Arthritis & Rheumatology最新文献

{"title":"Clinical manifestations of VEXAS syndrome across a broad spectrum of UBA1 mutation burden","authors":"Meghan Anderson, Defne Ercelen, Ashley Richardson, Jung Kim, Rebecca I. Torene, Maria Sirenko, Jeremy S. Haley, Adam Cook, Wesley Hill, James Dove, Kyle Retterer, Eitan Carroll, David J. Carey, Samira Asgari, Douglas R. Stewart, David B. Beck","doi":"10.1002/art.43327","DOIUrl":"https://doi.org/10.1002/art.43327","url":null,"abstract":"ObjectiveVEXAS is a progressive systemic autoinflammatory disorder caused by somatic variants in <jats:italic>UBA1</jats:italic> in blood. Previous analyses have shown discordant disease penetrance. In this study, we examine the associations between demographic features and <jats:italic>UBA1</jats:italic> variant allele frequency (VAF) with disease manifestations.MethodsWhole exome sequencing data from 192,584 participants from Geisinger MyCode Community Health Initiative and Mount Sinai Bio<jats:italic>Me</jats:italic> Biobank were analyzed for disease‐causing variants in <jats:italic>UBA1</jats:italic>. Clinical manifestations were analyzed across individuals with <jats:italic>UBA1</jats:italic>‐variant.ResultsNine <jats:italic>UBA1</jats:italic> variants (VAF range 2.9%‐79%), in 23 participants (69.6% male) were identified. Cases with high VAF (&gt;20%) developed macrocytic anemia more often (87.5%) than patients with low VAF (≤ 20%) variants (27%; p=0.009). Specifically at the time of genetic testing, 87.5% of high VAF cases had macrocytic anemia, compared to 13.3% of low VAF cases (p=0.001). However, there was no significant difference in the development of anemia or thrombocytopenia (p=0.53). In two high VAF cases, macrocytosis developed more than 5 years prior to time of sample collection, followed by anemia approximately at the time of sample collection. In one low VAF case with other inflammatory symptoms, macrocytic anemia did not develop until 5 years after sample collection.ConclusionVEXAS syndrome disease severity and penetrance increase at higher VAFs. Low VAF cases demonstrate incomplete penetrance and those with disease tend to be milder. Females are enriched in lower VAFs and have milder symptoms suggesting a protective role against disease severity. Low VAF cases, especially ≤ 10%, can be initially asymptomatic and later develop disease.<jats:boxed-text content-type=\"graphic\" position=\"anchor\"><jats:graphic xmlns:xlink=\"http://www.w3.org/1999/xlink\" mimetype=\"image/png\" position=\"anchor\" specific-use=\"enlarged-web-image\" xlink:href=\"graphic/art43327-toc-0001-m.png\"><jats:alt-text>image</jats:alt-text></jats:graphic></jats:boxed-text>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"26 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADAM9 promotes glycolysis in Th17 cells and autoimmunity through activation of IGF‐1 signaling","authors":"Kohei Karino, Masataka Umeda, Theodoros Vichos, Wenliang Pan, Michihito Kono, Maria G. Tsokos, George C. Tsokos","doi":"10.1002/art.43313","DOIUrl":"https://doi.org/10.1002/art.43313","url":null,"abstract":"ObjectivesIL‐17‐producing CD4<jats:sup>+</jats:sup> T helper (Th17) cells contribute to the pathogenesis of autoimmune diseases, including crescentic glomerulonephritis. Although a disintegrin and metalloproteinase 9 (ADAM9) has been reported to contribute to organ inflammation, the mechanism remains poorly understood. The goal of the current study was to investigate how ADAM9 alters T cell metabolism to promote the generation of Th17 cell differentiation.MethodsWe induced anti‐glomerular basement membrane (GBM) glomerulonephritis in <jats:italic>Adam9</jats:italic><jats:sup>+/+</jats:sup> and <jats:italic>Adam9</jats:italic><jats:sup>−/−</jats:sup> mice using sheep anti‐GBM IgG and compared disease severity. Glycolysis in Th17 cells was measured using a Seahorse XFp Extracellular Flux Analyzer, and metabolomic analysis was conducted on Th17 cells from both <jats:italic>Adam9</jats:italic><jats:sup>+/+</jats:sup> and <jats:italic>Adam9</jats:italic><jats:sup>−/−</jats:sup> mice. We measured the glucose transporter 1 (GLUT1) expression in Th17 cells from <jats:italic>Adam9</jats:italic><jats:sup>+/+</jats:sup> and <jats:italic>Adam9</jats:italic><jats:sup>−/−</jats:sup> mice and insulin like growth factor 1 (IGF‐1) treated Th17 cells. Finally, we assessed the protease activity of ADAM9 on IGF binding protein 4 (IGFBP4).ResultsMice deficient in ADAM9 had limited numbers of kidney‐infiltrating CD4+ T cells and suffered reduced kidney damage and inflammation following the injection of sheep anti‐GBM IgG. ADAM9 deficiency led to decreased GLUT1 expression and glycolysis in Th17 cells. Mechanistically, we found that ADAM9 cleaved IGFBP4 and enabled the release of IGF‐1, which enhanced the expression of GLUT1 and promoted glycolysis.ConclusionsBy cleaving IGFBP4, ADAM9 releases IGF‐1, which in turn upregulates GLUT1 expression and promotes glycolysis in Th17 cells. These findings suggest that targeting ADAM9 or blocking IGF‐1 should provide a therapeutic strategy for autoimmune diseases.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"47 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"B cells and systemic sclerosis interstitial lung disease.","authors":"Nina Goldman,Voon Ong,Christopher Denton","doi":"10.1002/art.43326","DOIUrl":"https://doi.org/10.1002/art.43326","url":null,"abstract":"Interstitial lung disease is an important complication of systemic sclerosis (SSc-ILD) with high mortality and morbidity. Recent clinical studies in SSc-ILD have led to FDA-approved therapies in SSc-ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune rheumatic diseases. Pathogenesis of SSc-ILD involves interplay between fibroblasts and the innate and adaptive immune system. A central role for the B cell compartment is supported by clinical and translational studies. We use a case from our centre as a basis to discuss the pathogenesis of SSc-ILD, autoantibodies in SSc-ILD and the role of B cells in the disease. We go on to consider treatment options for the case, the decision-making algorithm for treatment and also risks associated with treatment.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"109 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of specific pesticides and incident rheumatoid arthritis among female spouses in the Agricultural Health Study.","authors":"Christine G Parks,Darya Leyzarovich,Ghassan B Hamra,Karen H Costenbader,Dazhe Chen,Jonathan N Hofmann,Laura E Beane Freeman,Dale P Sandler","doi":"10.1002/art.43318","DOIUrl":"https://doi.org/10.1002/art.43318","url":null,"abstract":"OBJECTIVESGrowing evidence suggests farming and agricultural pesticide use may be associated with rheumatoid arthritis (RA), but few studies have examined specific pesticides and RA among farm women, who may personally use pesticides or be indirectly exposed. We investigated pesticide use and RA risk among female spouses of licensed pesticide applicators in the Agricultural Health Study.METHODSParticipants enrolled in 1993-1997 in North Carolina and Iowa (N=32,126). Incident RA cases were identified in follow-up questionnaires (1999-2021) and confirmed by medical records, relevant medication use, or Medicare claims data (1999-2016), or from Medicare claims if lacking questionnaire data on RA. Non-cases reported no RA and had no RA Medicare claims. Among those with complete covariate data (N=410 cases and 21,850 non-cases), we examined associations with pesticide classes and 32 specific pesticides (personal lifetime use reported at enrollment, updated in 1999-2003). We calculated odds ratios (OR) and 95% confidence intervals (CI), adjusting for age, state, education, smoking pack-years smoking, body mass index, and correlated pesticides (rho>0.35).RESULTSIncident RA was associated with use of organochlorine [DDT (1.89;1.30-2.75), lindane (1.97;1.12-3.47)] and organophosphate insecticides [coumaphos (2.32;1.29-4.19), malathion (1.21;0.91-1.62)], the carbamate insecticide carbofuran (1.87;0.97-3.63), and permethrin or pyrethroid insecticides use on crops (1.56;0.92-2.64) or livestock (1.69;1.07-2.68). RA was not associated with using herbicides, except for metribuzin (1.88;0.94-3.79). The fungicides captan (1.78;1.13-2.83) and metalaxyl (2.49;1.41-4.40) were also associated with RA.DISCUSSIONThese findings indicate that persistent organochlorine insecticides and some pesticides also used in public health or residential settings may increase RA risk in women.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"15 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of flame sign for acute gluteus medius calcific tendinitis.","authors":"De-An Qin,Qi-Jun An,Jie Yuan","doi":"10.1002/art.43321","DOIUrl":"https://doi.org/10.1002/art.43321","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"2 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply.","authors":"Walter P Maksymowych, Robert G Lambert, Jonathan Chan","doi":"10.1002/art.43314","DOIUrl":"10.1002/art.43314","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appendix Vasculitis in a Patient with Intestinal Behçet's Disease.","authors":"Hui Tian,Jing Ye,Zhao Li,Jingrun Zhao","doi":"10.1002/art.43331","DOIUrl":"https://doi.org/10.1002/art.43331","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"109 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144640192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoantibody Response Toward Chromatin in Patients With Juvenile Idiopathic Arthritis.","authors":"Viola Pitkänen, Terhi Remes-Pakarinen, Paula Vähäsalo, Milja Möttönen, Minna-Maija Grönlund, Miika Arvonen, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen, Johanna Lempainen, Anna-Mari Schroderus, Liisa Kröger, Tuure Kinnunen","doi":"10.1002/art.43315","DOIUrl":"https://doi.org/10.1002/art.43315","url":null,"abstract":"<p><strong>Objective: </strong>Patients with juvenile idiopathic arthritis (JIA) frequently exhibit antinuclear antibodies (ANAs), but the specific antigen target recognized by them and the presence of additional autoantibody specificities in patients with JIA remains elusive.</p><p><strong>Methods: </strong>Plasma samples from 110 untreated patients with active JIA, as well as from 14 children with unspecified arthritis and 151 age- and sex-matched healthy children, were analyzed with multiple modern clinical-grade autoantibody assays, including automated indirect immunofluorescence to screen for ANAs with HEp-2 cells, and specific immune assays to detect reactivity to individual autoantigens. In addition, a HuProt proteome microarray was used to screen for novel autoantibody targets in plasma samples from five patients with ANA-positive JIA and four ANA-negative healthy controls.</p><p><strong>Results: </strong>Homogeneous nuclear ANA staining, indicating reactivity toward chromatin, was detected in most (61.8%) patients with JIA but rarely in healthy controls (2.6%; P < 0.0001). No antibody reactivity to specific nuclear antigens or other autoantigens associated with connective tissue diseases was detected. However, 20% of patients with JIA harbored antibodies against double-stranded DNA (dsDNA)-nucleosome complexes (compared with 2.6% of controls, P < 0.0001). Finally, the proteome microarray revealed core histone H2A variant H2AFY, part of the nucleosome, to be the most widely recognized human protein by autoantibodies of patients with JIA.</p><p><strong>Conclusion: </strong>Autoantibody reactivity in JIA primarily targets chromatin, but the epitopes targeted are likely either posttranslationally modified or multimolecule epitopes, such as dsDNA-nucleosome complexes, rather than epitopes on individual native proteins or purified dsDNA.</p>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain:comment on the article by Maksymowych et al.","authors":"Qing Long,Yan Li","doi":"10.1002/art.43317","DOIUrl":"https://doi.org/10.1002/art.43317","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"34 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: “Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain”","authors":"","doi":"10.1002/art.43310","DOIUrl":"https://doi.org/10.1002/art.43310","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"93 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}