Pigment Cell & Melanoma Research最新文献_第10页

New insights into the pathogenesis of Hermansky–Pudlak syndrome Hermansky-Pudlak综合征发病机制的新见解

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2022-02-07 DOI: 10.1111/pcmr.13030

Wei Li, Chan-Juan Hao, Zhen-Hua Hao, Jing Ma, Qiao-Chu Wang, Ye-Feng Yuan, Juan-Juan Gong, Yuan-Ying Chen, Jia-Ying Yu, Ai-Hua Wei

引用次数: 6

Let’s talk about sex: A biological variable in immune response against melanoma 让我们来谈谈性:对抗黑色素瘤的免疫反应中的一个生物学变量

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2022-01-25 DOI: 10.1111/pcmr.13028

Panshak P. Dakup, Adam J. Greer, Shobhan Gaddameedhi

{"title":"Let’s talk about sex: A biological variable in immune response against melanoma","authors":"Panshak P. Dakup, Adam J. Greer, Shobhan Gaddameedhi","doi":"10.1111/pcmr.13028","DOIUrl":"https://doi.org/10.1111/pcmr.13028","url":null,"abstract":"As science culture gravitates toward a more holistic inclusion of both males and females in research design, the outlining of sex differences and their respective intersections with disease physiology and pathophysiology should see reciprocal expansion. Melanoma skin cancer, for example, has observed a female advantage in incidence, mortality, and overall survival since the early 1970s. The exact biological mechanism of this trend, however, is unclear and further complicated by a layering of clinical variables such as skin phototype, age, and body mass index. In this perspective, we highlight epidemiological evidence of sex differences in melanoma and summarize the landscape of their potential origin. Among several biological hallmarks, we make a note of sex-specific immune profiles—along with divergent hormonal regulation, social practices, DNA damage and oxidative stress responses, body composition, genetic variants, and X-chromosome expression—as probable drivers of disparity in melanoma initiation and progression. This review further focuses the conversation of sex as an influencing factor in melanoma development and its potential implication for disease management and treatment strategies.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"35 2","pages":"268-279"},"PeriodicalIF":4.3,"publicationDate":"2022-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.13028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6035449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Artificial intelligence and melanoma: A comprehensive review of clinical, dermoscopic, and histologic applications 人工智能与黑色素瘤:临床、皮肤镜和组织学应用的综合综述

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2022-01-17 DOI: 10.1111/pcmr.13027

Katherine M. Stiff, Matthew J. Franklin, Yufei Zhou, Anant Madabhushi, Thomas J. Knackstedt

引用次数: 12

Prediagnostic serum 25-hydroxyvitamin D and leptin in relation to melanoma-specific death and overall death 诊断前血清25-羟基维生素D和瘦素与黑色素瘤特异性死亡和总体死亡的关系

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2022-01-02 DOI: 10.1111/pcmr.13026

Jo S. Stenehjem, Nathalie C. St?er, Reza Ghiasvand, Tom K. Grimsrud, Ronnie Babigumira, Judy R. Rees, Lill Tove Nilsen, Bj?rn Johnsen, Per M. Thorsby, Marit B. Veier?d, Trude E. Robsahm

引用次数: 0

Eosinophils and melanoma: Implications for immunotherapy 嗜酸性粒细胞和黑色素瘤:免疫治疗的意义

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2021-12-20 DOI: 10.1111/pcmr.13025

India Robinson, Gabriella Santa Lucia, Andraia Li, Nathaniel Oberholtzer, John Plante, Kristen M. Quinn, Daniel Reuben, Shikhar Mehrotra, Manuel Valdebran

引用次数: 3

Impact of a SLC24A5 variant on the retinal pigment epithelium of a Japanese patient with oculocutaneous albinism type 6 SLC24A5变异对日本6型眼皮肤白化病患者视网膜色素上皮的影响

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2021-12-06 DOI: 10.1111/pcmr.13024

Toru Saito, Ken Okamura, Rika Kosaki, Kazumasa Wakamatsu, Shosuke Ito, Osamu Nakajima, Hidetoshi Yamashita, Yutaka Hozumi, Tamio Suzuki

{"title":"Impact of a SLC24A5 variant on the retinal pigment epithelium of a Japanese patient with oculocutaneous albinism type 6","authors":"Toru Saito, Ken Okamura, Rika Kosaki, Kazumasa Wakamatsu, Shosuke Ito, Osamu Nakajima, Hidetoshi Yamashita, Yutaka Hozumi, Tamio Suzuki","doi":"10.1111/pcmr.13024","DOIUrl":"https://doi.org/10.1111/pcmr.13024","url":null,"abstract":"Oculocutaneous albinism (OCA) 6 is a non-syndromic type of OCA that has distinct ocular symptoms and variable cutaneous hypopigmentation. The causative gene of OCA6 is SLC24A5, which encodes NCKX5, a K+-dependent Na+/Ca2+ exchanger 5. NCKX5 is involved in the maturation of melanosomes, but its function is still unclear. In this study, we characterized a Japanese patient with OCA6. Genetic analysis revealed compound heterozygous variants in SLC24A5, c.590 + 1dupG, and c.598G>A (p.G200R). To clarify the functional significance of the missense variant, we generated a knock-in (KI) mouse model carrying the mouse homolog of the G200R variant using the CRISPR/Cas9 system. Chemical analysis showed decreased amounts of eumelanin in the hair and skin of KI mice, while levels of benzothiazine units in pheomelanin were significantly increased in their hair. Retinal pigment was also decreased in KI mice. Notably, a histopathologic study revealed a significant pigment loss in the retinal pigment epithelium (RPE) but not in the choroid. Immunohistochemically, the expression of NCKX5 in the RPE was decreased but was maintained in the choroid of KI mice. These findings could explain the difference in phenotypic severity between eye symptoms and hypopigmentation in the skin/hair.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"35 2","pages":"212-219"},"PeriodicalIF":4.3,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6100282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Ulcerated melanoma: Systems biology evidence of inflammatory imbalance towards pro-tumourigenicity 溃疡性黑色素瘤:炎性失衡致致致瘤性的系统生物学证据

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2021-11-26 DOI: 10.1111/pcmr.13023

John Davies, Sathya Muralidhar, Juliette Randerson-Moor, Mark Harland, Sally O’Shea, Joey Diaz, Christy Walker, Jérémie Nsengimana, Jon Laye, Tracey Mell, May Chan, Lizzie Appleton, Sofia Birke?lv, David J. Adams, Graham P. Cook, Graham Ball, David T. Bishop, Julia A. Newton-Bishop

{"title":"Ulcerated melanoma: Systems biology evidence of inflammatory imbalance towards pro-tumourigenicity","authors":"John Davies, Sathya Muralidhar, Juliette Randerson-Moor, Mark Harland, Sally O’Shea, Joey Diaz, Christy Walker, Jérémie Nsengimana, Jon Laye, Tracey Mell, May Chan, Lizzie Appleton, Sofia Birke?lv, David J. Adams, Graham P. Cook, Graham Ball, David T. Bishop, Julia A. Newton-Bishop","doi":"10.1111/pcmr.13023","DOIUrl":"https://doi.org/10.1111/pcmr.13023","url":null,"abstract":"Microscopic ulceration is an independent predictor of melanoma death. Here, we used systems biology to query the role of host and tumour-specific processes in defining the phenotype. Albumin level as a measure of systemic inflammation was predictive of fewer tumour-infiltrating lymphocytes and poorer survival in the Leeds Melanoma Cohort. Ulcerated melanomas were thicker and more mitotically active (with corresponding transcriptomic upregulated cell cycle pathways). Sequencing identified tumoural p53 and APC mutations, and TUBB2B amplification as associated with the phenotype. Ulcerated tumours had perturbed expression of cytokine genes, consistent with protumourigenic inflammation and histological and transcriptomic evidence for reduced adaptive immune cell infiltration. Pathway/network analysis of multiomic data using neural networks highlighted a role for the β-catenin pathway in the ulceration, linking genomic changes in the tumour to immunosuppression and cell proliferation. In summary, the data suggest that ulceration is in part associated with genomic changes but that host factors also predict melanoma death with evidence of reduced immune responses to the tumour.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"35 2","pages":"252-267"},"PeriodicalIF":4.3,"publicationDate":"2021-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.13023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6059734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

List of reviewers for PCMR (01.01.2021–30.09.2021) PCMR审稿人名单(01.01.2021-30.09.2021)

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2021-11-17 DOI: 10.1111/pcmr.13016

引用次数: 0

New insights into segmental vitiligo: A clinical and immunological comparison with nonsegmental vitiligo 对节段性白癜风的新认识:与非节段性白癜风的临床和免疫学比较

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2021-11-15 DOI: 10.1111/pcmr.13022

Xinya Xu, Min Jiang, Chengfeng Zhang, Zhuhui Qiao, Wenjie Liu, Yan Le, Jiaqiang Wu, Wenjuan Ma, Leihong Flora Xiang

{"title":"New insights into segmental vitiligo: A clinical and immunological comparison with nonsegmental vitiligo","authors":"Xinya Xu, Min Jiang, Chengfeng Zhang, Zhuhui Qiao, Wenjie Liu, Yan Le, Jiaqiang Wu, Wenjuan Ma, Leihong Flora Xiang","doi":"10.1111/pcmr.13022","DOIUrl":"https://doi.org/10.1111/pcmr.13022","url":null,"abstract":"The overlaps between segmental vitiligo (SV) and nonsegmental vitiligo (NSV) suggest the underlying features of SV, which may be helpful for treating SV. In this study, 379 vitiligo patients were recruited and divided into SV (33.2%), mild-to-moderate NSV (M-NSV, affected body affected area [BSA] ≤10%, 34.0%), and severe NSV (S-NSV, affected BSA >10%, 32.7%) groups. Demographics and clinical data were collected through in-person interviews. The disease activity, progression, and prognosis were assessed through 6 months’ follow-up. Serum cytokines profile and tissue-infiltrating immune cells were measured by ELISA assay and immunofluorescence, respectively. The SV exhibited lower rates of autoimmune comorbidities and recurrence than the S-NSV, but performed similar to the M-NSV. Moreover, the disease activity, progression, serum cytokines profile, and tissue-infiltrating Th/c1 cells in the active SV and M-NSV were comparable, but differed significantly from those of the active S-NSV. The clinical and immunological similarities between SV and M-NSV presented a deeper autoimmune understanding of SV. Additionally, a classification of active vitiligo according to disease extent may be more clinically meaningful than subtypes for guiding immunomodulatory treatment.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"35 2","pages":"220-228"},"PeriodicalIF":4.3,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5874569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) sensitize melanoma cells to MEK inhibition and inhibit metastasis and relapse by inducing degradation of AXL 非甾体抗炎药(NSAIDs)使黑色素瘤细胞对MEK抑制敏感，并通过诱导AXL降解来抑制转移和复发

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2021-11-08 DOI: 10.1111/pcmr.13021

Yingshi Chen, Yiwen Zhang, Siqi Chen, Weiwei Liu, Yingtong Lin, Hui Zhang, Fei Yu

{"title":"Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) sensitize melanoma cells to MEK inhibition and inhibit metastasis and relapse by inducing degradation of AXL","authors":"Yingshi Chen, Yiwen Zhang, Siqi Chen, Weiwei Liu, Yingtong Lin, Hui Zhang, Fei Yu","doi":"10.1111/pcmr.13021","DOIUrl":"https://doi.org/10.1111/pcmr.13021","url":null,"abstract":"Melanoma is highly heterogeneous with diverse genomic alterations and partial therapeutic responses. The emergence of drug-resistant tumor cell clones accompanied by a high AXL expression level is one of the major challenges for anti-tumor clinical care. Recent studies have demonstrated that high AXL expression in melanoma cells mediated drug resistance, epithelial-mesenchymal transition (EMT), and elevated survival of cancer stem cells (CSCs). Given that we have identified several non-steroidal anti-inflammatory drugs (NSAIDs) including aspirin potently induce the degradation of AXL, we questioned whether NSAIDs could counteract the AXL-mediated neoplastic phenotypes. In this study, we found that NSAIDs downregulate PKA activity via the PGE2/EP2/cAMP/PKA signaling pathway and interrupt the PKA-dependent interaction between CDC37 and HSP90, resulting in an incorrect AXL protein folding and finally AXL degradation through the ubiquitination-proteasome system (UPS) pathway. Furthermore, NSAIDs not only sensitized the MEK inhibitor treatment but also reduced EMT and relapse mediated by AXL in tumor tissue. Our findings suggest that the combination of inhibitors and NSAIDs, especially aspirin, could be a simple but efficient modality to treat melanoma in which AXL is a key factor for drug resistance, metastasis, and relapse.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"35 2","pages":"238-251"},"PeriodicalIF":4.3,"publicationDate":"2021-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"6144631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4