Acta neurologica Belgica最新文献

Assessment of quality of life in patients with cervical dystonia and hemifacial spasm after botulinum toxin injections.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-24 DOI: 10.1007/s13760-025-02742-x

Haidy Elshebawy, Gihan M Ramzy, Mohammed Salama, Shaimaa El-Jaafary

{"title":"Assessment of quality of life in patients with cervical dystonia and hemifacial spasm after botulinum toxin injections.","authors":"Haidy Elshebawy, Gihan M Ramzy, Mohammed Salama, Shaimaa El-Jaafary","doi":"10.1007/s13760-025-02742-x","DOIUrl":"https://doi.org/10.1007/s13760-025-02742-x","url":null,"abstract":"Background: Botulinum toxin is now used to treat a variety of neurological and non-neurological disorders. Despite the fact that injections of botulinum neurotoxin may significantly reduce the involuntary muscular contractions associated with focal dystonia and hemifacial spasm (HFS), it is less certain whether the motor effect would result in an improvement in health-related quality of life (HR-QoL).Our goal was to evaluate how botulinum toxin affected individuals with cervical dystonia and hemifacial spasm in terms of their quality of life, self-esteem, pain, sleep, and depression.Methods: This is a prospective study that included 40 patients diagnosed with cervical dystonia or hemifacial spasm treated with Botulinum toxin. Quality of life, self-esteem, pain, sleep and depression were all assessed in the studied patients by self-reporting questionnaires to assess the impact of botulinum toxin on them.Results: The quality of life with its components (physical, physical role, emotional role, vitality, mental health, social functioning and pain) showed significant improvement at the end of follow up compared to baseline with p values ≤ 0.001. Also, there was a significant improvement of self-esteem score, depression score, at the end of follow up period compared to baseline assessment with p value 0.012, < 0.001 respectively. Moreover, there was a significant improvement of all pain scales and sleep quality scores with p values < 0.05 except the habitual sleep efficiency.Conclusion: botulinum toxin is an effective therapy for motor and non-motor manifestations associated with focal cervical dystonia and hemifacial spasm as well as the quality of life and to conclude that its effectiveness is dependent not only on the elimination of physical symptoms, but also on improving the patients' and their families' emotional and social status to help providing the drug to all eligible patients.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychometric properties of the headache needs assessment (HANA) survey in tension type headache: Turkish version, reliability, and validity study.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-24 DOI: 10.1007/s13760-025-02749-4

Halime Arikan, Dilara Onan, Uğur Kulu

{"title":"Psychometric properties of the headache needs assessment (HANA) survey in tension type headache: Turkish version, reliability, and validity study.","authors":"Halime Arikan, Dilara Onan, Uğur Kulu","doi":"10.1007/s13760-025-02749-4","DOIUrl":"https://doi.org/10.1007/s13760-025-02749-4","url":null,"abstract":"Background: Scales and questionnaires measure various variables, such as health symptoms, functionality, and quality of life. The Headache Needs Assessment (HANA) survey evaluates the chronic impact of migraine on quality of life, focusing on frequency and bothersomeness.Objective: This study aimed to adapt and validate the Turkish version of the HANA, a concise and practical tool for assessing tension-type headache-related needs.Methods: A total of 86 individuals with tension-type headaches were included in the test phase, while 79 participants with tension-type headaches were involved in the retest phase. Exploratory and Confirmatory Factor Analyses (EFA and CFA) were used to assess structural validity. Reliability was evaluated using Intraclass Correlation Coefficients (ICC) and Cronbach's α, and convergent validity was tested by correlating HANA scores with the Henry Ford Hospital Headache Disability Inventory (HDI) and Headache Impact Test-6 (HIT-6).Results: Test-retest reliability was strong (ICC 0.789-0.840), and internal consistency was high (α = 0.882-0.913). Good correlations with HDI (r = 0.545; p = 0.000) and HIT-6 (r = 0.484; p = 0.000) supported convergent validity, while it was observed a low correlation with Visual Analog Scale (r = 0.342; p = 0.001). There were no floor or ceiling effects observed.Conclusion: The Turkish version of the HANA is a valid and reliable tool in individuals with tension-type headache that is easy to administer in both clinical and research contexts.Clinicaltrials: Gov number: NCT06675292.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG abnormalities in a 3-year-old child with developmental delay and autistic-like behavior: a case of Phelan-McDermid syndrome.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-24 DOI: 10.1007/s13760-025-02725-y

Massimiliano Raso, Miriana Guarino, Francesco Chiarelli, Sara Matricardi, Giovanni Prezioso

引用次数: 0

A case of MOG antibody-positive unilateral optic neuritis following a pulmonary tuberculosis infection.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-17 DOI: 10.1007/s13760-025-02745-8

Mi Xiong, Rui Gu, Yan Liu

引用次数: 0

MTH1 in the disorders of the central nervous system: scope beyond brain tumors and challenges.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-17 DOI: 10.1007/s13760-025-02747-6

Lekshmi Padmakumar, Ramshekhar N Menon, Srinivas Gopala, George C Vilanilam

{"title":"MTH1 in the disorders of the central nervous system: scope beyond brain tumors and challenges.","authors":"Lekshmi Padmakumar, Ramshekhar N Menon, Srinivas Gopala, George C Vilanilam","doi":"10.1007/s13760-025-02747-6","DOIUrl":"https://doi.org/10.1007/s13760-025-02747-6","url":null,"abstract":"Human MutT homolog 1 (MTH1) plays a crucial role in sanitizing oxidized DNA precursors by enzymatically hydrolyzing oxidized nucleotides. The absence of MTH1 activity in the cells results in the accumulation of oxidized nucleotides within the nucleus and mitochondria, leading to mutations, abnormal proteins, and neurodegeneration (in the central nervous system). It has garnered interest as a potential target for anticancer treatment through targeted inhibitor molecules but remains largely understudied in other neurological disorders. This review explores the understanding of MTH1 expression in glioma and its potential role in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease concerning disease mechanism and prognosis. Neurodegeneration, activation of glial cells, and mitochondrial dysfunction are common mechanisms involved in the progression of these diseases. This review also tries to identify the unexplored associations and research gaps that can reveal novel applications of the enzyme in epilepsy, in which MTH1 is studied less. The influence of the ROS environment and cell type on MTH1 expression and function is crucial to be studied for elucidating its role in a multitude of CNS pathologies. The involvement of microglial cell-mediated inflammatory responses through ROS production in epileptogenesis in mouse models highlights the interplay between oxidative stress and neuroinflammation in epilepsy. The possible existence of a similar association between MTH1 expression and pathogenesis of the discussed neurological disorders in vivo demands further exploration preclinically and in patient samples.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-AMPA receptor encephalitis combined with myasthenia gravis: a case report.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-12 DOI: 10.1007/s13760-025-02743-w

Jiawei Huang, Jie Gao, Lei Xia, Di Wu, Minmin Ma

引用次数: 0

A post-operative duro-pleural fistula rapidly confirmed by an innovative use of the P-Tau181 protein.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-12 DOI: 10.1007/s13760-025-02738-7

Crabbé Florence, Noël Julie, Carestia Luciano, Bayart Jean-Louis

引用次数: 0

Magnetic resonance spectroscopy for discriminating primary angiitis of the central nervous system from gliomas and lymphomas.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-11 DOI: 10.1007/s13760-025-02744-9

Ping Lu, Lingyun Cui, Lulin Zhang, Huabing Wang, Linlin Yin, Decai Tian, Xinghu Zhang

{"title":"Magnetic resonance spectroscopy for discriminating primary angiitis of the central nervous system from gliomas and lymphomas.","authors":"Ping Lu, Lingyun Cui, Lulin Zhang, Huabing Wang, Linlin Yin, Decai Tian, Xinghu Zhang","doi":"10.1007/s13760-025-02744-9","DOIUrl":"https://doi.org/10.1007/s13760-025-02744-9","url":null,"abstract":"Objective: Conventional imaging often struggles to differentiate between primary angiitis of the central nervous system (PACNS) and intracranial tumors. This study aims to evaluate the application value of proton magnetic resonance spectroscopy (1H-MRS) in distinguishing PACNS from intracranial tumors.Methods: This study collected data from 10 patients with PACNS and 15 patients with intracranial tumors (10 gliomas and 5 lymphomas) confirmed by pathological biopsy. The levels of choline (Cho), creatine (Cr), and N-acetylaspartate (NAA) in the lesion areas and contralateral normal brain tissue were measured and analyzed using 1H-MRS, and the ratios of Cho/Cr, NAA/Cr, and Cho/NAA were calculated. The diagnostic efficacy of 1H-MRS in distinguishing PACNS from intracranial tumors was evaluated using receiver operating characteristic (ROC) curves and area under the curve (AUC).Results: Compared to contralateral normal brain tissue, significant differences were observed in the ratios of Cho/Cr, NAA/Cr, and Cho/NAA between the lesion areas of PACNS and intracranial tumors (P < 0.001). After correcting for the corresponding normal brain tissue spectra, the NAA/Cr ratio in PACNS lesion areas was significantly higher than in intracranial tumor lesions (0.90 vs. 0.25, P < 0.001), and the Cho/NAA ratio was significantly lower in PACNS lesions (1.98 vs. 9.00, P < 0.001), while the difference in Cho/Cr was not significant (1.59 vs. 1.94, P = 0.405). When the corrected NAA/Cr ratio was ≥ 0.71, the ROC-AUC for diagnosing PACNS was 1.00, with both specificity and sensitivity at 100%. The subgroup analysis of glioma/lymphoma yielded similar results.Conclusion: The ratios of NAA/Cr and NAA/Cho are significantly meaningful in differentiating PACNS from intracranial tumors, and 1H-MRS can be an effective tool for distinguishing these two conditions.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143389843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory function in Wilson's disease-systematic literature review.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-10 DOI: 10.1007/s13760-025-02741-y

Jan Paweł Bembenek, Tomasz Litwin, Agnieszka Piechal, Anna Członkowska, Agnieszka Antos, Adam Przybyłkowski

{"title":"Olfactory function in Wilson's disease-systematic literature review.","authors":"Jan Paweł Bembenek, Tomasz Litwin, Agnieszka Piechal, Anna Członkowska, Agnieszka Antos, Adam Przybyłkowski","doi":"10.1007/s13760-025-02741-y","DOIUrl":"https://doi.org/10.1007/s13760-025-02741-y","url":null,"abstract":"In Wilson's disease (WD) improper copper metabolism results in copper accumulation in various organs, mainly brain and liver. The sense of smell is today one of the focuses of interest in aging and neurodegenerative diseases research. However, in WD olfactory function (OF) is still poorly investigated. Our aim was to perform a systematic review of the studies evaluating OF in WD. We searched PubMed for original papers evaluating olfactory function in WD and retrieved five articles. Additionally, one article was identified while viewing the references lists of the included studies. Finally, we included 6 studies. The number of patients ranged from 12 to 68 (altogether 222 WD patients) and their clinical characteristics were variable. Differences in methodology (mainly various tests used for OF evaluation) made it impossible to meta-analyze the data. OF was worse in WD than in controls in all studies. In 3 studies OF was impaired significantly in neurologic phenotype vs hepatic, which was not confirmed in 2 other studies. Correlation between OF and presence of brain lesions in magnetic resonance imaging was inconsistent across two studies. Only one study assessed brain regions involved in the olfactory tract by evaluating olfactory bulb volume. There was no effect of WD treatment, including its type and duration on OF (4 studies). One study additionally assessed taste which was preserved in WD. Although OF was found to be abnormal in WD, this area remains insufficiently explored. Further studies conducted on larger cohorts, with a focus on olfactory tract damage, is essential.","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

It is not so easy to objectively detect cognitive fluctuations in dementia with Lewy bodies.

IF 2 4区医学

Acta neurologica Belgica Pub Date : 2025-02-08 DOI: 10.1007/s13760-025-02737-8

Yasuhiro Nagahama, Shinya Yuki, Hiroko Suga, Sotaro Hieda

引用次数: 0