The Roles of PTEN in Melanoma Suppression

IF 2.6 3区 医学 Q2 CELL BIOLOGY
Gennie L. Parkman, Xiaonan Xu, Sheri L. Holmen, Florian A. Karreth
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引用次数: 0

Abstract

Since its discovery more than a quarter century ago, PTEN has emerged as one of the most potent tumor suppressors and its loss of function is common to numerous cancer types including glioblastoma, prostate cancer, small cell lung cancer, and melanoma. PTEN is a lipid and protein phosphatase that contributes to various cellular processes, primarily by regulating key signaling pathways. Extensive research over the past two decades has uncovered many aspects of PTEN regulation and function and highlighted the role of PTEN in tumor suppression. PTEN loss-of-function is associated with the progression of a substantial portion of melanoma cases, and while its role in melanoma suppression is often ascribed to its inhibition of the PI3K/AKT signaling pathway, recent studies may hint at a more complex role for PTEN in melanoma. In this review, we provide an overview of how PTEN suppresses melanomagenesis.

Abstract Image

PTEN在黑色素瘤抑制中的作用
自25年前发现PTEN以来,PTEN已成为最有效的肿瘤抑制因子之一,其功能丧失在许多癌症类型中都很常见,包括胶质母细胞瘤、前列腺癌、小细胞肺癌和黑色素瘤。PTEN是一种脂质和蛋白磷酸酶,主要通过调节关键信号通路参与各种细胞过程。在过去的二十年中,大量的研究揭示了PTEN的调控和功能的许多方面,并强调了PTEN在肿瘤抑制中的作用。PTEN功能丧失与大部分黑色素瘤病例的进展有关,虽然其在黑色素瘤抑制中的作用通常归因于其对PI3K/AKT信号通路的抑制,但最近的研究可能暗示PTEN在黑色素瘤中的作用更为复杂。在这篇综述中,我们提供了PTEN如何抑制黑色素瘤形成的概述。
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来源期刊
Pigment Cell & Melanoma Research
Pigment Cell & Melanoma Research 医学-皮肤病学
CiteScore
8.90
自引率
2.30%
发文量
54
审稿时长
6-12 weeks
期刊介绍: Pigment Cell & Melanoma Researchpublishes manuscripts on all aspects of pigment cells including development, cell and molecular biology, genetics, diseases of pigment cells including melanoma. Papers that provide insights into the causes and progression of melanoma including the process of metastasis and invasion, proliferation, senescence, apoptosis or gene regulation are especially welcome, as are papers that use the melanocyte system to answer questions of general biological relevance. Papers that are purely descriptive or make only minor advances to our knowledge of pigment cells or melanoma in particular are not suitable for this journal. Keywords Pigment Cell & Melanoma Research, cell biology, melatonin, biochemistry, chemistry, comparative biology, dermatology, developmental biology, genetics, hormones, intracellular signalling, melanoma, molecular biology, ocular and extracutaneous melanin, pharmacology, photobiology, physics, pigmentary disorders
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