cardiac death, and target vessel revascularization (TVR). A random-effects model was used to calculate pooled risk ratios (RRs) with 95% confidence intervals (CIs).Results: Nine studies with 838,902 patients (38,949 IVUS-guided and 796,953 angiography-guided) were included. IVUS-guided PCI significantly reduced all-cause mortality (RR 0.74, 95% CI 0.70-0.78, p < 0.001), MACE (RR 0.88, 95% CI 0.82-0.95, p = 0.001), cardiac death (RR 0.67, 95% CI 0.52-0.87, p = 0.003), and TVR (RR 0.86, 95% CI 0.75-0.98, p = 0.024) compared to angiography-guided PCI. Moderate heterogeneity was observed, but sensitivity analyses confirmed result stability.Conclusion: This meta-analysis indicates that IVUS-guided PCI in AMI patients improves clinical outcomes, including lower mortality, MACE, cardiac death, and TVR rates, compared to angiography guidance. Further research is needed to address barriers to wider IVUS adoption.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-9"},"PeriodicalIF":2.5,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144787967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Contrast echocardiography cracks the case: left atrial sarcoma disguised as myxoma. 超声造影破例：左心房肉瘤伪装为黏液瘤。

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-05 DOI: 10.1080/00015385.2025.2510017

Wei Yan, Wenjun Deng, Mengran Yan, Xiaojing Ma

引用次数: 0

Effect of successful percutaneous balloon mitral valvotomy on aortic elastic properties in mitral stenosis. 经皮球囊二尖瓣切开术对二尖瓣狭窄患者主动脉弹性特性的影响。

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-01 Epub Date: 2025-04-25 DOI: 10.1080/00015385.2025.2493975

M Sudhakar Rao, Sravan K Reddy, Kanhai Lalani, Sree Madhurya Reddy

{"title":"Effect of successful percutaneous balloon mitral valvotomy on aortic elastic properties in mitral stenosis.","authors":"M Sudhakar Rao, Sravan K Reddy, Kanhai Lalani, Sree Madhurya Reddy","doi":"10.1080/00015385.2025.2493975","DOIUrl":"10.1080/00015385.2025.2493975","url":null,"abstract":"Background: Aortic elastic properties in mitral stenosis have not been much studied. To date, only a few studies have studied the effect of percutaneous balloon mitral valvotomy (BMV) on aortic elastic properties. This was the first study done in Indian subcontinent in a tertiary care hospital in South India studying the effect of BMV on aortic stiffness in severe rheumatic mitral stenosis. We studied the relationship between aortic elastic properties and mitral stenosis and the effect of BMV on the same. Results: A total of thirty-two patients satisfying the criteria for severe mitral stenosis underwent balloon mitral valvotomy. All parameters were compared with age and sex-matched healthy volunteers. Aortic elastic properties were assessed by aortic strain and aortic stiffness index (ASI). The aortic strain was significantly higher in the patients with mitral stenosis 24-48 h after BMV, whereas the ASI was significantly lower. There was a significant decrease in mitral mean gradient and systolic pulmonary artery pressure after BMV. Mitral valve area significantly increased after BMV. Conclusions: Aortic elastic properties, as assessed by aortic stiffness, are usually impaired in patients with mitral stenosis, which improves following balloon mitral valvotomy.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"565-571"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beneficial effects of doxycycline on atrial electrical remodelling in a rat model of atrial fibrillation. 强力霉素对大鼠房颤模型心房电重构的有益作用。

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-01 Epub Date: 2025-05-08 DOI: 10.1080/00015385.2025.2500888

Kai Zhang, Zuowang Ma, Yu Yang, Guangping Li

{"title":"Beneficial effects of doxycycline on atrial electrical remodelling in a rat model of atrial fibrillation.","authors":"Kai Zhang, Zuowang Ma, Yu Yang, Guangping Li","doi":"10.1080/00015385.2025.2500888","DOIUrl":"10.1080/00015385.2025.2500888","url":null,"abstract":"Background: Previous studies showed that doxycycline (Dox) can attenuate chronic intermittent hypoxia (CIH)-induced atrial fibrosis in rats. On this basis, we further investigated the effects of Dox on CIH-induced atrial electrical remodelling.Methods: Rats were randomised into 3 groups: Control group, CIH group, and CIH with Dox treatment (CIH-D) group (n = 30). CIH and CIH-D rats were subjected to CIH 8 h/d for 6 weeks. After collecting the basic parameters of the rats, atrial fibrillation (AF) inducibility, conduction inhomogeneity, and epicardial conduction velocity were examined by in vitro cardiac electrophysiology experiments. The expression levels of ion channel subunits in the atrium were detected by Western blotting. Whole-cell patch clamp experiments were used to recorded action potential (AP), ICa-L, Ito, and the kinetic parameters.Results: Compared to the Control rats, CIH rats showed increased AF inducibility, conduction inhomogeneity, and expression levels of p-RyR2, p-CaMKII, Kv11.1, Kir2.3, KCa3.1, whereas the epicardial conduction velocity, ICa-L, Ito, and expression levels of Cav1.2, Kv1.5, Kv4.3 were decreased. Dox-treatment significantly improved the expression levels of Kv1.5, Kv4.3 and Kir2.3 in CIH-D rats.Conclusion: CIH caused atrial electrical remodelling in our rats, which was improved by Dox treatment. These changes indicated the potential effects of Dox in AF.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"593-603"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aetiology, clinical characteristics, and risk factors influencing mortality in patients with infective endocarditis: a retrospective study. 感染性心内膜炎患者的病因、临床特征和影响死亡率的危险因素：一项回顾性研究。

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-01 Epub Date: 2025-06-03 DOI: 10.1080/00015385.2025.2511519

Özkan Vural, Özcan Yılmaz, Ömer Gedikli, Alperen Taş

{"title":"Aetiology, clinical characteristics, and risk factors influencing mortality in patients with infective endocarditis: a retrospective study.","authors":"Özkan Vural, Özcan Yılmaz, Ömer Gedikli, Alperen Taş","doi":"10.1080/00015385.2025.2511519","DOIUrl":"10.1080/00015385.2025.2511519","url":null,"abstract":"Introduction: Infective endocarditis is defined as an infection of the endothelial surfaces in the heart (valves and endocardium), prosthetic heart valves, and intracardiac devices (such as pacemaker leads and ventricular assist devices). Due to diagnostic challenges, determining the true incidence of infective endocarditis is difficult. Despite advancements in diagnosis and treatment, incidence and mortality rates have not decreased. In this study, we evaluated the clinical and laboratory parameters of patients with infective endocarditis followed in our hospital between 2005 and 2018 and assessed their relationship with in-hospital and one-year mortality.Methods: This study retrospectively analysed 145 patients aged ≥18 years who were diagnosed with infective endocarditis and followed in our hospital between 2005 and 2018. Data were analysed using IBM SPSS V23. Statistical analyses included the Shapiro-Wilk test, T-test, Mann-Whitney U test, and Chi-square test.Results: The average age of the patients was 53 (18-86), and 52.4% (n = 76) were male. In 34% (n = 37) of our patients, the predisposing factor for infective endocarditis was rheumatic valve disease. In-hospital mortality was 31.7%, and one-year mortality was 40.6%. A statistically significant difference in in-hospital mortality was found between combination therapy (23%) and medical therapy (40.8%). Mitral valve involvement was the most common, occurring in 48.3% of patients. Staphylococci were the most frequently isolated microorganisms in blood cultures (41.4%). Heart failure was the most common complication and was associated with the highest mortality rate (23.4%). NYHA was an independent predictor of in-hospital mortality.Conclusion: In our study, surgical intervention, i.e. combination therapy, applied after two weeks of antibiotic treatment, was found to be more effective. Early combination therapy may be life-saving.","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"623-630"},"PeriodicalIF":2.5,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144207350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recognition and management of occult oesophageal perforation following radiofrequency ablation. 射频消融术后隐匿性食道穿孔的识别和处理。

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-01 Epub Date: 2024-08-29 DOI: 10.1080/00015385.2024.2396753

Jie Wang, Ping Hu, Yu-Hang Wang, Xiao-Jing Ma

引用次数: 0

Clonal haematopoiesis of indeterminate potential and risk of atrial fibrillation. 房颤的潜力和风险不确定的克隆造血。

IF 2.5 4区医学

Acta cardiologica Pub Date : 2025-08-01 Epub Date: 2025-02-25 DOI: 10.1080/00015385.2025.2471655

Paschalis Karakasis, Eleftheria Lefkou, Dimitrios Patoulias, Nikolaos Fragakis

引用次数: 0