Pigment Cell & Melanoma Research最新文献

Alteration of Hair Melanin in Patients With Mowat–Wilson Syndrome: The Role of the ZEB2 Gene in Regulating Melanogenesis Through SLC45A2 mowatt - wilson综合征患者头发黑色素的改变：ZEB2基因通过SLC45A2调控黑色素生成的作用

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-05-26 DOI: 10.1111/pcmr.70028

Mayuko Yamamoto, Hiroyuki Morisaka, Yuka Shibata, Mika Teraishi, Kentaro Ohko, Mikiro Takaishi, Kimiko Nakajima, Kazumasa Wakamatsu, Shosuke Ito, Shigetoshi Sano

{"title":"Alteration of Hair Melanin in Patients With Mowat–Wilson Syndrome: The Role of the ZEB2 Gene in Regulating Melanogenesis Through SLC45A2","authors":"Mayuko Yamamoto, Hiroyuki Morisaka, Yuka Shibata, Mika Teraishi, Kentaro Ohko, Mikiro Takaishi, Kimiko Nakajima, Kazumasa Wakamatsu, Shosuke Ito, Shigetoshi Sano","doi":"10.1111/pcmr.70028","DOIUrl":"https://doi.org/10.1111/pcmr.70028","url":null,"abstract":"<div>\u0000 \u0000 Mowat–Wilson syndrome (MOWS) is a congenital disease characterized by intellectual disability, delayed motor development, characteristic facial features, epilepsy, and a wide spectrum of neurocristopathies. MOWS is caused by de novo heterozygous loss-of-function mutations or deletions in the zinc finger E-box-binding homeobox2 (ZEB2) gene, which is a multifunctional regulator of neuronal development and cancer progression/metastasis through epithelial-to-mesenchymal transition. We recognized that patients with MOWS have brown to red hair. In the present study, we report that hair from patients with MOWS has reduced eumelanin and elevated pheomelanin contents, resulting in an increased pheomelanin-to-eumelanin ratio. Furthermore, ZEB2-mutated human epidermal melanocytes show a predominance of pheomelanin biosynthesis over eumelanin and decreased expression of SLC45A2, the gene responsible for oculocutaneous albinism 4. Our results suggest that ZEB2 plays a role in mixed melanogenesis by regulating the melanosomal ion transporter gene, SLC45A2.\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 3","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Profiling of Acral Lentiginous Melanoma Reveals Downregulated Immune Activation Compared to Cutaneous Melanoma 与皮肤黑色素瘤相比，肢端黄斑性黑色素瘤的综合分析显示免疫激活下调

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-05-22 DOI: 10.1111/pcmr.70027

Stephanie J. Wang, Joanne Xiu, Katherine M. Butcher, Brittney K. DeClerck, Gene H. Kim, Justin Moser, Geoffrey T. Gibney, Leonel F. Hernandez-Aya, Jose Lutzky, Farah Abdulla, Kim A. Margolin, Patrícia Abrão Possik, Carla Daniela Robles-Espinoza, Fumito Ito, Gino K. In

{"title":"Comprehensive Profiling of Acral Lentiginous Melanoma Reveals Downregulated Immune Activation Compared to Cutaneous Melanoma","authors":"Stephanie J. Wang, Joanne Xiu, Katherine M. Butcher, Brittney K. DeClerck, Gene H. Kim, Justin Moser, Geoffrey T. Gibney, Leonel F. Hernandez-Aya, Jose Lutzky, Farah Abdulla, Kim A. Margolin, Patrícia Abrão Possik, Carla Daniela Robles-Espinoza, Fumito Ito, Gino K. In","doi":"10.1111/pcmr.70027","DOIUrl":"https://doi.org/10.1111/pcmr.70027","url":null,"abstract":"Acral lentiginous melanoma (ALM) is a rare and insufficiently understood subtype of melanoma lacking in effective treatment options. Recent work has demonstrated that the response of ALM to immune checkpoint blockade is inferior to that of cutaneous melanoma (CM). Here we performed bulk genomic and transcriptomic sequencing of tumor tissue from 28 ALM and 5692 CM cases. Similar to prior studies, ALM was associated with a significantly lower incidence of point mutations, including in the TERT promoter and BRAF, but increased numbers of gene amplifications, notably of CCND1, HMGA2, and MDM2. Reactome pathway analysis revealed enhancement of keratinization and PI3K/AKT signaling pathways. Overall immunogenicity was decreased in ALM, which possessed lower IFNγ (p < 0.001) and T-cell inflammatory (p = 0.03) pathway scores than CM. Despite higher computationally inferred levels of myeloid dendritic cells (p = 0.006), neoantigen load independent of predicted HLA binding affinity was lower (p < 0.01) in ALM versus CM. Assessment of classical and nonclassical HLA mRNA levels revealed upregulation of HLA-G, suggesting alternative ALM immune evasion pathways in the setting of lower PD-L1 expression (p = 0.005). Additional research is needed to better understand and therapeutically target signaling networks in the ALM tumor microenvironment.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 3","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144117843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Function of Melanin-Based Colour Polymorphism in Cattle, Sheep and Goats 基于黑色素的牛、绵羊和山羊颜色多态性的功能

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-05-21 DOI: 10.1111/pcmr.70024

Venkatesh K.M., Alexandre Roulin

{"title":"The Function of Melanin-Based Colour Polymorphism in Cattle, Sheep and Goats","authors":"Venkatesh K.M., Alexandre Roulin","doi":"10.1111/pcmr.70024","DOIUrl":"https://doi.org/10.1111/pcmr.70024","url":null,"abstract":"Natural selection has rarely promoted the evolution of colour polymorphism in wild mammals. However, it is more common in domestic mammals due to artificial selection. For this reason, domestication could provide valuable insights into the mechanisms underlying the evolution of colour diversity. This raises the question of whether the associations between coat colour and other phenotypes in domestic animals are similar to those in free-living animals. Our literature review of cows, goats and sheep suggests that these associations can differ not only between species but also within and between breeds. This pattern holds for all the traits that we considered: morphology, behaviour, physiology, reproduction, milk production and parasitism. The only consistent association we found in the literature was the attraction of flies towards dark-coloured cows. The relationships between same colour morph, cortisol and thermoregulation varied across environments, suggesting a possible condition-dependent expression of multiple traits. We conclude that artificial selection may lead to a different integration of multiple phenotypes compared to animals living in the wild. Therefore, colour variation may not always serve the same functional roles in domestic animals as it does in wild ones.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 3","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144100415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Dominant Mutation in Gαs-Protein Increases Hair Pigmentation g αs蛋白的显性突变增加头发色素沉着

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-05-12 DOI: 10.1111/pcmr.70025

Philip S. Goff, Peter Budd, Darren W. Logan, Margaret Keighren, Marta Cantero, Lisa McKie, Lluis Montoliu, Ian J. Jackson, Elena V. Sviderskaya

{"title":"A Dominant Mutation in Gαs-Protein Increases Hair Pigmentation","authors":"Philip S. Goff, Peter Budd, Darren W. Logan, Margaret Keighren, Marta Cantero, Lisa McKie, Lluis Montoliu, Ian J. Jackson, Elena V. Sviderskaya","doi":"10.1111/pcmr.70025","DOIUrl":"https://doi.org/10.1111/pcmr.70025","url":null,"abstract":"We have identified a chemically induced mouse mutation which increases the eumelanic hair pigmentation. We identify a coding mutation, A3533G, resulting in an amino acid substitution Y1133C, in the Gnas gene encoding the Gαs subunit of the tripartite G-protein, consistent with an activation of signalling via MC1R. In addition heterozygous mutant females are significantly lighter than wild type littermates. In cultured melanocytes, derived from mutant mice crossed to C57BL6 mice carrying Cdkn2atm1Rdp, basal pigmentation is higher than wild type melanocytes derived from litter mates. However, the addition of exogenous NDP-MSH does not increase pigmentation in mutant melanocytes in contrast to the pigmentation response of non-mutant melanocytes. The mutant and wild type cells respond in the same way to agouti signalling protein (ASP), consistent with ASP signalling mediated through a pathway other than Gαs-protein.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 3","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Pigment Cell Distributions and Skin Structure of Xenopus 爪蟾皮肤色素细胞分布与皮肤结构

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-05-06 DOI: 10.1111/pcmr.70022

Weizheng Liang, Chenyang Hou, Zhenpeng Zhu, Peng Wang, Xiran Wang, Zhongwu Li, Jun Xue, Rensen Ran

引用次数: 0

BAP1 Loss Affords Lipotoxicity Resistance in Uveal Melanoma BAP1缺失导致葡萄膜黑色素瘤脂毒性抵抗

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-04-29 DOI: 10.1111/pcmr.70021

C. J. Cunanan, A. Amirfallah, A. B. Sanders, K. C. Gallant, M. R. Cavallo, E. A. Homer, O. S. El Naggar, J. K. Farnan, G. Romano, J. L. Hope, J. G. Jackson, E. J. Hartsough

{"title":"BAP1 Loss Affords Lipotoxicity Resistance in Uveal Melanoma","authors":"C. J. Cunanan, A. Amirfallah, A. B. Sanders, K. C. Gallant, M. R. Cavallo, E. A. Homer, O. S. El Naggar, J. K. Farnan, G. Romano, J. L. Hope, J. G. Jackson, E. J. Hartsough","doi":"10.1111/pcmr.70021","DOIUrl":"https://doi.org/10.1111/pcmr.70021","url":null,"abstract":"Uveal melanoma (UM) is an aggressive intraocular malignancy. Despite effective control of primary tumors, ~50% of UM patients develop metastases, with the liver being the predominant secondary site. BAP1 deficiency, present in ~80% of metastatic UM cases, is strongly associated with increased metastatic risk and poor prognosis. In silico analysis of UM patient samples suggests that reduced BAP1 is linked to enhanced expression of genes involved in fatty acid processing; therefore, we hypothesize that BAP1 deficiency primes UM cells for survival in the hepatic microenvironment by enhancing lipid tolerance and oxidative stress responses. Our findings demonstrate BAP1-mutant UM resist lipotoxicity, whereas BAP1-competent UM exhibit sensitivity due to lipid peroxide accumulation—a hallmark of ferroptotic-like stress, and a response that can be mitigated by ferroptosis inhibition. Using an ex vivo liver slice model, we found that disrupting lipid metabolism with atorvastatin, an HMG-CoA reductase inhibitor, reduced tumor burden of BAP1-mutant UM. Moreover, we demonstrate a positive correlation between BAP1 and an epigenetic regulator of lipid homeostasis, ASXL2. Notably, ASXL2 depletion in BAP1-competent UM phenocopies the lipotoxicity resistance observed in BAP1-mutant UM—an effect that may be mediated by altered PPAR expression. This study reveals a novel mechanism linking BAP1 expression to lipid sensitivity via ASXL2, providing insights into liver tropism and potential therapeutic avenues for metastatic uveal melanoma.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 3","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality Analysis of Measurement Properties of Patient-Reported Outcome Measures for Vitiligo and of the Studies Assessing Them: A Systematic Review 白癜风患者报告结果测量指标及其评估研究的质量分析：系统性综述

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-04-21 DOI: 10.1111/pcmr.70014

Jolien Duponselle, Sandrine Herbelet, Liesbeth Delbaere, Zoë De Schryver, Caroline B. Terwee, Albert Wolkerstorfer, Julien Seneschal, Phyllis Spuls, Amit Garg, Iltefat Hamzavi, Reinhart Speeckaert, Nanja van Geel

{"title":"Quality Analysis of Measurement Properties of Patient-Reported Outcome Measures for Vitiligo and of the Studies Assessing Them: A Systematic Review","authors":"Jolien Duponselle, Sandrine Herbelet, Liesbeth Delbaere, Zoë De Schryver, Caroline B. Terwee, Albert Wolkerstorfer, Julien Seneschal, Phyllis Spuls, Amit Garg, Iltefat Hamzavi, Reinhart Speeckaert, Nanja van Geel","doi":"10.1111/pcmr.70014","DOIUrl":"https://doi.org/10.1111/pcmr.70014","url":null,"abstract":"Evaluating measurement properties (MPs) of Patient Reported Outcome Measures (PROMs) in vitiligo is essential for evidence-based recommendations and identifying research gaps. This study assesses the quality of PROMs used in vitiligo. A systematic search of PubMed, Embase, and the Cochrane Library (up to 20 February 2024) included studies on PROM analysis or development, excluding those validating other tools. Quality assessments followed the COSMIN guidelines. PROMs with the highest number MPs rated sufficient (supported by moderate/high Quality of Evidence [QoE]) were reported per construct category, and information related to content validity specifically was provided. Forty articles on 24 PROMs (=161 MP studies) were analyzed. In the QoL group, the VIT, VLQI, VIP-FS, and ViPPO had the highest number of MPs rated sufficient (n = 3). For severity-related constructs, the Self-Assessment Vitiligo Extent Score (SA-VES) had the most MPs rated sufficient (n = 3). For treatment-related PROMs, the BMQ had the highest number MPs rated sufficient (n = 2). Content validity was limitedly assessed in 12 different PROMs. Comprehensive MP assessment and further validation of vitiligo PROMs are necessary to make definitive conclusions. These systematic reviews are registered at PROSPERO (CRD42020216338). Only English publications were included, which may limit the scope. Additionally, systematic searches conducted by different reviewers in consecutive updates may introduce subjectivity.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 3","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Dermoscopy Pattern in Nevus-Associated Melanomas 痣相关黑色素瘤的新皮肤镜检查模式

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-04-19 DOI: 10.1111/pcmr.70015

Nelson Lobos-Guede, Dan Hartmann, Valentina Darlic, Cristina Carrera, Llucia Alos, Susana Puig

{"title":"New Dermoscopy Pattern in Nevus-Associated Melanomas","authors":"Nelson Lobos-Guede, Dan Hartmann, Valentina Darlic, Cristina Carrera, Llucia Alos, Susana Puig","doi":"10.1111/pcmr.70015","DOIUrl":"https://doi.org/10.1111/pcmr.70015","url":null,"abstract":"<div>\u0000 \u0000 Melanomas can appear de novo or in association with a pre-existing nevus. The association of melanomas with pre-existing nevi and its role as a melanoma precursor is a controversial issue. Dermoscopy can increase melanoma's diagnostic accuracy and help us suspect nevus-associated melanomas (NAM). Differentiating NAMs clinically and dermoscopically can be challenging. There are few published studies so far describing dermoscopic features of NAM that have differentiated from de novo melanomas, such as multi-component pattern, multifocal pigmentation, atypical pigment network, regression structures, negative pigment network, irregular globules, and streaks. Here, we report four acquired compound NAMs showing a starburst pattern (SP) within the lesion. No publications have reported NAMs with melanoma components in the form of SP arising within the center of the lesion. Therefore, when faced with a compound or intradermal nevus with incipient central reticulated pigmentation, especially if there is no history of trauma or previous surgery, we must pay alert to the possibility of an early development of melanoma.\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 3","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurological Mechanisms Exploration and Therapeutic Targets in Segmental Vitiligo Accompanied by White Hair 节段性白癜风伴白发的神经机制探讨及治疗靶点

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-04-19 DOI: 10.1111/pcmr.70020

Shiqi Fu, Bo Xie, Xiuzu Song

引用次数: 0

PURPL Represses Radiation-Induced Apoptosis to Promote Radioresistance in Cutaneous Melanoma by Direct Interfering With BID Cleavage PURPL 通过直接干扰 BID 分裂，抑制辐射诱导的细胞凋亡，从而增强皮肤黑色素瘤的抗辐射能力

IF 3.9 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-04-14 DOI: 10.1111/pcmr.70018

Xue Li, Shuo Han, Xiaoting Liang, Jieyu Liu, Ke Wang, Yi Jin, Chunting Zhang, Minna Xu, Jiabin Liu, Li Ma, Liang Zhou

{"title":"PURPL Represses Radiation-Induced Apoptosis to Promote Radioresistance in Cutaneous Melanoma by Direct Interfering With BID Cleavage","authors":"Xue Li, Shuo Han, Xiaoting Liang, Jieyu Liu, Ke Wang, Yi Jin, Chunting Zhang, Minna Xu, Jiabin Liu, Li Ma, Liang Zhou","doi":"10.1111/pcmr.70018","DOIUrl":"https://doi.org/10.1111/pcmr.70018","url":null,"abstract":"<div>\u0000 \u0000 The rise of radioresistance in treating cutaneous melanoma challenges the efficacy of radiotherapy. Transcriptomic sequencing highlights PURPL as one of the top upregulated long noncoding RNAs in response to ionizing radiation (IR) treatment in melanoma cells, suggesting its role in radioresistance. To explore such hypothesis, loss-of-function experiments were conducted to assess the impact of PURPL on melanoma cell viability, colony formation, and migration. Mechanistic studies using RNA pulldown identified BID as the interacting protein partner of PURPL. Further analysis explored the relationship among PURPL, BID, and Caspase-8 in the context of IR-induced DNA damage and apoptosis through loss-of- and gain-of-function experiments. The findings demonstrated that silencing PURPL significantly repressed melanoma cell viability, colony formation, migration, and invasiveness, indicating its potential role in promoting radioresistance. Moreover, PURPL was shown to repress IR-induced DNA damage and apoptosis, supporting its involvement in melanoma radioresistance. Mechanistically, PURPL inhibited the interaction between BID and Caspase-8, thereby modulating the mitochondrial apoptosis pathway and promoting radioresistance. In conclusion, this study provides evidence supporting the pro-radioresistance role of PURPL in melanoma. In vivo assays further corroborated the in vitro findings, highlighting the potential clinical relevance of targeting PURPL in radioresistant melanoma. By interfering with the association between BID and Caspase-8, PURPL may serve as a novel therapeutic target for clinical radiotherapy during the treatment of melanoma.\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 3","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0