Acta neurologica Belgica最新文献

{"title":"Posterior auricular neuropathy as a complication of facial nerve palsy in a patient with polyneuritis cranialis.","authors":"Olivia Pype, Sofie Carrette","doi":"10.1007/s13760-025-02907-8","DOIUrl":"https://doi.org/10.1007/s13760-025-02907-8","url":null,"abstract":"<p><p>Ipsilateral facial, neck, or retroauricular pain is a common but often underrecognized feature of peripheral facial nerve palsy. We report a rare case of posterior auricular nerve neuropathy following facial nerve palsy in the context of polyneuritis cranialis. This case highlights posterior auricular nerve neuropathy as a potential complication of peripheral facial nerve palsy and polyneuritis cranialis. Accurate identification of neuropathic pain and appropriate management are essential. Clinicians should remain vigilant for atypical pain patterns during the course of facial nerve palsy, particularly in the setting of polyneuritis cranialis.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elucidate biomarkers and the molecular pathways associated with genetic variants that contribute to the etiology of Parkinson's disease.","authors":"Hai Duc Nguyen","doi":"10.1007/s13760-025-02897-7","DOIUrl":"https://doi.org/10.1007/s13760-025-02897-7","url":null,"abstract":"<p><p>Genetic variants can affect signaling pathways that are important in the pathophysiology of Parkinson's disease (PD). Comprehending their relationship is crucial for the development of diagnostic instruments and preventative drugs for PD. We thoroughly analyzed data from 68 genome-wide association studies to uncover significant genetic variations and clarify the molecular pathways underlying the etiology of Parkinson's disease (PD) resulting from genetic variants. Six common biomarkers linked to PD were found in all 68 investigations: SNCA, TMEM175, BST1, RIT2, LRRK2, and MCCC1. SNCA (↑rs5019538 and ↑rs356182), LRRK2 (↑rs34637584 and ↑rs76904798), and SH3GL2 (↑rs10756907 and ↓rs13294100) were the main biomarkers associated with PD. The clinical traits of PD, such as age at onset, cognitive progression, motor progression, composite progression, tremor dominant, and postural instability gait difficulty, have been found to be underpinned by additional biomarkers, including APOE, NTRK2, SLCO1B3, SLC28A3, AQP10, SNCAIP, ANO2, CADM1, PTPRD, GPR32, GPR321, SQOR, SULT1C2, GABRG2, CYP4Z1, CDH13, and FANCF. Significant evidence was found linking genetic variants linked to an increased risk of PD to reduced dopamine production, receptor recycling, oxidoreductase activity, and increased amyloid-beta accumulation. Considerable evidence links genetic variations with a lower risk of PD due to improved synaptic vesicle signaling, neuron projection development, controlled histone methylation, and excitatory postsynaptic potential. Additionally, we found MYT1L and hsa-miR-20a-5p, which are essential for understanding the genetic variations linked to PD. These findings provide a solid underpinning for future therapeutic approaches aimed at PD, with a focus on the genetic variants and processes connected to the illness.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of migraine menstrual, migraine and risk factors in women of reproductive age; a multi-centre study.","authors":"Meryem Erdoğan Acar, Gonca Buran, Yasemin Özyer Güvener, Çiler Yeygel, Ayşegül Dönmez, Nurten Denizhan Kırcan","doi":"10.1007/s13760-025-02893-x","DOIUrl":"https://doi.org/10.1007/s13760-025-02893-x","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the prevalence and risk factors associated with migraine and menstrual migraine in women of reproductive age.</p><p><strong>Method: </strong>This multicenter cross-sectional study included 2049 women who were successfully contacted between May and December 2023. The data were collected via an online interview method using the Individual Identification Form, which was created by the researchers and consists of three parts.</p><p><strong>Results: </strong>The mean age of the study participants was determined to be 24.19 ± 7.76 years. The prevalence of migraine was found to be 16.4%, while the prevalence of menstrual migraine was 56.4%. A statistically significant relationship was identified between migraine diagnosis and a number of variables, including marital status, educational status, employment status, social security status, income status, family type, smoking habits, alcohol consumption and coffee intake (p < 0.05). A statistically significant relationship was found between menstrual headache and marital status, working in a gainful job, presence of social security, income status, family type, smoking, alcohol use and coffee consumption (p < 0.05).</p><p><strong>Conclusion: </strong>Many sociodemographic characteristics and habits in women's daily lives are among the risk factors for migraine and menstrual migraine. It is advisable for health professionals to provide comprehensive counseling services to facilitate the adoption of healthy behaviors in relation to these risk factors.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145190679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of serum glucagon-like peptide-1 and dipeptidyl peptidase-4 levels in patients with migraine.","authors":"Melis Gultekin, Fatih Davran, Nehir Yuksel, Ozge Beyazcicek, Serif Demir","doi":"10.1007/s13760-025-02894-w","DOIUrl":"https://doi.org/10.1007/s13760-025-02894-w","url":null,"abstract":"<p><strong>Background: </strong>Migraine is a prevalent neurovascular disorder affecting over one billion people globally, imposing significant daily life limitations. Migraine headaches are linked to the activation of trigeminal nerve endings. Glucagon-like peptide-1 (GLP-1) is a hormone involved in insulin regulation and plays neuroprotective roles in the central nervous system (CNS). Dipeptidyl peptidase-4 (DPP-4) is a protease enzyme that degrades GLP-1, rendering it inactive, and modulates metabolic and neurological pathways. This study investigates the association between serum GLP-1 and DPP-4 levels and migraine pathophysiology to propose a novel therapeutic approach for migraine.</p><p><strong>Methods: </strong>The study included 42 migraine patients and 42 healthy controls. After fasting for at least 8 h, blood samples were collected. Serum GLP-1 and DPP-4 levels were measured using ELISA, and statistical analyses were conducted with SPSS 24.0.</p><p><strong>Results: </strong>Serum GLP-1 and DPP-4 levels were significantly lower in migraine patients compared to controls (p < 0.001). Patients with migraine with aura had significantly lower GLP-1 levels compared to those with migraine without aura (p = 0.016). A significant decrease in GLP-1 levels was observed in patients experiencing pain localized in the occipital lobe (p = 0.01).</p><p><strong>Conclusions: </strong>Serum GLP-1 and DPP-4 levels were lower in migraine patients. Given the role of GLP-1 in the central nervous system, reduced GLP-1 may contribute to migraine pain. Similarly, low DPP-4, which metabolizes GLP-1, may be linked to these findings and could trigger attacks by increasing blood CGRP levels.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An atypical case of FA2H-related HSP35 with subtle neuroimaging findings and a novel variant in a young adult with spastic paraparesis.","authors":"Subhajit Roy, Pooja Mailankody, Gautham Arunachal, Rohan R Mahale, Hansashree Padmanabha","doi":"10.1007/s13760-025-02899-5","DOIUrl":"https://doi.org/10.1007/s13760-025-02899-5","url":null,"abstract":"<p><p>We report a young Indian woman with a homozygous deletion in FA2H manifesting with a progressive spastic paraparesis, skeletal deformities, and subtle oculomotor signs, thereby broadening the phenotypic spectrum of HSP35. Except for diffuse spinal cord atrophy in MRI, other investigations were non-contributory. Whole exome sequencing with mitochondrial analysis revealed a homozygous variant c.32_34delTCT (p.Phe11del) in FA2H gene in Exon 1 of chromosome 16-a likely pathogenic, autosomal recessive mutation (ACMG: PM2,PM4,PP4-Moderate). This report underscores the importance of considering FA2H-related HSP even in late-onset or atypical presentations of adult-onset spastic paraparesis, especially in consanguineous populations, even when classical imaging findings are absent. Genetic testing remains crucial for diagnosis, prognostication, and counselling.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145172093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of patient education interventions on non-motor symptoms and disease outcomes in parkinson's disease: a systematic review.","authors":"Lisa Van Doeselaer, Kaat Colman, David Crosiers, Femke Dijkstra","doi":"10.1007/s13760-025-02900-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02900-1","url":null,"abstract":"<p><p>Parkinson's disease is the second most common neurodegenerative disease, characterized by both motor symptoms (MS) and non-motor symptoms (NMS). While MS have traditionally been the primary focus of treatment and research, NMS significantly contribute to disease burden. However, knowledge regarding NMS in Parkinson's patients seems particularly lacking. Educational interventions have previously shown a positive effect on health outcomes in chronic illnesses such as Alzheimer's disease and diabetes, warranting investigation into their impact on NMS in Parkinson's disease. We conducted a systematic review to evaluate whether education interventions on non-motor symptoms (NMS) in Parkinson's disease (PD) patients contribute to better disease outcomes. Education interventions showed significant effects on various patient-reported and physician-reported outcomes, including quality of life, motor symptoms, depression, fatigue, adherence to treatment, acceptance of diagnosis, satisfaction with care, psychosocial adjustment, and independence in activities of daily living. Some effects were temporary, implying the need for booster sessions in future education interventions. There was limited focus on the direct impact of education interventions on NMS other than depression and anxiety. No studies directly compared different education interventions, preventing conclusions on which type of intervention leads to the best outcome. In conclusion, education interventions on NMS in PD have significant effects on disease outcomes. Future research should determine the optimal timing for booster sessions and further investigate their impact on NMS beyond depression and anxiety. Direct comparisons between different education interventions are needed to identify the most effective approach.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145147346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep abnormalities in patients with idiopathic intracranial hypertension: a cross-sectional study.","authors":"Vaishali Sharma, Sucharita Ray, Pramod Avti, Swapnajeet Sahoo, Aastha Takkar, Shiv Lal Soni, Kamalesh Chakravarty","doi":"10.1007/s13760-025-02892-y","DOIUrl":"https://doi.org/10.1007/s13760-025-02892-y","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic Intracranial Hypertension (IIH) has been associated with comorbid sleep disorders. Although emerging evidence suggests a link between IIH and sleep disorders, yet this association remains underexplored. This case -control study aims to evaluate the prevalence of sleep-related abnormalities in patients with IIH using validated screening and severity assessment tools.</p><p><strong>Methods: </strong>120 newly diagnosed, drug naive IIH patients and 40 age and gender matched controls were enrolled. Baseline characteristics and clinical parameters were evaluated. Headache severity was assessed using MIDAS and HIT6 questionnaires. Sleep disturbances were assessed using the Pittsburg Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Insomnia Severity Index (ISI), restless leg syndrome (RLS) scale, Berlin Questionnaire, and STOP-BANG questionnaire. Statistical analysis was conducted using SPSS v27.</p><p><strong>Results: </strong>The mean age of patients was 34.92 (9.42) years. IIH cases were predominately female (85%). Cases had significantly higher BMI (85% were overweight and obese). Poor sleep quality (PSQI ≥ 5) was significantly more common in IIH patients (46.67%) than controls (15%) (p < 0.001). High OSA risk was also more prevalent in IIH patients based on Berlin and STOP-BANG scores (p = 0.013 and p = 0.044 respectively). Although rates of Daytime sleepiness, RLS and Insomnia were higher in the IIH group, these differences were not statistically significant.</p><p><strong>Conclusion: </strong>Patients with IIH exhibit significantly higher rates of sleep disturbances, particularly poor sleep quality, and increased risk of OSA based on screening tools, which were also associated with higher BMI and psychiatric comorbidities. These findings underscore the importance of routine sleep screening in IIH patients.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145111484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of virtual reality (VR) in the rehabilitation of neurological disorders: a systematic review and meta-analysis of treatment parameters.","authors":"Mingyue Xiong, Manwa L Ng, Jiadong Lv","doi":"10.1007/s13760-025-02891-z","DOIUrl":"https://doi.org/10.1007/s13760-025-02891-z","url":null,"abstract":"<p><strong>Purpose: </strong>The present study evaluates the impact of virtual reality (VR) technology on balance function in patients with different neurological disorders, and explores the effects of diverse VR parameters on treatment efficacy.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Cochrane Library, EMBASE, Web of Science, and Scopus databases was conducted up to December 15, 2024. Data from 44 studies Involving 2,019 patients were independently screened and extracted by two researchers. Risk of bias was assessed using the Cochrane Collaboration's Risk of Bias Tool, and meta-analysis was performed using RevMan 5.4.1 software. The quality of evidence was evaluated using GRADE.</p><p><strong>Results: </strong>VR significantly improved balance ability in patients with different neurological disorders (SMD = 0.75; 95% CI: 0.62-0.87; Z = 11.96; p < 0.001), with the most pronounced effect in Parkinson's disease (SMD = 0.95; 95% CI: 0.67-1.22; Z = 6.75; p < 0.001). Significant improvements were also noted in static balance (SMD = 0.73; 95% CI: 0.42-1.04; Z = 4.59; p < 0.001), Berg Balance Scale (SMD = 0.76; 95% CI: 0.61-0.90; Z = 10.25; p < 0.001), Timed Up and Go (SMD = - 0.30; 95% CI: - 0.50 to - 0.09; Z = 2.87; p = 0.004), and Tinetti Scale (SMD = 0.53; 95% CI: 0.18-0.88; Z = 2.94; p = 0.003). However, improvements in the Activities-specific Balance Confidence scale (SMD = 0.29; 95% CI: - 0.04-0.61; Z = 1.72; p = 0.09) and Functional Reach Test scores (SMD = 0.17; 95% CI: - 0.30-0.63; Z = 0.70; p = 0.49) were not significant. Combining VR with other therapies yielded better results (SMD = 0.78; 95% CI: 0.63-0.93; Z = 10.29; p < 0.001). Treatments lasting no more than 30 min (SMD = 0.78; 95% CI: 0.63-0.94; Z = 9.73; p < 0.001) and Intervention periods not exceeding 6 weeks (SMD = 0.78; 95% CI: 0.61-0.95; Z = 9.02; p < 0.001) were more effective.</p><p><strong>Conclusion: </strong>VR technology effectively improves balance In patients with neurological disorders. Optimal results are achieved with sessions under 30 min and intervention periods less than six weeks.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"People with epilepsy and intellectual disability.","authors":"C P J A Monté, J B A M Arends, R H C Lazeron, I Y Tan, P A J M Boon","doi":"10.1007/s13760-025-02884-y","DOIUrl":"https://doi.org/10.1007/s13760-025-02884-y","url":null,"abstract":"<p><p>The prevalence of epilepsy is high in people with intellectual disability (ID) and increases with growing severity of the ID. People with epilepsy and ID are not only at risk of different types of seizure-related complications (such as injuries and sudden unexpected death) but also of different types of physical impairments and of psychiatric, cognitive and behavioral comorbidities. ID is also associated with drug-resistant epilepsy (OR 3.38). Polytherapy is frequent in this population and leads to (among others) psycho-behavioral and bone health adverse events. All these factors together complicate the care for these persons and cause a great deal of social dependency. They function at a lower level than the severity of the ID alone would predict. Due to the common intractability of the epilepsy, alternative treatments are needed such as ketogenic diet and in specific cases neurosurgery and neuromodulation. The behavioral disorder is mostly multifactorial and the treatment may be complex. The family burden and stress should be taken into account, as well as the transition from child to adult neurologist and the possibility of admission to institutes.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of COVID-19 in patients with parkinson's disease and the impact of parkinson's disease on COVID-19 prognosis.","authors":"Demet Yildiz, Nilüfer Büyükkoyuncu Pekel, Melih Yüksel, Aksel Özdemir, Ebru Çetin Kenan, Muhammed Furkan Öztürkci","doi":"10.1007/s13760-025-02888-8","DOIUrl":"https://doi.org/10.1007/s13760-025-02888-8","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to retrospectively evaluate the prevalence of COVID-19 infection among patients with Parkinson's disease (PD), along with the clinical course and factors associated with mortality.</p><p><strong>Methods: </strong>A total of 1,786 patients diagnosed with Parkinson's disease and registered at our hospital were screened. Among these, 222 had undergone PCR testing for COVID-19, of whom 76 tested negative and 152 tested positive, indicating a COVID-19 prevalence of 8.51% in the PD population. Due to insufficient data, 63 of the COVID-19 positive patients were excluded. The final study cohort included 177 patients: 89 patients with PD (50.3%) and 88 age- and sex-matched controls (49.7%). Clinical, laboratory, and prognostic parameters were compared between groups.</p><p><strong>Results: </strong>The prevalence of dementia was significantly higher in the PD group. Mortality at both 28 and 90 days was also significantly increased among patients with PD. Notably, those receiving combined therapy with dopamine agonists and levodopa had lower mortality rates at both time points. In patients who died within 28 or 90 days, levels of age, neutrophil count, lymphocyte count, D-dimer, ferritin, C-reactive protein (CRP), and troponin differed significantly compared to survivors.</p><p><strong>Conclusion: </strong>Patients with Parkinson's disease represent a vulnerable population at increased risk for adverse outcomes from COVID-19. Close clinical monitoring, continuous dopaminergic treatment, and a personalized approach are essential for optimizing management during COVID-19 infection.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}