Alimentary Pharmacology & Therapeutics最新文献

{"title":"Letter: Exclusive Enteral Nutrition in Ulcerative Colitis—The Path Ahead Needs Careful Consideration","authors":"Sarah Melton, Akhilesh Swaminathan, Jessica Fitzpatrick","doi":"10.1111/apt.70091","DOIUrl":"https://doi.org/10.1111/apt.70091","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"26 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Afamin and Apolipoprotein F Associated With Liver Steatosis From People Living With HIV: A Discovery Study","authors":"Mario Frías, Eduardo Chicano-Gálvez, Antonio Rivero-Juárez, Ana Gordon, Diana Corona-Mata, José María Moyano, Ángela Peralbo-Molina, Ángela Camacho, Ignacio Pérez-Valero, María del Mar Malagón, Antonio Rivero","doi":"10.1111/apt.70119","DOIUrl":"https://doi.org/10.1111/apt.70119","url":null,"abstract":"Liver steatosis (LS) is a condition that is characterised by hepatic fat accumulation unrelated to significant alcohol consumption. This study explored the serum proteomic profile associated with LS in people living with HIV (PLWH).","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"72 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143737073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Enhancing the Diagnostic Performance of the Oral Cholate Challenge Test: Implications for Avoidance of Potentially Unnecessary Endoscopy","authors":"Tarek Hassanein, Andrew P. Keaveny, Parvez Mantry, Mitchell Shiffman, Michael Leise, Kamran Qureshi, Alastair D. Smith, Michael P. McRae, Joanne C. Imperial, Gregory T. Everson","doi":"10.1111/apt.70116","DOIUrl":"https://doi.org/10.1111/apt.70116","url":null,"abstract":"<p>In our previous publications in Alimentary Pharmacology & Therapeutics [<span>1, 2</span>], we highlighted the diagnostic performance of the disease severity index (DSI) derived from the oral cholate challenge test [<span>3-5</span>] (HepQuant DuO) to rule out large oesophageal varices (LEV) and other significant lesions of portal hypertension. In these publications, two criteria were evaluated: (1) using DSI ≤ 18.3 alone and (2) using DSI ≤ 24 or < 25 with platelet count > 135,000 μL<sup>−1</sup>. The sensitivity cut-off for rule-out of LEV was based on Baveno VII criteria for miss rate < 5% (sensitivity > 95%) [<span>6</span>]. The diagnostic performance for DSI ≤ 18.3 was previously reported [<span>1, 2</span>], but the diagnostic performance of DSI with platelet count was not. Table 1 shows the combination of DSI ≤ 18.3 or DSI ≤ 24 with PLT > 135,000 μL<sup>−1</sup> for the HepQuant DuO test. The HepQuant DuO test had miss rates < 5% (sensitivity > 95%), negative predictive values (NPV) > 99% and negative likelihood ratios (NLR) ≤ 0.08. Specificity was 63.8% for LEV and 58.3% for all significant lesions of portal hypertension.</p>\u0000<div>\u0000<header><span>TABLE 1. </span>Diagnostic performance (95% CI) of the combination of DSI ≤ 18.3 with DSI ≤ 24 and platelet count > 135,000 μL<sup>−1</sup> from the oral cholate challenge test (HepQuant DuO) to rule out of large oesophageal varices (LEV) and all portal hypertensive lesions (defined as oesophageal varices needing treatment, LEV, large gastric varices or severe portal hypertensive gastropathy).</header>\u0000<div tabindex=\"0\">\u0000<table>\u0000<thead>\u0000<tr>\u0000<td></td>\u0000<th>Large oesophageal varices</th>\u0000<th>All portal hypertensive lesions</th>\u0000</tr>\u0000</thead>\u0000<tbody>\u0000<tr>\u0000<td>Sensitivity (%)</td>\u0000<td>95.9 (86.0, 99.5)</td>\u0000<td>97.2 (85.5, 99.9)</td>\u0000</tr>\u0000<tr>\u0000<td>Specificity (%)</td>\u0000<td>63.8 (58.9, 68.5)</td>\u0000<td>58.3 (51.1, 65.2)</td>\u0000</tr>\u0000<tr>\u0000<td>Positive likelihood ratio</td>\u0000<td>2.65 (2.30, 3.05)</td>\u0000<td>2.33 (1.96, 2.77)</td>\u0000</tr>\u0000<tr>\u0000<td>Negative likelihood ratio</td>\u0000<td>0.06 (0.02, 0.25)</td>\u0000<td>0.05 (0.01, 0.33)</td>\u0000</tr>\u0000<tr>\u0000<td>Prevalence (%)</td>\u0000<td>10.8 (8.1, 14.1)</td>\u0000<td>15.3 (11.0, 20.6)</td>\u0000</tr>\u0000<tr>\u0000<td>Positive predictive value (%)</td>\u0000<td>24.4 (21.8, 27.1)</td>\u0000<td>29.7 (26.2, 33.4)</td>\u0000</tr>\u0000<tr>\u0000<td>Negative predictive value (%)</td>\u0000<td>99.2 (97.1, 99.8)</td>\u0000<td>99.1 (94.4, 99.9)</td>\u0000</tr>\u0000<tr>\u0000<td>Miss rate (%)</td>\u0000<td>4.1</td>\u0000<td>2.8</td>\u0000</tr>\u0000<tr>\u0000<td>EGDs avoided (%)</td>\u0000<td>57.3</td>\u0000<td>49.8</td>\u0000</tr>\u0000</tbody>\u0000</table>\u0000</div>\u0000<div></div>\u0000</div>\u0000<p>From this analysis, we conclude that the combined criteria of DSI ≤ 18.3 with DSI ≤ 24 plus platelet count > 135,000 μL<sup>−1</sup> may be sufficient to rule out LEV and aid the decision to avoid endoscopy (EGD) (Table 1). When used in combination, the diagnostic performance for LEV is maintained with a low miss rate (4.1%) but a much higher likelihood to avoid endoscopy (57.3%). The","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"52 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143734412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Balancing Cost and Consequence of Colon Capsule Endoscopy in Colorectal Cancer Pathways—Finding the Sweet Spot","authors":"Ian Io Lei, Ramesh P. Arasaradnam, Anastasios Koulaouzidis","doi":"10.1111/apt.70104","DOIUrl":"https://doi.org/10.1111/apt.70104","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"13 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Featured Cover","authors":"Kai Markus Schneider,&nbsp;Feng Cao,&nbsp;Helen Ye Rim Huang,&nbsp;Lanlan Chen,&nbsp;Yazhou Chen,&nbsp;Rongpeng Gong,&nbsp;Anastasia Raptis,&nbsp;Kate Townsend Creasy,&nbsp;Jan Clusmann,&nbsp;Felix van Haag,&nbsp;Paul-Henry Koop,&nbsp;Adrien Guillot,&nbsp;Tom Luedde,&nbsp;Rohit Loomba,&nbsp;Sven Francque,&nbsp;Carolin Victoria Schneider","doi":"10.1111/apt.70110","DOIUrl":"https://doi.org/10.1111/apt.70110","url":null,"abstract":"<p>The cover image is based on the article <i>The Lipidomic Profile Discriminates Between MASLD and MetALD</i> by Kai Markus Schneider et al., https://doi.org/10.1111/apt.70012 \u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"61 8","pages":"i"},"PeriodicalIF":6.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/apt.70110","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Balancing Cost and Consequence of Colon Capsule Endoscopy in Colorectal Cancer Pathways—Finding the Sweet Spot. Authors' Reply","authors":"James Turvill, Monica Haritakis, Scott Pygall, Emily Bryant, Harriet Cox, Greg Forshaw, Crispin Musicha, Victoria Allgar, Robert Logan, Mark McAlindon","doi":"10.1111/apt.70105","DOIUrl":"https://doi.org/10.1111/apt.70105","url":null,"abstract":"<p>The authors of the large English colon capsule endoscopy (CCE) diagnostic accuracy study are grateful to Dr. Lei et al. for their informed and thoughtful observations [<span>1, 2</span>]. We think that there are two important and related observations of our own to make in response.</p>\u0000<p>First, on an ‘intention to investigate’ basis, rather than in complete and adequately prepared CCE, more polyps were detected by CCE than colonoscopy. This meant that an informed management plan could be made for many patients even when CCE was incomplete or inadequately prepared. Second, as you infer, CCE was introduced to mitigate the impact of the Covid-19 pandemic on colorectal cancer diagnosis. That is, its purpose was primarily to inform risk rather than prevent onward investigation, as one might plan for in the future.</p>\u0000<p>We very much agree that multiple, mitigatable factors, not yet fully defined, may contribute to the onward investigation rate and so inform how best CCE should complement a future colorectal diagnostics pathway. Beyond patient selection, touched on above, all of the factors outlined are absolutely pertinent. Our own view about polyp overdiagnosis is uncertain. Double counting seems unlikely since polyp detection was recorded on both a per patient and per polyp basis. The high false positivity of polyps ≥ 10 mm in those who had matched investigations, both of which were complete and adequately prepared, suggests that the reference standard may need to be revisited.</p>\u0000<p>We believe other factors are also important, such as shared decision making, patient choice, and the purpose of CCE in a clinical setting. We very much agree that such should help generate a ‘balanced approach’ for future recommendations. Our study importantly allows us to move beyond the safety and accuracy across a broad clinical setting and into that exciting new space where we can optimise.</p>","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"57 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Chrononutrition and MASLD—Its About Time (Restricted Feeding)!","authors":"Hannah Mohr, Jonathan G. Stine","doi":"10.1111/apt.70078","DOIUrl":"https://doi.org/10.1111/apt.70078","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"9 43 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143713050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Chrononutrition and MASLD—It is About Time (Restricted Feeding)! Authors' Reply","authors":"Sofia Tsitsou, Magdalini Adamantou, Triada Bali, Aristi Saridaki, Kalliopi‐Anna Poulia, Dimitrios S. Karagiannakis, Emilia Papakonstantinou, Evangelos Cholongitas","doi":"10.1111/apt.70107","DOIUrl":"https://doi.org/10.1111/apt.70107","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"11 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143713053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Trial: Effect of Abdominal Vibration Combined With Walking Exercise Programme on Bowel Preparation in Older Patients With Constipation","authors":"Yuan-Yuan Zhang, Ramoo Vimala, Ping Lei Chui, Ida Normiha Hilmi","doi":"10.1111/apt.70103","DOIUrl":"https://doi.org/10.1111/apt.70103","url":null,"abstract":"Older patients with constipation are at an increased risk of inadequate bowel preparation.","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"57 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter: Disappearing Microbe, Emerging Disease? Nuancing the Protective Effects of Helicobacter pylori Against Eosinophilic Oesophagitis. Authors' Reply","authors":"Irene Spinelli, Gianluca Ianiro","doi":"10.1111/apt.70099","DOIUrl":"https://doi.org/10.1111/apt.70099","url":null,"abstract":"","PeriodicalId":121,"journal":{"name":"Alimentary Pharmacology & Therapeutics","volume":"4 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}