{"title":"Understanding stigma in multiple sclerosis: workplace discrimination, social challenges and psychological impacts.","authors":"Nazlı Gamze Bülbül, Abdulkadir Tunç, Sena Destan Bünül, Serkan Demir, Meral Seferoğlu, Ali Özhan Sıvacı, Selma Aksoy, İpek Güngör Doğan, Ülgen Yalaz Tekan, Nefise Eda Arslanoğlu, Samet Öncel, Rıfat Erdem Toğrol, Hüsnü Efendi","doi":"10.1007/s13760-025-02826-8","DOIUrl":"https://doi.org/10.1007/s13760-025-02826-8","url":null,"abstract":"<p><strong>Background: </strong>Stigmatization in MS patients is an important problem that affects social interaction, work life and daily life. In this study, we investigated the prevalence, severity and especially the effects of stigmatization on work life in MS patients.</p><p><strong>Methods: </strong>A cross-sectional study of 420 people living with MS (PwMS) assessed stigma using the NeuroQoL Stigma Short Form and a direct stigma survey. Demographic, clinical, workplace, and social data were collected through an online survey. Statistical analyses were performed.</p><p><strong>Results: </strong>Stigma was prevalent, with 77% reporting stigma in direct surveys and 67.6% scoring > 8 on the NeuroQoL Stigma Short Form. Stigma was more severe in patients with progressive MS and higher EDSS scores. The most disturbing symptoms were fatigue (73.3%), imbalance (46.7%) and attention deficit 50.5%). The most prominent complaint affecting work life was fatigue (41.2%). Only 7.3% of the patients had sought psychological support for this issue. 57.4% of patients had disclosed their illness to their employer and 68.1% to their coworkers.</p><p><strong>Conclusions: </strong>Stigma in MS is pervasive, linked to clinical severity, workplace challenges, and social withdrawal. Interventions targeting stigma's psychological and social dimensions, along with workplace education and support are essential.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vasiliki Zouvelou, Dimitra Tzavella, Thomas Zambelis
{"title":"Eyelid twitching in MuSK-myasthenia gravis.","authors":"Vasiliki Zouvelou, Dimitra Tzavella, Thomas Zambelis","doi":"10.1007/s13760-025-02811-1","DOIUrl":"https://doi.org/10.1007/s13760-025-02811-1","url":null,"abstract":"<p><p>A 22-year-old female suffering from MuSK-myasthenia gravis presented with fatigable eyelid ptosis, fluctuated bulbar symptoms and bilateral eyelid twichings which were greatly reinforced after tight closure of eyes and contraction of orbicularis oculi muscles. The patient never received acetylcholinesterase inhibitor treatment. Persistent twichings, irrespectively of clinical status, were signs of cholinergic hyperactivity. MuSK antibodies disrupt MuSK-collagen Q interaction with resultant deficient binding of acetylcholinesterase at synaptic cleft and impaired breakdown of acetylcholine. In myasthenia gravis, clinical signs of cholinergic hyperactivity may point to seropositivity of MuSK antibodies with therapeutic implications in clinical practice.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adult-onset opsoclonus-myoclonus-ataxia syndrome accompanying an infection with tick-borne encephalitis virus: A case report.","authors":"Tin Nožić Škerjanec, Rok Berlot","doi":"10.1007/s13760-025-02820-0","DOIUrl":"https://doi.org/10.1007/s13760-025-02820-0","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Carolina Restrepo-Carvajal, Isabel Martínez-Fernández, Tomás Segura, María Monteagudo, Alvaro Sanchez-Larsen
{"title":"Auditory Charles Bonnet syndrome: description of two cases and literature review.","authors":"Laura Carolina Restrepo-Carvajal, Isabel Martínez-Fernández, Tomás Segura, María Monteagudo, Alvaro Sanchez-Larsen","doi":"10.1007/s13760-025-02824-w","DOIUrl":"https://doi.org/10.1007/s13760-025-02824-w","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Linear high signal of brain CT in a patient with leukemic encephalopathy.","authors":"Shulai Zhu, Xinxin Pan, Yonghong Wang","doi":"10.1007/s13760-025-02825-9","DOIUrl":"https://doi.org/10.1007/s13760-025-02825-9","url":null,"abstract":"<p><p>Leukemic encephalopathy is a syndrome characterized by neurological and psychiatric abnormalities caused by meningeal and brain tissue lesions resulting from leukemia and its complications. The incidence of leukemic encephalopathy is relatively low, but it may increase in certain types of leukemia, such as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The specific incidence varies among reports and studies, with some indicating an occurrence rate of about 5%, while domestic reports suggest that the incidence of leukemic encephalopathy in acute myeloid leukemia is generally less than 3%. In the chronic phase of chronic myeloid leukemia, leukemic encephalopathy is occasionally observed, but during the acute phase, especially during acute lymphoblastic leukemia, the likelihood of developing leukemic encephalopathy increases. There are few reports regarding its occurrence during acute transformation. Here, we present a case of acute transformation of chronic myeloid leukemia accompanied by leukemic encephalopathy treated at our hospital, aiming to enhance clinical understanding of leukemic encephalopathy.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lise Janssens, Sophie Broux, Annelies Terwecoren, Sofie De Blauwe, Johan Ghekiere
{"title":"Successful transcirculation thrombectomy through the posterior communicating artery for acute MCA occlusion: a case report","authors":"Lise Janssens, Sophie Broux, Annelies Terwecoren, Sofie De Blauwe, Johan Ghekiere","doi":"10.1007/s13760-025-02806-y","DOIUrl":"10.1007/s13760-025-02806-y","url":null,"abstract":"<div><p>In a transcirculation thrombectomy, the communicating arteries are used to access the anterior circulation via the posterior circulation, or vice versa. This approach can be used in patients where traditional anterograde endovascular approaches are challenging due to complex vascular anatomy or chronic lesions involving extracranial and intracranial vessels. Up until now only a few articles addressed this approach. Here, we present a case of a 68-year-old woman who presented with a sudden-onset left-sided weakness. CT angiography showed an occlusion of the common carotid artery (CCA) on the right side and an ipsilateral occlusion in the M1 segment of the middle cerebral artery (MCA). A transcirculation approach was used to perform a successful embolectomy for the right MCA occlusion through the patent posterior communicating artery (Pcomm). At discharge, the patient had mild deficits and fully recovered at 1-month follow-up. Our case highlights the effectiveness and safety of this technique, despite potential complications like prolonged procedure time. Further research is needed to optimize patient selection and technique.</p></div>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 4","pages":"1117 - 1120"},"PeriodicalIF":2.1,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}