Acta neurobiologiae experimentalis最新文献

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Does binocular instability influence static body balance in adults with developmental dyslexia? 双眼不稳是否会影响成人发展性阅读障碍患者的静态身体平衡?
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-07-31 DOI: 10.55782/ane-2025-2593
Anna Przekoracka-Krawczyk, Alicja Brenk-Krakowska, Patrycja Rusiak, Paweł Nawrot, Ryszard Naskręcki
{"title":"Does binocular instability influence static body balance in adults with developmental dyslexia?","authors":"Anna Przekoracka-Krawczyk, Alicja Brenk-Krakowska, Patrycja Rusiak, Paweł Nawrot, Ryszard Naskręcki","doi":"10.55782/ane-2025-2593","DOIUrl":"https://doi.org/10.55782/ane-2025-2593","url":null,"abstract":"<p><p>The aim of the study was to investigate if body balance control deficits in dyslexia are present in dyslexic adults and if unstable binocular fixation relates to impaired body balance. Fifteen dyslexics adults and 15 age‑matched non‑dyslexics participated in the study. Posturography data were collected in two sessions: during quiet standing (single‑task) and while performing a mental task while standing on the platform (dual‑task). Each session was conducted under three distinct visual conditions: monocular fixation, binocular fixation, and eyes closed. Four parameters of the center of pressure (CoP) signal were analysed: medio‑lateral sway (XSD), antero‑posterior sway (YSD), sway area (Area95) and mean CoP velocity (Vavg). A psycho‑physical tests with Wesson card and a modified Mallett test were used to measure fixation disparity (FD). Slight underconvergence at the fixation point results in exo‑FD, and conversely, overconvergence results in eso‑FD. The results indicated that in dyslexics, the exo‑FD values were higher than in controls. In both groups, body stabilization was better with binocular fixation compared to eyes closed (lowest value of Vavg and CoP sway). Moreover, dyslexic adults demonstrated impaired body balance. The posturographic deficits remained unaltered by the viewing conditions, indicating that binocular fixation did not contribute to body instability, despite the higher incidence of fixation disparity in the dyslexic group. The existence of both posturographic deficits and the presence of FD may reflect deficits at the cerebellar level.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 2","pages":"105-116"},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coenzyme Q10 ameliorates anxiety and depression‑like behavior associated with chronic opioid use and increases GDNF expression in the hippocampus of morphine‑dependent rats. 辅酶Q10改善与慢性阿片类药物使用相关的焦虑和抑郁样行为,并增加吗啡依赖大鼠海马中的GDNF表达。
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-07-31 DOI: 10.55782/ane-2025-2581
Mobina Gheibi, Somayeh Nazari, Fahimeh Mohseni, Pooria Salehi Sangani, Farzaneh Felehkari, Saba Niknamfar, Hamed Ghazvini, Seyedeh Masoumeh Seyedhosseini Tamijani, Hamid Kalalian-Moghaddam, Hamid Jomehpour, Raheleh Rafaiee
{"title":"Coenzyme Q10 ameliorates anxiety and depression‑like behavior associated with chronic opioid use and increases GDNF expression in the hippocampus of morphine‑dependent rats.","authors":"Mobina Gheibi, Somayeh Nazari, Fahimeh Mohseni, Pooria Salehi Sangani, Farzaneh Felehkari, Saba Niknamfar, Hamed Ghazvini, Seyedeh Masoumeh Seyedhosseini Tamijani, Hamid Kalalian-Moghaddam, Hamid Jomehpour, Raheleh Rafaiee","doi":"10.55782/ane-2025-2581","DOIUrl":"https://doi.org/10.55782/ane-2025-2581","url":null,"abstract":"<p><p>Opioid dependence is strongly associated with moderate to severe depression and anxiety. The primary objective of this investigation was to determine whether coenzyme Q10 (CoQ10) has the capacity to increase the level of glial cell line‑derived neurotrophic factor (GDNF), with the aim of ameliorating anxiety‑ and depression‑like behaviors in morphine (MOP)‑dependent rats. In this study, 40 male Wistar rats were randomly divided into five experimental groups: Oil group, MOP+Oil group, MOP+Q10‑100 group, MOP+Q10‑200 group, and MOP+Q10‑400 group. Rats received escalating doses of MOP (25 to 100 mg/kg, s.c.) once daily. After 21 days of drug dependency, CoQ10 was administered orally at doses of 100, 200, and 400 mg/kg once daily for four weeks. Behavioral assessments were conducted using the open field test, elevated plus maze, and forced swim test. GDNF expression in the hippocampus was evaluated using immunohistochemistry. Four weeks of CoQ10 treatment significantly improved anxiety‑ and depression‑like behaviors induced by MOP administration. Furthermore, CoQ10 significantly increased GDNF expression in the hippocampus. Oral administration of CoQ10 at doses of 100, 200, and 400 mg/kg over four weeks significantly reduced depressive‑ and anxiety‑related behaviors associated with prolonged MOP exposure. These behavioral improvements were accompanied by increased hippocampal GDNF expression.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 2","pages":"94-104"},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iron in multiple sclerosis - from pathophysiology to disease progression - a narrative literature review. 铁在多发性硬化症中的作用——从病理生理学到疾病进展——一篇叙述性文献综述。
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-07-31 DOI: 10.55782/ane-2025-2680
Karolina Kłodnicka, Jacek Januszewski, Alicja Forma, Weronika Pająk, Barbara Teresińska, Jacek Baj
{"title":"Iron in multiple sclerosis - from pathophysiology to disease progression - a narrative literature review.","authors":"Karolina Kłodnicka, Jacek Januszewski, Alicja Forma, Weronika Pająk, Barbara Teresińska, Jacek Baj","doi":"10.55782/ane-2025-2680","DOIUrl":"https://doi.org/10.55782/ane-2025-2680","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a chronic autoimmune illness characterized by demyelination and neurodegeneration, which causes physical disability and severe alterations in the neurological system, including gliosis and neuron loss. The disease primarily affects myelinated parts of the central nervous system (CNS), such as the optic nerves, cerebellum, brain stem, and spinal cord. T cells play an important role in MS pathogenesis by inducing demyelination, and risk factors include genetic predisposition, environmental effects, and lifestyle decisions. The prevalence of MS is rising, especially among women and the elderly population. Iron dysregulation is a critical element in MS pathogenesis, with excess iron causing neurodegeneration via ferroptosis and immune response modulation. Excess iron amplifies inflammation by triggering the activation of macrophages with inflammatory properties, and promoting microglial polarization toward the pro‑inflammatory phenotype. This causes increased oxidative stress, mitochondrial malfunction, and the release of reactive oxygen species, which harm neurons. Furthermore, proinflammatory cytokines like IL‑6 regulate iron metabolism and encourage the formation of Th17 cells, which exacerbates CNS inflammation. Macrophages and microglia, which are implicated in inflammatory responses, collect iron during MS, exacerbating neuroinflammation and demyelination. Disrupted iron homeostasis is a major contributor to MS pathology, with iron deficiency affecting immunological function and changing T‑cell responses, both of which are necessary for disease progression. Lumbar puncture, oligoclonal bands analysis, and magnetic resonance imaging are all used to diagnose MS and confirm disease activity and progression. The blood‑brain barrier is frequently disrupted in MS, allowing the influx of inflammatory cells. The aim of this paper is to demonstrate the cause‑effect relationship between the amount of iron and the health status of patients with MS.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 2","pages":"75-93"},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to: Fasudil alleviates cerebral ischemia‑reperfusion injury by inhibiting inflammation and improving neurotrophic factor expression in rats. 法舒地尔通过抑制炎症和改善神经营养因子表达减轻大鼠脑缺血再灌注损伤。
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-07-31 DOI: 10.55782/ane-2025-2708
{"title":"Corrigendum to: Fasudil alleviates cerebral ischemia‑reperfusion injury by inhibiting inflammation and improving neurotrophic factor expression in rats.","authors":"","doi":"10.55782/ane-2025-2708","DOIUrl":"https://doi.org/10.55782/ane-2025-2708","url":null,"abstract":"","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 2","pages":"117"},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: lncRNA MAFG‑AS1 enhances radioresistance of glioblastoma cells via miR‑642a‑5p/Notch1 axis. 缩回:lncRNA MAFG‑AS1通过miR‑642a‑5p/Notch1轴增强胶质母细胞瘤细胞的放射抗性。
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-07-31 DOI: 10.55782/ane-2025-2719
{"title":"Retraction: lncRNA MAFG‑AS1 enhances radioresistance of glioblastoma cells via miR‑642a‑5p/Notch1 axis.","authors":"","doi":"10.55782/ane-2025-2719","DOIUrl":"https://doi.org/10.55782/ane-2025-2719","url":null,"abstract":"","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 2","pages":"118"},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of methyl‑CpG binding domain 3 in seizures and epileptogenesis. 甲基CpG结合结构域3在癫痫发作和癫痫发生中的作用。
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-07-31 DOI: 10.55782/ane-2025-2706
Karolina Niźinska, Maciej Olszewski, Dorota Nowicka, Kinga Szydłowska, Kinga Nazaruk, Katarzyna Łukasiuk
{"title":"The role of methyl‑CpG binding domain 3 in seizures and epileptogenesis.","authors":"Karolina Niźinska, Maciej Olszewski, Dorota Nowicka, Kinga Szydłowska, Kinga Nazaruk, Katarzyna Łukasiuk","doi":"10.55782/ane-2025-2706","DOIUrl":"https://doi.org/10.55782/ane-2025-2706","url":null,"abstract":"<p><p>Methyl‑CpG binding domain protein 3 (Mbd3), a component of the NuRD chromatin remodeling complex, plays a role in transcriptional regulation and has been implicated in neuronal development; however, its role in epilepsy remains unclear. This study investigated the effects of Mbd3 downregulation on seizure susceptibility and behavior in rats, using adeno‑associated viral vectors that code for short hairpin RNA to downregulate Mbd3 expression in the basolateral amygdala. Behavioral assessments included the open field test, elevated plus maze test, and hyperexcitability test. Seizure susceptibility was evaluated using the PTZ challenge and PTZ kindling models. A decreased Mbd3 level significantly increased latency to seizure onset in the PTZ challenge, indicating a raised seizure threshold. Rats with reduced Mbd3 expression also exhibited increased anxiety‑like behavior in the open‑field test. Mbd3 downregulation did not affect the progression of epileptogenesis in the PTZ kindling model. These findings suggest that Mbd3 contributes to acute seizure susceptibility and emotional behavior but not to the long‑term development of epilepsy, highlighting its potential as an epigenetic modulator in seizure regulation.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 2","pages":"67-74"},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of chronic cuff electrode implantation and stimulation of the rat tibial nerve: ultrastructural analysis of myelinated axons and their microenvironment. 慢性袖带电极植入和刺激大鼠胫神经的影响:髓鞘轴突及其微环境的超微结构分析。
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-04-17 DOI: 10.55782/ane-2024-2660
Olga Gajewska-Woźniak, Julita Czarkowska-Bauch, Andrzej Szczepankiewicz, Małgorzata Skup
{"title":"Effects of chronic cuff electrode implantation and stimulation of the rat tibial nerve: ultrastructural analysis of myelinated axons and their microenvironment.","authors":"Olga Gajewska-Woźniak, Julita Czarkowska-Bauch, Andrzej Szczepankiewicz, Małgorzata Skup","doi":"10.55782/ane-2024-2660","DOIUrl":"https://doi.org/10.55782/ane-2024-2660","url":null,"abstract":"<p><p>Numerous experimental data point to therapeutic effects of electrical stimulation of peripheral nerves. Stimulation of low‑threshold proprioceptive afferents to motoneurons (MNs) innervating the ankle extensor muscles of the rat increases glutamatergic Ia MN inputs and spinal and muscle expression of neurotrophin‑3, instrumental for proprioceptive afferent‑MN connections. We aimed to examine morphological consequences of the cuff electrode implanted around the tibial nerve used for chronic stimulation which may cause unwanted effects through its long‑lasting contact with the nerve. We addressed also the questions if stimulation of low‑threshold proprioceptive afferents may contribute to neural damage, affect capillary vessels and macrophage morphology reflecting functional state of the nerve. Their consequences on axonal and nerve ultrastructure have not been previously evaluated. To examine the effect of cuff electrodes and of 7‑day low‑threshold stimulation applied in the 4th week post‑implantation on the tibial nerve, electrodes were implanted bilaterally, and a stimulation was added unilaterally. Non‑implanted group was the control. The counts of myelinated axons, their cross‑sectional area (>1 μm2) and circularity were measured on photomicrographs captured with use of light microscope from semi‑thin Epon sections stained with toluidine blue. Ultrastructural observations with TEM included myelin, axoplasm, Remak fibers, blood vessels, macrophages and fibroblasts. Four weeks after implantation of the cuff, the mean cross‑sectional area of the nerve, and counts, area and diameter of the myelinated fibers were lower compared to control. The largest fibers located in the external parts of the main nerve branches and dispersed in small branches were changed the most. No significant difference in either parameter between unstimulated (NS) and stimulated (S) nerve was found. Axons in Remak bundles were dispersed comparably in NS and S nerves. Thinly myelinated fibers demonstrating features of demyelination with remyelination were identified. We provide evidence that long-lasting presence of the cuff electrode is not neutral for nerve structure, causing mild shrinkage of large myelinated axons and impairment of organization of unmyelinated fibers. Since we demonstrated that low‑threshold proprioceptive stimulation of the tibial nerve results in a stable Hoffmann reflex and induces synaptic plasticity by increasing glutamatergic input to MNs, we conclude that the applied protocol maintains an adequate margin of safety.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 1","pages":"1-15"},"PeriodicalIF":1.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Status epilepticus‑induced neuronal degeneration in the immature rat zona incerta is confined to its rostral sector. 癫痫持续状态诱导的未成熟大鼠间带神经元变性局限于其吻侧区。
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-04-17 DOI: 10.55782/ane-2024-2447
Azzat Al-Redouan, Rastislav Druga, Martin Salaj, Hana Kubova
{"title":"Status epilepticus‑induced neuronal degeneration in the immature rat zona incerta is confined to its rostral sector.","authors":"Azzat Al-Redouan, Rastislav Druga, Martin Salaj, Hana Kubova","doi":"10.55782/ane-2024-2447","DOIUrl":"https://doi.org/10.55782/ane-2024-2447","url":null,"abstract":"<p><p>The distribution and morphology of neuronal degeneration were observed and analyzed in each sector of the zona incerta in a lithium‑pilocarpine (LiCl) Wistar rat model of status epilepticus in 12, 15, 18, 21, and 25‑day‑old rats and survival intervals of 4, 8, 12, 24, and 48 hours. Status epilepticus was induced via intraperitoneal (IP) injection of LiCl (3 mmol/kg) 24 hours before an injection of pilocarpine (40 mg/kg, IP). Motor seizures were suppressed by paraldehyde (0.3‑0.6 ml/kg, IP) two hours after status epilepticus onset. Animals were anesthetized using urethane and perfused with phosphate‑buffered saline followed by 4% paraformaldehyde. Brains were sectioned and Nissl stained for map guidance, with fluoro‑Jade B fluorescence used to detect degenerated neurons. Fluoro‑jade B‑positive neurons were plotted to a standard stereotaxic atlas, their distribution was quantified, and their long‑axis diameter was measured. Fluoro‑jade B‑positive neurons were found in pups aged 15 days and older 24 hours after status epilepticus, in which their numbers increased, and their perikaryon size decreased with advancing age. Thus, neuronal damage severity was dependent on age and survival interval. Neuronal damage was only found in the rostral sector of the zona incerta, a region that exhibits a small number of inhibitory neurons and is reciprocally connected to the limbic cortex. This system of hyperactivity, coupled with inhibitory neurons, may be the underlying cause of the neuronal degeneration and explain why it was confined to the rostral sector of the zona incerta.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 1","pages":"38-48"},"PeriodicalIF":1.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of co‑exposure to caffeine and heavy metals on learning and oxidative stress in mice. 咖啡因和重金属对小鼠学习和氧化应激的影响。
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-04-17 DOI: 10.55782/ane-2024-2647
Katarzyna Zygan-Filipiak, Piotr Adamczuk, Krzysztof Łukawski
{"title":"The effects of co‑exposure to caffeine and heavy metals on learning and oxidative stress in mice.","authors":"Katarzyna Zygan-Filipiak, Piotr Adamczuk, Krzysztof Łukawski","doi":"10.55782/ane-2024-2647","DOIUrl":"https://doi.org/10.55782/ane-2024-2647","url":null,"abstract":"<p><p>Caffeine, a widely consumed psychoactive substance, may affect the neurotoxicity of environmental toxins. The study aimed to investigate the effects of the combined administration of caffeine and heavy metal compounds (cadmium chloride and lead acetate) on brain tissue function, focusing on memory processes and oxidative stress parameters. Adult male Swiss mice were administered substances intraperitoneally for 10 days. A passive avoidance test evaluated long‑term memory, while the Y‑maze assessed spatial working memory. In addition, lipid peroxidation and glutathione levels, as well as superoxide dismutase, catalase, and acetylcholinesterase activity, were determined in mouse brains. The results showed that exposure to caffeine and cadmium or lead caused different neurotoxic effects. Unlike lead, cadmium interacted with caffeine in memory tests. Caffeine protected mice against cadmium‑induced spatial working memory impairment. The combination of caffeine and cadmium impaired learning in the passive avoidance test. Cadmium and lead caused oxidative stress in the brain, and caffeine had a preventive effect against it. The study showed that co‑exposure to caffeine and cadmium could affect learning and memory. The antioxidant activity of caffeine may play a protective role in cadmium‑induced spatial memory impairment.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 1","pages":"49-57"},"PeriodicalIF":1.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regional cerebral blood flow correlated with aphasia in dementia of the Alzheimer's type and frontotemporal lobar degeneration. 区域脑血流量与阿尔茨海默氏型痴呆和额颞叶变性失语症相关。
IF 1.4 4区 医学
Acta neurobiologiae experimentalis Pub Date : 2025-04-17 DOI: 10.55782/ane-2024-2621
Miho Ota, Yuko Koshibe, Ayako Kitabatake, Masashi Tamura, Takumi Takahashi, Kiyotaka Nemoto, Tetsuaki Arai
{"title":"Regional cerebral blood flow correlated with aphasia in dementia of the Alzheimer's type and frontotemporal lobar degeneration.","authors":"Miho Ota, Yuko Koshibe, Ayako Kitabatake, Masashi Tamura, Takumi Takahashi, Kiyotaka Nemoto, Tetsuaki Arai","doi":"10.55782/ane-2024-2621","DOIUrl":"https://doi.org/10.55782/ane-2024-2621","url":null,"abstract":"<p><p>Individuals with neurocognitive disorders such as dementia of the Alzheimer's type (DAT) and frontotemporal lobar degeneration sometimes show characteristic language dysfunctions. As neurocognitive disorders progress, different types of aphasia may present. To evaluate the disease‑related changes of language functions, and to determine the correlation between the regional cerebral blood flow (rCBF) and language dyfunctions in patients with DAT or the behavioral variant of frontotemporal dementia (bvFTD) or semantic dementia (SD), we used a scale for speech and reading impairment in Japanese (the Standard Language Test for Aphasia [SLTA]), and perfusion single photon emission computed tomography, and we analyzed the relationships among them. Significant differences were identified among the DAT, SD, and bvFTD groups in the SLTA subscales concerning kanji (morphographic) words. There were positive correlations between the SLTA subscales concerning kanji words and the rCBF in left temporo‑occipital regions. The patients with bvFTD showed relative rCBF preservation in the posterior cerebrum compared with the DAT and SD patients. Our results indicate that aphasia for Japanese kanji words might be related to the dysfunction of temporo‑occipital regions, and they suggest that in patients with bvFTD, preserving the CBF in the posterior cerebrum might help maintain the ability to handle morphographic words such as kanji.</p>","PeriodicalId":7032,"journal":{"name":"Acta neurobiologiae experimentalis","volume":"85 1","pages":"29-37"},"PeriodicalIF":1.4,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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