Pigment Cell & Melanoma Research最新文献

{"title":"Meeting Abstracts of the ESPCR 2025 (European Society for Pigment Cell Research)","authors":"","doi":"10.1111/pcmr.70045","DOIUrl":"https://doi.org/10.1111/pcmr.70045","url":null,"abstract":"","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Many Faces of Melanoma: A Comparison Between Cutaneous, Mucosal, Acral, Nail, and Ocular Malignancy","authors":"Julia Nowowiejska,&nbsp;Agata Joanna Ordon,&nbsp;Piotr Purpurowicz,&nbsp;Giuseppe Argenziano,&nbsp;Vincenzo Piccolo","doi":"10.1111/pcmr.70051","DOIUrl":"https://doi.org/10.1111/pcmr.70051","url":null,"abstract":"<p>A melanoma is a malignant neoplasm that originates from melanocytes. Melanocytes are found in various body sites—they are most commonly found in the skin (including acral sites and nail units), ocular structures, and mucosal membranes. This narrative review aims to comprehensively summarize the current information available regarding several types of melanomas and to analyze the existing evidence. Despite the same origin—melanocytes—melanomas appear to be a heterogeneous neoplasm. A thorough analysis of several types of melanomas reveals differing genetics, risk factors, epidemiology, and prognosis. The most common locations for melanomas are primarily the skin, followed by ocular structures and acral sites. Mucosal melanomas occur more frequently in older individuals than cutaneous melanomas; cutaneous melanomas occur more frequently in males. Mucosal and nail unit melanomas predominantly affect females, whereas ocular melanomas occur with similar frequencies in both sexes or are slightly more common in males. The highest incidence of amelanotic cases is observed in patients with mucosal, uveal, and conjunctival melanomas. Mucosal melanomas, including conjunctival, present as multifocal lesions more often than in other affected body areas. Additionally, the poorest survival rate is observed for mucosal melanomas.</p>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of Vitiligo-Specific-Belief About Therapy Questionnaire (BTQ-Vitiligo)","authors":"Sree Yazhini Ramar,&nbsp;Sivaranjini Ramassamy,&nbsp;Malathi Munisamy,&nbsp;Subitha Lakshminarayanan,&nbsp;Ruben Raj,&nbsp;Raja Rajeswari Thanmalagan,&nbsp;Remya Raj","doi":"10.1111/pcmr.70049","DOIUrl":"https://doi.org/10.1111/pcmr.70049","url":null,"abstract":"<div>\u0000 \u0000 <p>There is a need to capture therapy-related beliefs held by patients with conditions like vitiligo that have complex treatment regimens. Concerns about adverse effects and uncertainty about response to the prescribed treatment can impact adherence and the perceived treatment burden. This study aims to develop and validate a questionnaire on beliefs about therapy in patients with vitiligo. It is a cross-sectional study. A vitiligo-specific item pool was developed through literature review, in-depth interviews with patients with vitiligo (<i>n</i> = 10), and expert surveys (<i>n</i> = 8). The instrument was studied on 140 patients for psychometric properties using the Vitiligo Treatment Impact score (VITs) and Medication Adherence Rating Scale-5 (MARS-5); self-reported severity using PtGA (Patient Global Assessment) and Response VASI (Vitiligo Area Scoring Index). Exploratory factor analysis demonstrated a six-factor structure with 21 items. Discriminant validity was evidenced by correlation between response VASI and questionnaire subscales (<i>r</i> = −0.538). Correlation with VITs (<i>r</i> = −0.610), MARS-5 (<i>r</i> = 0.453), and PtGA (<i>r</i> = 0.486) demonstrated construct and criterion validity, respectively. BTQ-vitiligo demonstrated test–retest reliability (<i>r</i> = 0.779) during the follow-up visit. BTQ-vitiligo is a validated instrument that helps clinicians understand patients' perspectives about therapy and tailor it accordingly to ensure adherence and further response to therapy. We developed and validated a BTQ-vitiligo, a valuable tool for capturing therapy-related beliefs in vitiligo, a complex dermatological disease with medication challenges. Although several patient-reported outcome measures (PROMs) have been developed to assess various aspects of vitiligo, none exist to capture patients' beliefs about therapy, which is a key determinant of the perceived burden of treatment. Our questionnaire identifies general and specific medication beliefs across six domains, with 21 items included under it.</p>\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144881206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic and Predictive Value of ctDNA for Metastatic Uveal Melanoma: A Systematic Review and Meta-Analysis","authors":"Mariana Macambira Noronha,&nbsp;Luís Felipe Leite da Silva,&nbsp;Luiz Felipe Costa Almeida,&nbsp;Pedro Robson Costa Passos,&nbsp;Pedro Cotta Abrahão Reis,&nbsp;João Evangelista Ponte Conrado,&nbsp;Valbert Oliveira Costa Filho,&nbsp;Lucas Diniz da Conceição,&nbsp;Mauricio F. S. A. Ribeiro,&nbsp;Samuel D. Saibil,&nbsp;Erick F. Saldanha","doi":"10.1111/pcmr.70047","DOIUrl":"https://doi.org/10.1111/pcmr.70047","url":null,"abstract":"<p>Metastatic uveal melanoma (mUM) is a rare disease associated with poor prognosis and limited therapeutic options. Recent studies showed that detecting ctDNA is feasible and can aid treatment decisions for patients with mUM. We systematically searched PubMed, EMBASE, and Cochrane databases for eligible studies published up to May 2025 that included patients with mUM and reported data on the association between ctDNA and survival outcomes (OS and PFS). Statistical analyses were performed using Review Manager 5.4 software. Of the initial 450 records, seven studies met eligibility, including 518 patients with mUM. At baseline, ctDNA positivity was associated with significantly worse PFS (HR 2.34; 95% CI 1.56–3.51; <i>p</i> &lt; 0.01; <i>I</i>² = 0%) and OS (HR 3.32; 95% CI 2.09–5.29; <i>p</i> &lt; 0.01; <i>I</i>² = 48%). In patients treated with tebentafusp, ctDNA clearance was associated with superior OS (HR 0.19; 95% CI 0.07–0.49; <i>p</i> &lt; 0.01; <i>I</i>² = 46%) and any decrease in ctDNA was associated with better OS (HR 0.42; 95% CI 0.22–0.80; <i>p</i> &lt; 0.01; <i>I</i>² = 0%). This meta-analysis underscores ctDNA as a potential predictor of worse survival in patients with mUM, highlighting its potential to refine risk stratification and guide treatment strategies.</p><p><b>Trial Registration:</b> International Prospective Register of Systematic Reviews (PROSPERO): CRD42025638076</p>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144832935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Education in the Eye of the Beholder: Assessing the Effect of Skin Color Representation in Melanoma Educational Materials","authors":"Vissy M. Elad,&nbsp;Trevena Anton,&nbsp;Natalie C. Ganios,&nbsp;Erin M. Franks,&nbsp;Eliot N. Mostow,&nbsp;Vito W. Rebecca","doi":"10.1111/pcmr.70043","DOIUrl":"https://doi.org/10.1111/pcmr.70043","url":null,"abstract":"","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 5","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Pretreatment Tumour Microenvironment and Treatment Outcome in Patients With Locally Advanced Melanoma Treated With Isolated Limb Perfusion","authors":"Sanni K. A. Tulokas,&nbsp;Susanna Juteau,&nbsp;Siru P. Mäkelä,&nbsp;Katja E. Välimäki,&nbsp;Teijo Pellinen,&nbsp;Micaela M. Hernberg","doi":"10.1111/pcmr.70040","DOIUrl":"https://doi.org/10.1111/pcmr.70040","url":null,"abstract":"<p>As effective melanoma treatments have become available, utilizing isolated limb perfusion (ILP) to treat unresectable melanoma limited to the limb has decreased. However, some patients still receive long-term benefits from ILP. We aimed to identify features of the pretreatment tumor microenvironment (TME) to identify patients who may benefit from ILP. Pretreatment metastatic melanoma samples from 22 patients treated at Helsinki University Hospital with ILP from 2008 to 2018 were analyzed with multiplex immunohistochemistry (mIHC) and digital image analysis. Antibody panels evaluated the proportions of immune cells in the intratumoral and extratumoral compartments. We examined whether treatment response and median progression-free survival (PFS) after ILP correlated to findings in the TME. A statistically significant positive correlation was found between PFS and lower immune cell infiltrations in the intratumoral compartment (CD3+, CD4+, and CD11c+ cells), and increased numbers of immune cells in the extratumoral compartment were associated with longer PFS (CD3+, CD4+, CD8+, all expressing PD-1). Furthermore, the distribution of some immune cell subsets correlated with complete treatment response (PD-1/PD-L1-positive CD4+ and PD-1-positive CD8+ cells). Our results suggest that patients may have a better ILP outcome if the metastases exhibit a lower distribution of specific immune cell subtypes intratumorally and a higher extratumoral distribution of some immune cell subtypes.</p>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pigmentation and Retinal Pigment Epithelium Thickness: A Study of the Phenotypic and Genotypic Relationships Between Ocular and Extraocular Pigmented Tissues","authors":"Thomas H Julian,&nbsp;Tomas Fitzgerald,&nbsp;UK Biobank Eye and Vision Consortium,&nbsp;Ewan Birney,&nbsp;Panagiotis I. Sergouniotis","doi":"10.1111/pcmr.70038","DOIUrl":"https://doi.org/10.1111/pcmr.70038","url":null,"abstract":"<p>The retinal pigment epithelium (RPE) is a specialised monolayer of pigmented epithelial cells in the outer retina. The extent to which RPE pigmentation is related to that of other tissues remains unclear. We utilised RPE thickness measured using optical coherence tomography (OCT) imaging as an indicator of RPE melanin content. UK Biobank data was used to assess the relationships between RPE thickness and fundus pigmentation, hair colour, skin colour and ability to tan. We performed a genome-wide association study (GWAS) to identify genetic loci associated with RPE thickness. We explored the genetic correlation between RPE thickness and pigmentation-related traits. We found that RPE thickness was not phenotypically or globally genetically correlated with hair colour, skin colour or ability to tan. Whilst RPE thickness was phenotypically correlated with fundus pigmentation, there was not significant global genetic correlation. Despite this, variants in key pigmentation loci including <i>TYR</i> and <i>OCA2</i>-<i>HERC2</i> were significant in our GWAS of RPE thickness. We identified four genetic regions in which RPE thickness is locally genetically correlated with other pigmentation-related traits, all of which contain protein-coding genes that are central to melanogenesis and melanosome transport. Our study highlights shared and divergent features between RPE thickness and other pigmented traits.</p>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Proposed Categorization of Vitiligo Lesions on the Hands","authors":"Kazunori Yokoi,&nbsp;Yosuke Ishitsuka,&nbsp;Kanae Kusao,&nbsp;Jing Wang,&nbsp;Haruna Kawashima,&nbsp;Narumi Jikihara,&nbsp;Seitaro Nakagawa,&nbsp;Eiji Kiyohara,&nbsp;Noriko Arase,&nbsp;Manabu Fujimoto,&nbsp;Atsushi Tanemura","doi":"10.1111/pcmr.70039","DOIUrl":"https://doi.org/10.1111/pcmr.70039","url":null,"abstract":"<p>Vitiligo is a common depigmentation disorder characterized by patchy white macules. It has been reported that vitiligo lesions, particularly in exposed areas, such as the face and hands, cause severe psychological distress. Although the classification and outcome of facial vitiligo have been proposed, clinical analyses featuring hand vitiligo are very limited, irrespective of its severe psychological impact. In this study, we investigated hand lesions in nonsegmental vitiligo patients and found that the distribution of hand vitiligo was symmetric, whereas the dominant hand was more frequently affected. Moreover, our clustering analysis newly classified hand vitiligo lesions into four distinct subtypes (<i>n</i> = 140): focal/scattered (46.4%), distal digit (31.4%), universal (12.9%), and proximal digit (9.2%) and their clinical characteristics. The focal/scattered type is the most common subtype and exhibits a distinctive prevalence in pediatric cases. The distal digit type was suggested to be associated with smoking or the Koebner phenomenon. The universal type is a distinct subtype, with onset in older age and a poor response to treatment. The proximal digit type is the rarest subtype, with onset at a young age. In conclusion, these findings deepen our understanding of the heterogeneity of hand vitiligo and support the development of personalized treatment strategies.</p>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144598211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PRMT6 Inhibits Malignant Progression of Melanoma by Antagonizing Trimethylation of Histone H3K4 to Downregulate ALDH1A1 Levels","authors":"Man Cai,&nbsp;Liangyu Wang,&nbsp;Miao Sun,&nbsp;Meixi Liu,&nbsp;Yingchun Liu","doi":"10.1111/pcmr.70034","DOIUrl":"https://doi.org/10.1111/pcmr.70034","url":null,"abstract":"<div>\u0000 \u0000 <p>Protein arginine methyltransferase 6 (PRMT6), a member of the PRMT family capable of self-arginine methylation, is down-regulated in melanoma, but the specific mechanism is still unclear. Our work demonstrated that PRMT6 overexpression significantly inhibited the ability of melanoma cells to proliferate, tumorigenicity, migration, and invasion, whereas PRMT6 knockdown rescued these malignant behaviors of melanoma cells. Mechanistically, we identified aldehyde dehydrogenase 1A1 (ALDH1A1) as a critical downstream target of PRMT6. PRMT6 knockdown up-regulated ALDH1A1 expression, exacerbating melanoma aggressiveness in vitro. Further investigations revealed that PRMT6 modulates ALDH1A1 expression by catalyzing asymmetric dimethylation of histone H3 at arginine 2 (H3R2me2a) and antagonizing the enrichment of histone H3 lysine 4 trimethylation (H3K4me3) at the ALDH1A1 promoter. In addition, dual-luciferase experiments showed that the transcription factor KLF4 may bind to the −1800 ~ +45 sequence of PRMT6, thereby negatively regulating PRMT6 expression in melanoma. Our findings underscore the tumor-suppressive role of PRMT6 in melanoma pathogenesis, highlighting its potential as a novel therapeutic target, particularly for metastatic melanoma.</p>\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144589509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"YAP Upregulation Contributes to Acquired Resistance to BET Inhibitors in Uveal Melanoma","authors":"Yan-ling Zhou,&nbsp;Xiao-lian Liu,&nbsp;Si-Si Huang,&nbsp;Gui-ming Zhang,&nbsp;Xuan-yu Jin,&nbsp;Liang Chen,&nbsp;Le Yu,&nbsp;Yi-lei Li","doi":"10.1111/pcmr.70036","DOIUrl":"https://doi.org/10.1111/pcmr.70036","url":null,"abstract":"<div>\u0000 \u0000 <p>BET inhibitors have the potential to treat malignant tumors via the epigenetic modification mechanism. Although BET inhibitors show promise as anticancer agents for uveal melanoma (UM), the emergence of acquired resistance significantly limits their clinical efficacy. We developed isogenic OTX015-resistant UM cell models (OMM2.3R and OMM2.5R) via exposure to escalating OTX015 concentrations (0.04–0.5 μM over 6 months). These resistant cells demonstrated reduced sensitivity to OTX015-induced cytotoxicity. Moreover, the migratory ability of resistant cells was less affected by OTX015 compared to parental cells. Transcriptome analysis revealed an upregulation of YAP-activated genes in resistant cells. Notably, OTX015-resistant cells retained sensitivity to YAP inhibition via shRNA or pharmacological inhibitors. This study establishes YAP activation as a novel compensatory mechanism driving BET inhibitor resistance in UM. These findings position YAP inhibition as a potential therapeutic target to overcome BET inhibitor resistance, with clinical translational potential for resistant UM patients.</p>\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 4","pages":""},"PeriodicalIF":3.9,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144573167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}