Acta neurologica Belgica最新文献

{"title":"Subcortical shape alterations in spinocerebellar ataxia type 2: a longitudinal MRI-based analysis.","authors":"Hatice Tataroğlu, İrem Ceren Koç, Lütfi İncesu","doi":"10.1007/s13760-026-03131-8","DOIUrl":"https://doi.org/10.1007/s13760-026-03131-8","url":null,"abstract":"<p><strong>Background and purpose: </strong>Spinocerebellar ataxia type 2 (SCA2) is a progressive autosomal dominant neurodegenerative disorder characterized by cerebellar and extracerebellar involvement. Although volumetric MRI studies have demonstrated cerebellar and supratentorial gray matter changes, region-specific shape alterations of subcortical structures remain insufficiently characterized. This study aimed to investigate cross-sectional and longitudinal subcortical gray matter shape changes in genetically confirmed SCA2 using a vertex-based morphometric approach.</p><p><strong>Methods: </strong>Structural T1-weighted MRI data from nine patients with genetically confirmed SCA2 and sixteen age- and sex-matched healthy controls were obtained from the publicly available OpenNeuro repository. All participants underwent baseline imaging and follow-up scans after a mean interval of approximately 3.5 years. Subcortical structures were segmented using the FSL-FIRST framework. Vertex-wise shape analyses were performed using permutation-based statistics adjusted for age, sex, and total brain volume. eTIV-normalized subcortical volumetric analyses were also performed to assess cross-sectional and longitudinal volume differences between groups.</p><p><strong>Results: </strong>Compared with healthy controls, patients with SCA2 demonstrated localized outward shape deformations in the right hippocampus, left caudate nucleus, and left putamen (p < 0.05, FWE-corrected). Longitudinal analyses revealed more pronounced deformation patterns involving the left caudate nucleus, left pallidum, and left putamen in the SCA2 group compared with temporal changes observed in controls (p < 0.05, FWE-corrected). eTIV-normalized volumetric analyses demonstrated significantly reduced brainstem and bilateral thalamic volumes in patients with SCA2 at both baseline and follow-up assessments. In longitudinal analyses, significantly greater volume loss was observed in the left pallidum and bilateral hippocampi in the SCA2 group.</p><p><strong>Conclusions: </strong>Vertex-based shape analysis demonstrated progressive and region-specific subcortical abnormalities in SCA2 and revealed morphological alterations that were only partially captured by conventional volumetric measurements. The partial concordance between shape-based and volumetric findings, particularly in the left pallidum, supports the biological relevance of the observed structural changes. Together, shape and volumetric analyses provide complementary information and may improve the characterization of subcortical involvement and longitudinal disease-related changes in SCA2.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148443648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Repetitive transcranial magnetic stimulation-induced severe hypotension in a patient with Parkinson's disease: a case report.","authors":"Bora Yoon, In-Uk Song","doi":"10.1007/s13760-026-03137-2","DOIUrl":"https://doi.org/10.1007/s13760-026-03137-2","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Intraoperative tract mapping through the biopsy cannula during stereotactic biopsy of brainstem lesions: a prospective feasibility study\".","authors":"Chul Bum Cho","doi":"10.1007/s13760-026-03139-0","DOIUrl":"https://doi.org/10.1007/s13760-026-03139-0","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral neuropathy as a presenting feature of familial early onset Alzheimer's disease: a rare clinical association.","authors":"Chinmayi Chandrakant Seemikeri, Pooja Mailankody, R T Rajeswarie, Bhavana Chanda, Rohan R Mahale, Hansashree Padmanabha","doi":"10.1007/s13760-026-03142-5","DOIUrl":"https://doi.org/10.1007/s13760-026-03142-5","url":null,"abstract":"<p><p>We describe a patient with genetically confirmed familial early-onset Alzheimer's disease in whom sensory peripheral neuropathy preceded cognitive decline by almost a decade. A 40- year- old man presented with clinical and electrophysiological features of sensory neuropathy, and 9 years later developed memory disturbances. Genetic testing revealed a heterozygous PSEN1 c.349 C > T (p. Pro117Ser) mutation in exon 5. To the best of our knowledge, peripheral neuropathy as an initial manifestation of familial early-onset Alzheimer's disease has never been reported before and could be a possible manifestation of the underlying degenerative process. With this report, we highlight the rarity of this association and underscore the importance of a comprehensive clinical and electrophysiological evaluation in patients with familial early-onset Alzheimer's disease who present with sensory symptoms, gait disturbances, skin or trophic changes, or other clinical features suggestive of peripheral neuropathy.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute vestibular syndrome mimicking posterior circulation stroke after intralesional triamcinolone injection for earlobe keloid: a case report.","authors":"Alice Briozzo, Isabelle Mosnier, Mustapha Smail, Quentin Legois, Mikhael Makhoul","doi":"10.1007/s13760-026-03141-6","DOIUrl":"https://doi.org/10.1007/s13760-026-03141-6","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term recovery following delayed diagnosis of anti-NMDAR encephalitis presenting as catatonia due to a general medical condition (CDGMC).","authors":"Marion Thomas, Alexandre Niset, Susana Ferrao Santos","doi":"10.1007/s13760-026-03135-4","DOIUrl":"https://doi.org/10.1007/s13760-026-03135-4","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic index of plasma and high-sensitivity C-reactive protein: combined effects on stroke risk in a middle-aged and elderly non-diabetic cohort.","authors":"Xiaotong Yao, Liting Liang, Jia Chen, Manting Yang, Yanling Liang, Xiaobo Fang","doi":"10.1007/s13760-026-03134-5","DOIUrl":"https://doi.org/10.1007/s13760-026-03134-5","url":null,"abstract":"<p><strong>Background and aims: </strong>The predictive value of the atherogenic index of plasma (AIP) and high-sensitivity C-reactive protein (hsCRP) for stroke is established; however, evidence is largely derived from diabetic cohorts, limiting the generalizability of findings to non-diabetic populations. We therefore conducted this study to specifically assess their combined and interactive associations with stroke in individuals without diabetes.</p><p><strong>Methods: </strong>This study included 8,721 participants from the CHARLS baseline (wave1) with no history of stroke or diabetes at baseline. The AIP was calculated as lg[Triglycerides (mmol/L)/HDL-C(mmol/L)]. In a subset of 5,763 participants with repeated measurements, we further analyzed the associations of CumAIP and CumhsCRP with incident stroke.</p><p><strong>Results: </strong>The results showed that compared to individuals with both low AIP and low hsCRP, those with elevated levels of both had the highest overall risk of stroke (adjusted Hazard Ratio [aHR]: 1.715; 95% Confidence Interval (CI): 1.380-2.130). Compared with the traditional risk factor model, the model adding AIP and hsCRP improved the AUC from 0.664 to 0.673 (P < 0.05), with a continuous Net Reclassification Improvement (NRI) of 0.182 (95% CI: 0.075-0.289) and Integrated Discrimination Improvement (IDI) of 0.009 (95% CI: 0.003-0.015).A total of 435 stroke events were observed during the 5-year follow-up subanalysis, individuals with high levels of both cumulative exposures also had a significantly increased risk (aHR: 1.421; 95% CI: 1.133-1.783).Furthermore, using repeated measurements, mediation analyses demonstrated no statistically significant mediating effect of hsCRP in the association between AIP and stroke. In contrast, AIP exerted a significant mediating effect, accounting for 11.6% of the total effect of hsCRP on stroke.</p><p><strong>Conclusions: </strong>The study findings confirm that AIP and hsCRP exert combined effects on stroke risk among non-diabetic middle-aged and older adults. Notably, AIP plays a significant mediating role in the association between elevated hsCRP and stroke. Therefore, integrating both markers into risk assessment is recommended to refine primary stroke prevention and address residual risk among non-diabetic populations, particularly middle-aged adults.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148417880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship trust in individuals with multiple sclerosis: a network analysis approach.","authors":"Cristiana Văcăraș, Larisa Cristina Ioana Tînc, Veronica Văcăraș, Răzvan Predatu, Cătălina Crișan, Dafin F Mureșanu, Vitalie Văcăraș","doi":"10.1007/s13760-026-03130-9","DOIUrl":"https://doi.org/10.1007/s13760-026-03130-9","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to assess the pattern of mutual relations within the Relationship Trust Scale (RTS) in a sample of individuals diagnosed with multiple sclerosis.</p><p><strong>Methods: </strong>The participants comprised 189 individuals diagnosed with multiple sclerosis (M_age = 43.39 years; 123 females, 61 males, 5 missing). Analyses were conducted using RStudio and JASP.</p><p><strong>Results: </strong>The results indicated that, in terms of strength, the Cares node (Item: \"My partner cares about my worries, feelings, joys, and troubles\") had the highest strength in the network. Furthermore, regarding expected influence, the analysis revealed that the Cares node had the highest expected influence in the network, followed by the Availability node (Item: \"Whenever I am upset my partner is always available, supportive, and I feel like he/she's there for me\"), and Consideration in Decisions node (Item: \"My partner takes me into account when making a decision.\"). Also, the Cares node had the strongest associations with Consideration in Decisions, Safety, and Respect nodes. Network stability analyses indicated that interpretations should be focused primarily on expected influence (CS-coefficient = 0.286), which exceeded the minimum recommended threshold (Epskamp et al., 2018), while other centrality indices showed lower stability. Betweenness and closeness centrality were not interpreted, as these measures may be conceptually unsuitable for psychological networks (Bringmann et al., 2019). All findings should be considered exploratory and preliminary.</p><p><strong>Conclusion: </strong>These exploratory findings appear to highlight potentially relevant relationship processes among individuals diagnosed with multiple sclerosis that may be targeted to improve the overall quality of their relationships.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148403437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Humans vs. large language models in neurology board examination: performance, limitations, and reference reliability\".","authors":"S Purna Chandra Shekhar, Siva Bali Reddy Katasani, Aanchal Mal","doi":"10.1007/s13760-026-03133-6","DOIUrl":"https://doi.org/10.1007/s13760-026-03133-6","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148395506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of severe hypertension following unilateral iatrogenic glossopharyngeal nerve injury during tonsillectomy.","authors":"Erdinç Tunç, Ahmet Köder, İrem Hengirmen Acu, Engin Çalgüner, Hatice Aygun","doi":"10.1007/s13760-026-03136-3","DOIUrl":"https://doi.org/10.1007/s13760-026-03136-3","url":null,"abstract":"<p><p>Iatrogenic injuries of the nervus glossopharyngeus are usually seen during procedures such as tonsillectomy, adenectomy, carotid endarterectomy, and endotracheal intubation due to its close anatomical neighborhood. Damage to the nervus glossopharyngeus is characterized by specific and nonspecific symptoms such as sensory deficits, especially in the posterior 1/3 of the tongue and soft palate, sore throat, swallowing disorder, and decreased parotid gland secretion. The glossopharyngeal nerve has a close anatomical relationship with the palatine tonsil and is at risk during tonsillectomy. Thus, otolaryngologists are advised to perform tonsillectomy with minimal damage to the tonsil bed to minimize the risk of nerve injury. In our literature review, we found one case of hypertension due to bilateral glossopharyngeal nerve injury caused by tonsillectomy but no case of hypertension due to unilateral iatrogenic glossopharyngeal nerve injury. We report a case of hypertension due to unilateral iatrogenic glossopharyngeal nerve injury after tonsillectomy, which has never been encountered before.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148389671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}