Acta cardiologica最新文献

{"title":"The long journey of TAVR: from procedural feasibility to integrated clinical and biomechanical predictors of complications.","authors":"Tommaso Viva, Patrizio Lancellottib","doi":"10.1080/00015385.2026.2721692","DOIUrl":"https://doi.org/10.1080/00015385.2026.2721692","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":4.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148817030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for poor prognosis in patients with acute ischaemic stroke: a retrospective study.","authors":"Yan Shi, Yong-Tao Liu, Jing-Jing Sun, Bing Zhao, Su-Zhen Fu, Qing-Fan Xie","doi":"10.1080/00015385.2026.2631266","DOIUrl":"https://doi.org/10.1080/00015385.2026.2631266","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the risk factors for poor prognosis after thrombolysis and their predictive values in patients with large artery atherosclerosis (LAA).</p><p><strong>Methods: </strong>A total of 136 patients with acute ischaemic stroke who underwent intravenous thrombolysis with alteplase for the first time were retrospectively collected and divided into the 'good prognosis' group (<i>n</i> = 70) and the 'poor prognosis' group (<i>n</i> = 66) according to their score on the modified Rankin Scale (<3 or ≥3) at 90 days after admission. Related parameters were collected and compared.</p><p><strong>Results: </strong>The differences between the two groups of patients were statistically significant in age, National Institutes of Health Stroke Scale (NIHSS) scores, hypertension and the level of low-density lipoprotein cholesterol (LDL-C) (all <i>p</i> < 0.05). Older age (95%CI: 1.010-1.082) and higher NIHSS scores after thrombolysis (95%CI: 1.093-1.312) were risk factors for poor prognosis after thrombolysis in patients with LAA. The area under the curve to predict these poor prognoses after thrombolysis was 0.657 (95%CI: 0.562-0.746) for age, with a cut-off value of 66.50 years, and 0.730 (95%CI: 0.646-0.814) for the NIHSS score, with a cut-off value of 5.50 points.</p><p><strong>Conclusions: </strong>Older age and higher NIHSS scores after thrombolysis are risk factors for poor prognosis in patients with LAA, with certain predictive values.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-10"},"PeriodicalIF":4.0,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A null finding is not a negative finding: intramuscular penicillin prophylaxis and the perils of underpowered inference in mild rheumatic heart disease.","authors":"Minahil Iqbal","doi":"10.1080/00015385.2026.2722414","DOIUrl":"https://doi.org/10.1080/00015385.2026.2722414","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":4.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of systemic inflammation on exercise haemodynamics in unexplained dyspnoea and heart failure with preserved ejection fraction.","authors":"Giulio M Mondellini, Jannik Heemann, Xavier Galloo, Daniele Plein, Lucie Soens, Barry A Borlaug, Marco Guazzi, Frederik H Verbrugge","doi":"10.1080/00015385.2026.2721796","DOIUrl":"https://doi.org/10.1080/00015385.2026.2721796","url":null,"abstract":"<p><strong>Aim: </strong>Systemic inflammation in heart failure with preserved ejection fraction (HFpEF) predicts worse outcomes. This study investigates its impact on exercise haemodynamics in patients with unexplained dyspnoea.</p><p><strong>Methods: </strong>This prospective cohort study includes subjects referred for unexplained dyspnoea to a multidisciplinary dyspnoea clinic between January 2021 and August 2023 for cardiopulmonary exercise testing with concomitant exercise echocardiography. Systemic inflammation was defined as a high-sensitivity C-reactive protein level ≥2 mg/L. HFpEF was diagnosed with an H₂FPEF score ≥6, HFA-PEFF score ≥5, or in case of exercise pulmonary hypertension together with a left atrial reservoir strain <24.5% at rest or positive diastolic stress test during exercise.</p><p><strong>Results: </strong>A total of 70/191 consecutively evaluated subjects (37%) had systemic inflammation, which was linked with anthropometrics of increased adiposity. Subjects with vs. without systemic inflammation had smaller end-diastolic volume indices (40.9 ± 9.7 vs. 47.2 ± 13.3 mL/m², respectively; <i>p</i> = .002), a lower tricuspid annular plane systolic excursion over pulmonary artery systolic pressure ratio [0.96 (0.75-1.10) vs. 1.04 (0.85-1.28) mm/mmHg, respectively; <i>p</i> = .033], but otherwise similar echocardiography findings at rest. For a similar respiratory exchange ratio at peak exercise, they had lower peak oxygen consumption (16.9 ± 5.3 vs. 20.6 ± 6.6 mL/min/kg, respectively; <i>p</i> < .001). The right ventricular end-systolic pressure area ratio change with exercise indicated less right ventricular contractile reserve when systemic inflammation was present. In the HFpEF subgroup, patients with vs. without systemic inflammation had a decreased cardiac output reserve with exercise.</p><p><strong>Conclusion: </strong>In subjects with dyspnoea, systemic inflammation is linked to increased adiposity and lower exercise capacity because of impaired right ventricular reserve.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-12"},"PeriodicalIF":4.0,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined PAPi-PAC phenotyping after TAVI: interpretive and translational considerations.","authors":"Amna Faiz, Wazzuha Gulalai","doi":"10.1080/00015385.2026.2721764","DOIUrl":"https://doi.org/10.1080/00015385.2026.2721764","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":4.0,"publicationDate":"2026-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Joint association between FIB-4 index and advanced cardiovascular-kidney-metabolic syndrome with aortic valve calcification: a community cohort in China.","authors":"Yunteng Fang, Jiayi Shen, Junqiu Zhao, Xingwei Wei, Qiwen Huang, Guanyu Niu, Zhilin Wang, Haoxiang Xu, Xuan Wang, Yuesong Pan, Tiemin Wei, Lingchun Lv","doi":"10.1080/00015385.2026.2704739","DOIUrl":"https://doi.org/10.1080/00015385.2026.2704739","url":null,"abstract":"<p><strong>Background and aims: </strong>Aortic valve calcification (AVC) is common during the process of ageing. Based on available research, liver fibrosis, cardiovascular risk factors and impaired kidney function have been associated with AVC. This study aimed to analyse the relationship between fibrosis-4 (FIB-4) index and advanced Cardiovascular-Kidney-Metabolic (CKM) syndrome with AVC respectively and their joint effects on AVC.</p><p><strong>Methods: </strong>This study included 2884 participants from middle-aged and elderly Chinese population. AVC was evaluated by echocardiography and advanced CKM syndrome was defined by standard guidelines. We assessed associations between FIB-4 index, advanced CKM syndrome and AVC using logistic regression models. Combined effects were calculated by dividing the two indicators into four groups and 1.39 was the cut-off value of FIB-4 index. Subgroup analyses were performed to stratify results efficiently and investigate interaction effects in the relationships between the FIB-4 index, advanced CKM syndrome and AVC.</p><p><strong>Results: </strong>Of 2884 participants, the mean age was 61.22 ± 6.66 and 45.42% were male, with 257 AVC events. After covariates adjustment, advanced CKM syndrome was significantly associated with AVC with odds ratio (OR) of 1.28(1.13-1.45). As a continuous variable, FIB-4 index correlated with AVC with OR of 2.03(1.43-2.90). As a categorical variable, FIB-4 index also was connected with AVC. The joint effects of advanced CKM syndrome and FIB-4 index showed stronger association with AVC after adjusting for variables. Furthermore, the FIB-4 index exhibited a nonlinear association with AVC.</p><p><strong>Conclusion: </strong>Elevated FIB-4 index and advanced CKM syndrome were both related with AVC among middle-aged and elderly populations. Moreover, the combined exposure to elevated FIB‑4 and advanced CKM syndrome conferred a stronger correlative relationship with AVC.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-11"},"PeriodicalIF":4.0,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioresorbable scaffolds after absorb: a magnesium redemption or another false dawn?","authors":"Victor Weerts, Cédric Davidsen","doi":"10.1080/00015385.2026.2719102","DOIUrl":"https://doi.org/10.1080/00015385.2026.2719102","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":4.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of a high-sensitivity troponin-based early rule-out pathway for suspected myocardial infarction.","authors":"Nicholas Seton, Maria Gabriela Matta, Shobiga Sarvananda, Nivan Kaya, Dylan Young, Rhiannon Matthews, Rohan Jayasinghe","doi":"10.1080/00015385.2026.2714595","DOIUrl":"https://doi.org/10.1080/00015385.2026.2714595","url":null,"abstract":"<p><strong>Introduction: </strong>High-sensitivity cardiac troponins enable early rule-out of myocardial infarction (MI), but their effect on diagnostic specificity remains uncertain. We evaluated rates of type I MI and obstructive coronary artery disease (CAD) among patients triaged using the Suspected Acute Myocardial Infarction in Emergency (SAMIE) pathway.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on patients presenting with chest pain to an Australian Health Service Emergency Department between February 2023 and December 2024. Patients were classified as low-risk (troponin <5 ng/L), intermediate-risk (troponin ≥5 ng/L and Δ troponin <3 ng/L), or high-risk (troponin ≥5 ng/L and Δ troponin ≥3 ng/L or above sex-specific thresholds). All patients underwent expedited outpatient review through a rapid-access cardiac clinic. The primary outcome was type I MI within 30 days. Secondary outcomes included positive stress echocardiography and obstructive CAD on invasive coronary angiography.</p><p><strong>Results: </strong>Among 355 patients (mean age 59.4 ± 17.5 years), 64 (18.0%) were low-risk, 121 (34.1%) intermediate-risk, and 170 (47.9%) high-risk. The 30-day type I MI rate was 0.6% (two events), both occurring in the SAMIE high-risk group. Rates of obstructive CAD and positive stress echocardiography were similar across risk categories.</p><p><strong>Conclusions: </strong>Among a selected cohort managed through a structured rapid-access chest pain outpatient service, 30-day type I MI rates were low across all SAMIE risk categories. Both events occurred in the SAMIE high-risk group. Given the small number of events, these findings should be considered hypothesis-generating and require validation in larger prospective studies.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":4.0,"publicationDate":"2026-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous nitroglycerine in hypertensive acute heart failure: marker of severity or mediator of harm?","authors":"Sefa Erdi Ömür, Çağrı Zorlu","doi":"10.1080/00015385.2026.2718583","DOIUrl":"https://doi.org/10.1080/00015385.2026.2718583","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":4.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations in evaluating time-dependent outcomes after Magmaris implantation.","authors":"Jingying Wu","doi":"10.1080/00015385.2026.2718595","DOIUrl":"https://doi.org/10.1080/00015385.2026.2718595","url":null,"abstract":"","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-2"},"PeriodicalIF":4.0,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}