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Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury 活动期狼疮性肾炎患儿IgG异常糖基化改变足细胞代谢，引起足细胞损伤
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-29 DOI: 10.1002/art.43200
Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos
{"title":"Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury","authors":"Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos","doi":"10.1002/art.43200","DOIUrl":"https://doi.org/10.1002/art.43200","url":null,"abstract":"Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production. Based on these findings, we hypothesized that IgG glycosylation patterns differentiate SLE with and without LN and that this aberrant glycosylation reprograms podocyte metabolism.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"42 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Connections 临床联系
IF 11.4 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-29 DOI: 10.1002/art.43192
{"title":"Clinical Connections","authors":"","doi":"10.1002/art.43192","DOIUrl":"https://doi.org/10.1002/art.43192","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"77 5","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/art.43192","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143883826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to Guan, et al. 回复关等。
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-28 DOI: 10.1002/art.43206
Katherine A. Yates, Amanda E. Nelson
{"title":"Reply to Guan, et al.","authors":"Katherine A. Yates, Amanda E. Nelson","doi":"10.1002/art.43206","DOIUrl":"https://doi.org/10.1002/art.43206","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"9 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expert Perspectives on a Clinical Challenge: Hematologic Malignancies and Vasculitis 专家对临床挑战的看法：血液恶性肿瘤和血管炎
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-28 DOI: 10.1002/art.43195
Michelle L. Robinette, Hetty E. Carraway
{"title":"Expert Perspectives on a Clinical Challenge: Hematologic Malignancies and Vasculitis","authors":"Michelle L. Robinette, Hetty E. Carraway","doi":"10.1002/art.43195","DOIUrl":"https://doi.org/10.1002/art.43195","url":null,"abstract":"Systemic vasculitis describes a collection of rare diseases each caused by inflammation of blood vessel walls that can cause severe systemic complications [[3, 4]](#ref‐0003). The pattern of vascular inflammation and resultant damage is frequently variable and may be mimicked, or directly triggered, by infection or malignancy. Myeloid and lymphoid hematologic malignancy have long been recognized in association with vasculitis and were recognized by the 2012 Consensus Conference on the Nomenclature of Systemic Vasculitis as vasculitis associated with probable etiology (cancer‐associated) [[4]](#ref‐0004). We will refer to this as vasculitis with concomitant hematological malignancy (VCHM). This is a rapidly evolving field with limited but growing evidence base. Due to increased use of molecular diagnostics in hematologic clinical practice, rheumatologists should be aware of the diagnostic and treatment complexity in rare patients with VCHM, who often have refractory disease and are at risk of comorbidity from both hematologic and inflammatory disease and their treatments. Here, we discuss our collaborative approach to diagnosis and management of VCHM shared between rheumatology and hematology/oncology, in the context of relatively limited literature. We focus on myeloid neoplasia, as a clinically relevant model of the emerging recognition of overlap between our fields, with more limited discussion of associations with lymphoid forms of VCHM such as cryoglobulinemic vasculitis that have been previously discussed in the literature","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"35 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Targeting Long Noncoding RNA H19 in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in Osteoarthritis: Comment on the Article by Wang et al. 靶向软骨下骨细胞长链非编码RNA H19，缓解骨关节炎软骨退化——对Wang等文章的评论
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-28 DOI: 10.1002/art.43201
Suqi Wu, Guangyin Yu, Yankui Leng
{"title":"Targeting Long Noncoding RNA H19 in Subchondral Bone Osteocytes and the Alleviation of Cartilage Degradation in Osteoarthritis: Comment on the Article by Wang et al.","authors":"Suqi Wu, Guangyin Yu, Yankui Leng","doi":"10.1002/art.43201","DOIUrl":"https://doi.org/10.1002/art.43201","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"84 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to “Novel Genetic Loci in Early-Onset Gout Derived From Whole-Genome Sequencing of an Adolescent Gout Cohort” 更正“来自青少年痛风队列全基因组测序的早发性痛风新基因位点”
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-28 DOI: 10.1002/art.43178
{"title":"Correction to “Novel Genetic Loci in Early-Onset Gout Derived From Whole-Genome Sequencing of an Adolescent Gout Cohort”","authors":"","doi":"10.1002/art.43178","DOIUrl":"https://doi.org/10.1002/art.43178","url":null,"abstract":"<p>Ji A, Sui Y, Xuo X, et al. Novel Genetic Loci in Early-Onset Gout Derived From Whole-Genome Sequencing of an Adolescent Gout Cohort. Arthritis Rheumatol. 2025 Jan;77(1):107–115.</p>\u0000<p>In the article noted above, the author name Xiapeng Ji is misspelled. The correct spelling is Xiaopeng Ji.</p>\u0000<p>We apologize for this error.</p>","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"35 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143885072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the Numbers: Recognizing Disease Severity and Hidden Influences in Physical Therapy for Knee osteoarthritis 超越数字：认识疾病严重程度和隐藏的影响在膝骨关节炎的物理治疗
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-28 DOI: 10.1002/art.43205
Yadi Li
{"title":"Beyond the Numbers: Recognizing Disease Severity and Hidden Influences in Physical Therapy for Knee osteoarthritis","authors":"Yadi Li","doi":"10.1002/art.43205","DOIUrl":"https://doi.org/10.1002/art.43205","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"28 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply. 回复。
IF 11.4 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-28 DOI: 10.1002/art.43202
Tuhina Neogi, Maureen Dubreuil, Christine Peloquin, Lee Marinko, James Camarinos, David T Felson, Deepak Kumar
{"title":"Reply.","authors":"Tuhina Neogi, Maureen Dubreuil, Christine Peloquin, Lee Marinko, James Camarinos, David T Felson, Deepak Kumar","doi":"10.1002/art.43202","DOIUrl":"10.1002/art.43202","url":null,"abstract":"","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
3-year Results of Tapering TNFi to Withdrawal Compared to Stable TNFi Among Patients with Rheumatoid Arthritis in Sustained Remission: A Multicenter Randomized Trial 在持续缓解的类风湿关节炎患者中，逐渐减少TNFi至停药与稳定TNFi的3年结果：一项多中心随机试验
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-28 DOI: 10.1002/art.43199
Kaja E. Kjørholt, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Inge C. Olsen, Åse S. Lexberg, Tor M. Madland, Hallvard Fremstad, Christian A. Høili, Gunnstein Bakland, Cristina Spada, Hilde Haukeland, Inger M. Hansen, Ellen Moholt, Karen Holten, Till Uhlig, Tore K. Kvien, Daniel H. Solomon, Désirée van der Heijde, Espen A. Haavardsholm, Siri Lillegraven
{"title":"3-year Results of Tapering TNFi to Withdrawal Compared to Stable TNFi Among Patients with Rheumatoid Arthritis in Sustained Remission: A Multicenter Randomized Trial","authors":"Kaja E. Kjørholt, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Inge C. Olsen, Åse S. Lexberg, Tor M. Madland, Hallvard Fremstad, Christian A. Høili, Gunnstein Bakland, Cristina Spada, Hilde Haukeland, Inger M. Hansen, Ellen Moholt, Karen Holten, Till Uhlig, Tore K. Kvien, Daniel H. Solomon, Désirée van der Heijde, Espen A. Haavardsholm, Siri Lillegraven","doi":"10.1002/art.43199","DOIUrl":"https://doi.org/10.1002/art.43199","url":null,"abstract":"Tapering of tumor necrosis factor inhibitor (TNFi) treatment in rheumatoid arthritis (RA) remission is debated. We assessed the effect of tapering TNFi to withdrawal versus continued stable TNFi on flare-free survival and joint damage progression over three years.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"221 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to the comments on “Plasma proteomic profiles predict individual future osteoarthritis risk” 对“血浆蛋白质组学分析预测个体未来骨关节炎风险”评论的回应
IF 13.3 1区 医学
Arthritis & Rheumatology Pub Date : 2025-04-28 DOI: 10.1002/art.43204
Zijian Kang, Qiang Tong, Sheng-Ming Dai
{"title":"Response to the comments on “Plasma proteomic profiles predict individual future osteoarthritis risk”","authors":"Zijian Kang, Qiang Tong, Sheng-Ming Dai","doi":"10.1002/art.43204","DOIUrl":"https://doi.org/10.1002/art.43204","url":null,"abstract":"Click on the article title to read more.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"37 1","pages":""},"PeriodicalIF":13.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143880734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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