Cross-prevalence of large and small vessels disease in T2DM: overview from a Belgian academic centre.

IF 2.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Acta cardiologica Pub Date : 2025-06-27 DOI:10.1080/00015385.2025.2524239

Fabian O Lurquin, Elise L Petit, Sylvie A Ahn, Michel F Rousseau, Michel P Hermans

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引用次数: 0

Abstract

Aims: To document the cross-prevalence of overall macro- and microangiopathy in T2DM and identify common and vessel-size-specific variables associated with comorbidities.

Methods: Cross-sectional study of 876 T2DM patients to assess frequency of macrovascular and microvascular target organ damage (TOD). Logistic regressions were performed to identify common and specific variables linked to TODs.

Results: Overall prevalence of Mic and Mac were 41% and 33%, respectively; 45.5% had no comorbidities (Mic[-]Mac[-]); 21% had microangiopathy only (Mic[+]Mac[-]), 13.5% had macroangiopathy only (Mic[-]Mac[+]); 20% both (Mic[+]Mac[+]). Compared to Mic[-]Mac[-], the 3 TOD groups had more (micro)albuminuria. Mic[-]Mac[+] and Mic[+]Mac[+] had more diabetic foot (DF) and heart failure (HF) than Mic[-]Mac[-]. Mic[+]Mac[+] suffered more often from atrial fibrillation than Mic[-]Mac[-]. Mic[+]Mac[+] suffered twice more from peripheral artery disease and thrice higher DF, and 1.5 times more HF vs. Mic[-]Mac[+]. Non-HDL-C, remnant cholesterol, sleep apnoea and non-O blood group were associated with Mic/Mac.

Conclusions: This transversal analysis provides quantitative data on cross-prevalence of micro- and macroangiopathies in a 3rd line hospital. Small and large-vessel diseases are highly intertwined with atherosclerotic, cardiometabolic and cardiorenal co-morbidities.

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T2DM中大、小血管疾病的交叉流行：来自比利时学术中心的综述

目的：记录T2DM中宏观和微血管病变的交叉患病率，并确定与合并症相关的常见和血管大小特异性变量。方法：对876例T2DM患者进行横断面研究，评估大血管和微血管靶器官损伤（TOD）发生频率。进行逻辑回归以确定与tod相关的常见和特定变量。结果：Mic和Mac的总体患病率分别为41%和33%；45.5%无合并症（Mic[-]Mac[-]）；21%仅为微血管病变（Mic[+]Mac[-]）， 13.5%仅为大血管病变（Mic[-]Mac[+]）；20% （Mic[+]Mac[+]）。与Mic[-]Mac[-]组相比，3个TOD组有更多的（微量）蛋白尿。Mic[-]Mac[+]和Mic[+]Mac[+]的糖尿病足（DF）和心力衰竭（HF）发生率高于Mic[-]Mac[-]。Mic[+]Mac[+]比Mic[-]Mac[-]更容易发生房颤。与Mic[-]Mac[+]相比，Mic[+]Mac[+]患外周动脉疾病的人数增加了两倍，DF增加了三倍，HF增加了1.5倍。非hdl - c、残余胆固醇、睡眠呼吸暂停和非o型血与Mic/Mac相关。结论：该横向分析提供了三线医院微血管和大血管病变交叉患病率的定量数据。小血管和大血管疾病与动脉粥样硬化、心脏代谢和心肾合并症密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta cardiologica 医学-心血管系统

CiteScore

2.50

自引率

12.50%

发文量

115

审稿时长

2 months

期刊介绍： Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.