Arthritis & Rheumatology最新文献

{"title":"Granulomatosis with Polyangiitis Presenting as Strawberry Gingivitis: Diagnostic Challenges with Negative ANCA","authors":"Hanghang Liu, Wenting Qi, Qi Han, Linyi Liu, Yongle Shi, En Luo, Chongyun Bao, Xian Liu","doi":"10.1002/art.43119","DOIUrl":"https://doi.org/10.1002/art.43119","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"2 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142992174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An immunosenescent CD8+ T cell subset in patients with axial Spondyloarthritis and Psoriatic Arthritis links spontaneous motility to telomere shortening and dysfunction","authors":"Giorgia Paldino, Valentina Tedeschi, Valentina Proganò, Erica Salvati, Valerio Licursi, Eleonora Vertecchi, Alexandru L. Bivolaru, Emanuele Molteni, Rossana Scrivo, Mattia Congia, Alberto Cauli, Rosalba Caccavale, Marino Paroli, Martina Kunkl, Loretta Tuosto, Rosa Sorrentino, Maria Teresa Fiorillo","doi":"10.1002/art.43109","DOIUrl":"https://doi.org/10.1002/art.43109","url":null,"abstract":"A pathogenetic role of CD8+ T lymphocytes in radiographic axial spondyloarthritis (r-axSpA) and other spondyloarthritis (SpA) is sustained by genome-wide association studies (GWAS) and by the expansion of public T cell clonotypes in the target tissues. This study investigates the migration of CD8+ T cells, along with their phenotype and functions in patients with r-axSpA and psoriatic arthritis (PsA).","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"10 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A treatable cause of bilateral leg edema and pleural effusion: yellow nail syndrome with IgG4‐related disease","authors":"Seiya Oba, Yusuke Matsuo","doi":"10.1002/art.43116","DOIUrl":"https://doi.org/10.1002/art.43116","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"56 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on “Risk of Gastrointestinal Perforation in Patients With Rheumatic Diseases Exposed to Janus Kinase Inhibitors Versus Adalimumab: A Nationwide Cohort Study”","authors":"Jing‐jin Hu, Yang‐yang Lu, Jun‐kang Zhao, Dan Ma, James Cheng‐Chung Wei, Li‐yun Zhang","doi":"10.1002/art.43117","DOIUrl":"https://doi.org/10.1002/art.43117","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"31 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Gut Microbiome in Hyperuricemia and Gout","authors":"Robert Terkeltaub, Dylan Dodd","doi":"10.1002/art.43118","DOIUrl":"https://doi.org/10.1002/art.43118","url":null,"abstract":"Humans develop hyperuricemia via decreased urate elimination and excess urate production, consequently promoting monosodium urate crystal deposition and incident gout. Normally, approximately two thirds of urate elimination is renal. However, chronic kidney disease (CKD) and other causes of decreased renal urate elimination drive hyperuricemia in most with gout. This places more demand on elimination of urate via the gut, where diet, purine metabolism and microbiota intersect. Heritable impairment of urate transport into the gut is common, and promotes hyperuricemia, renal urate overload, and early onset and palpable tophaceous gout phenotypes. Lactobacilli, by sequestering and modifying ambient purines, are being studied for the potential to suppress diet-induced urate generation and associated gout flares. Landmark preclinical studies recently revealed much higher-capacity urate-lowering effects of diverse, obligate and facultative anaerobic human and murine gut microbiota (predominantly of Bacillota phylum) termed purine-degrading bacteria (PDB). A conserved gene cluster in PDB drives urate conversion to lactate or anti-inflammatory short chain fatty acids (SCFA). When mice are rendered deficient in hepatic uricase to mimic human uricase absence, microbiota depletion rapidly elevates both cecal and serum urate, reversible by PDB administration. In healthy human volunteers with normal renal function, antibiotic-induced gut microbiota depletion, decreases the urate-lowering gene cluster unique to PDB and elevates fecal urate. Also, prior exposure to antibiotics with anaerobic coverage has been linked to heightened incident gout risk. Notably, intestinal dysbiosis that includes Bacillota depletion has been observed in gout cohorts. Therefore, the capacity of diverse gut bacterial strains to biochemically compensate for human limits in urate disposition suggests novel probiotic treatment approaches for gout with inadequate pharmacologic control of both flares and hyperuricemia. This is particularly so for severe CKD, which limits the options and maximal doses for use of conventional oral urate-lowering drugs.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"30 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142990550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic profiling of the large‐vessel vasculitis spectrum identifies shared signatures of innate immune activation and stromal remodelling","authors":"Robert T. Maughan, Erin MacDonald‐Dunlop, Lubna Haroon‐Rashid, Louise Sorensen, Natalie Chaddock, Shauna Masters, Andrew Porter, Marta Peverelli, Charis Pericleous, Andrew Hutchings, James Robinson, Taryn Youngstein, Raashid A. Luqmani, Justin C. Mason, Ann W. Morgan, James E. Peters","doi":"10.1002/art.43110","DOIUrl":"https://doi.org/10.1002/art.43110","url":null,"abstract":"BackgroundTakayasu arteritis (TAK) and giant cell arteritis (GCA), the most common forms of large‐vessel vasculitis (LVV), can result in serious morbidity. Understanding the molecular basis of LVV should aid in developing better biomarkers and treatments.MethodsPlasma proteomic profiling of 184 proteins was performed in two cohorts. Cohort 1 included patients with established TAK (n=96) and large‐vessel GCA (LV‐GCA, n=35) in addition to healthy control participants (HCs, n=35). Cohort 2 comprised patients presenting acutely with possible cranial‐GCA in whom the diagnosis was subsequently confirmed (C‐GCA, n=150) or excluded (Not C‐GCA, n=89). Proteomic findings were compared to published transcriptomic data from LVV‐affected arteries.ResultsIn Cohort 1, comparison to HCs revealed 52 differentially abundant proteins (DAPs) in TAK and 72 in LV‐GCA. Within‐case analyses identified 16 and 18 disease activity‐associated proteins in TAK and LV‐GCA, respectively. In Cohort 2, comparing C‐GCA versus Not C‐GCA revealed 31 DAPs. Analysis within C‐GCA cases suggested the presence of distinct endotypes, with more pronounced proteomic changes in the biopsy‐proven subgroup. Cross‐comparison of TAK, LV‐GCA and biopsy‐proven C‐GCA revealed highly similar plasma proteomic profiles, with 26 shared DAPs including IL6, monocyte/macrophage related proteins (CCL7, CSF1), tissue remodelling proteins (TIMP1, TNC) and novel associations (TNFSF14, IL7R). Plasma proteomic findings reflected LVV arterial phenotype; for 42% of DAPs, the corresponding gene was differentially expressed in tissue.ConclusionsThese findings suggest shared pathobiology across the LVV spectrum involving innate immunity, lymphocyte homeostasis and tissue remodelling. Network‐based analyses highlighted immune‐stromal crosstalk and identified novel therapeutic targets (e.g. TNFSF14).","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"22 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The National Academies’ 2024 Diagnostic Criteria for Long COVID: Concerns that Could Affect the Rheumatology Community","authors":"Leonard H Calabrese, Michael Putman, Jeffrey A. Sparks, Zachary Wallace, Alfred H.J. Kim, Kevin L Winthrop, Cassandra Calabrese","doi":"10.1002/art.43114","DOIUrl":"https://doi.org/10.1002/art.43114","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"42 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply, SARD-ILD Screening and Monitoring Recommendations with low certainty evidence","authors":"Sindhu R Johnson, Marcy Bolster, Sonye K Danoff, Michael George, Gordon Guyatt, Dinesh Khanna, Reza Mirza, Aberdeen Allen, Amy Turner, Elana J. Bernstein","doi":"10.1002/art.43111","DOIUrl":"https://doi.org/10.1002/art.43111","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"7 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UV Light Exposure Induces a Type I Interferon Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes","authors":"Xizhang Sun, Jaime L Chao, Michael Gerner, Keith B Elkon","doi":"10.1002/art.43108","DOIUrl":"https://doi.org/10.1002/art.43108","url":null,"abstract":"Photosensitivity occurs in ~75% of lupus patients. Although ultraviolet light radiation (UVR) stimulates Type I interferon (IFN-I) in the skin, how UVR induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes DC to migrate from organs to draining lymph nodes (dLN) including a recently identified inflammatory DC subset (inf cDC2) that are potent antigen presenting cells. To explore links between UVR and the early immune response, we examined DC and lymphocyte subset migration to dLNs in normal and a lupus prone mouse strains as well as the role of IFN-I.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"40 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis-associated interstitial lung disease","authors":"Vanessa L. Kronzer, Yangyuna Yang, Punyasha Roul, James L. Crooks, Cynthia S. Crowson, John M. Davis, Jeffrey A. Sparks, Jeffrey R. Pierce, Katelyn O'Dell, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England","doi":"10.1002/art.43113","DOIUrl":"https://doi.org/10.1002/art.43113","url":null,"abstract":"Determine whether pollutants such as fire smoke-related particulate matter smaller than 2.5 microns (PM_2.5) are associated with incident rheumatoid arthritis (RA) and RA-associated interstitial lung disease (RA-ILD).","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"172 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}