Aberrant glycosylation of IgG in children with active lupus nephritis alters podocyte metabolism and causes podocyte injury

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2025-04-29 DOI:10.1002/art.43200

Rhea Bhargava, Rohit Upadhyay, Cong Zhao, Prasad Katakam, Scott Wenderfer, Jing Chen, Hua He, Richard Cummings, Maria G. Tsokos, George C. Tsokos

引用次数: 0

Abstract

Podocytes are integral to the maintenance of the glomerular filtration barrier. Their injury results in proteinuria and disease progression in lupus nephritis (LN). Aberrant IgG glycosylation drives podocyte injury in LN and leads to cytoskeletal rearrangement, motility changes and decreased nephrin production. Based on these findings, we hypothesized that IgG glycosylation patterns differentiate SLE with and without LN and that this aberrant glycosylation reprograms podocyte metabolism.

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活动期狼疮性肾炎患儿IgG异常糖基化改变足细胞代谢，引起足细胞损伤

足细胞对维持肾小球滤过屏障是不可或缺的。它们的损伤导致蛋白尿和狼疮肾炎（LN）的疾病进展。异常的IgG糖基化驱动LN足细胞损伤，导致细胞骨架重排、运动性改变和肾素产生减少。基于这些发现，我们假设IgG糖基化模式区分SLE伴LN和不伴LN，并且这种异常糖基化重新编程足细胞代谢。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.