Arthritis & Rheumatology最新文献_第8页

Journal Club 杂志俱乐部

IF 10.9 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-30 DOI: 10.1002/art.43335

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Reply. 回复。

IF 10.9 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-28 DOI: 10.1002/art.43343

Lisa R Sammaritano, Anca Askanase, Bonnie L Bermas, Maria Dall'Era, Ali Duarte-Garcia, Linda T Hiraki, Brad H Rovin, Mary Beth F Son, Amy S Turner, Reem A Mustafa

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Clinical Images: Transient perivascular inflammation of the carotid artery syndrome: Comment on the article by Namineni et al 临床影像：颈动脉短暂性血管周围炎症综合征：对Namineni等文章的评论

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-28 DOI: 10.1002/art.43344

Takao Nagashima

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Clinical Images: Methotrexate-induced melanonychia. Methotrexate-induced黑甲。

IF 10.9 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-28 DOI: 10.1002/art.43340

Yoshinori Taniguchi, Hirotaka Yamamoto

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"Making the most of advanced CT imaging techniques for medical decision making in arthritis imaging." “利用最先进的CT成像技术进行关节炎成像的医疗决策。”

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-28 DOI: 10.1002/art.43342

John A. Carrino

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Pharmacological Weight Loss in Gout Prevention: Emphasizing Dynamic Risk Assessment and Community Strategies. 痛风预防的药理学减肥：强调动态风险评估和社区策略。

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-25 DOI: 10.1002/art.43330

Xueneng Yang,Ruijuan Li

引用次数: 0

Serum urate levels alter the spatial distribution of urate crystals in synovium and correlate with synovitis and pain in non-gout female patients with anteromedial knee osteoarthritis. 血清尿酸水平改变了滑膜中尿酸盐晶体的空间分布，并与非痛风女性膝前内侧骨关节炎患者的滑膜炎和疼痛相关。

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-25 DOI: 10.1002/art.43337

Hao Xu,Peng Wang,Haiyang Fu,Longxiao Zhang,Fenggang Xiang,Shuai Xiang

{"title":"Serum urate levels alter the spatial distribution of urate crystals in synovium and correlate with synovitis and pain in non-gout female patients with anteromedial knee osteoarthritis.","authors":"Hao Xu,Peng Wang,Haiyang Fu,Longxiao Zhang,Fenggang Xiang,Shuai Xiang","doi":"10.1002/art.43337","DOIUrl":"https://doi.org/10.1002/art.43337","url":null,"abstract":"OBJECTIVEThis study aimed to investigate alterations in the spatial distribution of urate crystals in the osteoarthritic synovium of patients with different levels of serum uric acid (SUA). Additionally, we examined the association between SUA levels and severity of synovitis and pain in anteromedial osteoarthritis (AMOA) of the knee.METHODSPatients who underwent knee arthroplasty due to AMOA were prospectively enrolled. Blood, synovial fluid, and synovium samples were collected and UA levels were quantified. The degree of synovitis was evaluated histologically, and the levels of inflammatory cytokines in the synovial fluid were measured. The spatial distribution of urate crystals in the synovium was determined using Gomori methenamine silver staining, and the pain subscale of the Western Ontario McMaster Universities Osteoarthritis Index was used to evaluate knee pain. The relationships between SUA, degree of synovitis, and knee pain were assessed using Spearman rank correlation and multivariable analyses.RESULTSThe pattern of urate crystal deposition in the osteoarthritic synovium was significantly altered in populations with different SUA levels. The capillary wall, sublining layer, and lining cells were sequentially affected. SUA level was the only risk factor for high-grade synovitis and severe pain in the multivariate analysis. SUA level was also positively correlated with UA level in the synovial fluid and synovium, Krenn histological score of the synovium, knee pain, and inflammatory cytokine level in the synovial fluid.CONCLUSIONSpatial urate crystal distribution in the synovium was altered when SUA levels were elevated. Elevated SUA levels were also associated with aggravated synovitis and pain.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"13 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of serious infection in patients with rheumatoid arthritis-associated interstitial lung disease or bronchiectasis: A comparative cohort study. 类风湿关节炎相关间质性肺疾病或支气管扩张患者严重感染的风险：一项比较队列研究

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-25 DOI: 10.1002/art.43338

Qianru Zhang,Ying Qi,Xiaosong Wang,Gregory C McDermott,Sung Hae Chang,Mark Chaballa,Vadim Khaychuk,Misti L Paudel,Jeffrey A Sparks

{"title":"Risk of serious infection in patients with rheumatoid arthritis-associated interstitial lung disease or bronchiectasis: A comparative cohort study.","authors":"Qianru Zhang,Ying Qi,Xiaosong Wang,Gregory C McDermott,Sung Hae Chang,Mark Chaballa,Vadim Khaychuk,Misti L Paudel,Jeffrey A Sparks","doi":"10.1002/art.43338","DOIUrl":"https://doi.org/10.1002/art.43338","url":null,"abstract":"OBJECTIVETo investigate the association between rheumatoid arthritis-associated lung disease (RA-LD) and serious infection risk.METHODSWe conducted a retrospective cohort study using the MGB Biobank (Boston, Massachusetts), comparing RA-LD to RA patients without lung disease (RA-no LD), matched by age, sex, and RA duration. RA-LD cases were verified by medical record review and chest imaging for clinically apparent RA-associated interstitial lung disease (RA-ILD) and/or RA-associated bronchiectasis (RA-BR). The primary outcome was serious infection. Incidence rates and propensity score-adjusted subdistribution hazard ratios (sdHR) were calculated using Fine and Gray models to account for competing risk of death.RESULTSAmong 221 RA-LD cases (151 RA-ILD and 70 RA-BR) and 980 RA-no LD comparators, RA-LD had a significantly higher serious infection risk compared to RA-no LD comparators (55.8 vs. 25.8 per 1,000 person-years, sdHR 1.60, 95%CI 1.20-2.12). The increased risk remained significant for RA-ILD cases (sdHR 1.79, 95%CI 1.33-2.41), but not for RA-BR (sdHR 1.19, 95%CI 0.72-1.97). Anatomic sites of infection that were more common in RA-LD included pulmonary, skin and soft tissue, and ear, nose and throat; RA-LD was associated with various pathogen types: virus, bacteria, fungus, and mycobacteria. Specific pathogens with higher frequency in RA-LD cases, particularly among RA-BR, included influenza virus, respiratory syncytial virus, Staphylococcus, Pseudomonas, and nontuberculous mycobacteria.CONCLUSIONRA-LD, particularly RA-ILD, is associated with a significant increased risk of serious infection across anatomic sites and diverse pathogen types. RA-BR is associated with increased pulmonary infections. Prospective studies and trials are needed to clarify optimal approaches to treat patients with RA-LD and reduce infection risk.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"65 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distinct Cancer Risk Profiles in Patients with Systemic Sclerosis with Autoantibody Stratification. 自身抗体分层在系统性硬化症患者中的独特癌症风险概况

IF 13.3 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-25 DOI: 10.1002/art.43339

Arjun Mahajan,Maria Vazquez-Machado,Nikki Zangenah,Jeffrey A Sparks,Avery H LaChance

{"title":"Distinct Cancer Risk Profiles in Patients with Systemic Sclerosis with Autoantibody Stratification.","authors":"Arjun Mahajan,Maria Vazquez-Machado,Nikki Zangenah,Jeffrey A Sparks,Avery H LaChance","doi":"10.1002/art.43339","DOIUrl":"https://doi.org/10.1002/art.43339","url":null,"abstract":"BACKGROUND/PURPOSEPatients with systemic sclerosis (SSc) face increased cancer risk compared to the general population, yet current evidence on specific cancer patterns and their relationship to autoantibody status remains poorly characterized. This study seeks to evaluate cancer risk patterns in SSc patients and investigate associations between specific autoantibodies and cancer development.METHODSThis multi-center cohort study analyzed 5-year cancer incidences in 66,637 adults with SSc versus matched controls with seborrheic keratosis using electronic medical records from 128 healthcare organizations (from 2014-2024). Patients were stratified by autoantibody status (RNA polymerase III, anti-centromere, or anti-Scl-70) where available. Primary outcomes included 5-year incidences of hematologic and solid-organ cancers, with hazard ratios (HRs) calculated via Cox proportional hazards regression.RESULTSSSc patients demonstrated elevated 5-year all-type cancer risk (HR 1.17; 95% CI 1.11-1.23). Hematologic cancer risk was significantly increased (HR 1.68; 95% CI 1.50-1.88), particularly for multiple myeloma (HR 2.13; 95% CI 1.61-2.81) and myelodysplastic syndromes (HR 2.03; 95% CI 1.49-2.77). For solid organ cancers (HR 1.23; 95% CI 1.16-1.31), esophageal cancer showed the highest risk (HR 3.96; 95% CI 2.36-6.65), followed by lung cancer (HR 2.32; 95% CI 2.00-2.69). Among autoantibody subgroups, anti-Scl-70 positive patients showed increased overall cancer risk (HR 1.40; 95% CI 1.03-1.92), RNA Polymerase III positive patients had higher rates of hematologic cancers (HR 2.20; 95% CI 1.10-4.28), while anti-centromere positive patients demonstrated no increased cancer risks.CONCLUSIONSSc patients demonstrate significantly increased risks for both hematologic and solid organ cancers, with risk profiles varying by autoantibody status. These findings suggest the need for targeted cancer screening strategies in SSc and further research to confirm the generalizability of these findings.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"7 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144701225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alu Overexpression Leads to an Increased Double-stranded RNA Signature in Dermatomyositis. Alu过表达导致皮肌炎双链RNA特征增加。

IF 10.9 1区医学

Arthritis & Rheumatology Pub Date : 2025-07-22 DOI: 10.1002/art.43328

Rayan Najjar, Andrew Mammen, Tomas Mustelin

{"title":"Alu Overexpression Leads to an Increased Double-stranded RNA Signature in Dermatomyositis.","authors":"Rayan Najjar, Andrew Mammen, Tomas Mustelin","doi":"10.1002/art.43328","DOIUrl":"10.1002/art.43328","url":null,"abstract":"Objective: Dermatomyositis is an autoimmune condition characterized by a high interferon signature of unknown etiology. Because coding sequences constitute <1.2% of our genomes, there is a need to explore the role of the non-coding genome in disease pathogenesis. Our genomes include roughly 1.2 million Alu elements occupying about 10% of the genome, which can form double-stranded (ds)RNA capable of triggering MDA5 leading to interferon production.Methods: We aligned muscle biopsy RNA sequencing data to the Telomere-to-Telomere reference genome and quantified short interspersed elements including Alus. Since Alus have a propensity to form dsRNA and are the major targets of both ADAR and MDA5, we quantified A-to-I RNA editing, which reflects dsRNA in vivo.Results: Dermatomyositis muscle (n=39) showed a global elevation in Alu expression (including inverted repeat Alus with high potential to form dsRNA), as well as an increased expression of unique Alu elements (n=557, q<0.05) compared to healthy controls (n=34), in a pattern not seen in other myositis types (n=81). The majority (75.3%) of these Alus originated from genomic regions outside genes. A cluster of the uniquely overexpressed Alus (n=167) correlated with interferon stimulated genes and markers of myositis activity. Additionally, we found a uniquely expanded Alu A-to-I editome in dermatomyositis, reflecting an increase in dsRNA. Edited Alus clustered on chromosome 19, which is known to have the highest concentration of dsRNA.Conclusion: We hypothesize that overexpressed Alus in dermatomyositis form endogenous dsRNA that exceed the capacity of RNA editing enzymes and trigger dsRNA sensors leading to interferon production.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":10.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0