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Arthritis & Rheumatology最新文献

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Reply, SARD-ILD Screening and Monitoring Recommendations with low certainty evidence 答复：低确定性证据的SARD-ILD筛查和监测建议
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-12 DOI: 10.1002/art.43111
Sindhu R Johnson, Marcy Bolster, Sonye K Danoff, Michael George, Gordon Guyatt, Dinesh Khanna, Reza Mirza, Aberdeen Allen, Amy Turner, Elana J. Bernstein
{"title":"Reply, SARD-ILD Screening and Monitoring Recommendations with low certainty evidence","authors":"Sindhu R Johnson, Marcy Bolster, Sonye K Danoff, Michael George, Gordon Guyatt, Dinesh Khanna, Reza Mirza, Aberdeen Allen, Amy Turner, Elana J. Bernstein","doi":"10.1002/art.43111","DOIUrl":"https://doi.org/10.1002/art.43111","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"7 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
UV Light Exposure Induces a Type I Interferon Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes 紫外线照射诱发的I型干扰素依赖激活和炎症树突细胞迁移到局部淋巴结
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-12 DOI: 10.1002/art.43108
Xizhang Sun, Jaime L Chao, Michael Gerner, Keith B Elkon
{"title":"UV Light Exposure Induces a Type I Interferon Dependent Activation and Migration of Inflammatory Dendritic Cells to Local Lymph Nodes","authors":"Xizhang Sun, Jaime L Chao, Michael Gerner, Keith B Elkon","doi":"10.1002/art.43108","DOIUrl":"https://doi.org/10.1002/art.43108","url":null,"abstract":"Photosensitivity occurs in ~75% of lupus patients. Although ultraviolet light radiation (UVR) stimulates Type I interferon (IFN-I) in the skin, how UVR induced skin inflammation leads to downstream effects is poorly understood. Tissue inflammation causes DC to migrate from organs to draining lymph nodes (dLN) including a recently identified inflammatory DC subset (inf cDC2) that are potent antigen presenting cells. To explore links between UVR and the early immune response, we examined DC and lymphocyte subset migration to dLNs in normal and a lupus prone mouse strains as well as the role of IFN-I.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"40 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis-associated interstitial lung disease 火灾、烟雾和其他污染物与类风湿关节炎和类风湿关节炎相关间质性肺疾病的关系
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-12 DOI: 10.1002/art.43113
Vanessa L. Kronzer, Yangyuna Yang, Punyasha Roul, James L. Crooks, Cynthia S. Crowson, John M. Davis, Jeffrey A. Sparks, Jeffrey R. Pierce, Katelyn O'Dell, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England
{"title":"Associations of fire smoke and other pollutants with incident rheumatoid arthritis and rheumatoid arthritis-associated interstitial lung disease","authors":"Vanessa L. Kronzer, Yangyuna Yang, Punyasha Roul, James L. Crooks, Cynthia S. Crowson, John M. Davis, Jeffrey A. Sparks, Jeffrey R. Pierce, Katelyn O'Dell, Brian C. Sauer, Grant W. Cannon, Joshua F. Baker, Ted R. Mikuls, Bryant R. England","doi":"10.1002/art.43113","DOIUrl":"https://doi.org/10.1002/art.43113","url":null,"abstract":"Determine whether pollutants such as fire smoke-related particulate matter smaller than 2.5 microns (PM<sub>2.5</sub>) are associated with incident rheumatoid arthritis (RA) and RA-associated interstitial lung disease (RA-ILD).","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"172 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical role for Transglutaminase 2 in scleroderma skin fibrosis and in the development of dermal sclerosis in a mouse model of scleroderma 在硬皮病小鼠模型中，转谷氨酰胺酶2在硬皮病皮肤纤维化和真皮硬化症发展中的关键作用
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-12 DOI: 10.1002/art.43104
Angela Y.Y. Tam, Korsa Khan, Shiwen Xu, Marianne Bergin, Linghong Huang, Erik Arroyo Colon, Danyi Cheng, Elisabetta AM Verderio, Voon Ong, Christopher P Denton, John Atkinson, Tim S Johnson, David J. Abraham
{"title":"Critical role for Transglutaminase 2 in scleroderma skin fibrosis and in the development of dermal sclerosis in a mouse model of scleroderma","authors":"Angela Y.Y. Tam, Korsa Khan, Shiwen Xu, Marianne Bergin, Linghong Huang, Erik Arroyo Colon, Danyi Cheng, Elisabetta AM Verderio, Voon Ong, Christopher P Denton, John Atkinson, Tim S Johnson, David J. Abraham","doi":"10.1002/art.43104","DOIUrl":"https://doi.org/10.1002/art.43104","url":null,"abstract":"Scleroderma is a life-threatening autoimmune disease characterized by inflammation, tissue remodelling, and fibrosis. This study aimed to investigate the expression and function of transglutaminase 2 (TGM2) in scleroderma skin and experimentally-induced dermal fibrosis to determine its potential role and therapeutic implications.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"27 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune Aging in Rheumatoid Arthritis 类风湿关节炎的免疫老化
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-12 DOI: 10.1002/art.43105
Cornelia M. Weyand, Jörg J. Goronzy
{"title":"Immune Aging in Rheumatoid Arthritis","authors":"Cornelia M. Weyand, Jörg J. Goronzy","doi":"10.1002/art.43105","DOIUrl":"https://doi.org/10.1002/art.43105","url":null,"abstract":"Rheumatoid arthritis (RA) is a life-long autoimmune disease caused by the confluence of genetic and environmental variables that lead to loss of self-tolerance and persistent joint inflammation. RA occurs at the highest incidence in individuals &gt;65 years old, implicating the aging process in disease susceptibility. Transformative approaches in molecular immunology and in functional genomics have paved the way for pathway paradigms underlying the replacement of immune homeostasis with auto-destructive immunity in affected patients, including the process of immune aging. Patients with RA have a signature of premature immune aging, best understood for CD4<sup>+</sup> T cells which function as pathogenic effectors in this HLA class II-associated disease. Premature immune aging is present in healthy HLA-DRB1*04<sup>+</sup> individuals, placing accelerated immune aging prior to joint inflammation. Aging-related molecular abnormalities directly implicated in turning RA CD4<sup>+</sup> T cells into pro-inflammatory effector cells are linked to malfunction of subcellular organelles, such as mitochondria, lysosomes, lipid droplets and the endoplasmic reticulum. Resulting changes in T cell behavior include cellular hypermobility; tissue invasiveness; unopposed mTORC activation; excessive release of tumor necrosis factor α (TNF); lysosomal failure; clonal expansion and immunogenic cell death. Aged and metabolically reprogrammed T cells in RA patients are accompanied by age-associated B cells (ABC), which specialize in autoantibody production. Clonal hematopoiesis drives myeloid cell aging by producing aged monocytes and hypermetabolic macrophages (Mϕ) that sustain the process of inflammaging. Here, we synthesize insights into the relationship of RA risk and immune aging and discuss mechanisms through which immune aging can cause autoimmunity.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"29 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Air Pollution's Hidden Toll: Risks for Rheumatoid Arthritis and RA-Associated Lung Disease 空气污染的隐性代价：类风湿关节炎和ra相关肺部疾病的风险
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-12 DOI: 10.1002/art.43115
S. Ajeganova, J. Sokolove
{"title":"Air Pollution's Hidden Toll: Risks for Rheumatoid Arthritis and RA-Associated Lung Disease","authors":"S. Ajeganova, J. Sokolove","doi":"10.1002/art.43115","DOIUrl":"https://doi.org/10.1002/art.43115","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"21 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142967906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases 评论：2023年美国风湿病学会(ACR)/美国胸科医师学会（Chest）系统性自身免疫性风湿病患者间质性肺病筛查和监测指南
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-09 DOI: 10.1002/art.43106
Julian Segan, Michael Putman, Richard Conway
{"title":"Comment on: 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases","authors":"Julian Segan, Michael Putman, Richard Conway","doi":"10.1002/art.43106","DOIUrl":"https://doi.org/10.1002/art.43106","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"37 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: Limitations in the Real‐World Emulation of the HORIZON Pivotal Fracture Trial 回复：HORIZON关键骨折试验在现实世界模拟中的局限性
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-09 DOI: 10.1002/art.43103
Elvira D'Andrea, Shirley Wang
{"title":"Reply to: Limitations in the Real‐World Emulation of the HORIZON Pivotal Fracture Trial","authors":"Elvira D'Andrea, Shirley Wang","doi":"10.1002/art.43103","DOIUrl":"https://doi.org/10.1002/art.43103","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"101 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avoiding placebo as control treatment in rheumatology trials: can we do better? 在风湿病试验中避免安慰剂作为对照治疗：我们能做得更好吗？
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-09 DOI: 10.1002/art.43107
Maarten Boers
{"title":"Avoiding placebo as control treatment in rheumatology trials: can we do better?","authors":"Maarten Boers","doi":"10.1002/art.43107","DOIUrl":"https://doi.org/10.1002/art.43107","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"23 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Limitations in the Real‐World Emulation of the HORIZON Pivotal Fracture Trial HORIZON关键骨折试验仿真的局限性
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-01-09 DOI: 10.1002/art.43102
Peng Shih‐Kuei, Poi Kuo, James Cheng‐Chung Wei
{"title":"Limitations in the Real‐World Emulation of the HORIZON Pivotal Fracture Trial","authors":"Peng Shih‐Kuei, Poi Kuo, James Cheng‐Chung Wei","doi":"10.1002/art.43102","DOIUrl":"https://doi.org/10.1002/art.43102","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"56 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142936750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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