Arthritis & Rheumatology最新文献

{"title":"A Historical Perspective on Approaches to Understanding the Genetics of Systemic Lupus Erythematosus.","authors":"S Louis Bridges,Betty P Tsao,Peter K Gregersen","doi":"10.1002/art.43247","DOIUrl":"https://doi.org/10.1002/art.43247","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"79 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA class I-downregulated senescent epidermal basal cells orchestrate skin pathology in cutaneous lupus erythematosus.","authors":"Sena Yamamoto,Yuki Saito,Tsukasa Sato,Seina Nakano,Dain Kasseki,Ayaka Nagao,Norihiro Miura,Kentaro Nagaoka,Arisa Kita,Maki Miyajima,Shogo Ijima,Koji Taniguchi,Atsushi Niida,Takako S Chikenji","doi":"10.1002/art.43244","DOIUrl":"https://doi.org/10.1002/art.43244","url":null,"abstract":"OBJECTIVETo investigate the role of senescent epidermal basal cells in cutaneous lupus erythematosus (CLE) pathogenesis using skin samples from patients with CLE and a mouse model of systemic lupus erythematosus (SLE).METHODSCellular senescence profiling utilized datasets from the NCBI Gene Expression Omnibus database and Accelerating Medicines Partnership® (AMP®) Phase 1-Metro. Gene array data from GSE184989 (CLE: n = 68, control: n = 4), single-cell RNA sequencing data from GSE186476 (CLE: n = 7, control: n = 14), and AMP® Phase 1-Metro (SLE: n = 17) were utilized. In vitro experiments further examined the expression of p21WAF1/CIP1, type I interferon (IFN), human leukocyte antigen class I (HLA-I), and epidermal growth factor receptor (EGFR) signalling. Pharmacological clearance of senescent cells was performed using the senolytic drug fisetin in the SLE mouse model.RESULTSp21WAF1/CIP1-high senescent epidermal basal cells in patients with CLE exhibit high type I IFN expression. These cells enhance IFN signalling in surrounding normal epidermal basal cells, leading to increased HLA-I expression. In contrast, senescent epidermal cells upregulate EGFR signalling, which downregulates HLA-I expression, allowing them to evade immune surveillance. This heterogeneity of HLA-I expression promotes CD8-positive T-mediated toxicity against normal epidermal basal cells, resulting in their apoptosis. Pharmacological clearance of senescent epidermal basal cells improved SLE-like skin lesions.CONCLUSIONSenescent cells create a microenvironment that directs cytotoxic T-cell-mediated responses against normal epidermis in CLE, contributing to disease pathology. Targeting senescent cells and their signalling pathways may offer novel therapeutic strategies for CLE and SLE skin lesions.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"132 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Precision Medicine in Pediatric Autoimmunity: Leniolisib Treatment of Childhood-Onset Lupus Nephritis Due to Activated PI3K-Delta Syndrome (APDS).","authors":"Jonathan P Lim,Mansooreh Ahmadian,Hongyu Du,Christian Rickert,Tusharkanti Ghosh,Fuyong Xing,Angela Minic,Sara A Johnson,Jason P Weinman,Nicholas Willard,Clara Lin,Jennifer C Cooper,Melisha Hanna,Vijaya Knight,Debashis Ghosh,Kimberly R Jordan,Elena Wy Hsieh","doi":"10.1002/art.43254","DOIUrl":"https://doi.org/10.1002/art.43254","url":null,"abstract":"OBJECTIVETo investigate the mechanistic underpinnings and treatment response of lupus nephritis (LN) in activated PI3K-delta syndrome type 1 (APDS1) using pathway-specific therapy and advanced spatial proteomics.METHODWe conducted mechanistic investigation of refractory class V LN in an 18-year-old female with genetically confirmed APDS1 (PIK3CD c.3061G>A, p.E1021K mutation). Response to leniolisib, a selective PI3Kδ inhibitor, was evaluated through clinical parameters and flow cytometry of peripheral blood lymphocytes. Kidney tissue immune architecture was characterized using Multiplexed Ion Beam Imaging Time-of-Flight Spectrometry (MIBI-TOF), comparing the APDS1-LN tissue signature with 12 childhood-onset LN patients (cLN) and 5 healthy controls (HC).RESULTSLeniolisib treatment normalized hyperactive PI3Kδ signaling, resulting in significant improvements in proteinuria, complement levels, and peripheral edema after failing three years of conventional immunosuppressives. MIBI-TOF spatial proteomics revealed a distinct tissue-specific immunopathology with significantly increased proportions of CD8+ T cells (21.6% in APDS1 vs. 12.0% in typical LN, p=0.0410) and M1 macrophages (42.0% in APDS1 vs. 9.0% in typical LN, p=0.1445) clustering around glomeruli with immune complex deposition. This immune signature aligns with the constitutively active PI3Kδ pathway's effect on lymphocyte exhaustion and inflammatory phenotype.CONCLUSIONThis investigation advances rheumatology by demonstrating that APDS1-associated LN displays a specific tissue immune signature and responds to targeted inhibition of the causative molecular pathway. Our findings provide mechanistic insights into genetic drivers of autoimmunity and support pathway-specific therapeutic approaches for refractory autoimmune manifestations in primary immunodeficiencies.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"16 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hand swelling and other non-Raynaud's symptoms as the initial presentation of systemic sclerosis: prevalence and clinical associations in two U.S. cohorts.","authors":"Iqtidar Hanif,Shervin Assassi,Maureen D Mayes,Zsuzsanna H McMahan,Meng Zhang,Julio Charles,John M VanBuren,Jessica S Alvey,Kimia Ghaffari,Elana J Bernstein,Flavia V Castelino,Lorinda Chung,Luke Evnin,Tracy M Frech,Jessica K Gordon,Faye N Hant,Laura K Hummers,Dinesh Khanna,Kimberly S Lakin,Dorota Lebiedz-Odrobina,Yiming Luo,Ashima Makol,Jerry A Molitor,Duncan F Moore,Carrie Richardson,Nora Sandorfi,Ami A Shah,Ankoor Shah,Victoria K Shanmugam,Virginia D Steen,Elizabeth R Volkmann,Carleigh Zahn,Brian Skaug","doi":"10.1002/art.43237","DOIUrl":"https://doi.org/10.1002/art.43237","url":null,"abstract":"OBJECTIVERaynaud's phenomenon (RP) is often the initial clinical manifestation of systemic sclerosis (SSc), but some patients develop other manifestations first. To help elucidate the diversity of SSc presentation in its early stages, we describe the initial clinical manifestations and antinuclear antibody (ANA) profiles of patients in two early SSc cohorts.METHODSAll patient data in the GENISOS and CONQUER cohorts were reviewed. Both studies enrolled patients within five years of the first non-RP symptom.RESULTS194/439 (44.2%), and 292/938 (31.1%) patients in GENISOS and CONQUER, respectively, had a non-RP initial symptom, most commonly puffy fingers/hands. Black patients had a non-RP symptom prior to RP more commonly than other race and ethnicity categories. Non-RP first patients were more likely than RP first patients to have diffuse cutaneous involvement and joint contractures at enrollment and had a higher prevalence of RNA Polymerase III antibody positivity.CONCLUSIONIn two large U.S. cohorts, >30% of patients began to manifest SSc with puffy fingers/hands or other symptoms, without the \"warning sign\" of RP as their initial symptom. These patients presented with more severe skin and musculoskeletal disease on average, highlighting the importance of early recognition. The most common autoantibody associated with this presentation was RNA Polymerase III. These results should be considered in efforts to recognize SSc in its earliest stages. Puffy fingers/hands, even in the absence of RP, should prompt consideration of early SSc and testing for ANA and SSc-associated autoantibodies including RNA Polymerase III.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"128 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of thigh intramuscular fat infiltration with incident knee and hip osteoarthritis: a longitudinal cohort study: Comment on the article Weng Q et al.","authors":"Duygu Tecer,Sedat Yilmaz","doi":"10.1002/art.43246","DOIUrl":"https://doi.org/10.1002/art.43246","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"58 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of osteoarthritis attributable to high body mass index, 1990-2021: insights from the Global Burden of Disease study 2021.","authors":"Yi Lu,Wenyu Xiao,Kun Tao","doi":"10.1002/art.43241","DOIUrl":"https://doi.org/10.1002/art.43241","url":null,"abstract":"OBJECTIVEThis study quantifies the global burden of osteoarthritis (OA) attributable to high body mass index (BMI) from 1990 to 2021 using the Global Burden of Disease (GBD) 2021 data.METHODSUtilizing GBD 2021 data, this research examines the OA burden related to high BMI across 204 countries and regions. Statistical analyses were performed to profile disease burdens, and joinpoint regression was used to identify temporal trends. The study also investigated the relationship between the Socio-demographic Index (SDI) and OA burden attributable to high BMI.RESULTSFrom 1990 to 2021, years lived with disability (YLDs) due to OA attributable to high BMI increased threefold globally, from 1,449,681 to 4,422,954. The age-standardized YLD rates of OA attributable to high BMI increased from 33.97 (95% UI: -3.14, 102.31) to 50.59 (95% UI: -4.81, 141.35) per 100,000 population, with an average annual percentage change of 1.11 (95% CI: 1.07, 1.14). The burden of OA YLDs attributable to high BMI was higher in females than males across all age groups. The age-standardized rates of OA YLDs attributable to high BMI were positively correlated with SDI levels, with higher burdens observed in regions with higher SDI.CONCLUSIONBetween 1990 and 2021, the global burden of OA attributable to high BMI increased markedly, with a consistent upward trend across most regions. The burden was more pronounced among females, middle-aged and older adults, and populations in high SDI regions, reflecting a growing and uneven global health challenge.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"121 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A National Academies' Committee Reviews Women's Health Research at the NIH and Makes Recommendations.","authors":"Jane E Salmon,Nancy E Lane","doi":"10.1002/art.43234","DOIUrl":"https://doi.org/10.1002/art.43234","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trio whole exome sequencing in Chinese childhood-onset lupus reveals novel candidate genes.","authors":"Jianyang Ma,Yuting Qin,Soon-Min Hong,Thuvaraka Ware,Guojun Hou,Jingjing Tan,Chengmei Xie,Pingjing Zhang,Xiaoqian Wu,Todor Arsov,Lanfang Cao,T Daniel Andrews,Philip Wu,Qian Shen,Huihua Ding,Nan Shen,Carola G Vinuesa,Yuke He","doi":"10.1002/art.43243","DOIUrl":"https://doi.org/10.1002/art.43243","url":null,"abstract":"OBJECTIVESSystemic lupus erythematosus (SLE) is an autoimmune disease in which rare and common gene variants contribute to pathogenesis. Severe sporadic disease in children is often explained by 'de novo' variants that can be uncovered by trio sequencing.METHODSWhole exome sequencing was performed in 50 Chinese trios with childhood-onset SLE (cSLE). Rare coding variants in SLE-associated genes and all de novo variants were investigated. Gene pathway and expression analysis, and interferon-β luciferase assays were used to predict contribution to disease.RESULTSEach proband carried at least one rare variant in an SLE-associated gene with a median of six per child. At least two probands had monogenic disease and one third carried novel or rare variants in genes well accepted to cause monogenic SLE: ACP5, C3, C4A, C4B, DNASE1, IFIH1, NRAS, RNASEH2B, RNASEH2C and SAMHD1. Probands carried a median of one de novo, rare, coding variant. Intriguingly, although only 2 de novo variants occurred in genes previously associated with SLE, 12 of the 50 genes were enriched in the top 20 SLE-related pathways and were highly expressed in ABC/plasma B cells. These genes represent promising candidate lupus genes. Two de novo variants occurring in genes not previously linked to SLE or autoimmunity, DHX8 and ACTR5, enhanced type I IFN signaling.CONCLUSIONSThis study highlights the abundance of lupus-relevant rare gene variants in cSLE, supports frequent contribution of de novo variants to disease, and identifies genes that may constitute novel therapeutic targets of relevance to Chinese patients.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"32 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Peripheral Biomarker Signatures in Rheumatoid Arthritis-Associated Interstitial Lung Disease\".","authors":"Bi-Yun Yao,Ya-Zhen Su,Yang Liu,Li-Yun Zhang","doi":"10.1002/art.43245","DOIUrl":"https://doi.org/10.1002/art.43245","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"51 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiphospholipid syndrome: an antibody-mediated disease with emerging therapeutic opportunities.","authors":"Thalia G Newman,Jason S Knight","doi":"10.1002/art.43258","DOIUrl":"https://doi.org/10.1002/art.43258","url":null,"abstract":"Antiphospholipid syndrome (APS) is an autoimmune thrombo-inflammatory disorder characterized by vascular thrombosis, pregnancy morbidity, and other manifestations driven by antiphospholipid autoantibodies. In this review, we present a clinical case that illustrates some diagnostic and therapeutic challenges in managing severe, relapsing APS manifestations, including microvascular injury and diffuse alveolar hemorrhage. We then discuss recent advances in our understanding of APS pathophysiology, emphasizing the critical role of anti-beta-2 glycoprotein I antibodies in triggering cell-specific inflammatory and thrombotic pathways. Finally, we speculate that achieving definitive disease control will require strategies that eliminate or effectively neutralize these pathogenic antibodies.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"17 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144087548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}