Acta neurologica Belgica最新文献

{"title":"MICU1 myopathy revisited: phenotypic variability in a rare mitochondrial calcium disorder.","authors":"Pushkar Pazhani, Jayaram Saibaba, Rajeswari Aghoram, Vaibhav Wadwekar, Ankith K Jayan","doi":"10.1007/s13760-025-02815-x","DOIUrl":"https://doi.org/10.1007/s13760-025-02815-x","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144155469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coexistence of anti-MOG and anti-MAG antibodies in combined central and peripheral nervous system demyelination: a case of dual myelinopathy.","authors":"Rihab Ben Dhia, Yasmine Saad, Mariem Mhiri, Narjes Gouta, Mahbouba Frih-Ayed","doi":"10.1007/s13760-025-02787-y","DOIUrl":"https://doi.org/10.1007/s13760-025-02787-y","url":null,"abstract":"<p><strong>Background: </strong>Myelin oligodendrocyte glycoprotein-associated disease (MOG-AD) is a central nervous system (CNS) demyelinating disorder linked to anti-MOG antibodies, whereas anti-myelin associated glycoprotein (MAG) antibodies are associated with peripheral nervous system (PNS) demyelination. Their coexistence in a single patient has not been previously reported.</p><p><strong>Case presentation: </strong>We describe a 38-year-old male who developed rapidly progressive paraparesis, visual impairment, and sensory deficits. MRI revealed multifocal CNS demyelinating lesions, while nerve conduction studies later confirmed a demyelinating polyneuropathy. Serum testing showed concurrent anti-MOG and high-titer anti-MAG antibodies. Despite treatment with corticosteroids, IVIg, and plasma exchange, the patient exhibited a severe, relapsing course with persistent disability.</p><p><strong>Conclusion: </strong>This is the first documented case of anti-MOG and anti-MAG antibody coexistence, causing simultaneous CNS and PNS demyelination and suggesting a shared autoimmune mechanism. Anti-MAG antibodies may indicate a more aggressive course, warranting routine testing and intensive therapy. Further research is needed to clarify their pathogenic interplay and refine treatment strategies.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG microstate analysis in trigeminal neuralgia: identifying potential biomarkers for enhanced diagnostic accuracy.","authors":"Reza Ahmadi Lashaki, Zahra Raeisi, Abolfazl Sodagartojgi, Fatemeh Abedi Lomer, Elnaz Aghdaei, Hossein Najafzadeh","doi":"10.1007/s13760-025-02812-0","DOIUrl":"https://doi.org/10.1007/s13760-025-02812-0","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated EEG microstate dynamics in trigeminal neuralgia (TN) patients to understand the central nervous system's contribution to this neuropathic pain condition. Despite TN's traditional classification as a peripheral neuropathy, altered brain network organization may play a critical role in pain chronification and treatment resistance, making EEG microstates a valuable tool for capturing these dynamic neural signatures.</p><p><strong>Methods: </strong>We analyzed resting-state EEG recordings from 14 healthy individuals and 36 TN patients through a systematic analytical pipeline. After preprocessing with a fifth-order Butterworth band-pass filter (10-40 Hz), we employed k-means clustering to identify four distinct microstate configurations (4-7 states). From these configurations, we extracted temporal parameters (duration, occurrence, coverage, and mean global field power) and constructed transition probability matrices to characterize brain state dynamics. These features were then evaluated using ANOVA and utilized in machine learning classification models to assess their discriminative potential.</p><p><strong>Results: </strong>TN patients demonstrated distinct microstate abnormalities, including dramatically increased durations in specific microstates (5-6 times longer than controls) and consistently reduced global field power (0.03 vs. 0.35). Transition probability analyses revealed striking differences between groups: healthy subjects exhibited balanced bidirectional transitions (particularly B↔C at ~ 31-33%), whereas TN patients showed highly asymmetric patterns with strong directional flows (B→A: 33.5%, C→A: 35.2%, D→A: 34.4% in 4-state model). Most notably, state E functioned as a distinctive \"sink\" in TN patients, receiving significant transitions while exhibiting minimal outward flow (only 2.8-3.6% in 7-state model), suggesting trapped neural processing. Machine learning classification achieved exceptional discrimination between groups (91.9% accuracy with SVM), with optimal performance using four features in simpler 4-state models.</p><p><strong>Conclusion: </strong>Our findings establish EEG microstate analysis as a promising neurophysiological framework for understanding TN pathophysiology, revealing objective biomarkers that reflect altered brain network dynamics rather than simply peripheral nerve dysfunction. These distinctive microstate patterns align with contemporary pain processing theories and offer potential applications in diagnosis, treatment monitoring, and development of novel therapeutic approaches targeting the central mechanisms of TN.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endovascular thrombectomy plus intravenous thrombolysis versus endovascular thrombectomy alone for large ischemic stroke.","authors":"Mohamed Elfil, Abdallah Abbas, Hayes Fountain, Ebrahem Salah Abdul-Hamid, Mohammad Aladawi, Zaid Najdawi, Ahmed Elmashad, Hazem S Ghaith, Giana Dawod, Iman Moeini-Naghani, Suhail Abdulla AlRukn, Chaitanya Medicherla, Hosam Aljehani, Priyank Khandelwal, Gurmeen Kaur, Mohammad El-Ghanem, Chirag D Gandhi, Fawaz Al-Mufti","doi":"10.1007/s13760-025-02808-w","DOIUrl":"https://doi.org/10.1007/s13760-025-02808-w","url":null,"abstract":"<p><strong>Background: </strong>Endovascular thrombectomy (EVT) is the gold standard for eligible acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). A few trials studied EVT in AIS-LVO with large ischemic infarcts. We investigated the impact of intravenous thrombolysis (IVT) on EVT outcomes in those patients.</p><p><strong>Methods: </strong>We conducted a meta-analysis using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and Cochrane Handbook of Systematic Reviews and Interventions. We searched 4 databases and performed our analysis utilizing a pooled risk ratio (RR) with a 95% confidence interval (CI).</p><p><strong>Results: </strong>Three studies investigated EVT with and without IVT in AIS-LVO patients with large ischemic infarcts. Regarding the modified Rankin Scale (mRS) score of 0-2 at 3 months, there was a statistically significant difference favoring EVT plus IVT (RR: 1.48, 95%CI: 1.27, 1.72, P < 0.00001). In respect of mRS score of 0-3, the analysis also favored EVT plus IVT (RR: 1.25, 95%CI: 1.11, 1.41, P = 0.0003). Regarding early neurological improvement (ENI) at 24 and 36 hours, our analysis favored EVT plus IVT (RR: 1.16, 95%CI: 1.01, 1.34, P = 0.03). In terms of mortality, our analysis favored EVT plus IVT (RR: 0.88, 95%CI: 0.77, 1, P = 0.04). There was no difference between the two groups across different types of intracranial hemorrhage (ICH).</p><p><strong>Conclusion: </strong>Our results showed a beneficial impact of IVT on the outcomes of EVT in AIS-LVO patients with large ischemic infarcts in terms of functional outcomes and ENI. IVT was also associated with a lower mortality rate but not with an increased risk of ICH. Larger studies are needed to corroborate such results.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of stereotactic radiosurgery for petroclival meningiomas: A systematic review and Meta-Analysis.","authors":"Bardia Hajikarimloo, Salem M Tos, Ibrahim Mohammadzadeh, Mohammad Amin Habibi, Arman Hasanzade, Ehsan Bahrami Hezaveh, Fatemeh Ghorbanpouryami, Azin Ebrahimi","doi":"10.1007/s13760-025-02805-z","DOIUrl":"https://doi.org/10.1007/s13760-025-02805-z","url":null,"abstract":"<p><strong>Background: </strong>Managing petroclival meningiomas (PCMs) is challenging due to their deep-seated location and proximity to critical anatomical structures. Resection aimed at achieving gross total resection (GTR) has been the primary therapeutic approach for PCMs; however, GTR is associated with considerable complications. Stereotactic radiosurgery (SRS) has emerged as an effective and safe minimally invasive option for managing petroclival meningiomas. This study evaluated the role of primary or adjuvant SRS in the treatment of petroclival meningiomas.</p><p><strong>Methods: </strong>Following a comprehensive literature search, studies evaluating the role of primary or adjuvant SRS in petroclival meningiomas were included. The meta-analysis calculated the pooled estimates for local tumor control (LTC), progression-free survival (PFS), and adverse radiation effect (ARE).</p><p><strong>Results: </strong>A total of 10 studies involving 605 patients were included. The meta-analysis revealed a pooled LTC rate of 94% (95% CI: 88-98%), a 5-year PFS rate of 94% (95% CI: 81-100%), and a 10-year PFS rate of 87% (95% CI: 69-98%). The meta-analysis for the SRS indication demonstrated that both primary and adjuvant SRS were associated with substantial LTC rates, and the difference was not significant (Primary: 95% [95% CI: 83-100%] vs. Adjuvant: 92% [95% CI: 69-100%], P = 0.65). The meta-analysis for the ARE indicated a pooled rate of 5% (95% CI: 0-12%).</p><p><strong>Conclusion: </strong>Our findings suggest that primary and adjuvant SRS are associated with significant LTC and PFS rates, along with minimal complications. Primary SRS may be considered for individuals with small or asymptomatic lesions, while adjuvant SRS is advised for larger or recurrent lesions.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spastic paraplegia with short stature: Think of Troyer syndrome.","authors":"Aditya Nayan, Shivangi Mehta, Dheeraj Khurana, Sahil Mehta, Vivek Lal","doi":"10.1007/s13760-025-02810-2","DOIUrl":"https://doi.org/10.1007/s13760-025-02810-2","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pediatric chronic inflammatory demyelinating polyradiculoneuropathy associated with hypoglossal nerve involvement.","authors":"Nurşah Yeniay Süt, Miraç Yıldırım, Ömer Bektaş, Ayşe Tuğba Kartal, Serap Teber","doi":"10.1007/s13760-025-02798-9","DOIUrl":"https://doi.org/10.1007/s13760-025-02798-9","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of late-onset aura related to migraine: an overlooked phenomenon.","authors":"Arife Çimen Atalar, Emel Ur Özçelik, Ebru Nur Vanlı-Yavuz, Betül Baykan","doi":"10.1007/s13760-025-02799-8","DOIUrl":"https://doi.org/10.1007/s13760-025-02799-8","url":null,"abstract":"<p><p>The age of onset of migraine with aura (MwA), is frequently observed between the second and third decades. However, patients presenting with late-onset MwA (LOA) are not rare in clinical practice. This systematic review aimed to investigate the literature on the LOA after the age of 50 to shed light on this underexplored topic. A systematic literature search from PubMed and Cochrane databases was performed by using the search terms: \"migraine with aura and late onset or over 50 or after 50 or onset in elderly or delayed onset\" and \"late-life migraine accompaniments\" for articles published between July 1987 to October 2023. Out of the 660 papers that were scanned blindly, 8 eligible studies were finally evaluated in detail. A total of 394 patients with LOA were evaluated. Female/male ratio was 3/1. The mean age of onset was 56.25 ± 1.65 years. The most prominent type of aura was visual (93.6%) akin to the early age of onset (EAO) patients but the duration of auras was shorter (frequently ≤ 20 min). A substantial number of auras emerge solely (31.2%) and when aura was followed by a headache, non-migrainous headache features (50%) were more pronounced. The family history of headache (47.7%) was similar to the EOA. Secondary LOA-mimics were also reported but the neuroimaging data were very limited. In conclusion, the absence of an accompanying headache or the presence of non-migrainous headache characteristics are important in differential diagnosis of LOA. Future research is warranted to elucidate the underlying mechanisms.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adult onset refractory status epilepticus unraveling L2-Hydroxy glutaric aciduria: A novel clinico-genotypical presentation.","authors":"Shreyashi Jha, Santosh Kumar Pendyala, Consultant Neurologist, Mona Tiwari, Sumedha Singh","doi":"10.1007/s13760-025-02809-9","DOIUrl":"https://doi.org/10.1007/s13760-025-02809-9","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition from atypical dermatomal sensory loss to classical lateral medullary infarction: A case report.","authors":"Tsuyoshi Furuya, Takashi Matsushima, Sachiko Nakayama, Yasushi Shimo, Yoshiaki Furukawa","doi":"10.1007/s13760-025-02802-2","DOIUrl":"https://doi.org/10.1007/s13760-025-02802-2","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}