Hicaz Zencirkıran Ağuş, Serkan Kahraman, Sezgin Atmaca, İrem Türkmen, Mehmet Çiçek, Erhan Melikoğlu, Hasan Şahin, Abidin Emre Tırnaksız, Doğukan Salduz, Yusuf Karadağ, Mehmet Altunova, Ali Kemal Kalkan, Mehmet Ertürk
{"title":"HALP评分对冠状动脉分叉病变患者行双支架治疗的长期临床结果的影响。","authors":"Hicaz Zencirkıran Ağuş, Serkan Kahraman, Sezgin Atmaca, İrem Türkmen, Mehmet Çiçek, Erhan Melikoğlu, Hasan Şahin, Abidin Emre Tırnaksız, Doğukan Salduz, Yusuf Karadağ, Mehmet Altunova, Ali Kemal Kalkan, Mehmet Ertürk","doi":"10.1080/00015385.2025.2554397","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>Percutaneous coronary interventions (PCI) of coronary bifurcation lesions (CBL) are challenging lesions. Recently haemoglobin, albumin, lymphocyte, platelet index (HALP), has been used to determine the prognosis of many diseases and gives valuable information about the patient's nutritional status and systemic inflammation. Our study aimed to assess the impact of HALP on long-term major advers cardiac events (MACE) for patients undergoing true coronary bifurcation stenting (CBS) procedure.</p><p><strong>Methods: </strong>A total of 773 patients who underwent percutaneous coronary intervention for true non-left main CBL were retrospectively enrolled. The primary clinical endpoint was MACE defıned as the occurence of target lesion revascularization (TLR), target vessel myocardial infarction (TVMI) or cardiac mortality. Secondary endpoint was stent thrombosis (ST). According to the best cut-off value of HALP score of 31.891, the study samples were divided into two groups.</p><p><strong>Results: </strong>HALP score was negatively associated with the risk of MACE. Compared with patients whose HALP scores were >31.891, those who had HALP scores <31.891 seemed to have a high risk of MACE. In multivariate regression analysis HALP and CRP were determined as independent predictors of MACE. Kaplan-Meier survival curve analysis showed that the higher HALP group had a significantly better event-free survival regarding the occurrence of MACE, TVMI, TLR and cardiac mortality.</p><p><strong>Conclusion: </strong>Our study's findings indicate that, HALP score was a significant independent predictor of long-term majör advers cardiovascular events in patients undergoing coronary artery bifurcation stenting procedure.</p>","PeriodicalId":6979,"journal":{"name":"Acta cardiologica","volume":" ","pages":"1-8"},"PeriodicalIF":2.5000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Impact of HALP score on long-term clinical outcomes in patients with coronary bifurcation lesion undergoing 2-stent strategy.\",\"authors\":\"Hicaz Zencirkıran Ağuş, Serkan Kahraman, Sezgin Atmaca, İrem Türkmen, Mehmet Çiçek, Erhan Melikoğlu, Hasan Şahin, Abidin Emre Tırnaksız, Doğukan Salduz, Yusuf Karadağ, Mehmet Altunova, Ali Kemal Kalkan, Mehmet Ertürk\",\"doi\":\"10.1080/00015385.2025.2554397\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objectives: </strong>Percutaneous coronary interventions (PCI) of coronary bifurcation lesions (CBL) are challenging lesions. Recently haemoglobin, albumin, lymphocyte, platelet index (HALP), has been used to determine the prognosis of many diseases and gives valuable information about the patient's nutritional status and systemic inflammation. Our study aimed to assess the impact of HALP on long-term major advers cardiac events (MACE) for patients undergoing true coronary bifurcation stenting (CBS) procedure.</p><p><strong>Methods: </strong>A total of 773 patients who underwent percutaneous coronary intervention for true non-left main CBL were retrospectively enrolled. The primary clinical endpoint was MACE defıned as the occurence of target lesion revascularization (TLR), target vessel myocardial infarction (TVMI) or cardiac mortality. Secondary endpoint was stent thrombosis (ST). According to the best cut-off value of HALP score of 31.891, the study samples were divided into two groups.</p><p><strong>Results: </strong>HALP score was negatively associated with the risk of MACE. Compared with patients whose HALP scores were >31.891, those who had HALP scores <31.891 seemed to have a high risk of MACE. In multivariate regression analysis HALP and CRP were determined as independent predictors of MACE. Kaplan-Meier survival curve analysis showed that the higher HALP group had a significantly better event-free survival regarding the occurrence of MACE, TVMI, TLR and cardiac mortality.</p><p><strong>Conclusion: </strong>Our study's findings indicate that, HALP score was a significant independent predictor of long-term majör advers cardiovascular events in patients undergoing coronary artery bifurcation stenting procedure.</p>\",\"PeriodicalId\":6979,\"journal\":{\"name\":\"Acta cardiologica\",\"volume\":\" \",\"pages\":\"1-8\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta cardiologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/00015385.2025.2554397\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta cardiologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00015385.2025.2554397","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Impact of HALP score on long-term clinical outcomes in patients with coronary bifurcation lesion undergoing 2-stent strategy.
Objectives: Percutaneous coronary interventions (PCI) of coronary bifurcation lesions (CBL) are challenging lesions. Recently haemoglobin, albumin, lymphocyte, platelet index (HALP), has been used to determine the prognosis of many diseases and gives valuable information about the patient's nutritional status and systemic inflammation. Our study aimed to assess the impact of HALP on long-term major advers cardiac events (MACE) for patients undergoing true coronary bifurcation stenting (CBS) procedure.
Methods: A total of 773 patients who underwent percutaneous coronary intervention for true non-left main CBL were retrospectively enrolled. The primary clinical endpoint was MACE defıned as the occurence of target lesion revascularization (TLR), target vessel myocardial infarction (TVMI) or cardiac mortality. Secondary endpoint was stent thrombosis (ST). According to the best cut-off value of HALP score of 31.891, the study samples were divided into two groups.
Results: HALP score was negatively associated with the risk of MACE. Compared with patients whose HALP scores were >31.891, those who had HALP scores <31.891 seemed to have a high risk of MACE. In multivariate regression analysis HALP and CRP were determined as independent predictors of MACE. Kaplan-Meier survival curve analysis showed that the higher HALP group had a significantly better event-free survival regarding the occurrence of MACE, TVMI, TLR and cardiac mortality.
Conclusion: Our study's findings indicate that, HALP score was a significant independent predictor of long-term majör advers cardiovascular events in patients undergoing coronary artery bifurcation stenting procedure.
期刊介绍:
Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.