Acta neurologica Belgica最新文献

{"title":"Migraine treatment with CGRP monoclonal antibodies: patient evaluation of a mandatory treatment holiday in Belgium.","authors":"Ruben De Praeter, Evelien Tuerlinckx, Jean Schoenen, Elizabet Boon, Simona Liliana Sava, Frederik Debruyne, Koen Delmotte, Adinda De Pauw, Annelies Van Dycke, Cindy Van Humbeeck, Jan Versijpt","doi":"10.1007/s13760-025-02782-3","DOIUrl":"https://doi.org/10.1007/s13760-025-02782-3","url":null,"abstract":"<p><strong>Background: </strong>Monoclonal antibodies targeting the calcitonin gene-related peptide (CGRP) pathway have emerged as a promising preventive treatment for migraine. In Belgium, patients receiving these antibodies must adhere to a mandatory treatment holiday of three months. This study investigated the patients' experiences during this treatment holiday.</p><p><strong>Methods: </strong>A prospective study was conducted among 243 patients from nine headache clinics in Belgium receiving treatment with erenumab, fremanezumab or galcanezumab. Participants completed a structured questionnaire during their yearly follow-up visit after the treatment holiday. The questionnaire assessed the subjective migraine evolution and anxiety levels, and perceived usefulness of the treatment holiday.</p><p><strong>Results: </strong>The majority of patients (86.0%) reported worsening of migraine symptoms during the treatment holiday, 59.4% of them experiencing deterioration already within the first month. For 5.9% of patients, this occurred beyond the 3-month mandatory holiday period, delaying treatment resumption. Improvement was reported by 3.0% of patients, while 11.0% experienced no change. Anxiety surrounding the treatment holiday was reported by 45.0% of participants, with 18.6% experiencing very high levels of anxiety. A significant association was found between anxiety and subjective migraine deterioration (p = 0.012). Nearly half (49.1%) of the respondents found the drug holiday overall useful in gaining insight into the need for continued treatment, 22.6% considered it even very useful.</p><p><strong>Conclusion: </strong>A rigid, mandatory treatment holiday of two to three months poses significant challenges for a substantial subset of patients, leading to rapid migraine deterioration and increased anxiety. The observed association between migraine deterioration and anxiety highlights the need for patient education strategies. Policy makers should consider these findings to develop more flexible, patient-centered treatment approaches that optimize outcomes.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acta neurologica belgica regarding the manuscript entitled 'Safety and efficacy of extended versus standard interval dosing of natalizumab in multiple sclerosis patients: a systematic review and meta-analysis'.","authors":"Mike Boggild, Zinat Mohammadpour, Liza van Eijk, Lachlan Williams","doi":"10.1007/s13760-025-02781-4","DOIUrl":"https://doi.org/10.1007/s13760-025-02781-4","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental smoking before childbirth and multiple sclerosis onset in their child: a case-control study.","authors":"Sanaz Khodadadi, Sahar Nikkhah Bahrami, Shima Jahani, Nasim Rezaeimanesh, Zahra Ebadi, Khadijeh Haji Naghi Tehrani, Abdorreza Naser Moghadasi, Mohammad Ali Sahraian","doi":"10.1007/s13760-025-02777-0","DOIUrl":"https://doi.org/10.1007/s13760-025-02777-0","url":null,"abstract":"<p><strong>Background: </strong>Multiple sclerosis (MS) pathogenesis involves both environmental and genetic factors. Any stage of life, including the prenatal and perinatal years, may be impacted by environmental factors linked to the onset and progression of MS. It is essential to assess these environmental elements in order to avoid the start of illness. However, there is a lack of research on the effects of parental smoking before childbirth.</p><p><strong>Objective: </strong>This study aimed to investigate the association between MS and parental cigarette consumption before childbirth.</p><p><strong>Design and methods: </strong>We conducted a case-control study at Sina Hospital, Tehran, Iran, from June 2023 to June 2024. MS diagnosis was confirmed using 2017 revised McDonald's criteria. Experts created a questionnaire to gather information on parental smoking habits, sex, and age. Patients with incomplete questionnaires or parents with MS were not included in the analysis. The control group comprised patients' companions at the Surgical Ward of Sina Hospital. Binary logistic regression was used to estimate the adjusted odds ratios (AOR) and 95% confidence intervals (CI) for MS onset due to paternal and maternal cigarette smoking, adjusting for potential confounders.</p><p><strong>Results: </strong>A total of 379 MS patients and 379 controls were included in the study. The mean age of the MS patients was 37.97 ± 9.09 years, while the control group had a mean age of 36.13 ± 12.93 years. Our findings indicated that paternal daily cigarette consumption before pregnancy, adjusted for age and sex, increased the risk of MS onset in offspring by 65% (AOR = 1.65, 95% CI: 1.17-2.31, p < 0.004). Furthermore, paternal daily cigarette consumption during maternal pregnancy increased the risk by 71% (AOR = 1.71, 95% CI: 1.21-2.42, p < 0.002). However, no significant association was found between maternal cigarette smoking, either before or during pregnancy, and the onset of MS in offspring.</p><p><strong>Conclusions: </strong>Paternal cigarette smoking, before and during pregnancy, significantly increased the risk of MS in offspring. These findings highlight the need for further investigation and public awareness, as paternal smoking may represent a preventable risk factor for MS development.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between migraine and gut microbiota: a systematic review.","authors":"Alon Gorenshtein, Kamel Shihada, Liron Leibovitch, Tom Liba, Avner Goren","doi":"10.1007/s13760-025-02779-y","DOIUrl":"https://doi.org/10.1007/s13760-025-02779-y","url":null,"abstract":"<p><strong>Introduction: </strong>Recent studies suggest a link between gut microbiota and neurological diseases, implicating the microbiome's role in neurological health. However, the specific alterations in the microbiome associated with migraine remain underexplored. This study aims to systematically review the existing literature to determine whether migraine patients are associated with changes in gut microbiota composition.</p><p><strong>Methods: </strong>A systematic review was conducted in accordance with the PRISMA statement. We included original empirical studies investigating the microbiome in migraine patients. Data extracted included study design, participant demographics, microbiome differences at various taxonomic levels, and measures of microbial diversity (alpha and beta diversity). The search and selection process involved four independent reviewers who assessed abstracts and full texts to ensure eligibility. The gut microbiota was evaluated using relative abundance and diversity indices.</p><p><strong>Results: </strong>Six studies, encompassing various regions including China, Korea, and Italy, were included in the analysis. The results indicated significant differences in gut microbiota between migraine patients and controls. Key findings include a reduction in Faecalibacterium, a genus known for its anti-inflammatory properties, in migraine patients, including those with chronic migraine. Conversely, Veillonella exhibited elevated abundance compared to controls. Other taxa, such as Prevotella and Parabacteroides, showed variable associations with migraine across different studies, suggesting a dysbiotic gut environment in migraine patients.</p><p><strong>Conclusion: </strong>This review highlights that migraines are associated with specific alterations in gut microbiota, including decreased microbial diversity and changes in the abundance of key taxa. These findings suggest that gut microbiota dysbiosis may play a role in migraine pathophysiology. Further research is needed to explore the potential causal relationships and therapeutic implications, particularly targeting the microbiome in migraine management.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial transthecal fat migration after spontaneous rupture of a lumbar dermoid cyst.","authors":"Benjamin Hebant, Sophie Le Couteulx, Linda Zourdani, Laurine Wucher","doi":"10.1007/s13760-025-02780-5","DOIUrl":"https://doi.org/10.1007/s13760-025-02780-5","url":null,"abstract":"<p><p>We report here a very rare case of a 54-year-old patient admitted for acute headache, vertigo and dizziness, 48 h after a sudden episode of transient low back pain. Noncontrast CT scan of the head and brain MRI showed several fat droplets with a distribution in the subarachnoid spaces, the lateral ventricles and basal cisterns. Because no underlying intracranial fat-containing lesion was found on brain MRI, a lumbosacral spine MRI scan was performed and showed an intrathecal multilobulated lesion within the spinal canal at the L4 level highly suggestive of a partial rupture of a dermoid cyst with communication into the adjacent CSF space, explaining the transthecal fat migration. Resection of the cyst was recommended to prevent further cranial fat embolism. However, she decided not to undergo surgery. At her 3-months follow-up visit, she was still asymptomatic. The detection of intracranial fat droplets should initiate prompt investigations to discover the source of the emboli to prevent potential complications.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porphyria presenting as posterior reversible encephalopathy syndrome.","authors":"Ashwin Kumar Panda, Pratik Pravin Babel, Himanshu Shakya, Suman Kumar Sahu, Aldrin Anthony","doi":"10.1007/s13760-025-02773-4","DOIUrl":"https://doi.org/10.1007/s13760-025-02773-4","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A diagnostic challenge of myasthenia in elderly with significant cardiovascular risk factors","authors":"Umang Thakrar,&nbsp;Yousif Elzein,&nbsp;Ei Zune The","doi":"10.1007/s13760-025-02774-3","DOIUrl":"10.1007/s13760-025-02774-3","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 2","pages":"583 - 584"},"PeriodicalIF":2.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delayed onset muscle soreness in neurological rehabilitation: an overlooked challenge","authors":"Roberto Tedeschi","doi":"10.1007/s13760-025-02775-2","DOIUrl":"10.1007/s13760-025-02775-2","url":null,"abstract":"","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":"125 2","pages":"585 - 586"},"PeriodicalIF":2.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Missense genetic variant in IQCA1 gene in patients with meningioma.","authors":"Sepideh Jahangiri, Zahra Abdan, Mehdi Totonchi, Fariba Allahmoradi, Seyed Ahmad Mousavi, Mozaffar Aznab, Majid Kobraei, Kimiya Padidar","doi":"10.1007/s13760-025-02760-9","DOIUrl":"https://doi.org/10.1007/s13760-025-02760-9","url":null,"abstract":"<p><strong>Background: </strong>Meningioma, a tumor arising from the meninges of the central nervous system, is generally considered benign. Familial meningiomas are extremely rare, and the genetic basis of this condition remains largely elusive, especially in under-represented populations. This study investigates a family from Kashan, Isfahan province, Iran-an under-explored region in genetic research-with the goal of identifying novel germline variants contributing to meningioma development.</p><p><strong>Methods: </strong>Whole Exome Sequencing (WES) was performed on a family with multiple meningioma cases (n = 3). Bioinformatic analyses identified candidate variants, which were further validated in additional family members and a cohort of 23 idiopathic, sporadic meningioma patients.</p><p><strong>Results: </strong>A novel heterozygous missense mutation in the IQCA1 gene (NM_001270584: c.C787T; p.R263W) was found to segregate with the disease, supporting an autosomal dominant inheritance pattern. In silico analysis suggests that this mutation may disrupt IQCA1's ATP hydrolysis activity, potentially contributing to tumorigenesis. This is the first report linking IQCA1 to familial meningioma, providing new insights into its pathogenesis.</p><p><strong>Conclusion: </strong>Our findings reveal a novel IQCA1 p.R263W mutation in a familial meningioma case, with implications for genetic counseling and surveillance in at-risk populations. This study highlights the importance of studying under-represented populations and contributes new insights into meningioma genetics and oncogenesis.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting multidisciplinary intervention goals for spinal muscular atrophy patients utilizing the international classification of functioning, disability, and health: a pilot study in a small sample sizes.","authors":"Gabriele Giannotta, Marta Ruggiero, Greta Pirani, Maria Carmela Oliva, Camilla Ferrante, Antonio Trabacca","doi":"10.1007/s13760-025-02771-6","DOIUrl":"https://doi.org/10.1007/s13760-025-02771-6","url":null,"abstract":"<p><strong>Background: </strong>Spinal Muscular Atrophy (SMA) is a genetic neuromuscular disorder causing progressive motor function loss, respiratory and swallowing impairments, and significant limitations in activities of daily living (ADLs) and social participation. While gene therapies have enhanced life expectancy, functional management remains crucial. Despite the International Classification of Functioning Disability and Health for Children and Youth (ICF-CY) being a valuable framework for patient-centered care, its integration in setting multidisciplinary rehabilitation goals for SMA patients is underexplored.</p><p><strong>Objective: </strong>This study aimed to assess the use of the ICF-CY framework in developing multidisciplinary intervention goals for SMA patients.</p><p><strong>Methods: </strong>A cross-sectional study involving 6 SMA patients was conducted at a pediatric neurorehabilitation hospital. Data were collected using a standardized ICF-CY-based case record form and analysed to identify patterns of impairment, activity limitations, and environmental factors.</p><p><strong>Results: </strong>Results demonstrated the multifaceted nature of SMA, with significant impairments in motor function, respiratory function, and swallowing, as well as limitations in activities of daily living and social participation. Environmental factors, particularly social support and accessibility, emerged as crucial determinants of overall well-being.</p><p><strong>Conclusions: </strong>The study underscores the importance of a multidisciplinary approach and the use of ICF-CY framework for developing comprehensive and patient-centered care plans for SMA patients.</p>","PeriodicalId":7042,"journal":{"name":"Acta neurologica Belgica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}