Arthritis & Rheumatology最新文献

{"title":"Complement","authors":"Paul A. Monach","doi":"10.1002/art.42671","DOIUrl":"10.1002/art.42671","url":null,"abstract":"<p>The role of complement in human autoimmune, inflammatory, and infectious diseases is reviewed, focusing on clinical applicability. A typical case is presented in which serum testing for C3 and C4 is performed to help assess a syndrome with a broad differential diagnosis. The review includes a discussion of complement deficiency states, consumption of complement by diseases characterized by immune-complex formation and deposition, usefulness and interpretation of laboratory tests for complement, and development of drugs targeting specific components of the complement pathway for a growing number of indications.</p>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"76 1","pages":"1-8"},"PeriodicalIF":13.3,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10310705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the interplay of gout, genetic factors, and dietary influences: comment on the article by Lin et al","authors":"Wei-Chiao Kao,&nbsp;Po-Cheng Shih,&nbsp;James Cheng-Chung Wei","doi":"10.1002/art.42670","DOIUrl":"10.1002/art.42670","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"76 1","pages":"146"},"PeriodicalIF":13.3,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9951657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoantibody and Cancer Connection in Systemic Sclerosis: Type and Overlap Matter","authors":"Shervin Assassi","doi":"10.1002/art.42669","DOIUrl":"10.1002/art.42669","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"76 1","pages":"11-13"},"PeriodicalIF":13.3,"publicationDate":"2023-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10326459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tmem178 Negatively Regulates IL-1β Production Through Inhibition of the NLRP3 Inflammasome","authors":"Kunjan Khanna,&nbsp;Hui Yan,&nbsp;Muneshwar Mehra,&nbsp;Nidhi Rohatgi,&nbsp;Gabriel Mbalaviele,&nbsp;Elizabeth D. Mellins,&nbsp;Roberta Faccio","doi":"10.1002/art.42666","DOIUrl":"10.1002/art.42666","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Inflammasomes modulate the release of bioactive interleukin (IL)-1β. Excessive IL-1β levels are detected in patients with systemic juvenile idiopathic arthritis (sJIA) and cytokine storm syndrome (CSS) with mutated and unmutated inflammasome components, raising questions on the mechanisms of IL-1β regulation in these disorders.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To investigate how the NLRP3 inflammasome is modulated in sJIA, we focused on Transmembrane protein 178 (Tmem178), a negative regulator of calcium levels in macrophages, and measured IL-1β and caspase-1 activation in wild-type (WT) and <i>Tmem178</i>^−/− macrophages after calcium chelators, silencing of Stim1, a component of store-operated calcium entry (SOCE), or by expressing a Tmem178 mutant lacking the Stromal Interaction Molecule 1 (Stim1) binding site. Mitochondrial function in both genotypes was assessed by measuring oxidative respiration, mitochondrial reactive oxygen species (mtROS), and mitochondrial damage. CSS development was analyzed in <i>Perforin</i>^−/−/<i>Tmem178</i>^−/− mice infected with lymphocytic choriomeningitis virus (LCMV) in which inflammasome or IL-1β signaling was pharmacologically inhibited. Human <i>TMEM178</i> and <i>IL1B</i> transcripts were analyzed in data sets of whole blood and peripheral blood monocytes from healthy controls and patients with active sJIA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>TMEM178</i> levels are reduced in whole blood and monocytes from patients with sJIA while <i>IL1B</i> levels are increased. Accordingly, <i>Tmem178</i>^−/− macrophages produce elevated IL-1β compared with WT cells. The elevated intracellular calcium levels after SOCE activation in <i>Tmem178</i>^−/− macrophages induce mitochondrial damage, release mtROS, and ultimately promote NLRP3 inflammasome activation. In vivo, inhibition of inflammasome or IL-1β neutralization prolongs <i>Tmem178</i>^−/− mouse survival in LCMV-induced CSS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Down-regulation of <i>TMEM178</i> levels may represent a marker of disease activity and help identify patients who could benefit from inflammasome targeting.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"76 1","pages":"107-118"},"PeriodicalIF":13.3,"publicationDate":"2023-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10018845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Gephyrin Antibodies: A Novel Specificity in Patients With Systemic Sclerosis and Lower Bowel Dysfunction","authors":"Zsuzsanna H. McMahan,&nbsp;Subhash Kulkarni,&nbsp;Felipe Andrade,&nbsp;Jamie Perin,&nbsp;Chengxiu Zhang,&nbsp;Jody E. Hooper,&nbsp;Fredrick M. Wigley,&nbsp;Antony Rosen,&nbsp;Pankaj J. Pasricha,&nbsp;Livia Casciola-Rosen","doi":"10.1002/art.42667","DOIUrl":"10.1002/art.42667","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Autoantibodies are clinically useful in phenotyping patients with systemic sclerosis (SSc). Gastrointestinal (GI) function is regulated by the enteric nervous system (ENS) and commonly impaired in SSc, suggesting that the SSc autoimmune response may target ENS antigens. We sought to identify novel anti-ENS autoantibodies with an aim to clinically phenotype SSc GI dysfunction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Serum from a patient with SSc with GI dysfunction but without defined SSc-associated autoantibodies was used for autoantibody discovery. Immunoprecipitations performed with murine myenteric plexus lysates were on-bead digested, and autoantigens were identified by mass spectrometry. Prevalence was determined, and clinical features associated with novel autoantibodies were evaluated in a SSc cohort using regression analyses. The expression of gephyrin in human GI tract tissue was examined by immunohistochemistry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified gephyrin as a novel SSc autoantigen. Anti-gephyrin antibodies were present in 9% of patients with SSc (16/188) and absent in healthy controls (0/46). Anti-gephyrin antibody–positive patients had higher constipation scores (1.00 vs 0.50, <i>P</i> = 0.02) and were more likely to have severe constipation and severe distention/bloating (46% vs 15<i>%</i>, <i>P</i> = 0.005; 54% vs 25%, <i>P</i> = 0.023, respectively). Anti-gephyrin antibody levels were significantly higher among patients with severe constipation (0.04 vs 0.00<i>; P</i> = 0.001) and severe distention and bloating (0.03 vs 0.004<i>; P</i> = 0.010). Severe constipation was associated with anti-gephyrin antibodies even in the adjusted model. Importantly, gephyrin was expressed in the ENS, which regulates gut motility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Gephyrin is a novel ENS autoantigen that is expressed in human myenteric ganglia. Anti-gephyrin autoantibodies are associated with the presence and severity of constipation in patients with SSc.</p>\u0000 </section>\u0000 </div>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"76 1","pages":"92-99"},"PeriodicalIF":13.3,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10102460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposomal AntagomiR-155-5p Restores Anti-Inflammatory Macrophages and Improves Arthritis in Preclinical Models of Rheumatoid Arthritis","authors":"Audrey Paoletti,&nbsp;Bineta Ly,&nbsp;Catherine Cailleau,&nbsp;Fan Gao,&nbsp;Marie Péan de Ponfilly-Sotier,&nbsp;Juliette Pascaud,&nbsp;Elodie Rivière,&nbsp;Luxin Yang,&nbsp;Lilian Nwosu,&nbsp;Aziza Elmesmari,&nbsp;Franceline Reynaud,&nbsp;Magali Hita,&nbsp;David Paterson,&nbsp;Julien Reboud,&nbsp;Francois Fay,&nbsp;Gaetane Nocturne,&nbsp;Nicolas Tsapis,&nbsp;Iain B. McInnes,&nbsp;Mariola Kurowska-Stolarska,&nbsp;Elias Fattal,&nbsp;Xavier Mariette","doi":"10.1002/art.42665","DOIUrl":"10.1002/art.42665","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We previously reported an increased expression of microRNA-155 (miR-155) in the blood monocytes of patients with rheumatoid arthritis (RA) that could be responsible for impaired monocyte polarization to anti-inflammatory M2-like macrophages. In this study, we employed two preclinical models of RA, collagen-induced arthritis and K/BxN serum transfer arthritis, to examine the therapeutic potential of antagomiR-155-5p entrapped within PEGylated (polyethylene glycol [PEG]) liposomes in resolution of arthritis and repolarization of monocytes towards the anti-inflammatory M2 phenotype.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>AntagomiR-155-5p or antagomiR-control were encapsulated in PEG liposomes of 100 nm in size and −10 mV in zeta potential with high antagomiR loading efficiency (above 80%). Mice were injected intravenously with 1.5 nmol/100 μL PEG liposomes containing antagomiR-155-5p or control after the induction of arthritis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We demonstrated the biodistribution of fluorescently tagged PEG liposomes to inflamed joints one hour after the injection of fluorescently tagged PEG liposomes, as well as the liver's subsequent accumulation after 48 hours, indicative of hepatic clearance, in mice with arthritis. The injection of PEG liposomes containing antagomiR-155-5p decreased arthritis score and paw swelling compared with PEG liposomes containing antagomiR-control or the systemic delivery of free antagomiR-155-5p. Moreover, treatment with PEG liposomes containing antagomiR-155-5p led to the restoration of bone marrow monocyte defects in anti-inflammatory macrophage differentiation without any significant functional change in other immune cells, including splenic B and T cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The injection of antagomiR-155-5p encapsulated in PEG liposomes allows the delivery of small RNA to monocytes and macrophages and reduces joint inflammation in murine models of RA, providing a promising strategy in human disease.</p>\u0000 \u0000 <div>\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </div>\u0000 </section>\u0000 </div>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"76 1","pages":"18-31"},"PeriodicalIF":13.3,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.42665","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9916668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Connections","authors":"","doi":"10.1002/art.42207","DOIUrl":"10.1002/art.42207","url":null,"abstract":"cleavage of gasdermin superfamily proteins, leading to the formation of membrane pores. The formation of pores and the increased permeability of cell membranes promote the release of cellular contents that trigger and sustain inflammation. Ebata et al found that inhibiting noncanonical pyroptosis in chondrocytes suppressed the production of catabolic factors in vitro and cartilage degeneration in vivo. These data demonstrate that pyroptosis signaling represents an attractive target for preventing car tilage degeneration and the progression of OA.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"75 8","pages":""},"PeriodicalIF":13.3,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.42207","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5849358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal Club","authors":"","doi":"10.1002/art.42208","DOIUrl":"10.1002/art.42208","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"75 8","pages":""},"PeriodicalIF":13.3,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.42208","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5849359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information - General Info","authors":"","doi":"10.1002/art.42206","DOIUrl":"10.1002/art.42206","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"75 8","pages":""},"PeriodicalIF":13.3,"publicationDate":"2023-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.42206","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"5863606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease","authors":"Abhishek Abhishek,&nbsp;Sara K. Tedeschi,&nbsp;Tristan Pascart,&nbsp;Augustin Latourte,&nbsp;Nicola Dalbeth,&nbsp;Tuhina Neogi,&nbsp;Amy Fuller,&nbsp;Ann Rosenthal,&nbsp;Fabio Becce,&nbsp;Thomas Bardin,&nbsp;Hang Korng Ea,&nbsp;Georgios Filippou,&nbsp;John FitzGerald,&nbsp;AnnaMaria Iagnocco,&nbsp;Frédéric Lioté,&nbsp;Geraldine M. McCarthy,&nbsp;Roberta Ramonda,&nbsp;Pascal Richette,&nbsp;Francisca Sivera,&nbsp;Mariano Andres,&nbsp;Edoardo Cipolletta,&nbsp;Michael Doherty,&nbsp;Eliseo Pascual,&nbsp;Fernando Perez-Ruiz,&nbsp;Alexander So,&nbsp;Tim L. Jansen,&nbsp;Minna J. Kohler,&nbsp;Lisa K. Stamp,&nbsp;Janeth Yinh,&nbsp;Antonella Adinolfi,&nbsp;Uri Arad,&nbsp;Thanda Aung,&nbsp;Eva Benillouche,&nbsp;Alessandra Bortoluzzi,&nbsp;Jonathan Dau,&nbsp;Ernest Maningding,&nbsp;Meika A. Fang,&nbsp;Fabiana A. Figus,&nbsp;Emilio Filippucci,&nbsp;Janine Haslett,&nbsp;Matthijs Janssen,&nbsp;Marian Kaldas,&nbsp;Maryann Kimoto,&nbsp;Kelly Leamy,&nbsp;Geraldine M. Navarro,&nbsp;Piercarlo Sarzi-Puttini,&nbsp;Carlo Scirè,&nbsp;Ettore Silvagni,&nbsp;Silvia Sirotti,&nbsp;John R. Stack,&nbsp;Linh Truong,&nbsp;Chen Xie,&nbsp;Chio Yokose,&nbsp;Alison M. Hendry,&nbsp;Robert Terkeltaub,&nbsp;William J. Taylor,&nbsp;Hyon K. Choi","doi":"10.1002/art.42619","DOIUrl":"10.1002/art.42619","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Calcium pyrophosphate deposition (CPPD) disease is prevalent and has diverse presentations, but there are no validated classification criteria for this symptomatic arthritis. The American College of Rheumatology (ACR) and EULAR have developed the first-ever validated classification criteria for symptomatic CPPD disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Supported by the ACR and EULAR, a multinational group of investigators followed established methodology to develop these disease classification criteria. The group generated lists of candidate items and refined their definitions, collected de-identified patient profiles, evaluated strengths of associations between candidate items and CPPD disease, developed a classification criteria framework, and used multi-criterion decision analysis to define criteria weights and a classification threshold score. The criteria were validated in an independent cohort.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among patients with joint pain, swelling, or tenderness (entry criterion) whose symptoms are not fully explained by an alternative disease (exclusion criterion), the presence of crowned dens syndrome or calcium pyrophosphate crystals in synovial fluid are sufficient to classify a patient as having CPPD disease. In the absence of these findings, a score &gt;56 points using weighted criteria, comprising clinical features, associated metabolic disorders, and results of laboratory and imaging investigations, can be used to classify as CPPD disease. These criteria had a sensitivity of 92.2% and specificity of 87.9% in the derivation cohort (190 CPPD cases, 148 mimickers), whereas sensitivity was 99.2% and specificity was 92.5% in the validation cohort (251 CPPD cases, 162 mimickers).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The 2023 ACR/EULAR CPPD disease classification criteria have excellent performance characteristics and will facilitate research in this field.</p>\u0000 </section>\u0000 </div>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"75 10","pages":"1703-1713"},"PeriodicalIF":13.3,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.42619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41084350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}