Pigment Cell & Melanoma Research最新文献_第3页

SASH1 Modulates Melanin Synthesis and Melanoma Cell Metastasis via Suppression of the TGF-β Signaling Pathway SASH1通过抑制TGF-β信号通路调节黑色素合成和黑色素瘤细胞转移。

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-11-24 DOI: 10.1111/pcmr.70064

Hongzhou Cui, Jianhua Hao, Qiong Wang, Jie Han, Honggang Liang, Yingjie Zhang, Bo Liang, Shanshan Ge, Hongxia He, Xiaoli Ren, Shuping Guo

{"title":"SASH1 Modulates Melanin Synthesis and Melanoma Cell Metastasis via Suppression of the TGF-β Signaling Pathway","authors":"Hongzhou Cui, Jianhua Hao, Qiong Wang, Jie Han, Honggang Liang, Yingjie Zhang, Bo Liang, Shanshan Ge, Hongxia He, Xiaoli Ren, Shuping Guo","doi":"10.1111/pcmr.70064","DOIUrl":"10.1111/pcmr.70064","url":null,"abstract":"<div>\u0000 \u0000 Dyschromatosis universalis hereditaria (DUH) is characterized by autosomal dominant inheritance and widespread involvement of hyperpigmentation and depigmentation. In our previous study, we identified mutations in the SH3 domain-containing protein 1 (SASH1) associated with the DUH phenotype in Chinese families and predicted that the SASH1/THBS1/TGF-β1 signaling pathway mediates melanin production and melanocyte transport. However, the molecular regulatory mechanisms remain unclear. By modulating the expression of SASH1 and THBS1, we assessed the expression of genes within the SASH1/THBS1/TGF-β1 pathway and evaluated cell phenotypes and melanin synthesis in the A375 and PIG1 cell lines. Through in vivo subcutaneous injection of SASH1 knockdown A375 cells into nude mice, we tested whether SASH1-TGF-β1 signaling may regulate cancer growth. Our findings demonstrated that SASH1 inhibits proliferation, migration, invasion, epithelial–mesenchymal transition, and promotes melanin synthesis through TGF-β1 signaling, while THBS1 counteracts the increase in TGF-β1 levels induced by SASH1 knockdown. We further showed that SASH1 suppresses TGF-β1 through its regulatory effect on THBS1, thereby inhibiting melanin metastasis and promoting melanin synthesis, which offers potential therapeutic insights into the modulation of TGF-β1.\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145595459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PD-1/PD-L1 Checkpoint Dysfunction in Vitiligo: Novel Pathogenic Insights and Therapeutic Innovation 白癜风的PD-1/PD-L1检查点功能障碍：新的致病见解和治疗创新

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-11-14 DOI: 10.1111/pcmr.70067

Heba Ahmed, Hanan R. Nada, Ahmed Mourad, Laila A. Rashed, Ghada M. El-Hanafy, Nermeen M. A. Abdallah, Mohamed M. Abdelhady

{"title":"PD-1/PD-L1 Checkpoint Dysfunction in Vitiligo: Novel Pathogenic Insights and Therapeutic Innovation","authors":"Heba Ahmed, Hanan R. Nada, Ahmed Mourad, Laila A. Rashed, Ghada M. El-Hanafy, Nermeen M. A. Abdallah, Mohamed M. Abdelhady","doi":"10.1111/pcmr.70067","DOIUrl":"https://doi.org/10.1111/pcmr.70067","url":null,"abstract":"Vitiligo, a chronic autoimmune disorder characterized by progressive melanocyte destruction, remains challenging to treat due to an incomplete understanding of underlying immune mechanisms. Recent clinical observations from cancer immunotherapy have revealed an unexpected connection between vitiligo and immune checkpoint pathways. The development of vitiligo-like depigmentation in up to 25% of cancer patients receiving anti-PD-1/PD-L1 therapy provides compelling evidence that checkpoint dysfunction drives melanocyte autoimmunity. This review synthesizes emerging evidence demonstrating that vitiligo is characterized by a cascade of interconnected checkpoint failures: elevated PD-1 expression on chronically activated T cells, profound PD-L1 deficiency in melanocytes, compromised regulatory T cell function, and critically, the failure of vitiligo melanocytes to upregulate protective PD-L1 in response to interferon-gamma. This creates a vicious cycle where inflammatory cytokines drive melanocyte destruction without triggering natural protective responses. We propose a novel pathogenic framework positioning vitiligo as a disease of multiple simultaneous checkpoint failures affecting effector control, target protection, and regulatory oversight. This understanding reveals rational therapeutic strategies using checkpoint agonists to restore immune tolerance. Preclinical evidence demonstrates that PD-L1 fusion proteins can reverse depigmentation in mouse models, while next-generation melanocyte-targeted therapies promise localized effects with minimal systemic immunosuppression. These insights reframe vitiligo pathogenesis and provide mechanistic rationale for novel immunomodulatory treatments targeting checkpoint restoration.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145522182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of the Novel RAF Dimer Inhibitor Brimarafenib With the MEK Inhibitor Mirdametinib Is Effective Against NRAS Mutant Melanoma 新型RAF二聚体抑制剂Brimarafenib与MEK抑制剂Mirdametinib联合治疗NRAS突变型黑色素瘤有效

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-11-06 DOI: 10.1111/pcmr.70062

Flavia L. Tellenbach, Luzia Seiler, Mark Johnson, Hubert Rehrauer, Prachi Schukla, Julia Martinez-Gomez, Corinne I. Stoffel, Adeela Kamal, Reinhard Dummer, Mitchell P. Levesque, Ossia M. Eichhoff

{"title":"Combination of the Novel RAF Dimer Inhibitor Brimarafenib With the MEK Inhibitor Mirdametinib Is Effective Against NRAS Mutant Melanoma","authors":"Flavia L. Tellenbach, Luzia Seiler, Mark Johnson, Hubert Rehrauer, Prachi Schukla, Julia Martinez-Gomez, Corinne I. Stoffel, Adeela Kamal, Reinhard Dummer, Mitchell P. Levesque, Ossia M. Eichhoff","doi":"10.1111/pcmr.70062","DOIUrl":"10.1111/pcmr.70062","url":null,"abstract":"Metastatic melanoma, the most aggressive form of skin cancer, accounts for the majority of skin cancer-related deaths. While targeted kinase inhibitors have improved outcomes for patients with BRAF-mutated melanomas, their efficacy is often short-lived, and effective treatments for other mutations, such as NRAS, remain scarce. To address this clinical need, we investigated the combination of the novel panRAF inhibitor, brimarafenib, and the MEK inhibitor, mirdametinib, both of which target the MAPK pathway downstream of NRAS. This study demonstrates the efficacy of this combination in NRAS-mutated melanoma and is currently also investigated in a phase I/IIa clinical study. In vitro, the brimarafenib and mirdametinib combination exhibited synergistic effects, significantly inhibiting the growth of patient-derived NRAS-mutated melanoma cell lines. A colony formation assay showed that this combination prevented the emergence of drug-resistant clones, suggesting a strong potential to reduce disease relapse. Transcriptional and proteomic analyses revealed that the observed growth inhibition was due to modulation of MAPK signaling and induction of apoptosis. In vivo studies further validated these findings, showing that the combination treatment inhibited tumor growth and significantly prolonged survival in mouse models bearing patient-derived NRAS-mutated melanoma tumors. Given the tolerability of this combination in vivo, our results suggest that brimarafenib and mirdametinib represent a promising therapeutic strategy for patients with NRAS-mutated melanomas and potentially other RAS-mutated solid tumors.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/pcmr.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145456981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CPT1B-Mediated Fatty Acid Oxidation Induces Pigmentation in Solar Lentigo cpt1b介导的脂肪酸氧化诱导太阳斑色素沉着。

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-10-27 DOI: 10.1111/pcmr.70063

Yueun Choi, Uijeong Nam, Jihan Kim, Soo-Young Yoon, Nahyun Lee, Hanseul Cho, Seoyeon Kim, Sanghyeon Yu, Junghyun Kim, Hae-Na Moon, Bark-Lynn Lew, Yoonsung Lee, Man S. Kim, Soon-Hyo Kwon

{"title":"CPT1B-Mediated Fatty Acid Oxidation Induces Pigmentation in Solar Lentigo","authors":"Yueun Choi, Uijeong Nam, Jihan Kim, Soo-Young Yoon, Nahyun Lee, Hanseul Cho, Seoyeon Kim, Sanghyeon Yu, Junghyun Kim, Hae-Na Moon, Bark-Lynn Lew, Yoonsung Lee, Man S. Kim, Soon-Hyo Kwon","doi":"10.1111/pcmr.70063","DOIUrl":"10.1111/pcmr.70063","url":null,"abstract":"<div>\u0000 \u0000 Cellular senescence is associated with altered lipid metabolism, including increased cellular lipid uptake, upregulated lipid biosynthesis, and deregulated lipid breakdown. Previous studies have reported that carnitine palmitoyltransferase (CPT), the rate-limiting enzyme in fatty acid oxidation that catalyzes the conversion of acyl-CoA to acylcarnitine, is involved in various senescence-related diseases. Although solar lentigo (SL) is an age-related pigmentary disorder characterized by the accumulation of senescent cells, its role in metabolic dysregulation has rarely been investigated. Integrated transcriptomic profiling of SL skin samples, combining mRNA sequencing, differential gene expression, pathway enrichment analyses, metabolic flux simulations, and protein–protein interaction analysis, was conducted to demonstrate the molecular alterations in SL compared to perilesional normal skin. We found transcriptomic alterations in mitochondrial energy metabolism-associated genes. Metabolic flux simulations revealed that carnitine-associated reactions involved in fatty acid oxidation were upregulated. Using a multi-omics approach, CPT1B was selected as a potential marker for SL. Using a zebrafish model, CPT1B was implicated in melanogenesis. CPT1B-mediated metabolic alteration is a key driver of SL pathogenesis. Targeting CPT1B and the associated lipid metabolism pathways is a novel therapeutic approach for managing SL and age-related pigmentation disorders.\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145375385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Integrated Investigation of SOX10 in Feather Color in Domestic Rock Pigeon (Columba livia) 国内岩鸽羽毛颜色中SOX10的综合研究。

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-10-16 DOI: 10.1111/pcmr.70061

Eric T. Domyan, Shannon Baker, Whitney Brownlee, Brittany Burton, Kendrick Kiggins, Emily Naylor, Harrison Piper, Tyrel Porter, Brittany Strobelt, Dian-Rong Tsai, Nathan Walker, Zachary Walton, Jonathon T. Hill

{"title":"An Integrated Investigation of SOX10 in Feather Color in Domestic Rock Pigeon (Columba livia)","authors":"Eric T. Domyan, Shannon Baker, Whitney Brownlee, Brittany Burton, Kendrick Kiggins, Emily Naylor, Harrison Piper, Tyrel Porter, Brittany Strobelt, Dian-Rong Tsai, Nathan Walker, Zachary Walton, Jonathon T. Hill","doi":"10.1111/pcmr.70061","DOIUrl":"10.1111/pcmr.70061","url":null,"abstract":"<div>\u0000 \u0000 The transcription factor SOX10 plays an important role in promoting determination and differentiation of melanocytes, and mutations affecting SOX10 expression or function often result in dramatic pigment phenotypes. In domestic rock pigeon, homozygosity for either of two regulatory mutations upstream of Sox10 known as recessive red causes birds to display bright red pheomelanic plumage instead of wild-type blue/black eumelanic plumage. In this study, we identify a common set of differentially expressed melanogenic genes in feathers from recessive red birds homozygous for either mutant allele, most notably a downregulation of Tyrp1, Slc24a5, Pmel, Mlana, and Hpgds and upregulation of Slc7a11. Collectively, these changes may promote pheomelanin synthesis and inhibit eumelanin synthesis. We also identify other altered pathways including genes involved in galactolipid synthesis and stem cell biology. We further examined the chromatin occupancy of SOX10 in pigeon melanocytes by ChIPseq to identify the subset of differentially expressed genes that are most likely to be direct targets of SOX10 function, and uncover evidence that SOX10 promotes its own expression by binding to the mcs7 melanocyte enhancer. Together, these data provide a more comprehensive picture of the role that SOX10 plays in melanocyte biology.\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145306616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemiexcitation in Ex Vivo Porcine Skin Model 猪离体皮肤模型的化学激发。

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-10-14 DOI: 10.1111/pcmr.70060

Pavel Pospíšil, Vendula Paculová, Ankush Prasad, Michal Berecka

{"title":"Chemiexcitation in Ex Vivo Porcine Skin Model","authors":"Pavel Pospíšil, Vendula Paculová, Ankush Prasad, Michal Berecka","doi":"10.1111/pcmr.70060","DOIUrl":"10.1111/pcmr.70060","url":null,"abstract":"Chemiexcitation, the formation of electronically excited states via oxidative chemical reactions, has emerged as a potentially important contributor to skin photobiology beyond direct damage caused by ultraviolet (UV) radiation. This study investigates the hypothesis that UV radiation induces chemiexcitation in skin through the formation of triplet excited carbonyls, which may transfer energy to melanin and contribute to oxidative stress even after the termination of UV exposure. Using porcine skin as a model, we demonstrate that UV exposure leads to lipid peroxidation and the subsequent formation of organic radicals, including carbon-centered (alkyl) and oxygen-centered (peroxyl and alkoxyl) species, as detected by EPR spin-trapping spectroscopy. HPLC-MS analysis revealed that short-chain carbonyl compounds, such as formaldehyde and acetaldehyde, are the predominant electronically excited species in direct chemiexcitation. These triplet carbonyls can transfer their excitation energy to melanin through photon emission (radiative transfer) or direct electron exchange (non-radiative transfer), forming melanin-based secondary excited states via indirect chemiexcitation. These findings highlight a novel, light-independent mechanism of post-UV exposure oxidative damage in the skin and suggest a possible role for chemiexcitation in processes such as photoaging and photocarcinogenesis.","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12521798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proceeding Report of the Sixth Vitiligo International Symposium—December 13–15, 2024, Cairo, Egypt 第六届白癜风国际研讨会会议报告- 2024年12月13-15日，埃及开罗

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-10-10 DOI: 10.1111/pcmr.70059

Samia Esmat, Marwa Abdallah, Dalia Bassiony, Lamia H. Elgarhy, Rania M. Mogawer

引用次数: 0

Fusion Gene Detection in Driver Mutation-Negative Melanomas Using RNA-Based Anchored Multiplex Polymerase Chain Reaction 利用rna锚定多重聚合酶链反应检测驱动突变阴性黑色素瘤中的融合基因

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-09-30 DOI: 10.1111/pcmr.70056

Tokimasa Hida, Masashi Idogawa, Sayuri Sato, Yukiko Kiniwa, Junji Kato, Kohei Horimoto, Shintaro Sugita, Shoichiro Tange, Masae Okura, Ryuhei Okuyama, Takashi Tokino, Hisashi Uhara

{"title":"Fusion Gene Detection in Driver Mutation-Negative Melanomas Using RNA-Based Anchored Multiplex Polymerase Chain Reaction","authors":"Tokimasa Hida, Masashi Idogawa, Sayuri Sato, Yukiko Kiniwa, Junji Kato, Kohei Horimoto, Shintaro Sugita, Shoichiro Tange, Masae Okura, Ryuhei Okuyama, Takashi Tokino, Hisashi Uhara","doi":"10.1111/pcmr.70056","DOIUrl":"https://doi.org/10.1111/pcmr.70056","url":null,"abstract":"<div>\u0000 \u0000 Advanced melanoma is typically treated with immune checkpoint inhibitors (ICIs) and targeted therapies. However, their efficacy is limited in acral and mucosal melanomas, which are more prevalent in non-White populations and often exhibit low tumor mutational burden and lack BRAF mutations. Fusion genes, widely used as therapeutic targets in other cancers, may represent alternative targets in these melanoma subtypes. This study aimed to detect fusion genes in Japanese melanomas lacking major driver mutations (BRAF, RAS, NF1, or KIT) using a custom RNA-based anchored multiplex polymerase chain reaction (AMP) panel. RNA extracted from 14 tumors, primarily formalin-fixed paraffin-embedded specimens, was analyzed using a custom Archer FUSIONPlex panel. Libraries were successfully generated in 80% of cases, and two in-frame fusions—MAD1L1::BRAF and CIC::MEGF8—were identified (17%). MAD1L1::BRAF retained the BRAF kinase domain and may be targetable by MEK inhibitors. CIC::MEGF8, a novel fusion in melanoma, may result in transcriptional dysregulation through CIC loss of function. This Method paper outlines the AMP workflow, including troubleshooting strategies and quality control criteria, and demonstrates its applicability to clinical samples. Our findings support the utility of RNA-based fusion detection in driver-negative melanomas and the potential of fusion genes as actionable targets.\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noninvasive Assessment of Melasma Pathological Features: Side-By-Side Comparison of Two-Photon Microscopy and Reflectance Confocal Microscopy 黄褐斑病理特征的无创评估：双光子显微镜与反射共聚焦显微镜的对比

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-09-30 DOI: 10.1111/pcmr.70057

Xiaoli Ning, Jungang Yang, Hongfei Ouyang, Lingfan Jiang, Jiahui Han, Ziyuan Tian, Jingkai Xu, Yujun Sheng, Xianbo Zuo, Yong Cui

{"title":"Noninvasive Assessment of Melasma Pathological Features: Side-By-Side Comparison of Two-Photon Microscopy and Reflectance Confocal Microscopy","authors":"Xiaoli Ning, Jungang Yang, Hongfei Ouyang, Lingfan Jiang, Jiahui Han, Ziyuan Tian, Jingkai Xu, Yujun Sheng, Xianbo Zuo, Yong Cui","doi":"10.1111/pcmr.70057","DOIUrl":"https://doi.org/10.1111/pcmr.70057","url":null,"abstract":"<div>\u0000 \u0000 Melasma, a refractory hyperpigmentation disorder, requires noninvasive tools for accurate pathological assessment. This study compared two-photon microscopy (TPM) and reflectance confocal microscopy (RCM) for the in vivo characterization of melasma pathology. In this cross-sectional study, TPM and RCM features and imaging clarity were evaluated in 130 melasma patients. Spearman correlation analyses were performed between TPM-quantified epidermal melanin, the melanin index (MI), and the individual typology angle (ITA). Features were also compared between active and stable disease stages. TPM and RCM showed substantial agreement in detecting increased epidermal melanin (κ = 0.651), activated melanocytes at the dermal-epidermal junction (DEJ) (κ = 0.711), and flattened rete ridges (κ = 0.691) (all p < 0.001). TPM excelled in visualizing intracellular melanin distribution, pendulous melanocytes under the DEJ, and solar elastosis, while RCM better identified activated melanocytes at the DEJ. TPM-quantified epidermal melanin content correlated positively with MI and negatively with ITA. RCM-detected dermal inflammatory cells were more prevalent in active than in stable melasma. In conclusion, TPM and RCM synergistically capture critical melasma features, with TPM assessing disease severity via epidermal melanin quantification, whereas RCM reflects disease activity by detecting inflammatory cells. This provides clinicians with tailored imaging tools for precision management.\u0000 </div>","PeriodicalId":219,"journal":{"name":"Pigment Cell & Melanoma Research","volume":"38 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Germline CDKN2A Variant Cascade Testing Across Four Generations Reveals Familial Melanoma–Breast Cancer Genotype–Phenotype Correlation 四代种系CDKN2A变异级联检测揭示家族性黑色素瘤-乳腺癌基因型-表型相关性

IF 2.6 3区医学

Pigment Cell & Melanoma Research Pub Date : 2025-09-26 DOI: 10.1111/pcmr.70055

Jennifer Berkman, Ellie J. Maas, E. DeBortoli, Clare A. Primiero, H. Peter Soyer, Aideen McInerney-Leo

引用次数: 0