Arthritis & Rheumatology最新文献_第10页

Appendix Vasculitis in a Patient with Intestinal Behçet's Disease. 肠炎患者阑尾血管炎1例。

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-16 DOI: 10.1002/art.43331

Hui Tian,Jing Ye,Zhao Li,Jingrun Zhao

引用次数: 0

Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis. 青少年特发性关节炎患者对染色质的自身抗体反应。

IF 10.9 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-16 DOI: 10.1002/art.43315

Viola Pitkänen, Terhi Remes-Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna-Maija Grönlund, Miika Arvonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Anna-Mari Schroderus, Liisa Kröger, Tuure Kinnunen

{"title":"Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis.","authors":"Viola Pitkänen, Terhi Remes-Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna-Maija Grönlund, Miika Arvonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Anna-Mari Schroderus, Liisa Kröger, Tuure Kinnunen","doi":"10.1002/art.43315","DOIUrl":"https://doi.org/10.1002/art.43315","url":null,"abstract":"Objective: Patients with juvenile idiopathic arthritis (JIA) frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in patients with JIA remains elusive.Methods: Plasma samples from 110 untreated patients with active JIA, as well as from 14 children with unspecified arthritis and 151 age- and sex-matched healthy children, were analyzed with multiple modern clinical-grade autoantibody assays, including automated indirect immunofluorescence to screen for ANAs with HEp-2 cells, and specific immune assays to detect reactivity to individual autoantigens. In addition, a HuProt proteome microarray was used to screen for novel autoantibody targets in plasma samples from five patients with ANA-positive JIA and four ANA-negative healthy controls.Results: Homogeneous nuclear ANA staining, indicating reactivity toward chromatin, was detected in most (61.8%) patients with JIA but rarely in healthy controls (2.6%; P < 0.0001). No antibody reactivity to specific nuclear antigens or other autoantigens associated with connective tissue diseases was detected. However, 20% of patients with JIA harbored antibodies against double-stranded DNA (dsDNA)-nucleosome complexes (compared with 2.6% of controls, P < 0.0001). Finally, the proteome microarray revealed core histone H2A variant H2AFY, part of the nucleosome, to be the most widely recognized human protein by autoantibodies of patients with JIA.Conclusion: Autoantibody reactivity in JIA primarily targets chromatin, but the epitopes targeted are likely either posttranslationally modified or multimolecule epitopes, such as dsDNA-nucleosome complexes, rather than epitopes on individual native proteins or purified dsDNA.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain:comment on the article by Maksymowych et al. 银屑病、葡萄膜炎和结肠炎伴未确诊背痛的两组多中心队列中轴性脊柱炎的特征：对Maksymowych等人文章的评论

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-14 DOI: 10.1002/art.43317

Qing Long,Yan Li

引用次数: 0

Correction to: “Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain” 更正：“银屑病、葡萄膜炎和结肠炎伴未确诊背痛的两组多中心队列中轴性脊柱炎的特征”

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-14 DOI: 10.1002/art.43310

引用次数: 0

Deficiency of cartilage-specific Y-box binding protein 1 represses NF-κB signaling and alleviates osteoarthritis progression. 缺乏软骨特异性Y-box结合蛋白1可抑制NF-κB信号传导并缓解骨关节炎的进展。

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-14 DOI: 10.1002/art.43311

Xinyu Li,Zhao Zhang,Jinwei Xie,Weihua Guo,Zhenhan Deng,Zeyu Huang

{"title":"Deficiency of cartilage-specific Y-box binding protein 1 represses NF-κB signaling and alleviates osteoarthritis progression.","authors":"Xinyu Li,Zhao Zhang,Jinwei Xie,Weihua Guo,Zhenhan Deng,Zeyu Huang","doi":"10.1002/art.43311","DOIUrl":"https://doi.org/10.1002/art.43311","url":null,"abstract":"OBJECTIVETo explore the role of Y-box binding protein 1 (YBX1) in the pathogenesis of osteoarthritis (OA).METHODSThe proteome and phosphoproteome were compared between the intact and osteoarthritic regions of the cartilage from patients undergoing total knee arthroplasty, establishing a connection between the pathology and YBX1 upregulation. Normal C57BL/6 and cartilage-specific Ybx1-deficient mice underwent medial meniscal destabilization surgery; the behavior, micro-computed tomography, and histology were compared. YBX1 was overexpressed in the C28/I2 cell line, and potential binding partners were identified using immunoprecipitation and mass spectrometry. MedChemExpress drug libraries were screened for potential small-molecule inhibitors of YBX1, and candidates were injected intra-articularly into a mouse OA model.RESULTSThe total YBX1 and YBX1 phosphorylated levels at S102 were higher in the osteoarthritic than intact human cartilage. Ybx1 knockout in chondrocytes alleviated disease progression in an OA mouse model. Upregulation of YBX1 in chondrocytes activated NF-κB signaling. Phosphorylation of YBX1 at S102 promoted its entry into the nucleus, where it inhibited NF-κB-repressing factor (NKRF), upregulating target genes of NF-κB. Virtual drug screening identified hesperidin methychalcone and mulberroside A as candidates for inhibiting S102 phosphorylation, alleviating disease progression in an injury-induced OA mouse model.CONCLUSIONYBX1 contributes to OA progression by inhibiting NKRF, activating NF-κB signaling; therefore targeting YBX1 is a potential therapeutic strategy for the treatment of OA.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"9 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rheumatoid arthritis: femoral heads gone with the decade. 类风湿关节炎：股骨头随年代流逝。

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-14 DOI: 10.1002/art.43294

Ting Zhang,Jing Xue

引用次数: 0

Some More Equal Than Others: The Divergence of Cardiac Risk in the Use of NSAIDs Versus Colchicine for Treating and Preventing Gout. 一些比其他更平等：使用非甾体抗炎药与秋水仙碱治疗和预防痛风的心脏风险差异。

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-14 DOI: 10.1002/art.43324

Michael H Pillinger,Michael Toprover

引用次数: 0

C3a-C3aR1-mediated interactions between fibroblast-like synoviocytes and macrophages promote the progression of rheumatoid arthritis. c3a - c3ar1介导的成纤维细胞样滑膜细胞和巨噬细胞之间的相互作用促进类风湿关节炎的进展。

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-14 DOI: 10.1002/art.43319

Minglong Cai,Zhenyu Li,Xi Wen,Huizhi Jin,Yujing Li,Haibo Wu,Chao Yang,Zhu Chen

{"title":"C3a-C3aR1-mediated interactions between fibroblast-like synoviocytes and macrophages promote the progression of rheumatoid arthritis.","authors":"Minglong Cai,Zhenyu Li,Xi Wen,Huizhi Jin,Yujing Li,Haibo Wu,Chao Yang,Zhu Chen","doi":"10.1002/art.43319","DOIUrl":"https://doi.org/10.1002/art.43319","url":null,"abstract":"The inflammatory microenvironment in rheumatoid arthritis (RA) synovium is highly complex, comprising functional units known as cellular neighborhoods (CNs). However, how cell interactions within CNs shape the inflammatory microenvironment in RA remains unclear. Here, we utilized imaging mass cytometry (IMC) and single-cell RNA sequencing to dissect the CNs within RA synovium, uncovering critical cell-cell interactions and evaluating whether disrupting interaction signals could alleviate disease severity in collagen-induced arthritis (CIA) mouse model. Our findings revealed that CNs enriched with fibroblast-like synoviocytes (FLS) and immune cells, particularly FLS and macrophages, were more frequent in RA synovium compared to osteoarthritis (OA). Further single-cell RNA sequencing analysis showed that FLS specifically upregulated complement C3 while macrophages displayed high level of C3 receptor, C3aR1. Interestingly, C3a derived from FLS enhanced type I interferon response in macrophages, and blockade of the C3a-C3aR1 signaling reduced secretion of IFN-β in macrophages, thereby affecting FLS activation. Additionally, inhibition of C3a-C3aR1 signaling attenuated the severity of CIA mice with decreased immune cell infiltration, reduced FLS activation, and less bone destruction. Our study suggests that FLS promotes synovial inflammation via interaction with macrophages through a C3a-C3aR1 signaling-mediated positive feedback regulation. Thus, targeting C3a-C3aR1 signaling might provide a new therapeutic strategy for RA.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"93 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Familial Aggregation in Psoriatic Arthritis: Phenotypic Differences in Patients with and without a Family History of Psoriatic Disease 银屑病关节炎的家族聚集性：有和无银屑病家族史患者的表型差异

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-14 DOI: 10.1002/art.43325

Catherine Howe, Jiyuan Hu, Weixi Chen, Kyra Chen, Adamary Felipe, Stephanie Eichman, Margaret Coyle, Eileen Lydon, Andrea L. Neimann, Soumya Reddy, Jose U. Scher, Rebecca H. Haberman

{"title":"Familial Aggregation in Psoriatic Arthritis: Phenotypic Differences in Patients with and without a Family History of Psoriatic Disease","authors":"Catherine Howe, Jiyuan Hu, Weixi Chen, Kyra Chen, Adamary Felipe, Stephanie Eichman, Margaret Coyle, Eileen Lydon, Andrea L. Neimann, Soumya Reddy, Jose U. Scher, Rebecca H. Haberman","doi":"10.1002/art.43325","DOIUrl":"https://doi.org/10.1002/art.43325","url":null,"abstract":"ObjectivesWhile up to 45% of patients with psoriatic arthritis (PsA) have a family history of psoriatic disease, it is unclear whether this family history contributes to a distinct PsA phenotype and/or timing of disease onset. We aimed to identify differences in onset, domain involvement, and disease activity based on family history of psoriatic disease.Methods843 PsA patients were enrolled in an observational, longitudinal registry. Demographics, medical history, family history, and psoriatic phenotype and activity were collected.Results379 patients (45.0%) had at least one first‐degree (FDR) or second‐degree relative (SDR) with psoriatic disease. Those with a family history developed psoriasis and PsA earlier than those with no family history (27.6 vs. 32.2 years, p < 0.01; 37.6 vs. 40.3, p < 0.01) and were more likely to have entheseal involvement (36.7% vs. 30.0%, p < 0.05). Patients with an FDR/SDR with PsA were diagnosed with psoriasis and PsA earlier than those with an FDR/SDR with psoriasis alone, followed by those with no family history (26.3 vs. 27.8 vs. 32.2 years, p < 0.01; 36.5 vs. 37.9 vs. 40.3 years, p = 0.01).ConclusionIn this cohort, PsA patients with a family history of psoriatic disease were diagnosed with psoriasis and PsA earlier, and were more likely to have entheseal involvement, compared to those without a family history. Further research incorporating molecular and immune features is needed to investigate genetic, environmental and epigenetic factors that impact PsA phenotype and severity, as well as the transition from psoriasis to PsA.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"12 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of B Cell Tolerance in Health and Autoimmunity. 健康和自身免疫中的B细胞耐受机制。

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-10 DOI: 10.1002/art.43316

Sivasankaran Munusamy Ponnan,Shaun W Jackson

引用次数: 0