Pigment Cell & Melanoma Research最新文献_第3页

Checkpoint kinase 1 inhibitor + low-dose hydroxyurea efficiently kills BRAF inhibitor- and immune checkpoint inhibitor-resistant melanomas 检查点激酶1抑制剂+小剂量羟基脲可有效杀死对BRAF抑制剂和免疫检查点抑制剂耐药的黑色素瘤。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-08-23 DOI: 10.1111/pcmr.13120

Zhen Zeng, Hung Long Ngo, Martina Proctor, Helen Rizos, Riccardo Dolcetti, Jazmina Gonzalez Cruz, James W. Wells, Brian Gabrielli

引用次数: 0

Activated Akt expression is associated with the recurrence of primary melanomas and further refines the prognostic and predictive values for relapse in acral melanomas 活化的 Akt 表达与原发性黑色素瘤的复发有关，并进一步完善了尖锐湿疣黑色素瘤复发的预后和预测价值。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-08-18 DOI: 10.1111/pcmr.13119

Kohei Nojima, Masahiro Hayashi, Atsushi Tanemura, Hind Al-Busani, Toru Saito, Tamio Suzuki, Masashi Ishikawa, Taisuke Mori, Shogo Wada, Naoya Yamazaki, Ichiro Katayama, Hiroki Mori, Hiroo Yokozeki, Naoko Okiyama, Yoshiyuki Sasaki, Takeshi Namiki

{"title":"Activated Akt expression is associated with the recurrence of primary melanomas and further refines the prognostic and predictive values for relapse in acral melanomas","authors":"Kohei Nojima, Masahiro Hayashi, Atsushi Tanemura, Hind Al-Busani, Toru Saito, Tamio Suzuki, Masashi Ishikawa, Taisuke Mori, Shogo Wada, Naoya Yamazaki, Ichiro Katayama, Hiroki Mori, Hiroo Yokozeki, Naoko Okiyama, Yoshiyuki Sasaki, Takeshi Namiki","doi":"10.1111/pcmr.13119","DOIUrl":"10.1111/pcmr.13119","url":null,"abstract":"A PTEN deficiency leads to the activation of phospho-Akt at serine 473 (p-Akt) and promotes the tumorigenesis of melanomas by coupling with NUAK2 amplification. We tested the prognostic impact of p-Akt and/or NUAK2 expression on the relapse-free survival (RFS) and overall survival (OS) of melanoma patients. Primary tumors from patients with acral melanomas (112), Low-cumulative sun damage (CSD) melanomas (38), and High-CSD melanomas (18) were examined using immunohistochemistry and their prognostic significance was analyzed statistically. The expression of p-Akt was found in 32.1%, 68.4%, and 55.6% of acral, Low-CSD, and High-CSD melanomas, while NUAK2 expression was found in 46.4%, 76.3%, and 50.0%, respectively. Either p-Akt or NUAK2 expression was inversely correlated with the RFS of primary melanoma patients and acral melanoma patients (p-Akt: p < .0001, p < .0001; NUAK2; p = .0005, p < .0001, respectively). Strikingly, multivariate analyses revealed that p-Akt had a significant impact on RFS (Hazard ratio = 4.454; p < .0001), while NUAK2 did not. Further subset analyses revealed that p-Akt expression had an inferior RFS of patients with acral melanomas (Hazard ratio = 4.036; p = .0005). We conclude that the expression of p-Akt has a significant impact on RFS of patients with primary melanomas and can predict the relapse of patients with acral melanomas.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"37 1","pages":"36-44"},"PeriodicalIF":4.3,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10023550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Melanoma literacy among the general population of three western US states 美国西部三个州普通人群中的黑色素瘤识字率。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-08-13 DOI: 10.1111/pcmr.13106

Sancy A. Leachman, Emile Latour, Brian Detweiler-Bedell, Jerusha B. Detweiler-Bedell, Adrienne Zell, Elizabeth Wenzel, Elizabeth Stoos, Jacob H. Nelson, Jack Wiedrick, Elizabeth G. Berry, Jane Lange, Ruth Etzioni, Jodi A. Lapidus

{"title":"Melanoma literacy among the general population of three western US states","authors":"Sancy A. Leachman, Emile Latour, Brian Detweiler-Bedell, Jerusha B. Detweiler-Bedell, Adrienne Zell, Elizabeth Wenzel, Elizabeth Stoos, Jacob H. Nelson, Jack Wiedrick, Elizabeth G. Berry, Jane Lange, Ruth Etzioni, Jodi A. Lapidus","doi":"10.1111/pcmr.13106","DOIUrl":"10.1111/pcmr.13106","url":null,"abstract":"Melanoma is a significant cause of cancer death, despite being detectable without specialized or invasive technologies. Understanding barriers to preventive behaviors such as skin self-examination (SSE) could help to define interventions for increasing the frequency of early detection. To determine melanoma knowledge and beliefs across three high-incidence US states, 15,000 surveys were sent to a population-representative sample. We aimed to assess (1) melanoma literacy (i.e., knowledge about melanoma risks, attitudes, and preventive behaviors) and (2) self-reported SSE and its association with melanoma literacy, self-efficacy, and belief in the benefits of SSE. Of 2326 respondents, only 21.2% provided responses indicating high knowledge of melanoma, and 62.8% reported performing an SSE at any time in their lives. Only 38.3% and 7.3% reported being “fairly” or “very” confident about doing SSE, respectively. SSE performance among respondents was most strongly associated with higher melanoma knowledge, higher self-efficacy, and personal history of melanoma. Melanoma literacy among survey respondents was modest, with greater literacy associated with a higher likelihood of reported preventive behavior. This assessment establishes a baseline and provides guidance for public health campaigns designed to increase prevention and early detection of this lethal cancer.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"36 6","pages":"481-500"},"PeriodicalIF":4.3,"publicationDate":"2023-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10343621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling of pigmentation disorders associated with MITF mutation in Waardenburg syndrome revealed an impaired melanogenesis pathway in iPS-derived melanocytes 对华登堡综合征中与 MITF 突变相关的色素沉着病进行建模，发现 iPS 衍生黑色素细胞的黑色素生成途径受损。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-08-09 DOI: 10.1111/pcmr.13118

Jie Wen, Jian Song, Jiale Chen, Zhili Feng, Qiancheng Jing, Wei Gong, Xiaoming Kang, Lingyun Mei, Chufeng He, Lu Ma, Yong Feng

{"title":"Modeling of pigmentation disorders associated with MITF mutation in Waardenburg syndrome revealed an impaired melanogenesis pathway in iPS-derived melanocytes","authors":"Jie Wen, Jian Song, Jiale Chen, Zhili Feng, Qiancheng Jing, Wei Gong, Xiaoming Kang, Lingyun Mei, Chufeng He, Lu Ma, Yong Feng","doi":"10.1111/pcmr.13118","DOIUrl":"10.1111/pcmr.13118","url":null,"abstract":"Waardenburg Syndrome (WS) is a rare genetic disorder that leads to congenital hearing loss and pigmentation defects. Microphthalmia-associated transcription factor (MITF) is one of its significant pathogenic genes. Despite the comprehensive investigation in animal models, the pathogenic mechanism is still poorly described in humans due to difficulties accessing embryonic tissues. In this work, we used induced pluripotent stem cells derived from a WS patient carrying a heterozygous mutation in the MITF gene c.626A>T (p.His209Leu), and differentiated toward melanocyte lineage, which is the most affected cell type involved in WS. Compared with the wild-type cell line, the MITFmut cell line showed a reduced expression of the characteristic melanocyte-related genes and a lesser proportion of mature, fully pigmented melanosomes. The transcriptome analysis also revealed widespread gene expression changes at the melanocyte stage in the MITFmut cell line. The differentially expressed genes were enriched in melanogenesis and cell proliferation-related pathways. Interestingly, ion transport-related genes also showed a significant difference in MITFmut-induced melanocytes, indicating that the MITF mutant may lead to the dysfunction of potassium channels and transporters produced by intermediate cells in the cochlea, further causing the associated phenotype of deafness. Altogether, our study provides valuable insights into how MITF mutation affects WS patients, which might result in defective melanocyte development and the related phenotype based on the patient-derived iPSC model.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"37 1","pages":"21-35"},"PeriodicalIF":4.3,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10021062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort 黑色素瘤抗 PD-1 治疗结果的季节性变化--来自荷兰患者队列的结果。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-08-08 DOI: 10.1111/pcmr.13117

J. S. W. Borgers, F. H. Burgers, A. Schina, O. J. Van Not, A. J. M. van den Eertwegh, C. U. Blank, M. J. B. Aarts, F. W. P. J. van den Berkmortel, J. W. B. de Groot, G. A. P. Hospers, E. Kapiteijn, D. Piersma, R. S. van Rijn, A. M. Stevense-den Boer, A. A. M. van der Veldt, G. Vreugdenhil, M. J. Boers-Sonderen, M. W. J. M. Wouters, K. P. M. Suijkerbuijk, J. V. van Thienen, J. B. A. G. Haanen

{"title":"Seasonal variation of anti-PD-1 outcome in melanoma—Results from a Dutch patient cohort","authors":"J. S. W. Borgers, F. H. Burgers, A. Schina, O. J. Van Not, A. J. M. van den Eertwegh, C. U. Blank, M. J. B. Aarts, F. W. P. J. van den Berkmortel, J. W. B. de Groot, G. A. P. Hospers, E. Kapiteijn, D. Piersma, R. S. van Rijn, A. M. Stevense-den Boer, A. A. M. van der Veldt, G. Vreugdenhil, M. J. Boers-Sonderen, M. W. J. M. Wouters, K. P. M. Suijkerbuijk, J. V. van Thienen, J. B. A. G. Haanen","doi":"10.1111/pcmr.13117","DOIUrl":"10.1111/pcmr.13117","url":null,"abstract":"Despite the improved survival rates of patients with advanced stage melanoma since the introduction of ICIs, many patients do not have (long-term) benefit from these treatments. There is evidence that the exposome, an accumulation of host-extrinsic factors including environmental influences, could impact ICI response. Recently, a survival benefit was observed in patients with BRAF wild-type melanoma living in Denmark who initiated immunotherapy in summer as compared to winter. As the Netherlands lies in close geographical proximity to Denmark and has comparable seasonal differences, a Dutch validation cohort was established using data from our nationwide melanoma registry. In this study, we did not observe a similar seasonal difference in overall survival and are therefore unable to confirm the Danish findings. Validation of either the Dutch or Danish findings in (combined) patient cohorts from other countries would be necessary to determine whether this host-extrinsic factor influences the response to ICI-treatment.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"37 1","pages":"15-20"},"PeriodicalIF":4.3,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.13117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10237502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimisation of skin phototype classification 皮肤光型分类的优化。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-08-07 DOI: 10.1111/pcmr.13110

Sophie S. Lim, Tasneem F. Mohammad, Indermeet Kohli, Iltefat Hamzavi, Michelle Rodrigues

引用次数: 0

Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK) 由无性淋巴瘤激酶（ALK）基因融合引起的婴儿黑色素瘤。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-07-20 DOI: 10.1111/pcmr.13115

Ifeoma U. Perkins, Serena Y. Tan, Timothy H. McCalmont, Pauline M. Chou, Thaddeus W. Mully, Pedram Gerami, Jason H. Pomerantz, Miguel Reyes-Múgica, Daniel M. Balkin, Lacey L. Kruse, Benjamin Huang, Jennifer L. Reichek, Noopur Gangopadhyay, Simon Chiosea, Jared R. Green, Sarah L. Chamlin, Ilona J. Frieden, Boris C. Bastian, Iwei Yeh

{"title":"Melanoma in infants, caused by a gene fusion involving the anaplastic lymphoma kinase (ALK)","authors":"Ifeoma U. Perkins, Serena Y. Tan, Timothy H. McCalmont, Pauline M. Chou, Thaddeus W. Mully, Pedram Gerami, Jason H. Pomerantz, Miguel Reyes-Múgica, Daniel M. Balkin, Lacey L. Kruse, Benjamin Huang, Jennifer L. Reichek, Noopur Gangopadhyay, Simon Chiosea, Jared R. Green, Sarah L. Chamlin, Ilona J. Frieden, Boris C. Bastian, Iwei Yeh","doi":"10.1111/pcmr.13115","DOIUrl":"10.1111/pcmr.13115","url":null,"abstract":"We describe the first cases of pediatric melanoma with ALK fusion gene arising within giant congenital melanocytic nevi. Two newborn boys presented with large pigmented nodular plaques and numerous smaller satellite nevi. Additional expansile nodules developed within both nevi and invasive melanomas were diagnosed before 10 months of age in both boys. Oncogenic driver mutations in NRAS and BRAF were absent in both cases. Instead, oncogenic ZEB2::ALK fusion genes were identified in both the nevus and melanoma developing within the nevus. In both cases, tumors were noted by ultrasound in utero, demonstrated significant nodularity at birth, and progressed to melanoma in the first year of life suggesting that congenital nevi with ALK fusion genes may behave more aggressively than those with other mutations. As ALK kinase inhibitors are effective against a range of tumors with similar ALK fusion kinases, identifying ALK fusion genes in congenital melanocytic nevi may provide an opportunity for targeted therapy.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"37 1","pages":"6-14"},"PeriodicalIF":4.3,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9843171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathologic abundance of pigmentation correlates with disease-specific survival in malignant melanoma but is not independent of current AJCC pT stage 色素沉着的组织病理学丰度与恶性黑色素瘤的疾病特异性生存率相关，但与当前AJCC pT分期无关。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-07-20 DOI: 10.1111/pcmr.13114

Valentin Aebischer, Amar Abu-Ghazaleh, Gisela Metzler, Lena Riedl, Claus Garbe, Lukas Flatz, Thomas Eigentler, Stephan Forchhammer

{"title":"Histopathologic abundance of pigmentation correlates with disease-specific survival in malignant melanoma but is not independent of current AJCC pT stage","authors":"Valentin Aebischer, Amar Abu-Ghazaleh, Gisela Metzler, Lena Riedl, Claus Garbe, Lukas Flatz, Thomas Eigentler, Stephan Forchhammer","doi":"10.1111/pcmr.13114","DOIUrl":"10.1111/pcmr.13114","url":null,"abstract":"The increasing number of melanoma patients makes it necessary to develop best possible strategies for prognosis assessment in order to recommend appropriate therapy and follow-up. The prognostic significance of tumor cell pigmentation has not been fully elucidated. Hematoxylin and eosin (H&E)-stained sections of 775 melanomas diagnosed between 2012 and 2015 were independently assessed for melanin pigment abundance by two investigators, and the impact on melanoma-specific survival was calculated. Unpigmented melanomas (n = 99) had a melanoma-specific survival of 67.7%, melanomas with moderate pigmentation (n = 384) had a melanoma-specific survival of 85.9%, and strongly pigmented melanomas (n = 292) had a melanoma-specific survival of 91.4% (p < .001). In an analysis of melanoma-specific survival adjusted for pT stage and pigmentation, we found a nonsignificant impact of pigmentation abundance with a hazard ratio of 1.277 (p = .74). The study presented here provides evidence in a German cohort that patients with pigmented melanomas have a more favorable prognosis than those diagnosed with nonpigmented melanomas. Moreover, the abundance of pigmentation already seems to provide a first prognostic estimate. However, it does not appear to provide significant additional value for prognostic assessment according to the AJCC 2017 pT classification.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"36 6","pages":"512-521"},"PeriodicalIF":4.3,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10214128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survival benefit of sentinel lymph node biopsy in Asian melanoma patients 前哨淋巴结活检对亚洲黑色素瘤患者的生存益处。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-07-19 DOI: 10.1111/pcmr.13113

Che-Chia Hsu, Yi-Hua Liao, Yi-Shuan Sheen

{"title":"Survival benefit of sentinel lymph node biopsy in Asian melanoma patients","authors":"Che-Chia Hsu, Yi-Hua Liao, Yi-Shuan Sheen","doi":"10.1111/pcmr.13113","DOIUrl":"10.1111/pcmr.13113","url":null,"abstract":"Sentinel lymph node biopsy (SLNB) provides important prognostic information for early-stage melanomas. However, statistics regarding the survival comparison between SLNB and nodal observation in Asia, where acral lentiginous melanoma (ALM) predominates, are limited. This study aimed to identify if SLNB offered survival benefits over nodal observation in early-stage melanomas in Taiwan. The retrospective study included 227 patients who met the SLNB criteria according to the National Comprehensive Cancer Network guidelines and were treated at National Taiwan University Hospital from June 1997 to June 2021. Survival analysis was performed using Kaplan–Meier curves and Cox proportional hazards regression models. Of the study population, ALM accounted for 73.1%; 161 patients (70.9%) underwent SLNB and 66 patients (29.1%) were under nodal observation. Multivariate analysis showed significantly improved melanoma-specific survival (hazard ratio [HR], 0.6; p = .02) in the SLNB group. Among those who underwent completion lymph node dissection (CLND), the non-sentinel node positivity rate was 44.4%. Immediate CLND resulted in significantly longer melanoma-specific survival and distant-metastasis-free survival (DMFS) compared to nodal observation. (HR, 0.2; p = .01 for melanoma-specific survival. HR, 0.3; p = .046 for DMFS). In conclusion, SLNB may provide survival benefits of cutaneous melanoma over nodal observation in the Taiwanese population.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"36 6","pages":"522-530"},"PeriodicalIF":4.3,"publicationDate":"2023-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9840359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic regulation of chromatin accessibility during melanocyte stem cell activation 黑素细胞干细胞活化过程中染色质可及性的动态调节。

IF 4.3 3区医学

Pigment Cell & Melanoma Research Pub Date : 2023-07-18 DOI: 10.1111/pcmr.13112

Seoyeon Lee, Luye An, Paul D. Soloway, Andrew C. White

{"title":"Dynamic regulation of chromatin accessibility during melanocyte stem cell activation","authors":"Seoyeon Lee, Luye An, Paul D. Soloway, Andrew C. White","doi":"10.1111/pcmr.13112","DOIUrl":"10.1111/pcmr.13112","url":null,"abstract":"Melanocyte stem cells (McSCs) of the hair follicle are necessary for hair pigmentation and can serve as melanoma cells of origin when harboring cancer-driving mutations. McSCs can be released from quiescence, activated, and undergo differentiation into pigment-producing melanocytes during the hair cycle or due to environmental stimuli, such as ultraviolet-B (UVB) exposure. However, our current understanding of the mechanisms regulating McSC stemness, activation, and differentiation remains limited. Here, to capture the differing possible states in which murine McSCs can exist, we sorted melanocyte nuclei from quiescent (telogen) skin, skin actively producing hair shafts (anagen), and skin exposed to UVB. With these sorted nuclei, we then utilized single-nucleus assay for transposase-accessible chromatin with high-throughput sequencing (snATAC-seq) and characterized three melanocyte lineages: quiescent McSCs (qMcSCs), activated McSCs (aMcSCs), and differentiated melanocytes (dMCs) that co-exist in all three skin conditions. Furthermore, we successfully identified differentially accessible genes and enriched transcription factor binding motifs for each melanocyte lineage. Our findings reveal potential gene regulators that determine these melanocyte cell states and provide new insights into how aMcSC chromatin states are regulated differently under divergent intrinsic and extrinsic cues. We also provide a publicly available online tool with a user-friendly interface to explore this comprehensive dataset, which will provide a resource for further studies on McSC regulation upon natural or UVB-mediated stem cell activation.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"36 6","pages":"531-541"},"PeriodicalIF":4.3,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10399901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0