Alimentary Pharmacology & Therapeutics最新文献

{"title":"Editorial: Not All Fibres Are Created Equal—Fibre Supplements for Personalised Application. Authors' Reply","authors":"Neele Dellschaft, Joshua E. S. J. Reid, Gleb Yakubov, Amisha Modasia, Robin Spiller","doi":"10.1111/apt.71064","DOIUrl":"https://doi.org/10.1111/apt.71064","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"14 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149359923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Anticoagulation After Gastrointestinal Bleeding-Prognostic Associations are not Treatment Effects.","authors":"Kunal Mahajan, Abdul Basit, Anshul Yadav","doi":"10.1111/apt.71092","DOIUrl":"https://doi.org/10.1111/apt.71092","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149339979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Objective Follow Up of Inflammation After Therapy for Eosinophilic Oesophagitis.","authors":"Stephen E Attwood","doi":"10.1111/apt.71093","DOIUrl":"https://doi.org/10.1111/apt.71093","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149339978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: When It Comes to Gastrointestinal Bleeding, It's Not the Anticoagulant Therapy Itself That's the Problem, but How It's Being Managed.","authors":"Marc Bardou, Thomas Mouillot, Théophile Gerster","doi":"10.1111/apt.71089","DOIUrl":"https://doi.org/10.1111/apt.71089","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Microscopic Colitis-Are Medications Linked to Disease or Disease Investigation?","authors":"David Bergman, Jonas W Wastesson, Jonas F Ludvigsson","doi":"10.1111/apt.71086","DOIUrl":"https://doi.org/10.1111/apt.71086","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter on: 'Impact of Prior Biologic Mechanism of Action on Anti-TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study'. Authors' Reply.","authors":"Carmen Yagüe Caballero, Santiago García-López, Diego Casas-Deza","doi":"10.1111/apt.70950","DOIUrl":"https://doi.org/10.1111/apt.70950","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter on: 'Impact of Prior Biologic Mechanism of Action on Anti-TNF Effectiveness in Inflammatory Bowel Disease: An ENEIDA Registry Study'.","authors":"Bhumesh Tyagi, Parag J Ratnakar, Hima Bindu Mantravadi, Pankaj Nainwal, Hariharan Srinivasan","doi":"10.1111/apt.70944","DOIUrl":"https://doi.org/10.1111/apt.70944","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Therapeutic Drug Monitoring of Infliximab During Induction Therapy in IBD-Is This the Time for Model Informed Precision Dosing?","authors":"Benjamin Mecsas-Faxon, Konstantinos Papamichael, Adam S Cheifetz","doi":"10.1111/apt.71087","DOIUrl":"https://doi.org/10.1111/apt.71087","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149331769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Interpreting Rule‐Out and Rule‐In Enhanced Liver Fibrosis Thresholds in Metabolic Dysfunction‐Associated Steatotic Liver Disease. Authors' Reply","authors":"M. F. W. Gee, E. B. De Vol, H. R. Levy, A. T. Boltyenkov, Sanyal. AJ","doi":"10.1111/apt.71077","DOIUrl":"https://doi.org/10.1111/apt.71077","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"1 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149305037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Clinical and Biomarker-Based Score to Predict Microscopic Colitis in Patients With Chronic Watery Diarrhoea.","authors":"Laura Ruiz-Campos, Yamile Zabana, Lissette Batista, Danila Guagnozzi, Ingrid Fajardo, Pablo Ruiz-Ramírez, Carme Loras, Maria Esteve, Fernando Fernández-Bañares","doi":"10.1111/apt.71082","DOIUrl":"https://doi.org/10.1111/apt.71082","url":null,"abstract":"<p><strong>Background: </strong>Colonoscopy with stepwise colonic biopsies is the only method for confirming microscopic colitis in patients with chronic watery diarrhoea. Several clinical scores (Cotter, Kane and Atieh) have been proposed to guide biopsy decisions; however, their diagnostic accuracy remains limited.</p><p><strong>Aims: </strong>To develop a derivation-stage clinical and biomarker-based score incorporating faecal calprotectin to predict microscopic colitis in patients with chronic watery diarrhoea and to assess its diagnostic accuracy compared with previously reported scores.</p><p><strong>Methods: </strong>A prospective observational study was conducted at two centres, including adults with chronic watery diarrhoea. Clinical data, faecal calprotectin and colonoscopy with biopsies were recorded. Multivariate logistic regression was used to identify independent predictors of microscopic colitis. Score weights were derived from regression β coefficients. Diagnostic performance was assessed using ROC curve analysis, calibration metrics and bootstrap internal validation with 1000 resamples.</p><p><strong>Results: </strong>Among 111 patients, 41 were diagnosed with microscopic colitis. The final score, calculated in 101 patients with available faecal calprotectin, included stool frequency > 5/day, diarrhoea duration ≤ 8 months, body mass index ≤ 26 kg/m², and faecal calprotectin > 81 μg/g. It showed excellent discrimination with an AUC of 0.90 (optimism-corrected AUC 0.88), and no false-negative cases were observed at the sensitivity-driven cut-off. Previously published scores showed lower discrimination in this cohort, with AUCs ranging from 0.63 to 0.72.</p><p><strong>Conclusion: </strong>A score integrating simple clinical variables and faecal calprotectin showed promising diagnostic accuracy for microscopic colitis in this derivation cohort and may support future risk-stratification strategies in patients with chronic watery diarrhoea.</p>","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":" ","pages":""},"PeriodicalIF":6.8,"publicationDate":"2026-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149316355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}