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Sex Differences in B Cells from the Joints of Children with Oligoarticular Juvenile Idiopathic Arthritis 少关节幼年特发性关节炎儿童关节B细胞的性别差异
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-17 DOI: 10.1002/art.43157
Ki Pui Lam, Claudia Harris, Maria L Taylor, Daniela Fernandez-Salinas, Jing Cui, Biju Issac, Liang Sun, Indu Raman, Chengsong Zhu, Maryrose Hahn, Maryam Ashoor, Ahmad Bakhsh, Maria C Bryant, Siobhan Case, Mia Chandler, Joyce C Chang, Ezra Cohen, Fatma Dedeoglu, Olha Halyabar, Jonathan S Hausmann, Melissa Hazen, Daniel Ibanez, Liyoung Kim, Jeffrey Lo, Mindy S Lo, Esra Meidan, Megan Perron, Helene Powers, Mary Beth Son, Holly Wobma, Erin Janssen, Pui Y Lee, Peter A Nigrovic, Laurie Ohlms, A Eliot Shearer, Margaret H Chang, Maria Gutierrez-Arcelus, Lauren A Henderson
{"title":"Sex Differences in B Cells from the Joints of Children with Oligoarticular Juvenile Idiopathic Arthritis","authors":"Ki Pui Lam, Claudia Harris, Maria L Taylor, Daniela Fernandez-Salinas, Jing Cui, Biju Issac, Liang Sun, Indu Raman, Chengsong Zhu, Maryrose Hahn, Maryam Ashoor, Ahmad Bakhsh, Maria C Bryant, Siobhan Case, Mia Chandler, Joyce C Chang, Ezra Cohen, Fatma Dedeoglu, Olha Halyabar, Jonathan S Hausmann, Melissa Hazen, Daniel Ibanez, Liyoung Kim, Jeffrey Lo, Mindy S Lo, Esra Meidan, Megan Perron, Helene Powers, Mary Beth Son, Holly Wobma, Erin Janssen, Pui Y Lee, Peter A Nigrovic, Laurie Ohlms, A Eliot Shearer, Margaret H Chang, Maria Gutierrez-Arcelus, Lauren A Henderson","doi":"10.1002/art.43157","DOIUrl":"https://doi.org/10.1002/art.43157","url":null,"abstract":"Disordered T peripheral helper (Tph)-B cell interactions have been implicated in several forms of inflammatory arthritis, including oligoarticular juvenile idiopathic arthritis (oligo JIA). We sought to evaluate the Tph-B cell axis in oligo JIA through an analysis of intra-articular B cells.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"24 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143640801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of physical therapy care with utilization of intra-articular injections in people with knee osteoarthritis: a real-world cohort study 物理治疗护理与膝关节骨性关节炎患者关节内注射的关联：一项真实世界的队列研究
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-16 DOI: 10.1002/art.43155
Tuhina Neogi, Maureen Dubreuil, Christine Peloquin, Lee Marinko, James Camarinos, David T. Felson, Deepak Kumar
{"title":"Association of physical therapy care with utilization of intra-articular injections in people with knee osteoarthritis: a real-world cohort study","authors":"Tuhina Neogi, Maureen Dubreuil, Christine Peloquin, Lee Marinko, James Camarinos, David T. Felson, Deepak Kumar","doi":"10.1002/art.43155","DOIUrl":"https://doi.org/10.1002/art.43155","url":null,"abstract":"To assess the relation of physical therapy (PT) timing, dose, and type with risk of future intra-articular therapy use in people with knee osteoarthritis (OA) who receive PT.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"16 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of secukinumab on enthesiophyte and erosion progression in psoriatic arthritis –a one-year double-blind, randomized, placebo-controlled trial utilizing high-resolution peripheral quantitative computed tomography secukinumab对银屑病关节炎并发溃疡和糜烂进展的影响——一项为期一年的双盲、随机、安慰剂对照试验，利用高分辨率外周定量计算机断层扫描
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-14 DOI: 10.1002/art.43154
Yingzhao Jin, Isaac T Cheng, Ho So, Billy T Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk-Chun Szeto, Jack J. Lee, Ling Qin, Lai-Shan Tam
{"title":"Effects of secukinumab on enthesiophyte and erosion progression in psoriatic arthritis –a one-year double-blind, randomized, placebo-controlled trial utilizing high-resolution peripheral quantitative computed tomography","authors":"Yingzhao Jin, Isaac T Cheng, Ho So, Billy T Lai, Shirley K. Ying, Kitty Y. Kwok, James Griffith, Vivian Hung, Cheuk-Chun Szeto, Jack J. Lee, Ling Qin, Lai-Shan Tam","doi":"10.1002/art.43154","DOIUrl":"https://doi.org/10.1002/art.43154","url":null,"abstract":"This study aimed to ascertain the effect of secukinumab on erosion and enthesiophyte progression in psoriatic arthritis (PsA) by high-resolution peripheral quantitative computed tomography (HR-pQCT).","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"23 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nociplasticity: A Proposed Concept to Understand the Symptomatology of Systemic Lupus Erythematosus. 神经可塑性：理解系统性红斑狼疮症状学的一个概念。
IF 11.4 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-10 DOI: 10.1002/art.43152
David S Pisetsky, Jennifer L Rogers, Amanda M Eudy, Katherine T Martucci, Ru-Rong Ji, Peter E Lipsky
{"title":"Nociplasticity: A Proposed Concept to Understand the Symptomatology of Systemic Lupus Erythematosus.","authors":"David S Pisetsky, Jennifer L Rogers, Amanda M Eudy, Katherine T Martucci, Ru-Rong Ji, Peter E Lipsky","doi":"10.1002/art.43152","DOIUrl":"10.1002/art.43152","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antifibrotic effects of specific targeting of the 5-hydroxytryptamine 2B receptor (5-HT2BR) in murine models and ex vivo models of scleroderma skin. 特异性靶向5-羟色胺2B受体（5-HT2BR）在小鼠模型和硬皮病皮肤离体模型中显示出抗纤维化作用。
IF 11.4 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-10 DOI: 10.1002/art.43151
Thuong Trinh-Minh, Cuong Tran-Manh, Andrea-Hermina Györfi, Nicholas Dickel, Christoph Liebel, Xiang Zhou, Jiucun Wang, Meik Kunz, Helena Arozenius, Lars Pettersson, Sam Lindgren, Christina Wenglén, Jörg H W Distler
{"title":"Antifibrotic effects of specific targeting of the 5-hydroxytryptamine 2B receptor (5-HT<sub>2B</sub>R) in murine models and ex vivo models of scleroderma skin.","authors":"Thuong Trinh-Minh, Cuong Tran-Manh, Andrea-Hermina Györfi, Nicholas Dickel, Christoph Liebel, Xiang Zhou, Jiucun Wang, Meik Kunz, Helena Arozenius, Lars Pettersson, Sam Lindgren, Christina Wenglén, Jörg H W Distler","doi":"10.1002/art.43151","DOIUrl":"10.1002/art.43151","url":null,"abstract":"<p><strong>Objective: </strong>Systemic sclerosis (SSc) is a connective tissue disease with fibrotic remodeling of the skin and various internal organs. SSc is associated with the highest case-specific mortality of all rheumatic autoimmune diseases with limited antifibrotic treatment options. Here, we evaluated the therapeutic effects of the highly selective 5-hydroxytryptamine 2B receptor (5-HT<sub>2B</sub>R) inhibitor AM1476.</p><p><strong>Methods: </strong>The antifibrotic effects of AM1476 were evaluated in the mouse models of bleomycin-induced pulmonary fibrosis in Tsk-1 mice and in mice with sclerodermatous chronic graft-versus-host disease. For further validation, the antifibrotic effects of AM1476 were analyzed in precision cut skin (PCS) slices from patients with SSc.</p><p><strong>Results: </strong>AM1476 demonstrated high selectivity for 5-HT<sub>2B</sub>R over more than 200 other receptors, including other 5-HT receptors in vitro. AM1476 reduced accumulation of hydroxyproline and fibrotic tissue remodeling of skin and/or lungs in all three mouse models at well-tolerated doses with a comparable efficacy to that of nintedanib. In PCS of SSc skin, treatment with AM1476 reduced the expression of SSc-specific signature genes. AM1476 demonstrated more pronounced regulation of terms related to fibroblast activation and fibrotic remodeling than mycophenolate mofetil.</p><p><strong>Conclusion: </strong>We describe AM1476 as a highly selective inhibitor of 5-HT<sub>2B</sub>R. Treatment with AM1476 ameliorated fibrosis in three mouse models of SSc and normalized the expression of fibrosis-related genes directly in SSc skin. Because AM1476 also demonstrated good tolerability in a phase 1 trial, further clinical trials with AM1476 are currently in the planning stage.</p>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Minimal Tofacitinib dose for Maintenance in Axial Spondyloarthritis: Real world data from a Resource-limited setting 用于维持轴型脊柱炎的最小托法替尼剂量：来自资源有限环境的真实世界数据
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-03 DOI: 10.1002/art.43147
Anu Sreekanth, Justin George, Sakir Ahmed, Pankti Mehta, Sanjo Saijan, Aparna R Menon, Bhowmik Meghnathi, Padmanabha Shenoy D
{"title":"Minimal Tofacitinib dose for Maintenance in Axial Spondyloarthritis: Real world data from a Resource-limited setting","authors":"Anu Sreekanth, Justin George, Sakir Ahmed, Pankti Mehta, Sanjo Saijan, Aparna R Menon, Bhowmik Meghnathi, Padmanabha Shenoy D","doi":"10.1002/art.43147","DOIUrl":"https://doi.org/10.1002/art.43147","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"5 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of pathogenic PD-1+CD8+ T cells for effective chimeric antigen receptor therapy in a murine model of Sjögren's disease 鉴定致病性PD-1+CD8+ T细胞在小鼠Sjögren病模型中的有效嵌合抗原受体治疗
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-03 DOI: 10.1002/art.43144
Jin-Fen Ma, Ting Xu, Hao-Xian Zhu, Xiao-Min Chen, Liang Li, Zhi-Bin Zhao, Liwei Lu, Yang Li, Zhe-Xiong Lian, Cai-Yue Gao
{"title":"Identification of pathogenic PD-1+CD8+ T cells for effective chimeric antigen receptor therapy in a murine model of Sjögren's disease","authors":"Jin-Fen Ma, Ting Xu, Hao-Xian Zhu, Xiao-Min Chen, Liang Li, Zhi-Bin Zhao, Liwei Lu, Yang Li, Zhe-Xiong Lian, Cai-Yue Gao","doi":"10.1002/art.43144","DOIUrl":"https://doi.org/10.1002/art.43144","url":null,"abstract":"Activated T cells play a pivotal pathogenic role in the progression of Sjögren's disease (SjD); however, there are currently no targeted therapies specifically designed to address them. This study aims to identify pathogenic CD8<sup>+</sup> T cells in SjD and develop targeted therapeutic strategies.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"84 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Concordance Between Ultrasound and Physical Examination in Enthesitis Assessment: A Call for Further Investigation 超声与体格检查在阑尾炎评估中的一致性：需要进一步研究
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-03 DOI: 10.1002/art.43150
Andrea Di Matteo, Stefano Di Donato, Emilio Filippucci
{"title":"Response to Concordance Between Ultrasound and Physical Examination in Enthesitis Assessment: A Call for Further Investigation","authors":"Andrea Di Matteo, Stefano Di Donato, Emilio Filippucci","doi":"10.1002/art.43150","DOIUrl":"https://doi.org/10.1002/art.43150","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"1 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concordance Between Ultrasound and Physical Examination in Enthesitis Assessment: A Call for Further Investigation 超声与体格检查在胃炎评估中的一致性：有待进一步研究
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-03 DOI: 10.1002/art.43148
Danxiang Shen, Di Jin, Hongye Xu, James Cheng-Chung Wei, Zhenhua Ying
{"title":"Concordance Between Ultrasound and Physical Examination in Enthesitis Assessment: A Call for Further Investigation","authors":"Danxiang Shen, Di Jin, Hongye Xu, James Cheng-Chung Wei, Zhenhua Ying","doi":"10.1002/art.43148","DOIUrl":"https://doi.org/10.1002/art.43148","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"8 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral Biomarker Signatures in Rheumatoid Arthritis-Associated Interstitial Lung Disease 类风湿关节炎相关间质性肺疾病的外周生物标志物特征
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-03-03 DOI: 10.1002/art.43149
Austin M. Wheeler, Joshua F. Baker, Thomas R. Riley, Tate M. Johnson, Yangyuna Yang, Punyasha Roul, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Gail Kerr, Dana P. Ascherman, Paul Monach, Andreas Reimold, Scott Matson, Jill A. Poole, Michael J. Duryee, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England
{"title":"Peripheral Biomarker Signatures in Rheumatoid Arthritis-Associated Interstitial Lung Disease","authors":"Austin M. Wheeler, Joshua F. Baker, Thomas R. Riley, Tate M. Johnson, Yangyuna Yang, Punyasha Roul, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Gail Kerr, Dana P. Ascherman, Paul Monach, Andreas Reimold, Scott Matson, Jill A. Poole, Michael J. Duryee, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England","doi":"10.1002/art.43149","DOIUrl":"https://doi.org/10.1002/art.43149","url":null,"abstract":"Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a significant cause of morbidity and mortality among patients with RA, yet effective risk stratification for RA-ILD is lacking. We sought to characterize unique peripheral blood biomarker signatures in RA that could improve RA-ILD discrimination beyond clinical and genetic risk factors.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"52 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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