Acta neurologica Belgica最新文献

{"title":"Cerebellar transcranial magnetic stimulation in essential tremor: a systematic review and meta-analysis of safety and efficacy.","authors":"Abdallah Abbas, Mohamed Abouzid, Haneen Sabet, Ahmed Mansour, Abdelfattah Arafa, Ahmed Elshahat, Ahmed Mostafa Amin, Mahmoud Tarek Hefnawy, Mohamed El-Moslemani, Amna Hussein, Mostafa Hossam El Din Moawad, Shereen M Olama, Ahmed Badry Shehata, Mahmoud G A Saleh, Ahmad Farag Ibrahim El-Adawy, Ahmed M Raslan, Mostafa Meshref","doi":"10.1007/s13760-025-02740-z","DOIUrl":"https://doi.org/10.1007/s13760-025-02740-z","url":null,"abstract":"<p><strong>Background: </strong>Essential tremor (ET) is a common neurological disorder that significantly impacts daily activities. This meta-analysis aims to evaluate the safety and efficacy of cerebellar repetitive Transcranial Magnetic Stimulation (rTMS) and cerebellar Theta Burst Stimulation (TBS) in treating ET.</p><p><strong>Methods: </strong>We searched through June 14, 2024, four databases (Scopus, PubMed, Web of Science, and Cochrane CENTRAL) to identify clinical trials investigating cerebellar rTMS or TBS in ET patients. Eligibility criteria included clinical trials reporting on safety and efficacy outcomes. Six reviewers screened and extracted data independently, resolving conflicts through consensus. Risk of bias was assessed. Statistical analyses involved pooling continuous outcomes using the mean difference (MD) and 95% confidence intervals (CI) with RevMan 5.3.</p><p><strong>Results: </strong>Out of 201 screened studies, nine studies were included, with a total of 261 participants (149 received rTMS, 112 were in control groups). The meta-analysis revealed no statistically significant difference between rTMS and sham groups for Fahn-Tolosa-Marin (FTM) subscores A (MD: -3.03, 95% CI: [-7.66, 1.60], P = 0.20), B (MD: -2.74, 95% CI: [-8.09, 2.61], P = 0.32), C (MD: -1.57, 95% CI: [-5.12, 1.97], P = 0.38), and FTM-Total (MD: -8.12, 95% CI: [-20.47, 4.23], P = 0.20). Sensitivity analysis confirmed these results. Adverse events were minimal: headaches (1/44 rTMS, 2/19 sham), dizziness (1/44 rTMS, 0/19 sham), and no reported seizures or syncope.</p><p><strong>Conclusion: </strong>While individual studies noted significant FTM score improvements post-rTMS treatment, the pooled analysis found no significant differences versus sham. Further research with standardized protocols and larger samples is required to optimize rTMS use for ET.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral carotid-cavernous fistulas following trauma: A rare case of diagnostic and management challenges.","authors":"Allahdad Khan, Nehan Zahoor, Humaira Siddique, Javed Iqbal","doi":"10.1007/s13760-025-02756-5","DOIUrl":"https://doi.org/10.1007/s13760-025-02756-5","url":null,"abstract":"<p><p>A 23-year-old male presented with a 6-month history of left eyelid swelling and a 2-week history of headaches following a road traffic accident. Examination revealed left eye proptosis (23 mm vs. 19 mm on the right, normal 16 mm), limited abduction of the right eye, incomplete closure of the right upper eyelid, and right facial nerve weakness. No relative afferent pupillary defect (RAPD) was noted. Musculoskeletal ultrasound of the left eyelid identified an elongated subcutaneous cystic lesion with intense vascularity, indicative of a vascular lesion. CT of the facial bones with 3D reconstruction revealed bilateral proptosis, dilated superior ophthalmic veins, and enlarged cavernous sinuses, consistent with bilateral carotid-cavernous fistulas (CCFs). Otomastoiditis with facial nerve canal dehiscence was also noted, suggesting facial nerve involvement. MRI brain and orbit with gadolinium contrast demonstrated multiple dilated tortuous vascular structures communicating with the cavernous sinuses, dilated bilateral superior ophthalmic veins (left > right), and left eye proptosis, consistent with high-flow fistulas. High-flow characteristics were supported by early arterial filling of the cavernous sinuses, retrograde venous drainage, and superior ophthalmic vein dilation on MR angiogram. Bilateral CCFs are rare, typically resulting from trauma, and often present with proptosis, cranial nerve deficits, and orbital symptoms. Fundus examination revealed engorged retinal veins and mild optic disc swelling in the left eye, consistent with venous stasis. Endovascular surgery is the gold standard for treatment; however, this patient was managed symptomatically with analgesics due to financial constraints. This case demonstrates the importance of imaging in diagnosis and highlights the challenges of managing CCFs in resource-limited settings.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143571631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aseptic meningitis with multiple cranial neuropathy: a rare complication of Infliximab therapy","authors":"Sarah Barthez,&nbsp;Thierry Duprez,&nbsp;Vincent Van Pesch,&nbsp;André Peeters","doi":"10.1007/s13760-025-02750-x","DOIUrl":"10.1007/s13760-025-02750-x","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 2","pages":"543 - 545"},"PeriodicalIF":2.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143565755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Expression of Concern to: The probable role of tissue plasminogen activator/neuroserpin axis in Alzheimer’s disease: a new perspective","authors":"Naif H. Ali,&nbsp;Hayder M. Al‑kuraishy,&nbsp;Ali I. Al‑Gareeb,&nbsp;Saud A. Alnaaim,&nbsp;Athanasios Alexiou,&nbsp;Marios Papadakis,&nbsp;Hebatallah M. Saad,&nbsp;Gaber El‑Saber Batiha","doi":"10.1007/s13760-025-02748-5","DOIUrl":"10.1007/s13760-025-02748-5","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 2","pages":"597 - 597"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hoffmann: the establishment of the first society for the French-speaking neurology residents in Belgium","authors":"Vincent Leclercq,&nbsp;Hessameldin Iranmanesh,&nbsp;Manon Dumoulin,&nbsp;Thomas Laurent,&nbsp;Florence Plumacker,&nbsp;Alissa Silva Gomes","doi":"10.1007/s13760-025-02735-w","DOIUrl":"10.1007/s13760-025-02735-w","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 2","pages":"281 - 282"},"PeriodicalIF":2.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the headache needs assessment (HANA) survey in tension type headache: Turkish version, reliability, and validity study.","authors":"Halime Arikan, Dilara Onan, Uğur Kulu","doi":"10.1007/s13760-025-02749-4","DOIUrl":"https://doi.org/10.1007/s13760-025-02749-4","url":null,"abstract":"<p><strong>Background: </strong>Scales and questionnaires measure various variables, such as health symptoms, functionality, and quality of life. The Headache Needs Assessment (HANA) survey evaluates the chronic impact of migraine on quality of life, focusing on frequency and bothersomeness.</p><p><strong>Objective: </strong>This study aimed to adapt and validate the Turkish version of the HANA, a concise and practical tool for assessing tension-type headache-related needs.</p><p><strong>Methods: </strong>A total of 86 individuals with tension-type headaches were included in the test phase, while 79 participants with tension-type headaches were involved in the retest phase. Exploratory and Confirmatory Factor Analyses (EFA and CFA) were used to assess structural validity. Reliability was evaluated using Intraclass Correlation Coefficients (ICC) and Cronbach's α, and convergent validity was tested by correlating HANA scores with the Henry Ford Hospital Headache Disability Inventory (HDI) and Headache Impact Test-6 (HIT-6).</p><p><strong>Results: </strong>Test-retest reliability was strong (ICC 0.789-0.840), and internal consistency was high (α = 0.882-0.913). Good correlations with HDI (r = 0.545; p = 0.000) and HIT-6 (r = 0.484; p = 0.000) supported convergent validity, while it was observed a low correlation with Visual Analog Scale (r = 0.342; p = 0.001). There were no floor or ceiling effects observed.</p><p><strong>Conclusion: </strong>The Turkish version of the HANA is a valid and reliable tool in individuals with tension-type headache that is easy to administer in both clinical and research contexts.</p><p><strong>Clinicaltrials: </strong></p><p><strong>Gov number: </strong>NCT06675292.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG abnormalities in a 3-year-old child with developmental delay and autistic-like behavior: a case of Phelan-McDermid syndrome","authors":"Massimiliano Raso,&nbsp;Miriana Guarino,&nbsp;Francesco Chiarelli,&nbsp;Sara Matricardi,&nbsp;Giovanni Prezioso","doi":"10.1007/s13760-025-02725-y","DOIUrl":"10.1007/s13760-025-02725-y","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 2","pages":"571 - 575"},"PeriodicalIF":2.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MTH1 in the disorders of the central nervous system: scope beyond brain tumors and challenges.","authors":"Lekshmi Padmakumar, Ramshekhar N Menon, Srinivas Gopala, George C Vilanilam","doi":"10.1007/s13760-025-02747-6","DOIUrl":"https://doi.org/10.1007/s13760-025-02747-6","url":null,"abstract":"<p><p>Human MutT homolog 1 (MTH1) plays a crucial role in sanitizing oxidized DNA precursors by enzymatically hydrolyzing oxidized nucleotides. The absence of MTH1 activity in the cells results in the accumulation of oxidized nucleotides within the nucleus and mitochondria, leading to mutations, abnormal proteins, and neurodegeneration (in the central nervous system). It has garnered interest as a potential target for anticancer treatment through targeted inhibitor molecules but remains largely understudied in other neurological disorders. This review explores the understanding of MTH1 expression in glioma and its potential role in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease concerning disease mechanism and prognosis. Neurodegeneration, activation of glial cells, and mitochondrial dysfunction are common mechanisms involved in the progression of these diseases. This review also tries to identify the unexplored associations and research gaps that can reveal novel applications of the enzyme in epilepsy, in which MTH1 is studied less. The influence of the ROS environment and cell type on MTH1 expression and function is crucial to be studied for elucidating its role in a multitude of CNS pathologies. The involvement of microglial cell-mediated inflammatory responses through ROS production in epileptogenesis in mouse models highlights the interplay between oxidative stress and neuroinflammation in epilepsy. The possible existence of a similar association between MTH1 expression and pathogenesis of the discussed neurological disorders in vivo demands further exploration preclinically and in patient samples.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-AMPA receptor encephalitis combined with myasthenia gravis: a case report","authors":"Jiawei Huang,&nbsp;Jie Gao,&nbsp;Lei Xia,&nbsp;Di Wu,&nbsp;Minmin Ma","doi":"10.1007/s13760-025-02743-w","DOIUrl":"10.1007/s13760-025-02743-w","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 2","pages":"569 - 570"},"PeriodicalIF":2.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A post-operative duro-pleural fistula rapidly confirmed by an innovative use of the P-Tau181 protein","authors":"Crabbé Florence,&nbsp;Noël Julie,&nbsp;Carestia Luciano,&nbsp;Bayart Jean-Louis","doi":"10.1007/s13760-025-02738-7","DOIUrl":"10.1007/s13760-025-02738-7","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 2","pages":"565 - 567"},"PeriodicalIF":2.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}