Acta neurologica Belgica最新文献

{"title":"Synergistic pain relief in cervical radiculopathy: A randomized trial of topical methylcobalamin gel with phonophoresis and Mulligan mobilization.","authors":"Imran Ahmad Khan, Iqra Bibi, Komal Ammar Bukhari, Maliha Khalid Khan","doi":"10.1007/s13760-026-03128-3","DOIUrl":"https://doi.org/10.1007/s13760-026-03128-3","url":null,"abstract":"<p><strong>Objectives: </strong>Cervical radiculopathy is a neuropathic disorder caused by nerve root compression that presents as pain that refers to the upper limb, numbness, and weakness. The purpose of this study was to evaluate the clinical efficacy of topical MeCbl gel 6% w/w formulation by phonophoresis along with Mulligan traction/mobilization, compared to Mulligan mobilization alone.</p><p><strong>Patients and methods: </strong>A single-blinded, randomized clinical trial was conducted in Pakistan between November 2024 and April 2025, involving 370 (consented) patients with cervical radiculopathy. Patients were randomly divided into two groups: Group A received treatment of MeCbl gel, along with phonophoresis plus Mulligan traction and mobilization, whereas Group B received Mulligan traction and mobilization with topical MeCbl gel without phonophoresis. Both groups received 12 sessions over a period of four weeks. Outcomes were measured using the validated 0-10 Numerical Pain Rating Scale (NPRS), a measure of pain intensity, and the Neck Disability Index (NDI), which measures cervical functional impairment on a scale from 0 to 50.</p><p><strong>Results: </strong>The outcome demonstrated significantly increased pain reductions (NPRS, p < 0.01) and disability (NDI, p < 0.01) in Group A compared to Group B, along with an improvement in cervical range of motion (p < 0.02).</p><p><strong>Conclusion: </strong>The findings of this study suggests that efficacy of MeCbl gel application by phonophoresis in combination with Mulligan manual therapy is higher when compared with conventional MeCbl gel application and Mulligan manual therapy in the treatment of cervical radiculopathy. The improved results from the use of phonophoresis are most probably due to increased absorption of medication and its deep penetration into the tissues.</p><p><strong>Trial registration: </strong>Iranian registry of clinical trial IRCT20241220064105N2.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148374274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of coexistence of spinal intradural capillary hemangioma and craniocervical junction dural arteriovenous fistula.","authors":"Satoshi Kawajiri, Makoto Isozaki, Ken Matsuda, Hidetaka Arishima, Kenichiro Kikuta","doi":"10.1007/s13760-026-03126-5","DOIUrl":"https://doi.org/10.1007/s13760-026-03126-5","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing cranial tremors in a case of spinocerebellar ataxia type 12: a unique positional tremor.","authors":"Shreyashi Jha, Adreesh Mukherjee, Abhishek B Gohel, Atanu Biswas, Amlan Mandal","doi":"10.1007/s13760-026-03127-4","DOIUrl":"https://doi.org/10.1007/s13760-026-03127-4","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148366684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Content quality and reliability of youtube exercise videos for parkinson's disease\".","authors":"Pulen Das, Saon Sanyal Bhowmik, Tiyasa Hoom","doi":"10.1007/s13760-026-03122-9","DOIUrl":"https://doi.org/10.1007/s13760-026-03122-9","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148358891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel CHMP2B variant of uncertain significance in a patient with apathy, hyperorality, and mild language impairment.","authors":"Alessio Rocco Sangiorgio, Carlo Manco, Delia Righi, Silvia Bianchi, Domenico Plantone","doi":"10.1007/s13760-026-03125-6","DOIUrl":"10.1007/s13760-026-03125-6","url":null,"abstract":"<p><p>Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder linked to specific genetic mutations, including those in the CHMP2B gene, which encodes a component of the ESCRT-III complex involved in endosomal trafficking and autophagy. Here, we report a 62-year-old woman presenting with apathy, hyperorality, and language impairment, harbouring a novel heterozygous c.440 A > G CHMP2B variant of uncertain significance, causing D147G substitution. Neuropsychological evaluation revealed severe apathy, whereas MRI and 18FDG-PET were consistent with an early left prefrontal impairment. The D147G substitution is located in proximity to the D148Y mutation, previously associated with semantic variant primary progressive aphasia, suggesting it may similarly disrupt protein conformation or stability. Our findings raise the possibility that this variant may be relevant in the context of an FTD-like phenotype. This case highlights the importance of investigating missense variants to further elucidate the pathogenic mechanisms of ESCRT-III dysfunction in neurodegeneration.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148358831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photon-counting CT-angiography in comparison to digital subtraction angiography and MR-angiography for assessing intra-aneurysmal flow disrupting devices.","authors":"Frederic De Beukelaer, Laura L Wuyts, Martin Wiesmann, Hani Ridwan, Steven Van Hedent, Charlotte S Weyland","doi":"10.1007/s13760-026-03112-x","DOIUrl":"10.1007/s13760-026-03112-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the potential of Photon-Counting Detector CT Angiography (PCD-CTA) for the post-interventional assessment of intraaneurysmal flow disrupting devices (IAFD).</p><p><strong>Methods: </strong>This retrospective analysis evaluates consecutive patients with intracranial aneurysms treated with IAFD between April 2023 and April 2025, who underwent PCD-CTA, MR angiography and DSA as part of their clinical diagnostic work-up routine. Polyenergetic images, iodine and virtual monoenergetic imaging reconstructions with different keV levels (40 and 80) and with different Head vessel kernels (Hv56 and Hv72) were acquired with and without iterative metal artifact reduction. Three independent readers assessed image quality using a 5-point Likert scale and region of interest analysis. The different kernels, keV and the optimized spectral reconstructions were compared in descriptive analysis.</p><p><strong>Results: </strong>A total of 10 patients (mean age 60.41 ± 11.43 (43-74) years; 6 women) with intracranial aneurysms treated with either Contour device (n = 6) or WEB device (n = 4) were included. Reconstructions using Hv56 and a 40 keV yielded increased signal and contrast to noise ratios and were preferred for visualizing the parent vessel lumen compared to Hv72 and higher keV levels (p < 0.001). Assessing the different spectral reconstructions virtual monoenergetic reconstructions proved to be best to evaluate the parent vessel lumen (p = 0.040).</p><p><strong>Conclusion: </strong>Spectral reconstructions of PCD-CTA with a smoother reconstruction kernel and a low keV level seem to be beneficial to achieve optimal image quality for the diagnostic evaluation of patients with intracranial IAFD.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148350409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multinodular vacuolating neuronal tumor (MVNT) on MRI: distinctive, benign and often overlooked.","authors":"Deborah Van Melkebeke, Eva Verhellen, Elien De Schamphelaere","doi":"10.1007/s13760-026-03119-4","DOIUrl":"https://doi.org/10.1007/s13760-026-03119-4","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148337267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rare Listeria monocytogenes brain abscess presenting as a tunnel-like lesion in an immunocompromised patient.","authors":"Teymine Andreasyan, Tim Vanderhasselt","doi":"10.1007/s13760-026-03123-8","DOIUrl":"https://doi.org/10.1007/s13760-026-03123-8","url":null,"abstract":"<p><p>Cerebral abscesses caused by Listeria monocytogenes are very rare and mainly occur in immunocompromised and elderly patients. Brain abscesses caused by Listeria monocytogenes are characterized by a typical tunnel-like appearance, which may be considered a pathognomonic MRI feature and is thought to be the result of intra-axonal spread of the pathogen.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small-fiber neuropathy and autonomic neuropathy probably related to isolated hyperhomocysteinemia.","authors":"Fabian H Rossi, Joshua Rossi","doi":"10.1007/s13760-026-03114-9","DOIUrl":"https://doi.org/10.1007/s13760-026-03114-9","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of CSF and plasma pTau-181, pTau-217, and pTau-231 for Alzheimer's disease: a diagnostic meta-analysis.","authors":"Hazem E Mohammed, Mohamed E Haseeb, Mohamed Nasser, George Hanen, Mohamed Salem Abdelkader, Hatem Yaser, Shehab Yaser, Ahmed Samir, Yusra Arafeh, Mohamed Wagdy, Mohamed Khalafalla Darwish","doi":"10.1007/s13760-026-03107-8","DOIUrl":"https://doi.org/10.1007/s13760-026-03107-8","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) remains the most common cause of dementia worldwide, yet achieving an accurate early diagnosis continues to pose a major challenge. Recent advances highlight phosphorylated tau (pTau) isoforms-pTau-181, pTau-217, and pTau-231-detected in cerebrospinal fluid (CSF) and plasma as promising biomarkers capable of distinguishing AD from non-Alzheimer's dementias and cognitively healthy individuals (HC). This study aimed to comprehensively assess the diagnostic accuracy of these pTau isoforms through a systematic review and diagnostic meta-analysis.</p><p><strong>Methods: </strong>Following PRISMA 2020 guidelines and PROSPERO registration (CRD42025632278), we performed a systematic search of PubMed, Scopus, and Web of Science databases through September 2025. Eligible studies evaluated the diagnostic performance of pTau-181, pTau-217, or pTau-231 in CSF or plasma using established AD reference standards. Pooled sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC) were calculated using random-effects models. Clinical applicability was assessed via Fagan's nomogram, and publication bias was examined using Deeks' funnel plot asymmetry test.</p><p><strong>Results: </strong>Forty-eight studies encompassing diverse international cohorts met inclusion criteria. In differentiating AD from HC, CSF pTau-217 demonstrated the highest diagnostic precision (sensitivity = 0.95; specificity = 0.91), outperforming pTau-181 and pTau-231 (AUC = 0.90 each). Plasma biomarkers also exhibited strong diagnostic value: plasma pTau-181 achieved sensitivity of 0.88, specificity of 0.81, and AUC of 0.91, while plasma pTau-231 displayed sensitivity of 0.84, specificity of 0.87, and AUC of 0.86, with low interstudy heterogeneity. Comparative analyses confirmed significantly higher pTau concentrations in AD relative to both non-AD dementias and healthy controls. The overall certainty of evidence ranged from moderate to high, supporting the robustness of these findings.</p><p><strong>Conclusions: </strong>This meta-analysis supports the strong diagnostic performance of pTau isoforms, particularly CSF pTau-217, in distinguishing Alzheimer's disease from healthy controls and non-Alzheimer's dementias. However, evidence for CSF pTau-217 is limited and largely derived from limited number of studies. Although plasma pTau-181 and pTau-231 show promising diagnostic accuracy, further real-world validation, assay standardization, and assessment within established diagnostic pathways are needed.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148325331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}