3-year Results of Tapering TNFi to Withdrawal Compared to Stable TNFi Among Patients with Rheumatoid Arthritis in Sustained Remission: A Multicenter Randomized Trial

IF 11.4 1区医学 Q1 RHEUMATOLOGY

Arthritis & Rheumatology Pub Date : 2025-04-28 DOI:10.1002/art.43199

Kaja E. Kjørholt, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Inge C. Olsen, Åse S. Lexberg, Tor M. Madland, Hallvard Fremstad, Christian A. Høili, Gunnstein Bakland, Cristina Spada, Hilde Haukeland, Inger M. Hansen, Ellen Moholt, Karen Holten, Till Uhlig, Tore K. Kvien, Daniel H. Solomon, Désirée van der Heijde, Espen A. Haavardsholm, Siri Lillegraven

引用次数: 0

Abstract

Tapering of tumor necrosis factor inhibitor (TNFi) treatment in rheumatoid arthritis (RA) remission is debated. We assessed the effect of tapering TNFi to withdrawal versus continued stable TNFi on flare-free survival and joint damage progression over three years.

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在持续缓解的类风湿关节炎患者中，逐渐减少TNFi至停药与稳定TNFi的3年结果：一项多中心随机试验

肿瘤坏死因子抑制剂（TNFi）治疗在类风湿关节炎（RA）缓解中的逐渐减少是有争议的。我们评估了逐渐减少TNFi至停药与持续稳定TNFi对三年无耀斑生存和关节损伤进展的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arthritis & Rheumatology RHEUMATOLOGY-

CiteScore

20.90

自引率

3.00%

发文量

371

期刊介绍： Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.