Sharon Dowell,Brittany Banbury,Christopher Jenkins,Emily E Holladay,Fenglong Xie,Jingyi Zhang,Grace C Wright,Jeffrey R Curtis,Gail S Kerr
{"title":"种族、民族和历史背景对银屑病负担和临床结局的影响","authors":"Sharon Dowell,Brittany Banbury,Christopher Jenkins,Emily E Holladay,Fenglong Xie,Jingyi Zhang,Grace C Wright,Jeffrey R Curtis,Gail S Kerr","doi":"10.1002/art.43397","DOIUrl":null,"url":null,"abstract":"OBJECTIVE\r\nTo evaluate the association of neighborhood deprivation and structural barriers with disease burden in racial and ethnic subsets of patients with psoriatic arthritis (PsA).\r\n\r\nMETHODS\r\nPsA patients in the ACR RISE registry with reported race, region, and ≥3 years of follow-up, were evaluated. Demographic factors, disease activity measures, social deprivation, defined by the area deprivation index (ADI) and therapeutic agents were stratified by race. Subgroup analyses were conducted to examine demographic and clinical characteristics across residential areas graded by the Home Owners' Loan Corporation (HOLC), from 'Best' (HOLC 1 - predominantly White residents) to 'Hazardous' (HOLC 4 or redlined - predominantly Black residents) based on investment risk.\r\n\r\nRESULTS\r\nThe cohort included 21,429 predominantly female (57.7%), obese (56.1% BMI>30) PsA patients with median age 55 (12.8) years. High social deprivation was prevalent among Black patients (25.7 % vs. 2.3% Asian, 12.5% White and 17.3% Other), as was High Disease Activity (HDA, 40.2% vs. 25.8% Asian, 29.6% White, and 33.5% Other). Approximately 7% of PsA patients lived in HOLC-graded districts. Smoking, obesity, high social deprivation, federal insurance and HDA were more prevalent in patients in HOLC 4 areas compared to HOLC 1 areas. HOLC 4 patients also had longer median [IQR] periods of HDA (105.0 [0, 690] person-days) and fewer days in remission (1.0 [0, 5457] person-days).\r\n\r\nCONCLUSION\r\nIn the US, Black PsA patients have prevalent HDA and high social deprivation. Additionally, the enduring effects of structural racism appear to negatively influence PsA disease characteristics of patients living in historically redlined areas.","PeriodicalId":129,"journal":{"name":"Arthritis & Rheumatology","volume":"16 1","pages":""},"PeriodicalIF":10.9000,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Influence of Race, Ethnicity and Historical Redlining on Psoriatic Disease Burden and Clinical Outcomes.\",\"authors\":\"Sharon Dowell,Brittany Banbury,Christopher Jenkins,Emily E Holladay,Fenglong Xie,Jingyi Zhang,Grace C Wright,Jeffrey R Curtis,Gail S Kerr\",\"doi\":\"10.1002/art.43397\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"OBJECTIVE\\r\\nTo evaluate the association of neighborhood deprivation and structural barriers with disease burden in racial and ethnic subsets of patients with psoriatic arthritis (PsA).\\r\\n\\r\\nMETHODS\\r\\nPsA patients in the ACR RISE registry with reported race, region, and ≥3 years of follow-up, were evaluated. Demographic factors, disease activity measures, social deprivation, defined by the area deprivation index (ADI) and therapeutic agents were stratified by race. Subgroup analyses were conducted to examine demographic and clinical characteristics across residential areas graded by the Home Owners' Loan Corporation (HOLC), from 'Best' (HOLC 1 - predominantly White residents) to 'Hazardous' (HOLC 4 or redlined - predominantly Black residents) based on investment risk.\\r\\n\\r\\nRESULTS\\r\\nThe cohort included 21,429 predominantly female (57.7%), obese (56.1% BMI>30) PsA patients with median age 55 (12.8) years. High social deprivation was prevalent among Black patients (25.7 % vs. 2.3% Asian, 12.5% White and 17.3% Other), as was High Disease Activity (HDA, 40.2% vs. 25.8% Asian, 29.6% White, and 33.5% Other). Approximately 7% of PsA patients lived in HOLC-graded districts. Smoking, obesity, high social deprivation, federal insurance and HDA were more prevalent in patients in HOLC 4 areas compared to HOLC 1 areas. HOLC 4 patients also had longer median [IQR] periods of HDA (105.0 [0, 690] person-days) and fewer days in remission (1.0 [0, 5457] person-days).\\r\\n\\r\\nCONCLUSION\\r\\nIn the US, Black PsA patients have prevalent HDA and high social deprivation. Additionally, the enduring effects of structural racism appear to negatively influence PsA disease characteristics of patients living in historically redlined areas.\",\"PeriodicalId\":129,\"journal\":{\"name\":\"Arthritis & Rheumatology\",\"volume\":\"16 1\",\"pages\":\"\"},\"PeriodicalIF\":10.9000,\"publicationDate\":\"2025-09-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Arthritis & Rheumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/art.43397\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arthritis & Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/art.43397","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
The Influence of Race, Ethnicity and Historical Redlining on Psoriatic Disease Burden and Clinical Outcomes.
OBJECTIVE
To evaluate the association of neighborhood deprivation and structural barriers with disease burden in racial and ethnic subsets of patients with psoriatic arthritis (PsA).
METHODS
PsA patients in the ACR RISE registry with reported race, region, and ≥3 years of follow-up, were evaluated. Demographic factors, disease activity measures, social deprivation, defined by the area deprivation index (ADI) and therapeutic agents were stratified by race. Subgroup analyses were conducted to examine demographic and clinical characteristics across residential areas graded by the Home Owners' Loan Corporation (HOLC), from 'Best' (HOLC 1 - predominantly White residents) to 'Hazardous' (HOLC 4 or redlined - predominantly Black residents) based on investment risk.
RESULTS
The cohort included 21,429 predominantly female (57.7%), obese (56.1% BMI>30) PsA patients with median age 55 (12.8) years. High social deprivation was prevalent among Black patients (25.7 % vs. 2.3% Asian, 12.5% White and 17.3% Other), as was High Disease Activity (HDA, 40.2% vs. 25.8% Asian, 29.6% White, and 33.5% Other). Approximately 7% of PsA patients lived in HOLC-graded districts. Smoking, obesity, high social deprivation, federal insurance and HDA were more prevalent in patients in HOLC 4 areas compared to HOLC 1 areas. HOLC 4 patients also had longer median [IQR] periods of HDA (105.0 [0, 690] person-days) and fewer days in remission (1.0 [0, 5457] person-days).
CONCLUSION
In the US, Black PsA patients have prevalent HDA and high social deprivation. Additionally, the enduring effects of structural racism appear to negatively influence PsA disease characteristics of patients living in historically redlined areas.
期刊介绍:
Arthritis & Rheumatology is the official journal of the American College of Rheumatology and focuses on the natural history, pathophysiology, treatment, and outcome of rheumatic diseases. It is a peer-reviewed publication that aims to provide the highest quality basic and clinical research in this field. The journal covers a wide range of investigative areas and also includes review articles, editorials, and educational material for researchers and clinicians. Being recognized as a leading research journal in rheumatology, Arthritis & Rheumatology serves the global community of rheumatology investigators and clinicians.